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Ferulic acid mediates prebiotic responses of cereal-derived arabinoxylans on host health

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Animal Nutrition 2022年第2期9卷 31-38页

作者： zeyu zhang Pan Yang Jinbiao Zhao State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityBeijing 100193China

Dietary fiber is named as “the 7th nutrient” for humans, which is beneficial to improve intestinal healthand prevent metabolic disease of the host. Mechanisms of dietary fiber administration on improved hosthealth are mediated by short chain fatty acids (SCFA), which are reported to activate G protein-coupledreceptors (GPR) and suppress activity of histone deacetylase (HDAC) to down-regulate expression ofnuclear factor-к-gene binding (NF-кB) signaling. Arabinoxylan is fermented by gut microbiota to produceSCFA and improved microbial community composition, intestinal barrier functions and host ***, the latest publications have observed that ferulic acid combined with the arabinose inarabinoxylans from various cereal grains can be released through gut microbial fermentation. Ferulic acidcan improve antioxidase activity and decrease reactive oxygen species (ROS) concentration by activatingthe signaling pathway of Kelch-like ECH-associated protein-1 and nuclear factor E2-related factor-2(Keap1-Nrf2). However, the role of ferulic acid in cooperation with SCFA produced from microbialfermentation of cereal-derived arabinoxylan to regulate the intestinal health and host metabolisms, hasbeen widely unclear. This review summarizes the potential mechanisms of ferulic acid from microbialfermentation of cereal-derived arabinoxylans on immunological functions and physiological metabolismsof the host. The evidence presented in the review indicates that dietary supplementation withcereal-derived arabinoxylans improves antioxidant capacity of intestinal epithelial cells due to theproduction of ferulic acid and SCFA from microbial fermentation. Ferulic acid can cooperate with SCFA toregulate intestinal integrity and immunological functions of the host. Peroxisome proliferator activatedreceptorg (PPARg) may play an important role in integrating ferulic acid and SCFA to regulate host healthand metabolism.

关键词： Arabinoxylan Short-chain fatty acid Ferulic acid Gut health Energy metabolism

Anomalous Hall effect of facing-target sputtered ferrimagnetic Mn_(4)N epitaxial films with perpendicular magnetic anisotropy

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Chinese Physics B 2022年第4期31卷 653-659页

作者： zeyu zhang Qiang zhang Wenbo Mi Tianjin Key Laboratory of Low Dimensional Materials Physics and Preparation Technology School of ScienceTianjin UniversityTianjin 300354China Core Technology Platforms New York University Abu DhabiP.O.Box 129188Abu DhabiUnited Arab Emirates

Epitaxial Mn_(4)N films with different thicknesses were fabricated by facing-target reactive sputtering and their anomalous Hall effect(AHE)is investigated *** Hall resistivity shows a reversed magnetic hysteresis loop with the magnetic *** magnitude of the anomalous Hall resistivity sharply decreases with decreasing temperature from300 K to 150 *** AHE scaling law in Mn_(4)N films is influenced by the temperature-dependent magnetization,carrier concentration and interfacial *** scaling laws are used to distinguish the various contributions of AHE *** scaling exponentγ>2 for the conventional scaling in Mn_(4)N films could be attributed to the residual resistivityρ_(xx0).The longitudinal conductivityσ_(xx)falls into the dirty *** scaling ofρ_(AH)=αρ_(xx0)+bρ_(xx)~nis used to separate out the temperature-independentρ_(xx0)from extrinsic ***,the relationship betweenρ_(AH)and pxx is fitted by the proper scaling to clarify the contributions from extrinsic and intrinsic mechanisms of AHE,which demonstrates that the dominant mechanism of AHE in the Mn4 N films can be ascribed to the competition between skew scattering,side jump and the intrinsic mechanisms.

关键词： Mn_(4)N epitaxial film anomalous Hall effect scaling law

Recent advances in amino acid-metal coordinated nanomaterials for biomedical applications

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Chinese Journal of Chemical Engineering 2021年第10期34卷 30-42页

作者： Shaobo Wang Yunchao Zhao zeyu zhang Yalong zhang Linlin Li School of Chemistry and Chemical Engineering Center on Nanoenergy ResearchGuangxi UniversityNanning 530004China Beijing Institute of Nanoenergy and Nanosystems Chinese Academy of SciencesBeijing 100083China School of Nanoscience and Technology University of Chinese Academy of SciencesBeijing 100049China

Metal and amino acid(AA),as two kinds of entities,have been widely involved in biomaterials and ***,the marriage of them has developed new nanoformulations,amino acid-metal coordinated nanomaterials(AMCNs),which show great biomedical application potential in cancer therapy,antibacterial applications,biomedical imaging,*** the respective characteristics of metal and AA with rich biological and chemical properties,AMCNs can not only act as drug carriers with specific tumor targeting ability,but also realize synergistic therapy and imaging-guided *** the design and synthesis of amino acid-metal coordinated nanomaterials have been in-depth investigated,there are few systematic reviews on their biomedical *** this review,we give a comprehensive summary of recent progresses in the design,fabrication,and biomedical applications of *** also propose the future outlooks and challenges in aforementioned *** expect that this review would contribute some inspiration for future research and development for amino acid metal coordinated nanomaterials.

