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High-Al-composition AlGaN/GaN MISHEMT on Si with fof 320 GHz

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Science China(Information Sciences) 2024年

作者： Hanghai DU Lu HAO Zhihong LIU zeyu song Yachao ZHANG Kui DANG Jin ZHOU Jing NING Zan LI Jincheng ZHANG Yue HAO Guangzhou Wide Bandgap Semiconductor Innovation Center Guangzhou Institute of TechnologyXidian University State Key Laboratory of Integrated Services Networks School of Communication EngineeringXidian University State Key Laboratory of Wide Bandgap Semiconductor Devices and Integrated Technology School of MicroelectronicsXidian University

GaN-based metal-insulator-semiconductor high-electronmobility-transistors (MISHEMTs) have many excellent performances compared with the Si and GaA s counterparts,and are prime candidates for applications in communication base stations, radars, and satellites. Most of the current GaNRF transistors for the below Ka-band applications adopt a conventional AlGaN/GaN heterostructure with a typical Al-composition from 0.25 to 0.3 for the barrier layer. For higher frequency applications, the thin barrier AlN/GaN heterojunction or InA lN/GaN heterojunction is preferred [1].

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嗜热毛壳菌端粒酶的表达纯化及酶学特性分析

西北农业学报 2024年第3期33卷 532-541页

作者：尹虎宋泽玉奚绪光西北农林科技大学生命科学学院陕西杨凌712100

为进一步探究端粒酶的酶学特性,以嗜热毛壳菌(Chaetomium thermophilum, Thermo)端粒酶为研究对象,通过生物化学、生物信息学等方法得到4种不同长度的Thermo端粒酶蛋白,分别与体外转录得到的Thermo端粒酶RNA进行组装。通过端粒酶体外延... 详细信息

为进一步探究端粒酶的酶学特性,以嗜热毛壳菌(Chaetomium thermophilum, Thermo)端粒酶为研究对象,通过生物化学、生物信息学等方法得到4种不同长度的Thermo端粒酶蛋白,分别与体外转录得到的Thermo端粒酶RNA进行组装。通过端粒酶体外延伸试验检测组装体的反转录活性,进一步分析影响其反转录活性的各种因素。结果表明,4种不同长度的Thermo端粒酶蛋白重组质粒经大肠杆菌表达系统诱导表达后均可得到相应的Thermo端粒酶蛋白,且纯度均在90%以上;体外孵育试验表明,在10 mmol/L HEPES-KOH(pH 8.0)、1 mmol/L MgCl2、100 mmol/L NaCl、3 mmol/L KCl、体积分数25%Glycerol、10units/μL Rnasin的条件下,端粒酶蛋白与RNA的摩尔浓度比达到1∶1及以上时,两者能有效复合;端粒酶体外延伸试验发现,结构完整的Thermo端粒酶组装体具有很强的反转录活性,可使18nt-DNA引物反复延伸。TEN结构域不完整并未减弱Thermo端粒酶组装体的反转录活性,说明其在反转录过程中未发挥显著作用。T-PK区或TWJ区缺失的组装体均不能使18nt-DNA引物发生延伸,表明RNA结构的完整性是端粒酶发挥反转录功能的必要条件。

关键词： Thermo端粒酶蛋白表达纯化 RNA体外转录反转录活性

Chromium trioxide modified spiro-OMeTAD for highly efficient and stable planar perovskite solar cells

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Journal of Energy Chemistry 2021年第10期30卷 386-394,I0011页

作者： Xiaobing Wang Jihuai Wu Yuqian Yang Guodong Li zeyu song Xuping Liu Weihai Sun Zhang Lan Peng Gao Engineering Research Centre of Environment-Friendly Functional Materials Ministry of Education/Fujian Engineering Research Centre of Green Functional MaterialsHuaqiao UniversityXiamen 361021FujianChina Fujian Institute of Research on Structure Matter Chinese Academy ScienceCASXiamen 361021FujianChina

Hole transporting materials(HTMs)play an unparalleled role in heightening the stability and photovoltaic performance of perovskite solar cells(PSCs).The organic small molecule spiro-OMeTAD is frequently utilized for HTM in PSCs.However,the raw spiro-OMeTAD without dopant would be harmful to the development of highly efficient PSCs,due to its unsatisfied hole mobility and conductivity.Therefore,we introduce an inorganic dopant(chromium trioxide,CrO_(3))into the lithium-salt doped spiro-OMeTAD.Because of the exclamatory oxidizability of CrO_(3),it can accelerate the oxidation of spiro-OMeTAD and thereby enhancing the hole mobility of HTM.The introduction of CrO_(3) not only substantially decreases the density of defects,but also adjusts spiro-OMeTAD energy band,and thus effectively suppresses the hysteresis and improving stability of PSCs.In the end,we obtained a power conversion efficiency(PCE)as high as 22.6%after doping CrO_(3) in spiro-OMeTAD.The facile,low cost and outstanding photovoltaic performance render CrO_(3) an excellent dopant for HTMs in PSCs.

