检索结果-南通市图书馆

Diagnosis,treatment and prevention of severe acute respiratory syndrome coronavirus 2 infection in children:experts'consensus statement updatedforthe Omicron variant

引用

World Journal of Pediatrics 2024年第3期20卷 272-286页

作者： Rong-Meng Jiang zh.ng-De Xie Yi Jiang Xiao-Xia Lu Run-Ming Jin Yue-Jie zh.ng Yun-Xiao Shang Bao-Ping Xu zhi-Sheng Liu Gen Lu Ji-Kui Deng Guang-Hua Liu Xiao-Chuan Wang Jian-She Wang Lu-zhao Feng Wei Liu Yi zh.ng Sai-Nan Shu Min Lu Wan-Jun Luo Miao Liu Yu-Xia Cui Le-Ping Ye A-Dong Shen Gang Liu Li-Wei Gao Li-Juan Xiong yan Bai Li-Kai Lin zhuang Wei Feng-Xia Xue Tian-You Wang Dong-Chi zhao Jian-Bo Shao Daniel Kwok-keung ng Gary Wing-kin Wong zh.ng-yan zhao Xing-Wang Li Yong-Hong yang Kun-Ling Shen Diagnosis and Treatment Center of Infectious Diseases Beijing Ditan HospitalCapital Medical UniversityBeijing 100015China Beijing Key Laboratory of Pediatric Respiratory Infection Diseases Key Laboratory of Major Diseases in ChildrenMinistry of EducationNational Clinical Research Center for Respiratory DiseasesResearch Unit of Critical Infection in ChildrenChinese Academy of Medical Sciences2019RU016Laboratory of Infection and VirologyBeijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijing 100045China Department of Pediatrics Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Respiratory Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Pediatrics Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430022China Department of Respiratory Shenzhen Children's HospitalShenzhen 518038China Department of Pediatric Respiratory Shengjing Hospital Affiliated to China Medical UniversityShenyang 110004China Department of Respiratory Beijing Children's HospitalCapital Medical UniversityNational Clinical Research Center for Respiratory DiseasesNational Center for Children's HealthBeijing 100045China Department of Neurology Wuhan Children's HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430016China Department of Respiratory Guangzhou Women and Children's Medical CenterGuangzhou 510623China Department of Infectious Diseases Shenzhen Children's HospitalShenzhen 518038China Department of Pediatrics Fujian Branch of Shanghai Children's Medical CenterFujian Children's HospitalFuzhou350005China Department of Clinical Immunology and Allergy Children's Hospital of Fudan UniversityNational Center for Children's HealthShanghai 201102China Department of Infectious Diseases Children's Hospital of Fudan UniversityNational Center for Children's Health.Shanghai

It has been more than 3 years since the novel coronavirus(SARS-CoV-2)pandemic raged *** coronavirus disease 2019(COVID-19)has greatly influenced human *** to data from the World Health Organization(WHO),there were ove... 详细信息

关键词： prevention infection statement

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

引用

World Journal of Gastrointestinal Oncology 2024年第9期16卷 3875-3886页

作者： Lu zh.ng yan-Ping Chen Min Ji Le-Qian Ying Chun-Chun Huang Jing-Yi zhou Lin Liu Department of Oncology Zhongda HospitalMedical School of Southeast UniversityNanjing 210009Jiangsu ProvinceChina

