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Macrocyclic peptide construction th.ough.C-h.activation strategy

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Science Bulletin 2018年第19期63卷 1238-1240页

作者： Kai Ch.n bing-Feng Sh. Department of Ch.mistry Zhejiang University Division of Ch.mistry and Ch.mical Engineering California Institute of Technology

Peptides are biomolecules th.t commonly engage in biological activities of native bio-systems, and h.ve also been inspiringly investigated, synth.sized and utilized by h.man beings for clinical purposes. Th. function of a peptide is typically dependent on its amino acid sequence and th.ee-dimensional structure. Among all types of peptides, macrocyclic ones th.t confer well-defined con-

关键词：激活肽生物活动氨基酸

FLOW STRESS MODEL FOR h.RD MACh.NING OF AISI h.3 WORK TOOL STEEL

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Acta Metallurgica Sinica(English.Letters) 2005年第6期18卷 741-748页

作者： h. Yan J. h.a R. Sh.vpuri Sch.ol of Mech.nical-Electrical Engineering Nanchang University Nanchang 330029China Th. Oh.o State University Columbus OH 43210 USA

An approach.is presented to ch.racterize th. stress response of workpiece in h.rd mach.ning, accounted for th. effect of th. initial workpiece h.rdness, temperature, strain and strain rate on flow stress. AISI h.3 work tool steel was ch.sen to verify th.s meth.dology. Th. proposed flow stress model demonstrates a good agreement with.data collected from publish.d experiments. Th.refore, th. proposed model can be used to predict th. corresponding flow stress-strain response of AISI h.3 work tool steel with.variation of th. initial workpiece h.rdness in h.rd mach.ning.

关键词： flow stress model h.rd mach.ning AISI h.3 work tool steel

Dynamic stress concentration in an infinitely long cylindrical cavity due to a point sph.rical source embedded with.n a fluid-saturated poroelastic formation of infinite extent

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Applied Math.matics and Mech.nics(English.Edition) 2025年第1期46卷 139-156页

作者： h.h.SSEINI O.BALILASh.KI Department of Mech.nical Engineering Faculty of EngineeringGolestan University

Th. effects of a h.rmonically exciting monopole source on an infinitely long cylindrical cavity embedded entirely with.n a fluid-saturated poroelastic formation of infinite extent are examined th.oretically. It is assumed th.t th. source is located outside th. cavity at a specified distance from th. boreh.le axis. Th. magnitudes of th. h.op and radial stresses beside th. pore pressures exerted on th. interface and inside th. porous medium surrounding th. boreh.le are calculated and discussed. Biot's poroelastic modeling along with.th.ee types of boundary conditions for th. cylindrical interface including th. ideal fluid, empty boreh.le, and rigid inclusion with.a h.rd boundary is employed for th. analysis. Utilizing a proper translational addition th.orem for expressing th. incident sph.rical wave in terms of cylindrical wave expansions, th. proposed boundary conditions at th. interface are satisfied. Stresses are formulated by means of wave potential functions in a th.ee-dimensional(3D) manner. Th. effects of th. frequency and th. radial distance between th. source and boreh.le on th. induced stresses are examined for th. first cylindrical modes over frequency spectra. Two permeability conditions for th. interface and th.ee types of soils for th. porous formation are considered th.ough.ut th. analysis. To give an overall outline of th. study, a numerical example is presented. Th. results clearly indicate th.t th. distance is a key parameter and h.s considerable effects on th. induced stress values. In addition, th. interface permeability condition and soil ch.racteristics play an important role in determining th. dynamic response of th. boreh.le. Finally,th. obtained results are compared with.th. relevant analyses existing in th. literature for some limit cases, and good agreement is ach.eved.

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Neuroinflammation as a th.rapeutic target in h.ntington's disease

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Neural Regeneration Research 2025年第3期20卷 817-818页

作者： Andrea Kwakowsky Th.lani h.Palpagama Center for Brain Research.and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Ph.rmacology and Th.rapeutics School of MedicineGalway Neuroscience CentreUniversity of GalwayGalwayIreland

In 1872, George h.ntington presented h.s essay “On Ch.rea” to th. Meigs and Mason Academy of Medicine and, in doing so, detailed a disease th.t would later bear h.s name. h.ntington's disease(h.) is a genetic, neurodegenerative disease th.t manifests as th. loss of motor control,cognitive impairment,and mood and psych.atric ch.nges in paents.

关键词： h.ntington inflammation Medicine

Glial response in th. midcingulate cortex in h.ntington’s disease

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Neural Regeneration Research 2025年第1期20卷 207-208页

作者： Th.lani h.Palpagama Andrea Kwakowsky Center for Brain Research.and Department of Anatomy and Medical Imaging Faculty of Medical and Health SciencesUniversity of AucklandAucklandNew Zealand Ph.rmacology and Th.rapeutics School of MedicineGalway Neuroscience CenterUniversity of GalwayGalwayIreland

h.ntington’s disease(h.)is a genetic disease ch.racterized by th. progressive degeneration of th. striatum and *** can present with.a variety of symptoms th.t can broadly be classified into motor symptoms,inclusive of ch.reatic movements and rigidity,mood and psych.atric symptoms,such.as depression and apath.,and cognitive symptoms,such.as cognitive *** causal mutation underlying h. results from an expansion of a CAG repeat sequence on th. IT15 gene,resulting in th. formation and accumulation of a mutant h.ntingtin protein.

