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Dimethyl Sulfoxide/Visible-Light Comediated Chemoselective C-S Bond Formation Between Tryptophans and Thiophenols Enables Site-Selective Functionalization of Peptides

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CCS Chemistry 2024年第6期6卷 1547-1556页

作者： Guangjun Bao Peng Wang Jingyue Li Xinyi Song Tingli Yu Jiao Zhang Yiping Li zeyuan he Ruiyao E Xiaokang Miao Junqiu Xie Jingman Ni Rui Wang Wangsheng Sun Key Laboratory of Preclinical Study for New Drugs of Gansu Province School of Basic Medical Sciences&Research Unit of Peptide ScienceChinese Academy of Medical Sciences2019RU066Lanzhou UniversityLanzhou 730000 State Key Laboratory of Bioactive Substance and Function of Natural Medicines Institute of Materia MedicaChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100050

Late-stage peptide modification showcases a huge potential for the construction of peptide libraries,and the investigation of structure-activity *** we report a dimethyl sulfoxide/visible light comediated chemoselective modification of tryptophan residue by forging the C-S structure using thiophenols irradiated with blue light-emitting diodes at room *** method shows excellent chemoselectivity toward the C-2 position of the tryptophan residue and good compatibility with diverse thiophenol derivatives bearing various functional *** protected oligopeptides and unmasked bioactive peptides smoothly underwent site-selective modification,furnishing the corresponding *** all,this study provides a new competent toolkit for late-stage peptide modification,labelling,and peptide-drug conjugation and provides a clue for protein bioconjugation.

关键词： peptide modification late-stage diversification photocatalysis tryptophan thiophenol

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川中秋林油田伴生气轻烃回收工艺方案的探讨

石油与天然气化工 1999年第1期28卷 11-13页

作者：尹荣辅贺泽元四川石油局川中油气勘探开发公司

介绍了川中秋林油田伴生气的简单工况及进行轻烃回收的三种工艺方案，并对三种方案进行了对比分析，推荐了其中一种作为拟建轻烃回收装置的工艺方案。

关键词：轻烃回收工艺方案天然气油田伴生气

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关于我国地方政府债定价市场化的分析

财政科学 2018年第12期 57-72页

作者：何泽源中国财政科学研究院研究生院

自2015年我国推出地方政府全面自发自还的地方政府债以来,地方政府债已成为存量规模最大的债券品种,其一级市场发行利率偏低、二级市场流动性偏弱的情况持续受到研究者和债券市场投资者的关注。本文通过理论分析和模型分析的方法,探讨... 详细信息

自2015年我国推出地方政府全面自发自还的地方政府债以来,地方政府债已成为存量规模最大的债券品种,其一级市场发行利率偏低、二级市场流动性偏弱的情况持续受到研究者和债券市场投资者的关注。本文通过理论分析和模型分析的方法,探讨了我国地方政府债券利率定价市场化程度有待提高的问题,并对未来完善的方向进行了一些思考。

关键词：地方政府债定价市场化向量误差修正模型(VECM)

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磨溪气田腐蚀及防腐

天然气工业 1998年第5期18卷 67-71页

作者：杨小平贺泽元向伟四川石油管理局川中油气公司

磨溪气田的天然气中，Ｈ２Ｓ含量为１．６６％～２．３５％，ＣＯ２含量为０．３６％～０．８９％，少量地层水含有Ｈ２Ｓ、ＣＯ２、Ｃｌ－，其矿化度为６９６３０～２２２８２０ｍｇ／Ｌ。该气田自１９９４年３月正式投入开发后，气田... 详细信息

磨溪气田的天然气中，Ｈ２Ｓ含量为１．６６％～２．３５％，ＣＯ２含量为０．３６％～０．８９％，少量地层水含有Ｈ２Ｓ、ＣＯ２、Ｃｌ－，其矿化度为６９６３０～２２２８２０ｍｇ／Ｌ。该气田自１９９４年３月正式投入开发后，气田地下管串及地面集输系统受到严重腐蚀，导致油管断裂，油嘴、针阀被刺，水套炉、输气支线经常堵塞，集气干线超压，清管频繁，严重危及气田安全生产。研究发现，腐蚀以电化学腐蚀和Ｈ２Ｓ腐蚀为主，兼有ＣＯ２、硫酸盐还原菌（ＳＲＢ）等腐蚀。针对磨溪气田腐蚀特点而研制的ＣＺ３—１，３复合缓蚀剂，无论在常压条件下，还是在高压条件下，对气／液相均具有十分良好的缓蚀效果，只需很少用量，便可有效抑制Ｈ２Ｓ、ＣＯ２、Ｃｌ－及高矿化度引起的电化学腐蚀和Ｈ２Ｓ应力腐蚀。ＣＺ３—１，３复合缓蚀剂可广泛用于油气田开采和集输系统工艺流程中的井下套管、地面设施以及集输管网等的防腐。