BACKGROUND Inflammation-related markers including neutrophil-to-lymphocyte ratio(NLR),platelet-to-lymphocyte ratio(PLR),monocyte-to-lymphocyte ratio(MLR),systemic immune-inflammation index(SII),systemic inflammation response index(SIRI)and prognostic nutritional index(PNI)could reflect tumor immune microenvironment and predict prognosis of ***,it had not been explored in alpha-fetoprotein(AFP)producing gastric cancer(GC).AIM To determine the predictive value of inflammation-related peripheral blood markers including as NLR,PLR,MLR,SII,SIRI and PNI in the prognosis of AFPproducing GC(AFPGC).Besides,this study would also compare the differences in tumor immune microenvironment,clinical characteristics and prognosis between AFPGC and AFP-GC patients to improve the understanding of this *** 573 patients enrolled were retrospectively *** were divided into AFP+group(AFP≥20 ng/mL)and AFP-group(AFPng/mL),comparing the levels of NLR/PLR/MLR/SII/SIRI/PNI and *** AFP+group,the impact of NLR/PLR/MLR/SII/SIRI/PNI and their dynamic changes on prognosis were further *** Compared with AFP-patients,AFP+patients had higher NLR/PLR/MLR/SII/-SIRI and lower PNI levels and poorer overall survival(OS).In the AFP+group,mortality was significantly lower in the lower NLR/PLR/MLR/SII/SIRI group and higher PNI ***,the dynamic increase(NLR/PLR/MLR/SII/-SIRI)or decrease(PNI)was associated with the rise of mortality within 1 year of *** Compared with AFP-patients,the level of inflammation-related peripheral blood markers significantly increased in AFP+patients,which was correlated with OS of AFP+***,the gradual increase of SII and SIRI was associated with the risk of death within one year in AFP+*** should be considered as a separate type and distinguished from AFP-GC because of the difference in tumor immune *** requires basic experiments and large clinical samples in the f

关键词： Alpha-fetoprotein producing gastric cancer Inflammatory indicator Prognosis Dynamic changes Tumor immune microenvironment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Nitrous oxide emission by denitrifying phosphorus removal culture using polyhydroxyalkanoates as carbon source

引用

Journal of Environmental Sciences 2012年第9期24卷 1616-1623页

作者： yan zhou Melvin Lim Soekendro Harjono Wun Jern ng Advanced Environmental Biotechnology Center (AEBC-NEWRI) 60 Nanyang Avenue North Wing Level B2 Room O1 Nanyang Technological University 639798 Singapore Keppel Environmental Technology Centre Pte Ltd. 61 Old Toh Tuck Road 597656 Singapore Division of Environmental and Water Resources Engineering School of Civil and Environmental Engineering Nanyang Technological University 639798 Singapore

Nitrous oxide （N2O） emission has been reported to be enhanced during denitrification when internally-stored compounds are used as carbon sources. However, negligible N2O emissions have been detected in the few studies where polyhydroxyalkanoates （PHA） were specifically used. This study investigated and compared the potential enhancement of N2O production, based on utilization of an internally-stored polymer and external carbon （acetate） by a denitrifying phosphorus removal culture. Results indicated that at relatively low chemical oxygen demand-to-nitrogen （COD/N） ratios, more nitrite was reduced to N2O in the presence of an external carbon source as compared to an internal carbon source （PHA）. At relatively higher COD/N ratios, similar N2O reduction rates were obtained in all cases regardless of the type of carbon source available. N2O reduction rates were, however, generally higher in the presence of an internal carbon source. Results from the study imply that when the presence of an external carbon source is not sufficient to support denitrification, it is likely competitively utilized by different metabolic pathways of denitrifying polyphosphate accumulating organisms （DPAOs） and other ordinary denitfifiers. This study also reveals that the consumption of PHA is potentially the rate-limiting step for N2O reduction during denitrification.

关键词： N2O denitrification carbon source enhanced biological phosphorus removal DPAOs PHA

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Sirolimus can promote the disappearance of renal angiomyolipoma associated with tuberous sclerosis complex:a prospective cohort study

引用

World Journal of Pediatrics 2024年第6期20卷 602-610页

作者： Shuo Dun yang-yang Wang Lin Wan Qiu-Hong Wang Qian Lu Xiao-yan yang Qi zh.ng Hui-Min Chen Lu-Peng Qiu Li-Ping Zou Medical School of Chinese PLA Beijing 100853China Department of Pediatrics The First Medical CenterChinese PLA General HospitalBeijing 100853China Center of Epilepsy Beijing Institute for Brain DisordersBeijing 100069China

