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Absorbable 3D-printed pancreaticojejunostomy device with a dual-layer drug coating for the prevention of postoperative local recurrence of pancreatic cancer

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Journal of Materials Science & Technology 2023年第23期154卷 178-188页

作者： Maoen Pan Tingting Huang zeya xu Wei Luo Yuanyuan Yang Tianhong Teng Heguang Huang Department of General Surgery Fujian Medical University Union Hospital Fuzhou China Key Laboratory of Optoelectronic Materials Chemical and Physics Chinese Academy of Sciences Fujian Institute of Research on the Structure of Matter Fuzhou China

The high local recurrence rate of pancreatic cancer after surgery is one of the important risk factors affecting patient *** traditionally used silicone tube stent is not only complicated to operate but also lacks antitumor *** purpose of this study was to develop a dual-layer drug-coated pancreaticojejunostomy *** coating consisted of two layers,an outer basic fibroblast growth factor(bFGF)coating layer and an inner nanoparticle albumin-bound paclitaxel(nab-PTX)coating layer with chitosan as the drug-carrying *** to the diffusion barrier from the outer coating,the release of nab-PTX from the inner layer was delayed and slowed *** studied the degradation rates,mechanical properties,surface morphologies,drug release kinetics,promoting the growth of fibroblasts and antitumor properties of the coated *** was found that 100 ng of bFGF and 50µg of nab-PTX were suitable drug concentrations that can effectively promote the growth of fibroblasts and inhibit pancreatic cancer *** results also confirmed that the dual-layer drug-coated pancreaticojejunostomy device showed good antitumor activity both in vitro and in vivo without obvious systemic *** addition,the device has a suitable degradation *** conclusion,this biodegradable dual-layer drug-coated pancreaticojejunostomy device can potentially inhibit the local recurrence of pancreatic cancer after surgery and promote the healing of pancreaticointestinal *** device has great potential to treat pancreatic cancer in the future.

关键词： Pancreaticojejunostomy device 3D printing Drug coating Anti-tumor effect Pancreatic cancer

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Lanthanum doped octacalcium phosphate/polylactic acid scaffold fabricated by 3D printing for bone tissue engineering

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Journal of Materials Science & Technology 2022年第23期118卷 229-242页

作者： zeya xu Bin Lin Chaoqian Zhao Yanjin Lu Tingting Huang Yan Chen Jungang Li Rongcan Wu Wenge Liu Jinxin Lin Key Laboratory of Optoelectronic Materials Chemical and Physics Fujian Institute of Research on the Structure of MatterChinese Academy of Sciences155 West Yangqiao RoadFuzhou 350002China University of Chinese Academy of Sciences Beijing 100049China Orthopedics Department Fujian Medical University Union HospitalFuzhou 350001China

Lanthanum(La)has tremendous potential in the treatment and prevention of bone diseases especially osteoporosis and metabolic ***,controlling its distribution and keeping the release of La^(3+)ions sustained and steady in the body is still a big *** this study,we prepared La-OCP powders via co-precipitation method,and further prepared La-OCP/PLA porous scaffolds by 3 D ***^(3+)was successfully introduced into the OCP crystal structure and substituted Ca^(2+)at the Ca-5 and Ca-8 *** particular,some La^(3+)ions were deposited on the crystal surface in the form of *** octacalcium phosphate(OCP,Ca_(8)H_(2)(PO_(4))_6·5 H_(2)O)crystals and nanoparticles played as the carriers for La^(3+)*** La-OCP/PLA scaffolds displayed obvious mineralization effects and sustained release of La^(3+).The scaffolds contained a uniform structure with rough micro surface topography which acted as a suitable pathway for BMSCs cells to adhere,grow and *** a certain La^(3+)concentration,the extracts from La-OCP/PLA scaffolds increased the expression of osteogenesis-related genes,thus promoting the osteogenic differentiation of ***,the extracts regulated the immune *** experiment in vivo proved that La-OCP/PLA porous scaffolds were safe and could enhance bone defect regeneration in *** findings suggest that 3 D printed La-OCP/PLA porous scaffolds have promising potentials in bone tissue engineering.

关键词： Lanthanum Octacalcium phosphate Scaffold 3D printing Bone tissue engineering Polylactic acid

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基于THUMS数字人体模型的大倾角座椅正面碰撞乘员损伤分析

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汽车技术 2024年第4期4卷 15-23页

作者：许泽亚谢金萍雷飞兵蔡娅妮比亚迪汽车工业有限公司深圳518118

基于某大倾角座椅,利用THUMS数字人体模型,研究了座椅后倾姿态正面碰撞条件下的乘员损伤特征,并讨论了乘员损伤机理。研究结果表明,相较于常规坐姿,一方面大倾角座椅后倾姿态下传统约束系统无法实现乘员的有效约束,乘员易发生下潜而造... 详细信息

基于某大倾角座椅,利用THUMS数字人体模型,研究了座椅后倾姿态正面碰撞条件下的乘员损伤特征,并讨论了乘员损伤机理。研究结果表明,相较于常规坐姿,一方面大倾角座椅后倾姿态下传统约束系统无法实现乘员的有效约束,乘员易发生下潜而造成腹部、胸部、颈部的损伤风险,另一方面由于座椅的作用,乘员脊柱受到较大的轴向加速度载荷,存在损伤风险。最后,基于乘员的损伤特征及机理,进一步讨论了后倾姿态下乘员保护策略。

