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Management of cytomegalovirus infection after liver transplantation

World Journal of Transplantation 2024年第3期14卷 30-39页

作者： zeynep Burcin Yilmaz Funda Memisoglu Sami Akbulut Infectious Diseases and Clinical Microbiology Inonu University Faculty of MedicineMalatya 44280Türkiye Surgery and Liver Transplant Institute Inonu University Faculty of MedicineMalatya 44280Türkiye

Cytomegalovirus(CMV)infection is one of the primary causes of morbidity and mortality following liver transplantation(LT).Based on current worldwide guidelines,the most effective strategies for avoiding post-transplant CMV infection are antiviral prophylaxis and pre-emptive ***-IgG serology is the established technique for pretransplant screening of both donors and *** clinical presentation of CMV infection and disease exhibits variability,prompting clinicians to consistently consider this possibility,partic-ularly within the first year post-transplantation or subsequent to heightened *** annual symposia to discuss CMV prevention and how treatment outcomes can be improved,evidence on the incorporation of immune functional tests into clinical practice is presented,and the results of studies with new antiviral treatments are *** there are ongoing studies on the use of letermovir and maribavir in solid organ transplantation,a consensus reflected in the guidelines has not been *** the most appro-priate strategy at the individual level appears to be the key to enhancing *** prevention strategies reduce the risk of CMV disease,the disease can still occur in up to 50%of high-risk patients.A balance between the risk of infection and disease development and the use of immunosuppressants must be considered when talking about the proper management of CMV in solid organ transplant *** objective of this study was to establish a compre-hensive framework for the management of CMV in patients who have had LT.

关键词： Liver transplantation Cytomegalovirus Antiviral prophylaxis Preemptive treatment Valganciclovir Ganciclovir

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Effect of silicone oil removal on central corneal thickness

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International Journal of Ophthalmology(English edition) 2012年第3期5卷 374-376页

作者： Gul Arikan zeynep Ozbek F Hakan Oner Ismet Durak A Osman Saatci Department of Ophthalmology Dokuz Eylul UniversityIzmirTurkey

AIM:To evaluate the effect of silicone oil removal(SOR) on central corneal thickness(CCT) in aphakic and pseudophakic eyes prospectively.· METHODS:Patients who underwent SOR surgery between June 2005-August 2007 were included in this *** oil was actively removed behind the posterior capsule through the pars plana sclerotomy site(posterior approach) in pseudophakic eyes and through the pupil and the corneal tunnel incision(anterior approach) in aphakic eyes with the 18-gauge *** was assessed with Orbscan II corneal topography system preoperatively and at one month and three months postoperatively.A total of 34 eyes of 34 patients(26 males,8 females) comprised the study *** age was(55.6±12.3) years(Range:25-80 years).Twenty-six eyes(76.5%) were pseudophakic and 8(23.5%) *** time between silicone oil injection and removal was(15.1±13.6) months(Range:5-54 months).At baseline,CCT was 576.4±46.0μm in pseudophakic eyes and 611.6±36.2μm in aphakic eyes.· RESULTS:At the first postoperative month CCT was(573.3±40.1)μm and(630.9±72.9)μm in pseudophakic and aphakic eyes *** the third postoperative month,CCT was(582.7±49.5)μm and(614.5±82.4)μm in pseudophakic and aphakic eyes *** was no statistically significant difference in CCT measurements one month and 3 months after SOR when compared to preoperative values in both aphakic and pseudophakic eyes(P> 0.05).· CONCLUSION:Active SOR either by anterior or posterior approach did not affect the CCT.·

关键词： Aphakia central corneal thickness silicone oil pseudophakia

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Medical Radiation Exposure and Human Carcinogenesis-Genetic and Epigenetic Mechanisms

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Biomedical and Environmental Sciences 2014年第9期27卷 718-728页

作者： Yildiz Dincer zeynep Sezgin Department of Medical Biochemistry Istanbul University Cerrahpasa Medical Faculty Department of Medical Biochemistry Yeni Yuzy?l University Medical Faculty