Background Renal angiomyolipoma(RAML)is the most common kidney lesion in patients with tuberous sclerosis complex(TSC),affecting about 80%of *** is a benign tumor that grows over time,usually bilaterally,and can easily lead to kidney complications such as acute ***,we investigated the efficacy and safety of sirolimus in children with TSC-associated RAML and explored the factors affecting tumor disappearance under sirolimus treatment through subgroup *** A prospective cohort study was *** was initiated at 1 mg/(m^(2)×day),and dose adjustments were made by a 2-week titration period to attain a trough blood concentration of 5-10 ng/*** disappearance of RAML in chil-dren after sirolimus treatment was observed,and Cox regression was used to screen the factors affecting tumor *** One hundred and twenty-six patients who met the criteria were *** 3 months,6 months,12 months,and 24 months of follow-up,tumors disappeared in 18(14.3%),30(23.8%),39(31.0%),and 42(33.3%)children,*** disappeared in 50(39.7%)children by the last visit of each individual,and 30(60%)of them occurred within 6 *** multivariate Cox regression analysis showed that patients with a smaller maximum tumor diameter at baseline had a higher tumor disappearance ***-six(29%)patients had stomatitis during the entire treatment period,and no serious *** Sirolimus could promote the disappearance of TSC-related *** disappearance rate was correlated with the maximum diameter at baseline,and the smaller the tumor was,the higher the disappearance *** is well tolerated in the treatment of RAML associated with TSC.

关键词： Angiomyolipoma mTOR inhibitor Sirolimus Tuberous sclerosis

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Emerging non-antibody‒drug conjugates (non-ADCs) therapeutics of toxins for cancer treatment

引用

Acta Pharmaceutica Sinica B 2024年第4期14卷 1542-1559页

作者： Xiaolan Xu Jiaming zh.ng Tao Wang Jing Li Yukang Rong yanfang Wang Chenxia Bai Qing yan Xiaohua Ran Yingli Wang Tianhong zh.ng Jin Sun Qikun Jiang Wuya College of Innovation Shenyang Pharmaceutical UniversityShenyang 110016China School of Education University of NottinghamNottingham NG72RDUK Department of Pharmacy Linyi People's HospitalShandong UniversityLinyi 276000China State Key Laboratory of Natural and Biomimetic Drugs Peking UniversityBeijing 100871China

The non-selective cytotoxicity of toxins limits the clinical relevance of the *** recent years,toxins have been widely used as warheads for antibody-drug conjugates(ADCs)due to their eff-cient killing activity against various cancer *** ADCs confer certain targeting properties to the toxins,low drug loading capacity,possible immunogenicity,and other drawbacks also limit the po-tential application of ***,non-ADC delivery strategies for toxins have been extensively *** further understand the application of toxins in anti-tumor,this paper provided an over-view of prodrugs,nanodrug delivery systems,and biomimetic drug delivery *** addition,toxins and their combination strategies with other therapies were ***,the prospect and challenge of toxins in cancertreatmentwerealso summarized.

关键词： Toxins Non-antibody-drug conjugates Delivery strategies Prodrugs Nano drug delivery systems Biomimetic drugdelivery systems Combination strategies Cancer treatment

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Replacing what’s lost: a new era of stem cell therapy for Parkinson’s disease

引用

Translational Neurodegeneration 2020年第1期9卷 10-19页

作者： Yong Fan Winanto Shi-yan ng The Third Affiliated Hospital of Guangzhou Medical University Guangzhou 510150China Institute of Molecular and Cell Biology A^*STAR Research EntitiesSingapore 138673Singapore Yong Loo Lin School of Medicine(Physiology) National University of SingaporeSingapore 117456Singapore National Neuroscience Institute Singapore 308433Singapore