关键词： Amino acids Metal Coordination chemistry Cancer therapy Antibacterial applications Imaging

Studies of world carbon fiber industry from a perspective of patent analysis

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High Technology Letters 2016年第3期22卷 313-320页

作者：郑佳 Yuan Xuemin zhang zeyu Institute of Scientific and Technical Information of China Beijing 100038 P. R. China Institute of Scientific and Technical Information of Gansu Lanzhou 730000 P. R. China

Patents are the manifestation of the industry R&D endeavor; therefore,World carbon fiber industry from the perspective of patent analysis is studied. Findings from the analysis show a continual increase of carbon fibers patents since 1969,and the growth rate began even faster after the year of 2005. Five countries( Japan,China,US,Germany and Korea) took dominant positions in global carbon fibers R&D,and the sum of patents applied in these five countries accounted for 80% of the total patents in the world. Corporations do play an active role in global carbon fibers R&D,and over 60% of patents were applied by corporations. Among them,the top 3 corporations were all from Japan,which had much more patents than the other patent assignees. Furthermore,most corporations were not active in cooperation with others,except Toyota Motor Corp. Global carbon fibers R&D focused on sheet manufacture cloth,core wire layer,heat connect provide and filter activated *** there is big difference between Japan and China in the R&D focus. China's corporations have exhibited rapid growth in the number of patent applications in recent years,but there is still a large gap between China and foreign countries in view of global patent layout and influence. By providing the insight into the evolution of global carbon fibers industrial and technological development through the perspective of patent analysis,this study hopes to provide an objective statistic reference for future policy directions and academic researches.

关键词： carbon fiber world patent analysis Japan China corporation

MeOTf-catalyzed formal[4+2]annulations of styrene oxides with alkynes leading to polysubstituted naphthalenes through sequential electrophilic cyclization/ring expansion

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Chinese Chemical Letters 2022年第6期33卷 3021-3025页

作者： Song Zou zeyu zhang Chao Chen Chanjuan Xi MOE Key Laboratory of Bioorganic Phosphorus Chemistry&Chemical Biology Department of ChemistryTsinghua UniversityBeijing 100084China State Key Laboratory of Elemento-Organic Chemistry Nankai UniversityTianjin 300071China

Me OTf-catalyzed formal[4+2]annulation of styrene oxides with alkynes to afford polysubstituted naphthalenes has been realized,which undergoes sequential electrophilic cyclization/ring expansion.A range of substrates were tolerated in the formation of naphthalene derivatives with high regioselectivity in satisfactory *** reaction could also be carried out on gram scale.

关键词： Methyltriflate Catalytic reaction Annulation Ring expansion Polysubstituted naphthalenes

Hierarchical porous cellulose/lanthanide hybrid materials as luminescent sensor

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Journal of Rare Earths 2018年第10期36卷 1036-1043页

作者： Wentao Fan Jiaojiao Du Junfeng Kou zeyu zhang Fengyi Liu College of Chemistry and Chemical Engineering Yunnan Normal University

Photoluminescent hybrid materials containing carboxymethyl cellulose and lanthanide ions（Eu3＋, Tb3＋）were prepared by a facile method under ambient conditions. Lanthanide ions were covalently grafted to the cellulose framework through coordination with the carboxylic groups of the cellulose. Hybrid materials were fabricated as hydrogel and aerogel. As shown by SEM and pore parameters, aerogel materials which were obtained by supercritical CO2 drying show hierarchical porous structure. The photoluminescence spectrum of the hybrid materials shows the characteristic red emission of Eu3＋ ion and green emission of Tb3＋. Further luminescent investigations reveal that these hybrid materials can detect Fe3＋ with relative selectivity and high sensitivity, which suggests that the hybrid materials could be a promising luminescent probe for selectively sensing Fe3＋ ion.

关键词： Lanthanide Cellulose Hybrid materials Luminescent sensor Rare earths

Current progresses of 3D bioprinting based tissue engineering

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Frontiers of Electrical and Electronic Engineering in China 2017年第2期5卷 136-142页

作者： zeyu zhang Xiu-Jie Wang Key Laboratory of Genetic Network Biology Collaborative Innovation Center of Genetics and Development Institute of Genetics and Developmental Biology Chinese Academy of Sciences Beijing 100101 China University of Chinese Academy of Sciences Beijing 100049 China

Background： The shortage of available organs for transplantation is the major obstacle hindering the application of regenerative medicine, and has also become the desperate problem faced by more and more patients nowadays. The recent development and application of 3D printing technique in biological research （bioprinting） has revolutionized the tissue engineering methods, and become a promising solution for tissue regeneration. Results： In this review, we summarize the current application of bioprinting in producing tissues and organoids, and discuss the future directions and challenges of 3D bioprinting. Conclusions： Currently, 3D bioprinting is capable to generate patient-specialized bone, cartilage, blood vascular network, hepatic unit and other simple components/tissues, yet pure cell-based functional organs are still desired.

