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虹桥花瓣楼

建筑实践 2019年第6期 34-37页

作者： Jacob van Rijs Wenchian Shi Aser Giménez Ortega Daehee Suk John Tsang Antonio Luca Coco Qing Chen Jose Ignacio Velasco Martin Wing Yun zeying song Karl Nyqvist Ke Zhang Wei Zhu Michael Zhang Jaap Baselmans Jing Zhang Sharon Sin Johan Bergstrom 申强 MVRDV

MVRDV总体规划中的第一座建筑,花瓣形的标志性建筑,提供1.5万m2甲级写字楼,结合租赁灵活强大的身份。另外4.5万m2的地块在上海的虹桥机场边缘将包括共9栋MVRDV设计的办公楼及凯达环球设计的地下街。由MVRDV为协信地产集团设计的花瓣楼... 详细信息

MVRDV总体规划中的第一座建筑,花瓣形的标志性建筑,提供1.5万m2甲级写字楼,结合租赁灵活强大的身份。另外4.5万m2的地块在上海的虹桥机场边缘将包括共9栋MVRDV设计的办公楼及凯达环球设计的地下街。由MVRDV为协信地产集团设计的花瓣楼获得三星级绿色大厦标签,拥有在中国最好的节能等

关键词： MVRDV Jacob 零售空间 Michael

One droplet reaction for synthesis of multi-sized nanoparticles

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Nano Research 2023年第4期16卷 5850-5856页

作者： Bingda Chen Feifei Qin Meng Su Daixi Xie zeying Zhang Qi Pan Huadong Wang Xu Yang Sisi Chen Jingwei Huang Dominique Derome Jan Carmeliet Yanlin song Key Laboratory of Green Printing Institute of ChemistryChinese Academy of SciencesBeijing Engineering Research Center of Nanomaterials for Green Printing TechnologyBeijing National Laboratory for Molecular Sciences(BNLMS)Beijing 100190China University of Chinese Academy of Sciences Beijing 100049China Chair of Building Physics Department of Mechanical and Process EngineeringETH Zürich(Swiss Federal Institute of Technology in Zürich)Zürich 8092Switzerland Department of Civil and Building Engineering Universitéde SherbrookeSherbrooke QC J1K 2R1Canada

Reaction kinetics of nanoparticles can be controlled by tuning the Peclet number(Pe)as it is an essential parameter in synthesis of multi-sized ***,we propose to implement a self-driven multi-dimension microchannels reactor(MMR)for the one droplet synthesis of multi-sized *** carefully controlling the Pe at the gas-liquid interface,the newly formed seed crystals selectively accumulate and grow to a specific *** the combination of microchannels of different widths and lengths,one droplet reaction in the same apparatus achieves the synchronous synthesis of diverse *** enables precise control of nanoparticle diameter at 5 nm precision in the range of 10-110 *** use of MMR can be extended to the synthesis of uniform Ag,Au,Pt,and Pd nanoparticles,opening towards the production and engineering of nanostructured *** approach gives the chance to regulate the accumulation probability for precise synthesis of nanoparticles with different diameters.

关键词： gas-liquid interface accumulation effect one droplet reaction multi-sized nanoparticles

Nanoliposome-encapsulated caged-GABA for modulating neural electrophysiological activity with simultaneous detection by microelectrode arrays

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Nano Research 2020年第6期13卷 1756-1763页

作者： Jingyu Xie Yilin song Yuchuan Dai Ziyue Li Fei Gao Xuanyu Li Guihua Xiao Yu Zhang Hao Wang zeying Lu Xingyu Jiang Wenfu Zheng Xinxia Cai State Key Laboratory of Transducer Technology Institute of ElectronicsChinese Academy of SciencesBeijing100190China University of Chinese Academy of Sciences Beijing100049China Beijing Engineering Research Center for BioNanotechnology CAS Key Laboratory for Biological Effects of Nanomaterials and NanosafetyCAS Center for Excellence in NanoscienceNational Center for NanoScience and TechnologyBeijing100190China Department of Biomedical Engineering Southern University of Science and TechnologyShenzhen518055China