关键词： Perovskite solar cells Spiro-OMeTAD Hole transporting materials CrO_(3)

MODELS: a six-step framework for developing an infectious disease model

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贫困所致传染病(英文) 2024年第2期13卷 1-11页

作者： Rui Jia Li Kangguo Wei Hongjie Guo Xiaohao Zhao zeyu Wang Yao song Wentao Abudunaibi Buasiyamu Chen Tianmu State Key Laboratory of Vaccines for Infectious Diseases Xiang An Biomedicine Laboratory School of Public Health Xiamen University Xiamen city China State Key Laboratory of Molecular Vaccinology and Molecular Diagnostics National Innovation Platform for Industry-Education Integration in Vaccine Research Xiamen University Xiamen City China

Since the COVID-19 pandemic began, a plethora of modeling studies relatedto COVID-19 have been released. While some models stand out due to their innovative approaches, others are flawed in their methodology. To assist novices, frontline healthcare workers, and public health policymakers in navigating the complex landscape of these models, we introduced a structured framework named MODELS. This framework is designed to detail the essential steps and considerations for creating a dependable epidemic model, offering direction to researchers engaged in epidemic modeling endeavors.

关键词： Epidemic models Model construction MODELS framework

Influence of self-similar stresses on scenario earthquake construction:An example along the Tanlu Fault

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Science China Earth Sciences 2024年第5期67卷 1687-1697页

作者： Feng HU Huajian YAO Houyun YU zeyu LU Jieyi HOU song LUO Zhigang SHAO Xiaofei CHEN School of Earth and Space Sciences University of Science and Technology of ChinaHefei 230026China Mengcheng Geophysical National Field Scientific Observatory Hefei 230026China Department of Earth and Space Science Southern University of Science and TechnologyShenzhen 518055China Institute of Earthquake Prediction China Earthquake AdministrationBeijing 100036China

As a famous deep and large fault in eastern China,the Tanlu Fault passes through Anhui,Jiangsu,and Shandong and into northeastern China.It is important to improve the understanding of seismic hazard assessments in areas near faults.We start a scenario earthquake simulation in the M7.5 earthquake potential area of the Xinyi-Sihong segment of the Tanlu Fault.The fault rupture length and width are constrained according to the scaling law of large intraplate earthquakes,the background normal stress is depth dependent,and the initial shear stresses are determined using trial and error by matching the earthquake magnitude.Considering the 120 km rupture length of the M7.5 earthquake,we compare the horizontal uniform stress model and self-similar stress perturbation model.Our findings reveal that the seismic source time function of the horizontal uniform stress model is similar to that of the Haskell model and that of the self-similar stress perturbation model is more similar to that of a real earthquake case.We compare the dynamic rupture simulation and ground motion results under four different stress conditions and find that the shorter the characteristic length of the self-similar function is,the rougher the initial stress.For the M7.5earthquake with an epicenter in the vicinity of Suqian,the Xinyi-Tancheng segment,which is located in the IX-intensity zone north of the epicenter,vibrates more strongly on the northern side than on the southern side due to the influence of the lowvelocity zone and the peak slip rate.The response spectra analysis at stations in the study area is useful for improving the earthquake resistance capability.