Background Stem cells hold tremendous promise for regenerative medicine because they can be expanded infinitely,giving rise to large numbers of differentiated cells required for *** cells can be derived from fetal sources,embryonic origins(embryonic stem cells or ESCs)or reprogrammed from adult cell types(induced pluripotent stem cells or iPSCs).One unique property of stem cells is their ability to be directed towards specific cell types of clinical interest,and can mature into functional cell types in *** transplantations of fetal or ESC-derived tissues are known to illicit a host immunogenic response,autologous transplantations using cell types derived from one’s own iPSCs eliminate risks of tissue rejection and reduce the need for ***,even with these benefits,cell therapy comes with significant hurdles that researchers are starting to *** this review,we will discuss the various steps to ensure safety,efficacy and clinical practicality of cell replacement therapy in neurodegenerative diseases,in particular,Parkinson’s *** body Parkinson’s disease(PD)results from a loss of dopaminergic neurons from the substantia nigra and is an ideal target for cell replacement *** trials using fetal midbrain material in the late 1980s have resulted in long term benefit for some patients,but there were multiple shortcomings including the non-standardization and quality control of the transplanted fetal material,and graft-induced dyskinesia that some patients experience as a *** the other hand,pluripotent stem cells such as ESCs and iPSCs serve as an attractive source of cells because they can be indefinitely cultured and is an unlimited source of *** cell technologies and our understanding of the developmental potential of ESCs and iPSCs have deepened in recent years and a clinical trial for iPSC-derived dopaminergic cells is currently undergoing for PD patients in *** this focused review,w

关键词： Parkinson’s disease Induced pluripotent stem cells Cell therapy Regenerative medicine

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

基于农村内源性发展模式的新型夯土建筑策略——以“一专一村”西南农村地区项目为例

引用

建筑学报 2024年第1期 105-111页

作者：万丽吴恩融迟辛安柏文峰周来香港中文大学建筑学院中国香港999077 昆明理工大学建筑与城市规划学院昆明650500

提出内源性发展理念与当地生土建筑相结合的农村建设思路,以“一专一村”计划的一系列新型夯土建筑实践为例,从与环境和谐相处、发掘本土价值、尊重当地人的主体性、引入外部智力资源几个方面进行深入分析,总结出“科学方法、适宜技术... 详细信息

提出内源性发展理念与当地生土建筑相结合的农村建设思路,以“一专一村”计划的一系列新型夯土建筑实践为例,从与环境和谐相处、发掘本土价值、尊重当地人的主体性、引入外部智力资源几个方面进行深入分析,总结出“科学方法、适宜技术”的创新思路及“本土材料、本土技术、本土工匠”的组织原则,探讨系统性、跨学科、跨部门联动,提升乡村发展内生动力的建造模式。

关键词：内源性发展内生动力夯土建筑可持续发展

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Expanding the targeting scope of CRISPR/Cas9-mediated genome editing by Cas9 variants in Brassica

引用

aBIOTECH 2024年第2期5卷 202-208页

作者： Wenjing Li Xuan Li Chunyang Wang Guanzh.ng Huo Xinru zh.ng Jintai Yu Xiaoxiao Yu Jing Li Chao zh.ng Jianjun zhao yan Li Jun Li State Key Laboratory of North China Crop Improvement and Regulation College of Life SciencesHebei Agricultural UniversityBaoding 071001China Hebei Key Laboratory of Plant Physiology and Molecular Pathology Hebei Agricultural UniversityBaoding 071001China Key Laboratory of Vegetable Germplasm Innovation and Utilization of Hebei Collaborative Innovation Center of Vegetable Industry in HebeiCollege of HorticultureHebei Agricultural UniversityBaoding 071001China College of Modern Science and Technology Hebei Agricultural UniversityBaoding 071001China

CRISPR/Cas9,presently the most widely used genome editing technology,has provided great potential for functional studies and plant ***,the strict requirement for a protospacer adjacent motif(PAM)has hindered the application of the CRISPR/Cas9 system because the number of targetable genomic sites is ***,the engineered variants Cas9-ng,SpG,and SpRY,which recognize non-canonical PAMs,have been successfully tested in plants(mainly in rice,a monocot).In this study,we evaluated the targeted mutagenesis capabilities of these Cas9 variants in two important Brassica vegetables,Chinese cabbage(Brassica rapa ***)and cabbage(Brassica oleracea ***).Both Cas9-ng and SpG induced efficient mutagenesis at ngN PAMs,while SpG outperformed Cas9-ng at ngC and ngT *** achieved efficient editing at almost all PAMs(NRN>NYN),albeit with some self-targeting activity at transfer(T)-DNA *** SpRY-induced mutants were detected in cabbage plants in a PAM-less ***,an adenine base editor was developed using SpRY and TadA8e deaminase that induced A-to-G conversions within target sites using non-canonical ***,the toolboxes developed here induced successful genome editing in Chinese cabbage and *** work further expands the targeting scope of genome editing and paves the way for future basic research and genetic improvement in Brassica.