Effective and precise neural modulation with real-time detection in the brain is of great importance and represents a significant ***-encapsulated light-sensitive compounds have excellent characteristics such as high temporal and spatial resolution,delayed drug clearance,and restricted drug biodistribution for neural *** this study,we developed a nanoliposome-based delivery system for ruthenium-based caged GABA compounds(Nanolipo-Ru)to modulate neural activity and allow for real-time monitoring using the microelectrode arrays(MEAs).The Nanolipo-Ru nanoparticles had an average size of 134.10±4.30 nm and exhibited excellent stability for seven *** the in vivo experiment in the rat,release of GABA by Nanolipo-Ru under blue light illumination resulted in an average firing rate reduction in interneurons and pyramidal neurons in the same brain region of 79.4%and 81.6%,***,the average power of local field potentials in the 0–15 Hz range degraded from 4.34 to 0.85 *** addition,the Nanolipo-Ru nanoparticles have the potential to provide more flexible timing of modulation than unencapsulated RuBi-GABA in the *** results indicated that Nanolipo-Ru could be an effective platform for regulating neuronal ***,nanoliposomes with appropriate modifications would render promising utilities for targeting of specific types of neurons in the future.

关键词： neural modulation nanoliposome microelectrode array light-sensitive drug

Transpiration-inspired Capillary for Synchronous Synthesis and Patterning of Silver Nanoparticles

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Chemical Research in Chinese Universities 2023年第1期39卷 133-138页

作者： CHEN Bingda ZHANG Zelong SU Meng QIN Feifej PAN Qi XIE Daixi YANG Xu ZHANG Kun ZHANG zeying XIE Hongfei CARMELIET Jan song Yanlin Key Laboratory of Green Printing Institute of ChemistryChinese Academy of SciencesBeijing Engineering Research Center of Nanomaterials for Green Printing TechnologyBeijing National Laboratory for Molecular Sciences(BNLMS)Beijing100190P.R.China University of Chinese Academy of Sciences Beijing100049P.R.China Institute of Extreme Mechanics and School of Aeronautics Northwestern Polytechnical UniversityXi’an710072P.R.China Chair of Building Physics Department of Mechanical and Process EngineeringETH ZürichZürich8092Switzerland

Traditional synthesis strategy of nanomaterials with complicated process and high cost limits their ***,we propose a facile process for the synchronous synthesis and patterning of silver nanoparticles(Ag NPs)through the self-driven microchannel reactor with the capillary effect inspired by *** evaporation contributes to capillary and accumulation effects in the *** silver reactant-containing droplets can be spontaneously divided and distributed in multiple microchannels during the whole fabrication process by the capillary *** newly formed Ag NPs at the gas-liquid interface can be assembled on both sides of the microchannels by the accumulation *** capillary effect decreases the disturbances,which ensures the uniformity of the *** the combination of microchannels with different widths,various Ag NPs-assembled patterns with stable electrical properties are *** efficient strategy with a simple fabrication procedure is towards the technological engineering of nanoscale architected materials.

关键词： Transpiration Capillary effect Droplet manipulation Nanoparticle Patterning

Smartphone-based rapid and visual pathological diagnosis of glioma using perovskite probes

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InfoMat 2023年第11期5卷 40-48页

作者： Dongdong Wu Jimei Chi Junzhen Fan Lijun Cheng Xuning Wang Xu Yang Meng Zhang Zewei Lian Zengqi Huang Huadong Wang Hongfei Xie Sisi Chen Qi Pan zeying Zhang Bingda Chen Guochen Sun Bainan Xu Meng Su Yanlin song Department of Neurosurgery The First Medical CentreChinese PLA General Hospital BeijingBeijingthe People's Republic of China Medical School of Chinese PLA Beijingthe People's Republic of China Key Laboratory of Green Printing CAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of Sciences(ICCAS)Beijing Engineering Research Center of Nanomaterials for Green Printing TechnologyBeijing National Laboratory for Molecular Sciences(BNLMS)Beijingthe People's Republic of China University of Chinese Academy of Sciences Beijingthe People's Republic of China Department of Pathology Third Medical CenterChinese PLA General HospitalBeijingthe People's Republic of China Department of General Surgery The Air Force Hospital of Northern Theater PLAShenyangthe People's Republic of China Department of Neurosurgery The Second Hospital of Southern District of Chinese NavySanyathe People's Republic of China