关键词： h.ntington degeneration cortex

h.droth.rmal Synth.sis and Ch.racterization of [V_(16)O_(38)(Cl)][Cu(enMe)_2]_(3.5)·2h.2O Containing {V_(16)O_(38)} Cluster

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Ch.mical Research.in Ch.nese Universities 2004年第3期20卷 266-269页

作者： CUIXiao-bing zhENGSh.u-tian SUNYan-qiong YANGGuo-yu Coordinationandh.droth.rmalCh.mistryGroup StateKeyLaboratoryofStructuralChemistryFujianInstituteofResearchontheStructureofMatterChineseAcademyofSciencesFuzhou350002P.R.China StateKeyLaboratoryofCoordinationCh.mistry NanjingUniversityNanjing210093P.R.China

Compound [V_ 16 O_ 38 (Cl)][Cu(enMe)_2]_ 3.5 ·2h.2O(1) h.s been h.droth.rmally synth.sized and ch.racterized by means of single-crystal X-ray diffraction,elemental analysis,IR,EPR and TGA analysis. Th. X-ray crystallograph. sh.ws th.t compound 1 contains a new {V_ 16 O_ 38 } cluster sh.ll,wh.ch.is connected by [Cu(enMe)_2] 2+ coordination fragments into a 3-D framework. Th. compound crystallized in a monoclinic system with.space group P2(1)/n,M =2235.82,a =1.26076(3) nm,b =2.55802(6) nm,c =2.14742(4) nm,β =90.7380(10)°, V =6.9250(3) nm 3,Z =4,F (000)=4418,D _c=2.145 g·cm -3 , μ =3.227 mm -1 ,( Δ/σ )=0.000,S =1.066.

关键词： h.droth.rmal synth.sis Polyoxovanadate Crystal structure Th.ee-dimensional structure Open-framework

h.droth.rmal Synth.sis and Ch.racterization of a Novel Two-dimensional Framework Materials Constructed from Polyoxometalate and Coordination Groups: [h.2Mo_(5.5)V_(10.5)O_(40)(PO_4)][Cu(en)_2]_4·7h.2O

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Ch.mical Research.in Ch.nese Universities 2004年第1期20卷 10-14页

A novel compound [h.2Mo_ 5.5V_ 10.5O_ 40(PO_4)][Cu(en)_2]_4·7h.2O(1) was synth.sized from V_2O_5, MoO_3, CuCl_2·2h.2O, en, h.3PO4 and h.2O in an aqueous solution via th. h.droth.rmal meth.d and ch.racterized by means of single-crystal X-ray diffraction, elemental analyses, IR, EPR spectra and th.rmal analyses. C_ 16h. 80Cu_4Mo_ 5.5N_ 16O_ 51PV_ 10.5 crystallized in a triclinic system, th. space group is P1 with.M=2660.63, a= 1.283590(10) nm, b=1.289910(10) nm, c=1.387870(10) nm, V=1.80942(2) nm 3, Z=2, D_x=4.883 g/cm 3, F(000)=2599, μ=6.956 mm -1, (Δ/σ)=0.000, S=1.089. Th. crystal structure was solved by th. direct meth.ds with.th. final R=0.0752 and wR=0.1988 for 6311 observed reflections with.I≥2σ(I). Th. X-ray crystallograph. reveals th.t compound 1 is a novel two-dimensional framework material constructed from th. mixed Mo/V polyoxometalate and coordination groups.

关键词： h.droth.rmal synth.sis Two-dimensional framework Mixed Mo/V tetra-capped pseudo-Keggin structure Polyoxometalate

Comment on 'Math.matical structure of th. th.ee-dimensional (3D) Ising model'

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Ch.nese Ph.sics B 2013年第8期22卷 356-360页

作者： Jacques h. h. Perk Department of Ph.sics Oklahoma State UniversityStillwater OK 74078-3072 USA

Th. review paper by zhang zhi-Dong （zhang Z D 2013 Ch.n. Ph.s. B 22 030513, arXiv：1305.2956） contains many errors and is based on several earlier works th.t are equally wrong.

关键词： Ising model Lie algebra series analysis th.rmodynamic limit

Numerical Solution of th. Asymmetric Water Impact of A Wedge in Th.ee Degrees of Freedom

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Ch.na Ocean Engineering 2013年第3期27卷 313-322页

作者： h. Gh.zizade-Ah.aee A. h. Nikseresh. Faculty of Mech.nical & Aerospace Engineering Shiraz University of Technology

Impact problems associated with.water entry h.ve important applications in various aspects of naval arch.tecture and ocean engineering. Estimation of h.drodynamic impact forces especially during th. first instances after th. impact is very important and is of interest. Since th. estimation of h.drodynamic impact load plays an important role in safe design and also in evaluation of structural weigh. and costs, it is better to use a reliable and accurate prediction meth.d instead of a simple estimation resulted by analyzing meth.ds. In landing of flying boats, some ph.nomena such.as weath.r conditions and strong winds can cause asymmetric instead of symmetric descent. In th.s paper, a numerical simulation of th. asymmetric impact of a wedge, as th. step of a flying boat, considering dynamic equations in two-ph.se flow is taken into account. Th. dynamic motion of th. wedge in two-ph.se flow is solved based on finite volume meth.d with.volume of fluid （VOF） sch.me considering dynamic equations. Th.n th. effects of different angles of impact and water depth.on th. velocity ch.nge and slamming forces in an asymmetric impact are investigated. Th. comparison between th. simulation results and experimental data verifies th. accuracy of th. meth.d applied in th. present study.

关键词： slamming force asymmetric impact dynamic mesh dynamic equations fluid dynamics