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The role of lactose in weanling pig nutrition:a literature and meta-analysis review

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Journal of Animal Science and Biotechnology 2021年第2期12卷 462-478页

作者： Jinbiao Zhao zeyu zhang Shuai zhang Greg Page Neil W.Jaworski State Key Laboratory of Animal Nutrition College of Animal Science and TechnologyChina Agricultural UniversityNo.2 Yuanmingyuan West RoadBeijing 100193China Trouw Nutrition Innovation Stationsstraat 773800AG AmersfoortNetherlands

Lactose plays a crucial role in the growth performance of pigs at weaning because it is a palatable and easily digestible energy source that eases the transition from milk to solid ***,the digestibility of lactose declines after weaning due to a reduction in endogenous lactase activity in *** a result,some lactose may be fermented in the gastrointestinal tract of *** of lactose by intestinal microbiota yields lactic acid and volatile fatty acids,which may positively regulate the intestinal environment and microbiome,resulting in improved gastrointestinal health of weanling *** hypothesize that the prebiotic effect of lactose may play a larger role in weanling pig nutrition as the global feed industry strives to reduce antibiotic usage and pharmacological levels of zinc oxide and supra-nutritional levels of *** presented in this review indicates that high dietary lactose improves growth performance of piglets,as well as the growth of beneficial bacteria,particularly Lactobacillus,with the positive effects being more pronounced in the first 2 weeks after ***,the risk of post-weaning diarrhea may increase as pigs get older due to reduced lactase activity,high dietary lactose concentrations,and larger feed intakes,all of which may lead to excessive lactose fermentation in the intestine of the ***,dietary lactose levels exert different effects on growth performance and gastrointestinal physiological functions in different feeding phases of weanling ***,no formal recommendation of lactose for weanling pigs has been reported.A meta-analysis approach was used to determine that diets fed to swine should include 20%,15%,and 0 lactose from d 0-7,d 7-14,and d 14-35 post-weaning,***,sustainable swine production demands that economics must also be taken into account as lactose and lactose containing ingredients are ***,alternatives to lactose,so called“lactose equivalents

关键词： Growth performance Gut health Gut microbiota Lactose Lactose equivalents Weanling pig

Effects of sediment characteristics on the sediment transport capacity of overland flow

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International Soil and Water Conservation Research 2023年第1期11卷 75-85页

作者： Chenguang Liu Suhua Fu Zhanbin Li zeyu zhang Jianhui Zeng Institute of Soil and Water Conservation Northwest A&F UniversityYanglingShaanxi712100PR China State Key Laboratory of SoilErosion and Dryland Farming on the Loess Plateau Institute of Soil and Water ConservationChinese Academy of Sciences and Ministry of Water ResourceYanglingShaanxi712100PR China Beijing Key Laboratory of Environmental Remote Sensing and Digital City Faculty of Geographical ScienceBejing Normal UniversityBejing100875PR China

The transport of sediments is a crucial part of soil *** calculating the sediment transport capacity is key to the construction of soil erosion process *** on Tc has focused mainly on the dynamics of a single particle of sediment and hydraulic *** have been few studies of the impact of soil aggregates on the *** clarify how sediment characteristics,including those for single particles and aggregates,affect the Tc of overland flow with no raindrop import,flume experiments were implemented at slope gradients varying from 5.24%to 26.80%and flow discharges ranging from 0.68 to 5.41×10^(-3)m^(2)s^(-1).The experimental materials were five typical soils in *** results indicated that the correlation between the measured Tc and sediment mechanical composition indexes of the five soils was indistinctive in this *** sediment settling velocity with aggregates has a significant corre-lation with the measured *** equations,including for the sediment settling velocity with aggregatesωud75,were established to calculate the *** empirical equation that includedωud75,slope gradient and unit discharge performed greatly in predicting Tc(R^(2)=0.93,NSE=0.90).ωud75 can effectively improve the calculation accuracy of *** new equation including flow and sediment properties obtained through dimensional analysis performed well in predicting Tc(R^(2)=0.99,NSE=0.91),and the calculation accuracy was better than that of the empirical model derived in this *** findings indicate that the sediment settling velocity is an important variable in the equation for predicting sediment transport capacity of overland flow.

关键词： Sediment transport capacity Soil mechanical composition Soil aggregates Sediment settling velocity Dimensional analysis