Histopathology plays a great role in diagnosing various diseases,which is considered as a golden standard for tumor *** tissue constituents must be stained by visible labels for microscopic analysis by medical ***,this process is time-consuming,labor-intensive,and expensive,which requires rapid pathological approaches for diagnosis in the operating ***,we present an easy-to-process and high-performance perovskite biological probes for rapid and visual pathological diagnosis of *** quantum dots can be encapsulated by the copolymer into nanocrystals(PNCs)with a diameter of 100 nm,which is modified with chlorotoxin to achieve the specific recognition of *** from the super photoluminescence quantum yield(above 93%)of EVA@PNCs aqueous solution,the glioma can be clearly imaged and captured via a smartphone under the excitation of a handheld UV *** demonstrate the visualization and efficiency of PNC probes,different malignant grades of brain tumor sections can be distinguished in no more than 5 *** strategy provides a general auxiliary diagnosis platform for achieving the histopathology analysis near the operating bed,which is currently not feasible with standard histochemical staining methods.

关键词： glioma pathological diagnosis perovskite nanocrystal smartphone-based imaging

基于纳米光子技术检测SARS-CoV-2研究进展

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化学学报 2022年第1期80卷 80-88页

作者：杨旭张泽英苏萌宋延林中国科学院化学研究所绿色印刷重点实验室北京100190 中国科学院大学北京100049

新型冠状病毒(SARS-CoV-2)的大规模爆发导致全球性大面积人员感染甚至死亡,严重影响了人们的正常生活.全球化贸易和便捷交通极大加速了疫情的传播速度,使疫情防控困难重重.因此,快速准确地诊断感染者和筛查无症状感染者有重要意义.目前... 详细信息

新型冠状病毒(SARS-CoV-2)的大规模爆发导致全球性大面积人员感染甚至死亡,严重影响了人们的正常生活.全球化贸易和便捷交通极大加速了疫情的传播速度,使疫情防控困难重重.因此,快速准确地诊断感染者和筛查无症状感染者有重要意义.目前使用最广泛的SARS-CoV-2检测方法是逆转录聚合酶链式反应(Reverse Transcription Polymerase Chain Reaction, RT-PCR),但是存在样品储运繁琐、检测步骤复杂等问题,需要专业人员和设备,难以满足疫情常态化形势下快速、简便、高效、大规模检测的要求.近年来,随着纳米光子学的快速发展和纳米制备技术的不断完善,基于纳米光子学技术检测生物标志物的研究已成为新的研究热点.最新研究的利用纳米光子结构检测生物标志物新方法,包括表面等离子共振(Surface Plasmon Resonance,SPR)、表面增强拉曼散射(Surface Enhanced Raman Scattering, SERS)、回音壁模式(Whispering Gallery Mode, WGM)与比色法,特异性强、检测速度快、简单高效.这些检测技术为高灵敏快速生物检测提供了新的平台.本综述对近年来发展的纳米光子学生物检测技术进行了总结与概述,阐述了纳米光子学检测生物标志物的机制,并分析其用于SARS-CoV-2检测的可能性.针对目前纳米光子结构制造困难的问题,提出了利用纳米绿色印刷微纳制造技术大面积制备纳米光子结构的新思路,为实现疫情的精准有效防控提供理论和技术基础.