关键词： Brassica Cas9 variants CRISPR Genome editing Non-canonical PAM

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Impact of undissociated volatile fatty acids on acidogenesis in a two-phase anaerobic system

引用

Journal of Environmental Sciences 2016年第4期28卷 196-201页

作者： Keke Xiao yan zhou Chenghong Guo Yogananda Maspolim Wun Jern ng Advanced Environmental Biotechnology Centre Nanyang Environment and Water Research InstituteNanyang Technological University School of Civil and Environmental Engineering Nanyang Technological University

This study investigated the degradation and production of volatile fatty acids（VFAs）in the acidogenic phase reactor of a two-phase anaerobic system.20 mmol/L bromoethanesulfonic acid（BESA）was used to inhibit acidogenic methanogens（which were present in the acidogenic phase reactor）from degrading *** impact of undissociated volatile fatty acids（un VFAs）on＂net＂VFAs production in the acidogenic phase reactor was then evaluated,with the exclusion of concurrent VFAs degradation.＂Net＂VFAs production from glucose degradation was partially inhibited at high un VFAs concentrations,with 59%,37% and 60% reduction in production rates at 2190 mg chemical oxygen demand（COD）/L undissociated acetic acid（un HAc）,2130 mg COD/L undissociated propionic acid（un HPr）and 2280 mg COD/L undissociated n-butyric acid（un HBu）,*** profile of VFAs produced further indicated that while an un VFA can primarily affect its own formation,there were also un VFAs that affected the formation of other VFAs.

关键词： Anaerobic process Waste treatment Substrate inhibition Undissociated volatile fatty acids Acidogenesis

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Determination of the archaeal and bacterial communities in two-phase and single-stage anaerobic systems by 454 pyrosequencing

引用

Journal of Environmental Sciences 2015年第10期27卷 121-129页

作者： Yogananda Maspolim yan zhou Chenghong Guo Keke Xiao Wun Jern ng Advanced Environmental Biotechnology Centre (AEBC) Nanyang Environment and Water Research Institute (NEWRI)Nanyang Technological University (NTU) School of Civil and Environmental Engineering Nanyang Technological University (NTU)

2-Phase anaerobic digestion（AD）, where the acidogenic phase was operated at 2 day hydraulic retention time（HRT） and the methanogenic phase at 10 days HRT, had been evaluated to determine if it could provide higher organic reduction and methane production than the conventional single-stage AD（also operated at 12 days HRT）. 454 pyrosequencing was performed to determine and compare the microbial communities. The acidogenic reactor of the 2-phase system yielded a unique bacterial community of the lowest richness and diversity, while bacterial profiles of the methanogenic reactor closely followed the single-stage reactor. All reactors were predominated by hydrogenotrophic methanogens, mainly Methanolinea. Unusually, the acidogenic reactor contributed up to 24%of total methane production in the 2-phase system. This could be explained by the presence of Methanosarcina and Methanobrevibacter, and their activities could also help regulate reactor alkalinity during high loading conditions through carbon dioxide production. The enrichment of hydrolytic and acidogenic Porphyromonadaceae, Prevotellaceae, Ruminococcaceae and unclassified Bacteroidetes in the acidogenic reactor would have contributed to the improved sludge volatile solids degradation, and ultimately the overall 2-phase system＇s performance. Syntrophic acetogenic microorganisms were absent in the acidogenic reactor but present in the downstream methanogenic reactor, indicating the retention of various metabolic pathways also found in a single-stage system. The determination of key microorganisms further expands our understanding of the complex biological functions in AD process.

关键词： Sewage sludge 2-Phase anaerobic digestion Microbial community 454 pyrosequencing Methanogen

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：