关键词： Scenario earthquakes Self-similar stress Tanlu Fault Dynamic rupture Ground motion

Double-layered skeleton of Li alloy anchored on 3D metal foam enabling ultralong lifespan of Li anode under high rate

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Chinese Chemical Letters 2024年第3期35卷 479-485页

作者： Chaohui Wei zeyu Yao Jin Ruan Zhicui song Aijun Zhou Yingze song Donghuang Wang Jicheng Jiang Xin Wang Jingze Li Yangtze Delta Region Institute(Huzhou) University of Electronic Science and Technology of ChinaHuzhou 313000China School of Materials and Energy University of Electronic Science and Technology of ChinaChengdu 611731China State Key Laboratory of Environmental-Friendly Energy Materials Tianfu Institute of Research and InnovationSchool of Materials and ChemistrySouthwest University of Science and TechnologyMianyang 621010China

The high specific capacity and low negative electrochemical potential of lithium metal anodes(LMAs),may allow the energy density threshold of Li metal batteries(LMBs)to be pushed higher.However,the existing detrimental issues,such as dendritic growth and volume expansion,have hindered the practical implementation of LMBs.Introducing three-dimensional frameworks(e.g.,copper and nickel foam),have been regarded as one of the fundamental strategies to reduce the local current density,aiming to extend the Sand'time.Nevertheless,the local environment far from the skeleton is almost the same as the typical plane Li,due to macroporous space of metal foam.Herein,we built a double-layered 3D current collector of Li alloy anchored on the metal foam,with micropores interconnected macropores,via a viable thermal infiltration and cooling strategy.Due to the excellent electronic and ionic conductivity coupled with favorable lithiophilicity,the Li alloy can effectively reduce the nucleation barrier and enhance the Li^(+)transportation rate,while the metal foam can role as the primary promotor to enlarge the surface area and buffer the dimensional variation.Synergistically,the Li composite anode with hierarchical structure of primary and secondary scaffolds realized the even deposition behavior and minimum volume expansion,outputting preeminent prolonged cycling performances under high rate.

关键词： Double-layered skeleton Li alloy 3D Metal foam Ultralong lifespan Lithium metal batteries High rate

Optimized new Shengmai powder(优化新生脉散方) inhibits myocardial fibrosis in heart failure by regulating the rat sarcoma/rapidly accelerated fibrosarcoma/mitogen-activated protein kinase kinase/extracellular regulated protein kinases signaling pathway

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Journal of Traditional Chinese Medicine 2024年第3期44卷 448-457页

作者： ZHANG zeyu JIA Zhuangzhuang song Yuwei ZHANG Xuan WANG Ci WANG Shuai ZHANG Peipei REN Qiuan WANG Xianliang MAO Jingyuan Department of Cardiovascular the First Teaching Hospital of Tianjin University of Traditional Chinese MedicineNational Clinical Research Center for Chinese Medicine Acupuncture and Moxibustion

OBJECTIVE: Exploring the effect of Optimized New Shengmai powder(优化新生脉散方, ONSMP) on myocardial fibrosis in heart failure(HF) based on rat sarcoma(RAS)/rapidly accelerated fibrosarcoma(RAF)/mitogen-activated protein kinase kinase(MEK)/extracellular regulated protein kinases(ERK) signaling pathway. METHODS: Randomized 70 Sprague-Dawley rats into sham(n = 10) and operation(n = 60) groups, then established the HF rat by ligating the left anterior descending branch of the coronary artery. We randomly divided the operation group rats into the model, ONSMP [including low(L), medium(M), and high(H) dose], and enalapril groups. After the 4-week drug intervention, echocardiography examines the cardiac function and calculates the ratios of the whole/left heart to the rat's body weight. Finally, we observed the degree of myocardial fibrosis by pathological sections, determined myocardium collagen(COL) Ⅰ and COL Ⅲ content by enzyme-linked immunosorbent assay, detected the m RNA levels of COL Ⅰ, COL Ⅲ, α-smooth muscle actin(α-SMA), and c-Fos proto-oncogene(c-Fos) by universal real-time, and detected the protein expression of p-RAS, p-RAF, p-MEK1/2, p-ERK1/2, p-ETS-like-1 transcription factor(p-ELK1), p-c-Fos, α-SMA, COL Ⅰ, and COL Ⅲ by Western blot. RESULTS: ONSMP can effectively improve HF rat's cardiac function, decrease cardiac organ coefficient, COL volume fraction, and COL Ⅰ/Ⅲ content, down-regulate the m RNA of COL Ⅰ/Ⅲ, α-SMA and c-Fos, and the protein of p-RAS, p-RAF, p-MEK1/2, p-ERK1/2, p-ELK1, c-Fos, COL Ⅰ/Ⅲ, and α-SMA. CONCLUSIONS: ONSMP can effectively reduce myocardial fibrosis in HF rats, and the mechanism may be related to the inhibition of the RAS/RAF/MEK/ERK signaling pathway.