关键词：纳米光子学生物标志物检测 SARS-CoV-2 纳米绿色印刷

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A fluid-guided printing strategy for patterning high refractive index photonic microarrays

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Science Bulletin 2021年第3期66卷 250-256,M0004页

作者： Meng Su Yali Sun Bingda Chen zeying Zhang Xu Yang Sisi Chen Qi Pan Dmitry Zuev Pavel Belov Yanlin song Key Laboratory of Green Printing CAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of Sciences(ICCAS)Beijing Engineering Research Center of Nanomaterials for Green Printing TechnologyBeijing National Laboratory for Molecular Sciences(BNLMS)Beijing 100190China Department of Physics and Engineering ITMO UniversitySaint Petersburg 197101Russia University of Chinese Academy of Sciences Beijing 100049China

High refractive index(HRI,n>1.8)photonic structures offer strong light confinement and refractive efficiencies,cover the entire visible spectrum and can be tuned by designing geometric arrayed ***,its practical applications are still hindered by the applicability and material limitation of lithography-based micro/nano fabrication ***,we demonstrate a fluid-guided printing process for preparing HRI selenium *** microstructured flexible template is replicated from the diced silicon wafer without any lithography-based *** heated above the glass transition temperature,the flow characteristics of selenium endows the structure downsizing and orientation patterning between the target substrate and the *** 10 times narrowing selenium microarrays(1.9μm width)are patterned from the non-lithography template(18μm width).HRI selenium microarrays offer high refractive efficiencies and strong optical confinement abilities,which achieve angledependent structurally coloration and ***,the color difference can be recognized under the one degree distinction of the angle between incident and refracted *** printing platform will facilitate HRI optical metasurfaces in a variety of applications,ranging from photonic sensor,polarization modulation to light manipulation.

关键词： Printing High refractive index Microarray Photonic Miniature

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Macrophage-secreted exosomal miR-29a promotes endothelial cell migration and tube formation in epithelial ovarian cancer

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Macrophage-secreted exosomal miR-29a promotes endothelial ce...

2018年浙江省妇科肿瘤学学术年会暨温台妇产科年会

作者： Xiang Ying zeying Chai Wei Zhou Kai Wang Liya Ye Baoping song Lingzhi Zheng Department of Gynecology Taizhou Hospital of Zhejiang ProvinceWenzhou Medical University

The Objective of the present study was to investigate the mechanisms underlying exosome secretion from tumor-associated macrophage cells(TAMs),which had separated from ascites of epithelial ovarian cancer(EOC)cells and may promote the angiogenesis of endothelial *** were isolated from TAMs that had separated from ascites of EOC cells;they were identified by transmission electron *** were analyzed using allophycocyanin-labeled anti-CD206 and phycoerythrin-labeled *** umbilical vein endothelial cells(HUVECs) were cultured with exosomes and following 24 h,the HUVECs were stained with PHK67 and DAPI prior to visualization using a fluorescent *** co-culture for 24 h,TAM secreted exosomes demonstrated an efficient uptake into *** order to investigate whether micro(mi)RNAs secreted from tumor cells and transferred into endothelial cells were functional in the recipient cells,the effects on HUVECS of the exosomal miRNAs derived from TAMs were ***,the present study separated TAMs from the ascites of EOC *** TAMs were cultured for 48 h and subsequently the cell supernatant was collected prior to isolation of the exosomes from the cell supernatant,using the total exosome isolation kit..Following co-culture for24 h,an efficient uptake of exosomes secreted from TAMs into HUVECs was *** to co-culture for24 h,in the exosome group,the migration and tube formation of HUVECs was significantly enhanced compared with the blank control(P<0.05).A significant difference between the expression levels of hsa-miR-29 a-3 p in exosomes secreted from TAMs and HUVECs was ***-miR-29 a-3 p mimics were transfected into HUVECs,and the migration and tube formation of HUVECs was significantly enhanced compared with the blank control(P<0.05).The present study concluded that exosomes secreted from TAMs and separated from ascites of EOC demonstrated an ability to enhance endothelial cell migratio

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无标记光学传感器用于病原体即时检测

Science Bulletin 2023年第8期68卷 791-794页

作者：张泽英连泽伟苏萌宋延林 Key Laboratory of Green Printing CAS Research/Education Center for Excellence in Molecular SciencesInstitute of ChemistryChinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

Infectious pathogens such as viruses,bacteria present an unprecedented threat to human lives,economics,and social *** smallpox to influenza,severe acute respiratory syndrome,Ebola and coronavirus infections,the requirements for the detection and monitoring of pathogens are *** World Health Organization has called for developing fast.

关键词：光学传感器即时检测无标记

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