Ionizing radiation （IR） is a potential carcinogen. Evidence for the carcinogenic effect of IR radiation has been shown after long-term animal investigations and observations on survivors of the atom bombs in Hiroshima and Nagasaki. However, IR has been widely used in a controlled manner in the medical imaging for diagnosis and monitoring of various diseases and also in cancer therapy. The collective radiation dose from medical imagings has increased six times in the last two decades, and grow continuously day to day. A large number of evidence has revealed the increased cancer risk in the people who had frequently exposed to x-rays, especially in childhood. It has also been shown that secondary malignancy may develop within the five years in cancer survivors who have received radiotherapv, because of IR-mediated damage to healthy cells. In this article, we review the current knowledge about the role of medical x-ray exposure in cancer development in humans, and recently recognized epigenetic mechanisms in IR-induced carcinogenesis.

关键词： DNAmethylation Medical Radiation Exposure and Human Carcinogenesis-Genetic and Epigenetic Mechanisms

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Apoptosis in the iris and trabecular meshwork of medically treated and untreated primary open angle glaucoma patients

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International Journal of Ophthalmology(English edition) 2013年第6期6卷 827-830页

作者： zeynep Aktas Emine Esra Karaca Ipek Isik Gonul Murat Hasanreisoglu Merih Onol Department of Ophthalmology Gazi University Medical Faculty Department of Pathology Gazi University Medical Faculty Department of Ophthalmology World Eye Hospital

AIM:To compare the trabecular meshwork(TM)and iris apoptosis of treated and untreated primary open angle glaucoma(POAG)***:Eight treatment-naive,newly diagnosed(group 1)and 11 medlcaiy treated(group 2)patients with POAG were included in the *** patient underwent a limbus-based *** TM and peripheral iris specimens were dissected out and were snap-frozen in liquid nitrogen and stored at-80t until they were *** in each group was assesed by TUNEL ***:The mean patient age was 60.6±5.8 years(53-68 years)vs 58.9±8.9 years(47-70 years)in group 1and group 2(P=0.859).The mean treatment time in group 2 was 22.2±7.3 months(12-34 months).Apoptotic indexes in TM and iris were significantly higher in POAG patients using medication(group 2)compared to treatment-naive POAG patients(group 1)(P=0.004,0.015;respectively).CONCLUSION:Long term administration of topical antiglaucoma medications causes additional toxic effects on TM.

关键词： glaucoma trabecular meshwork apoptosis

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Constraints on unconsolidated pyroclastic flow sediments related REE enrichments originated from potassic-alkaline Gölcük stratovolcano: Darıdere-Direkli-Yakaören (DDY) table 4deposits, southwestern Anatolia of Turkey

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Acta Geochimica 2021年第6期40卷 926-944页

作者： Murat Budakoglu Ali Tugcan Unluer zeynep Doner Huseyin Kocaturk Mustafa Kaya Mustafa Kumral M.Sezai Kirikoglu Department of Geological Engineering Faculty of MinesIstanbul Technical UniversityIstanbulTurkey

In the last five decades,Rare Earth Elements(REE)are mostly produced from carbonatite complexes and alkaline magmatic *** this respect,pyroclastic flows produced by the potassic-alkaline Gölcük volcanism in the Isparta(SW,Turkey)angle stand out as an important target area where REE enrichments can be *** study focuses on the REE potential,geochemical and mineralogical characteristics of REE-bearing minerals as well as formation modeling of unconsolidated pyroclastic flows in Darıdere-Direkli-Yakaören(DDY)deposits in ***-bearing minerals of DDY deposits which contain abundant trachytic-trachyandesitic rock fragments were determined as fluorapatite,britholite,and chevkinite by using XRD and SEM–EDX *** to the geochemical analysis,the vast majority of RREE(up to 996 ppm)content is LREE such as La,Ce and ***ıdere is the most REE enriched region followed by Yakaören and Direkli regions in terms of LREE(574.9 ppm),relative to MREE(38.5 ppm)and HREE(5.28 ppm)*** results are also on par with subduction-related Italian extrusive carbonatites such as Polino,Cupaello and San *** DDY deposits can also be comparable with intraplate extrusive REE deposits in terms of LREE enrichments,however,HREE,Nb,Th and Zr values are generally *** RREE concentrations tend to rise with the increasing contents of alkaline elements(Na and K),HFSE(such as Nb and U),as well as LILE(Ba,Sr and Rb)and are negatively affected by sedimentary carbonate *** economic value of the DDY deposits can gain importance due to the increasing global demand for LREE’s.