关键词： extracellular regulated protein kinases heart failure mitogen-activated protein kinases myocardial fibrosis optimized new Shengmai powder rapidly accelerated fibrosarcoma sarcoma

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血管内壁的脂滴形貌理论模型研究

医用生物力学 2022年第1期37卷 155-161页

作者：郑彦杰宋泽宇于洋北京理工大学宇航学院力学系北京100081

目的建立可描述血管内脂滴整体形貌的理论模型,为脂肪栓塞患者血管内壁脂滴整体形貌的研究与分析提供基础理论模型。方法建立液滴在圆柱管内壁的变半径模型理论描述脂滴在血管内壁的形貌,并利用Surface Evolver(SE)软件的仿真结果验证... 详细信息

目的建立可描述血管内脂滴整体形貌的理论模型,为脂肪栓塞患者血管内壁脂滴整体形貌的研究与分析提供基础理论模型。方法建立液滴在圆柱管内壁的变半径模型理论描述脂滴在血管内壁的形貌,并利用Surface Evolver(SE)软件的仿真结果验证理论模型准确性。根据理论模型,分析脂滴体积和接触角对脂滴在血管内无量纲黏附面积S_(b0)和阻塞比κ的影响规律。结果通过理论模型预测脂滴在血管内壁黏附形貌的轮廓参数,包括脂滴在方位角为0和π/2时的圆弧半径和高度,与SE模拟所得对应参数的相对误差小于10%。具有相同无量纲体积V;的脂滴,在血管内壁S_(b0)随着接触角的增加而减小,κ随着接触角的增加而增大。相同接触角条件下,V;越小的脂滴,S_(b0)和κ越小。结论所建立的变半径理论模型能很好描述脂滴在圆柱血管内壁的形貌特征,通过理论模型可准确、快速得到体积、接触角等参数对脂滴高度、黏附面积以及横截面积等形貌参数的影响规律,表明脂滴的接触角越大或无量纲体积越小,导致栓塞的概率越低。研究结果为相关疾病分析提供理论支撑。

关键词：脂肪栓塞血管内壁脂滴形貌接触角

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用于重建物理和虚拟抓取的可重构数据手套

Engineering 2024年第1期32卷 202-216页

作者： Hangxin Liu zeyu Zhang Ziyuan Jiao Zhenliang Zhang Minchen Li Chenfanfu Jiang Yixin Zhu song-Chun Zhu National Key Laboratory of General Artificial Intelligence Beijing Institute for General Artificial Intelligence(BIGAI)Beijing 100080China Center for Vision CognitionLearning and AutonomyUniversity of CaliforniaLos AngelesCA 90095USA Multi-Physics Lagrangian-Eulerian Simulations Laboratory Department of MathematicsUniversity of CaliforniaLos AngelesCA 90095USA Institute for Artificial Intelligence Peking UniversityBeijing 100871China Department of Automation Tsinghua UniversityBeijing 100084China

In this work,we present a reconfigurable data glove design to capture different modes of human hand-object interactions,which are critical in training embodied artificial intelligence(AI)agents for fine manipulation tasks.To achieve various downstream tasks with distinct features,our reconfigurable data glove operates in three modes sharing a unified backbone design that reconstructs hand gestures in real time.In the tactile-sensing mode,the glove system aggregates manipulation force via customized force sensors made from a soft and thin piezoresistive material;this design minimizes interference during complex hand movements.The virtual reality(VR)mode enables real-time interaction in a physically plausible fashion:A caging-based approach is devised to determine stable grasps by detecting collision events.Leveraging a state-of-the-art finite element method,the simulation mode collects data on fine-grained four-dimensionalmanipulation events comprising hand and object motions in three-dimensional space and how the object's physical properties(e.g.,stress and energy)change in accordance with manipulation over time.Notably,the glove system presented here is the first to use high-fidelity simulation to investigate the unobservable physical and causal factors behind manipulation actions.In a series of experiments,we characterize our data glove in terms of individual sensors and the overall system.More specifically,we evaluate the system's three modes by①recording hand gestures and associated forces,②improving manipulation fluency in VR,and③producing realistic simulation effects of various tool uses,respectively.Based on these three modes,our reconfigurable data glove collects and reconstructs fine-grained human grasp data in both physical and virtual environments,thereby opening up new avenues for the learning of manipulation skills for embodied AI agents.

关键词： Data glove Tactile sensing Virtual reality Physics-based simulation