关键词：腐蚀防腐气田机械设备

Reconstructing forest and grassland cover changes in China over the past millennium

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Science China Earth Sciences 2025年第1期68卷 94-110页

作者： Fanneng he Fan YANG Yafei WANG Key Laboratory of Land Surface Pattern and Simulation Institute of Geographic Sciences and Natural Resources Research Chinese Academy of Sciences Key Research Institute of Yellow River Civilization and Sustainable Development Henan University University of Chinese Academy of Sciences

Historical forest and grassland cover changes not only are critical indicators for quantifying ecological and environmental change processes but also serve as fundamental data for long-term climate change simulations and terrestrial ecosystem carbon emission assessments. However, because of limitations in historical data, quantitative estimations and spatially gridded reconstructions of these changes remain challenging, necessitating further methodological exploration. This study focused on China's present-day land area over the past millennium, objectively capturing the characteristics and drivers of forest and grassland cover changes. On this basis, using the forest transition theory and the space-for-time substitution method, we depicted the historical deforestation process as an inverted “S” curve and developed a model to reconstruct historical forest area changes based on the functional relationship between the forest area and population size dynamics. Subsequently, a gridded forest allocation model was established on the basis of deforestation tendencies. For the grassland cover, we implemented regionspecific methods, such as the cropland area deduction method and the habitat constraint method, to quantitatively reconstruct historical changes. Consequently, we obtained provincial forest and grassland area changes over the past millennium and mapped 10-km-resolution gridded data of forest and grassland cover. The results indicated the following.(1) The methods developed using population data as a proxy objectively reproduced the spatiotemporal evolution of forest and grassland cover in China over the past millennium. These feasible methods offer a novel pathway for the quantitative reconstruction of historical forest and grassland cover changes.(2) The data indicated that China's forest area generally decreased over the past millennium, characterized by a “decrease-then-increase” pattern. The forest area experienced three distinct phases: a slow decline(AD 1000

关键词： Land use and land cover change Forest Grassland Quantitative reconstruction Gridded reconstruction China historical period

Recent progress in constructing fluorinated solid-electrolyte interphases for stable lithium metal anodes

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International Journal of Minerals,Metallurgy and Materials 2025年第2期32卷 270-291页

作者： Di Zhang Pengfei Lv Wei Qin Xin he Yuanhua he Civil Aircraft Fire Science and Safety Engineering Key Laboratory of Sichuan Province College of Civil Aviation Safety EngineeringCivil Aviation Flight University of ChinaGuanghan 618307China School of Chemical Engineering Sichuan UniversityChengdu 610065China

Lithium metal batteries(LMBs)are emerging as a promising energy storage solution owing to their high energy density and specific ***,the non-uniform plating of lithium and the potential rupture of the solid-electrolyte interphase(SEI)during extended cycling use may result in dendrite growth,which can penetrate the separator and pose significant short-circuit *** a stable SEI is essential for the long-term operation of the ***-rich SEI has garnered significant attention for its ability to effectively passivate electrodes,regulate lithium deposition,and inhibit electrolyte *** the structural components and preparation methods of existing fluorinated SEI is crucial for optimizing lithium metal anode *** paper reviews the research on optimizing LiF passivation interfaces to protect lithium metal *** focuses on four types of compositions in fluorinated SEI that work synergistically to enhance SEI *** instance,combining compounds with LiF can further enhance the mechanical strength and ionic conductivity of the *** metals with LiF significantly improves electrochemical performance at the SEI/anode interface,with a necessary focus on reducing electron tunneling ***,incorporating polymers with LiF offers balanced improvements in interfacial toughness and ionic conductivity,though maintaining structural stability over long cycles remains a critical area for future *** alloys combined with LiF increase surface energy and lithium affinity,challenges such as dendrite growth and volume expansion *** summary,this paper emphasizes the crucial role of interfacial structures in LMBs and offers comprehensive guidance for future design and development efforts in battery technology.