关键词： Pyroclastic flows Rare Earth Elements(REE) Apatite Britholite Chevkinite Alkaline-Ultrapotasic magmatism

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Retinal vessel diameters and their correlation with retinal nerve fiber layer thickness in patients with pseudoexfoliation syndrome

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International Journal of Ophthalmology(English edition) 2015年第2期8卷 332-336页

作者： Mehmet Cuneyt Ozmen zeynep Aktas Burcin Kepez Yildiz Murat Hasanreisoglu Berati Hasanreisoglu Department of Ophthalmology Gazi University Medical School

AIM: To compare retinal artery-vein diameters(RAVDs)of patients with pseudoexfoliation(PSX) syndrome with healthy controls and investigate the correlations between retinal nerve fiber layer(RNFL) thickness parameters and ***: Seventeen eyes with PSX and 17 eyes of age-matched controls were included in the study. All participants underwent routine ophthalmological examination, Humphrey visual field and RNFL examination by using Stratus OCT. Retinal images were obtained by using a retinal camera(Topcon 501X).RAVDs were measured from inferior nasal, inferior temporal, superior nasal and superior temporal arcuates by using IMAGEnet software. Superior, inferior, nasal,temporal and average RNFL thicknesses were *** and RNFL parameters in groups and correlations were analyzed by Mann-Whitney U and Spearmann correlation ***: Only inferior quadrant and average RNFL thickness were detected thinner in the PSX group compared with control group(P =0.009, P =0.038,respectively). No statistically significant difference regarding RAVDs was found between two ***: RAVDs seems to be comparable in the PSX and control group. RNFL is thinner in the inferior quadrant in the PSX group. RNFL thickness and RAVDs show significant correlations in both groups. This correlation doesn’t seem to be specific to PSX.

关键词： pseudoexfoliation retinal nerve fiber layer thickness retinal artery-vein diameters

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Healthcare-associated Staphylococcus aureus infections in children in Turkey:A six-year retrospective,single-center study

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Asian Pacific Journal of Tropical Medicine 2023年第8期16卷 354-362页

作者： Nurhayat Yakut zeynep Ergenc Sevgi Aslan Tuncay Sezin Bayraktar Elvan Sayin Arzu Ilki Eda Kepenekli Division of Pediatric Infectious Diseases Department of PediatricsMarmara University School of MedicineIstanbulTurkey Department of Pediatrics Marmara University School of MedicineIstanbulTurkey Department of Medical Microbiology Marmara University School of MedicineIstanbulTurkey

Objective:To describe clinical and epidemiological characteristics,antimicrobial susceptibility and mortality-associated factors of healthcare-associated infections(HCAIs)caused by Staphylococcus(S.)aureus in ***:We conducted a retrospective,single-centre study of pediatric HCAIs caused by *** from a tertiary care hospital in Turkey between February 2014 and December *** clinical and epidemiological characteristics and antimicrobial susceptibility of the methicillin-susceptible and methicillin-resistant ***(MSSA and MRSA)isolates was ***:A total of 310 pediatric patients were ***,225(72.6%)isolates were MSSA and 85(27.4%)were *** *** isolates were susceptible to teicoplanin,vancomycin,linezolid,tigecycline,mupirocin,and *** resistance rates were high(89.0%),while fosfomycin,gentamicin,and clindamycin resistance rates were low(1.3%,1.0%,and 2.3%,respectively).Except susceptibility to fosfomycin,which was significantly lower in 2014 compared to 2018 and 2019,no significant difference was found in the antimicrobial susceptibility of *** isolates between the *** characteristics and mortality rate were similar comparing MRSA and MSSA causing *** mortality rate of HCAIs caused by *** was 6.5%(20 patients).Malignancy was an independent risk factor associated with mortality in the multivariate analysis(OR 5.446,95%CI 1.573-18.849).Conclusions:Our findings demonstrate that MSSA remained the most causative agent of HCAIs caused by *** mortality rate was 6.5%,the antibiotic resistance rate was quite high for penicillin and diagnosis of malignancy was the main risk factor for increasing mortality in *** findings could help improve the management of HCAIs caused by *** in children.