关键词： LiF lithium metal anodes solid-electrolyte interphase interface cycling stability

Breaking new ground in photocatalysis: lutetium texaphyrin as a trigger for pyroptosis through biomolecular photoredox reactions

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Science China Chemistry 2025年第1期68卷 1-2页

作者： Qihang Ding Mengrong he Meijia Gu Department of Chemistry Korea University Department of Ultrasound Medicine Union Hospital Tongji Medical College Huazhong University of Science and Technology Key Laboratory of Combinatorial Biosynthesis and Drug Discovery (MOE) School of Pharmaceutical Sciences Wuhan University

Malignant neoplasms consistently pose a significant threat to global public health [1,2]. In recent years, immunotherapy has demonstrated remarkable clinical success; however, its efficacy is limited by the scarcity of immune cell infiltration within tumor microenvironments. Cell pyroptosis, a gasdermin-mediated process characterized by cellular swelling,rupture, and the release of intracellular contents such as IL-1β, IL-18, ATP, HMGB1, plays a crucial role in this context[3,4].

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Dip2a regulates stress susceptibility in the basolateral amygdala

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Neural Regeneration Research 2025年第6期20卷 1735-1748页

作者： Jing Li Zixuan he Weitai Chai Meng Tian Huali Yu Xiaoxiao he Xiaojuan Zhu Key Laboratory of Molecular Epigenetics Ministry of Education Institute of Genetics and CytologyNortheast Normal UniversityChangchunJilin ProvinceChina

Dysregulation of neurotransmitter metabolism in the central nervous system contributes to mood disorders such as depression, anxiety, and post–traumatic stress disorder. Monoamines and amino acids are important types of neurotransmitters. Our previous results have shown that disco-interacting protein 2 homolog A(Dip2a) knockout mice exhibit brain development disorders and abnormal amino acid metabolism in serum. This suggests that DIP2A is involved in the metabolism of amino acid–associated neurotransmitters. Therefore, we performed targeted neurotransmitter metabolomics analysis and found that Dip2a deficiency caused abnormal metabolism of tryptophan and thyroxine in the basolateral amygdala and medial prefrontal cortex. In addition, acute restraint stress induced a decrease in 5-hydroxytryptamine in the basolateral amygdala. Additionally, Dip2a was abundantly expressed in excitatory neurons of the basolateral amygdala, and deletion of Dip2a in these neurons resulted in hopelessness-like behavior in the tail suspension test. Altogether, these findings demonstrate that DIP2A in the basolateral amygdala may be involved in the regulation of stress susceptibility. This provides critical evidence implicating a role of DIP2A in affective disorders.

关键词： 5-hydroxytryptamine acute restraint stress basolateral amygdala CaMKII neurons DIP2A metabolomics neurotransmitters principal component analysis stress susceptibility tryptophan

巴戟天化学成分、药理作用及质量标志物预测分析

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中华中医药学刊 2022年第7期40卷 251-258页

作者：黄清霞覃川娴何泽源冯旭韦建华广西中医药大学药学院广西南宁530200

巴戟天是我国“四大南药”之一,广泛分布在我国广西、广东、海南和福建等地。巴戟天中含蒽醌类、环烯醚萜类、糖类、挥发性物质、氨基酸类及微量元素等化合物,具补肾阳、强筋骨、祛风湿之功效。对巴戟天的化学成分和药理活性进行综述,... 详细信息

巴戟天是我国“四大南药”之一,广泛分布在我国广西、广东、海南和福建等地。巴戟天中含蒽醌类、环烯醚萜类、糖类、挥发性物质、氨基酸类及微量元素等化合物,具补肾阳、强筋骨、祛风湿之功效。对巴戟天的化学成分和药理活性进行综述,基于中药质量标志物的核心概念,对巴戟天的质量标志物进行预测分析,认为巴戟天蒽醌类、环醚烯萜苷类及糖类成分是巴戟天的质量标志物。

关键词：巴戟天化学成分药理作用质量标志物