关键词： Healthcare-associated infections Staphylococcus aureus Children Antimicrobial susceptibility Mortality

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Correlation of hepatitis B surface antigen expression with clinicopathological and biochemical parameters in liver biopsies: A comprehensive study

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World Journal of Hepatology 2022年第1期14卷 260-273页

作者： Anil Alpsoy Haydar Adanir zeynep Bayramoglu Gulsum Ozlem Elpek Department of Pathology Akdeniz UniversityMedical SchoolAntalya 07070Turkey Department of Gastroenterology Akdeniz UniversityMedical SchoolAntalya 07070Turkey

BACKGROUND Chronic viral B hepatitis(CHB)is a potentially life-threatening liver disease that may progress to liver failure and ***,although combinations of different laboratory methods are used in the follow-up and treatment of CHB,the failure of these procedures in some cases has led to the necessity of developing new *** CHB,the intrahepatic expression pattern of viral antigens,including hepatitis B surface antigen(HBsAg),is related to different phases of ***,many studies have focused on the intracytoplasmic properties of HBsAg staining,and HBsAg positivity in liver tissue has not been evaluated by objective quantitative *** To investigate the relationship of image analysis-based quantitative HBsAg expression and its staining patterns with clinicopathological factors and treatment in *** A total of 140 liver biopsies from treatment-naïve cases with CHB infection were included in this *** diagnosis,all patients were treated with entecavir(0.5 mg)and followed up at three-month *** percentage of immunohistochemical HBsAg(p-HBsAg)expression in the liver was determined in whole tissue sections of biopsies from each case by image *** immunohistochemical staining pattern was also evaluated separately according to 3 different previously defined *** A positive correlation between p-HBsAg and serum levels of hepatitis B virus(HBV)DNA and HBsAg was observed(P<0.001).The p-HBsAg value was significantly higher in younger patients than in older *** the groups were categorized according to the hepatitis B e antigen(HBeAg)status in HBeAgpositive cases,p-HBsAg was correlated with HBV DNA,hepatitis activity index(HAI)and fibrosis scores(P<0.001).In this group,p-HBsAg and HBsAg expression patterns were also correlated with the viral response(VR)and the serological response(SR)(P<0.001).Multivariate analysis revealed that p-HBsAg was an independent predictor of eit

关键词： Hepatitis B Hepatitis B surface antigens Hepatitis B e antigens Fibrosis Immunohistochemistry Image analysis

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Identification and antioxidant activity of natural functional microstructures produced with various neutral chemicals and bovine serum albumin

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Food Bioscience 2022年第5期49卷 833-841页

作者： zeynep Ziyade¨Ozacar Atheer Atiro˘glu Vesen Atiro˘glu Nuray Güy Mahmut¨Ozacar Sakarya University Science&Arts FacultyDepartment of Chemistry54187SakaryaTurkey Sakarya University BiomedicalMagnetic and Semiconductor Materials Application and Research Center(BIMAS-RC)54187SakaryaTurkey Sakarya University BiomaterialsEnergyPhotocatalysisEnzymeTechnologyNan&Advanced MaterialsAdditive ManufacturingEnvironmental Applications and Sustainability Research&Development Group(BIOENAMS R&D Group)54187SakaryaTurkey

Stress-related conditions are a product of modern practices,and different treatments,such as meditation,yoga,and antistress medications,are utilized to reduce disincentive stress *** medicines are rescued humanity from a variety of illnesses,and they could be able to provide adequate responses to stress-induced *** this article,bovine serum albumin(BSA)microparticles comprising germinated seeds wheat-ginger,germinated seeds wheat-rosemary loaded BSA microparticles(GSW-ROS-MPs),germinated seeds wheat-asafoetida loaded BSA microparticles(GSW-ASA-MPs),ginger-rosemary loaded BSA microparticles(GIN-ROS-MPs),resveratrol-ginger microspheres(RES-GIN-MSs),resveratrol-rosemary microspheres(RES-ROS-MSs),resveratrol-asafoetida microspheres(RES-ASA-MSs),and asafoetida-ginger microspheres(ASA-GIN-MSs)were enhanced to improve the biopharmaceutical features of the neutral *** all MPs kinds synthesized had a so-called spherical morphology,the microspheres were found to be non-porous and with a smooth spherical surface *** antiradical activities were *** activities of RES-ASA-MSs and GIN-ROS-MPs were found to be ***,BSA-containing RES-ASA-MSs and GIN-ROS-MPs can be alternative systems for improving the features of these compounds and administering them therapeutically *** conclusion,all prepared compounds in the present study displayed substantial in vitro free radical-scavenging capability which was dose dependent and be applicate in oxidative stress-based diseases.

关键词： Microstructures Asafoetida Rosemary Resveratrol and ginger

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Neuroprotective effect of systemic and/or intravitreal rosuvastatin administration in rat glaucoma model

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International Journal of Ophthalmology(English edition) 2016年第3期9卷 340-347页

作者： Metin Unlu zeynep Aktas Pinar Uyar Gocun Sevil Ozger Ilhan Murat Hasanreisoglu Berati Hasanreisoglu Department of Ophthalmology Erciyes University Schoolof Medicine Kayseri 38039 Turkey Department of Ophthalmology Gazi University School of Medicine Besevler Ankara 06560 Turkey Department of Pathology Gazi University School of Medicine Besevler Ankara 06560 Turkey Department of Pharmacology Gazi University School of Medicine Besevler Ankara 06560 Turkey

AIM： To evaluate the neuroprotective effect of rosuvastatin, in a rat experimental glaucoma model. METHODS： Ocular hypertension was induced in right eyes of Long-Evans rats （n=30） by cauterization of three episcleral veins. Left eyes were defined as controls. Rats were divided into five groups： oral rosuvastatin, intravitreal rosuvastatin, oral ＋intravitreal rosuvastatin, intravitreal sham and glaucoma without intervention. Rats were sacrificed at day 14. Retinal ganglion cell （RGC） number was assessed by histopathological analysis. Terminal deoxynucleotidyl transferase-mediated dUTP-nick end-labeling （TUNEL） staining and the expression of glial fibrillary acidic protein （GFAP） in RGC layer was also examined. RESULTS： A significant intraocular pressure （lOP） elevation was seen （P=0.002）. Elevated lOP resulted in a significant decrease in number of RGCs in group 5 （70.33 ±8.2 cells/mm2） when compared with controls （92.50 ±13.72 cells/mm2; P=0.03）. The RGC number in group 1 （92.4±7.3 cells/mm2） was significantly higher than group 5 （ρ=0.03）. The numbers of RGC in groups 2, 3 （57.3±8.2 cells/mm2, 60.5±12.9 cells/mm2） were comparable with that of group 5 （ρ=0.18 and P=0.31）. The apoptosis rates with TUNEL staining were also parallel to RGC number. Animals with experimentally induced glaucoma showed an increase in retinal GFAP immunoreacUvity. CONCLUSION： Decrease in RGC loss and apoptosis suggest the neuroprotective potential of oral rosuvastatin treatment in a rat model of ocular hypertension. Howeverintravitreal rosuvastatin showed a contrary effect and further studies are required.

关键词： KEYWORDS: rat glaucoma model retinal ganglion cellnumber rosuvastatin neuroprotection

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