关键词：乘员保护大倾角座椅数字人体模型损伤机理

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Selenium deficiency exacerbates ROS/ER stress mediated pyroptosis and ferroptosis induced by bisphenol A in chickens thymus

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Journal of Environmental Sciences 2025年第2期148卷 13-26页

作者： Kun Wang xu Shi Hongjin Lin Tong xu Shiwen xu College of Veterinary Medicine Northeast Agricultural UniversityHarbin 150030China Key Laboratory of the Provincial Education Department of Heilongjiang for Common Animal Disease Prevention and Treatment Harbin 150030China

Bisphenol A(BPA)is an industrial pollutant that can cause immune *** acts as an antioxidant,as selenium deficiency often accompanies oxidative stress,resulting in organ *** study is the first to demonstrate that BPA and/or selenium deficiency induce pyroptosis and ferroptosis-mediated thymic injury in chicken and chicken lymphoma cell(MDCC-MSB-1)via oxidative stress-induced endoplasmic reticulum(ER)*** established a broiler chicken model of BPA and/or selenium deficiency exposure and collected thymus samples as research subjects after 42 *** results demonstrated that BPA or selenium deficiency led to a decrease in antioxidant enzyme activities(T-AOC,CAT,and GSH-Px),accumulation of peroxides(H2O2 and MDA),significant upregulation of ER stress-relatedmarkers(GRP78,IER 1,PERK,EIF-2α,ATF4,and CHOP),a significant increase in iron ion levels,significant upregulation of pyroptosis-related gene(NLRP3,ASC,Caspase1,GSDMD,IL-18 and IL-1β),significantly increase ferroptosis-related genes(TFRC,COX2)and downregulate GPX4,HO-1,FTH,*** vitro experiments conducted in MDCC-MSB-1 cells confirmed the results,demonstrating that the addition of antioxidant(NAC),ER stress inhibitor(TUDCA)and pyroptosis inhibitor(Vx765)alleviated oxidative stress,endoplasmic reticulum stress,pyroptosis,and ***,this study concludes that the combined effects of oxidative stress and ER stress mediate pyroptosis and ferroptosis in chicken thymus induced by BPA exposure and selenium deficiency.

关键词： Bisphenol A Selenium deficiency ROS/ER stress Pyroptosis Ferroptosis Thymic injury

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Reducing the measurement errors in nonadiabatic holonomic quantum computers

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Science China(Physics,Mechanics & Astronomy) 2025年第1期68卷 60-66页

作者： Guo-Fu xu Department of Physics Shandong UniversityJinan 250100China

Nonadiabatic holonomic quantum computers serve as the physical platform for nonadiabatic holonomic quantum *** quantum computation has entered the noisy intermediate-scale era,building accurate intermediate-scale nonadiabatic holo-nomic quantum computers is clearly *** that measurements are the sole means of extracting information,they play an indispensable role in nonadiabatic holonomic quantum ***,developing methods to reduce measurement errors in nonadiabatic holonomic quantum computers is of great ***,while much attention has been given to the research on nonadiabatic holonomic gates,the research on reducing measurement errors in nonadiabatic holonomic quantum computers is severely *** this study,we propose a measurement error reduction method tailored for intermediate-scale nonadiabatic holonomic quantum *** reason we say this is because our method can not only reduce the measurement errors in the computer but also be useful in mitigating errors originating from nonadiabatic holonomic *** these features,our method significantly advances the construction of accurate intermediate-scale nonadiabatic holonomic quantum computers.

关键词： quantum holonomy quantum computation measurement errors

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Analysis of vibration response characteristics of subway station and superstructure with hard combination

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Earthquake Engineering and Engineering Vibration 2025年第1期24卷 271-281页

作者： Jia Jinglong xu Weiping Liu xu Wei Yong Key Laboratory of Transportation Tunnel Engineering Ministry of EducationSchool of Civil EngineeringSouthwest Jiaotong UniversityChengdu 610031China State Key Laboratory of Intelligent Geotechnics and Tunnelling Chengdu 610031China China Railway Eryuan Chongqing Survey and Design Institute Co.Ltd. Chongqing 400023China

The vibration response and noise caused by subway trains can affect the safety and comfort of *** study the dynamic response characteristics of subway stations and superstructures under train loads with a hard combination,a numerical model is developed in this *** indoor model test verified the accuracy of the numerical *** influence laws of different hard combinations,train operating speeds and modes were studied and evaluated *** results show that the frequency corresponding to the peak vibration acceleration level of each floor of the superstructure property is concentrated at 10–20 *** vibration response decreases in the high-frequency parts and increases in the lowfrequency parts with increasing distance from the ***,the factors,such as train operating speed,operating mode,and hard combination type,will affect the vibration of the *** vibration response under the reversible operation of the train is greater than that of the unidirectional *** operating speed of the train is proportional to its vibration *** vibration amplification area appears between the middle and the top of the superstructure at a higher train *** vibration acceleration level will exceed the limit value of relevant regulations,and vibration-damping measures are *** the scope of application,this study provides some suggestions for constructing subway stations and superstructures.

关键词： subway station superstructure vibration response hard combination

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Enantio-divergent C–H borylation with two different ligands from a single chiral source

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Science China Chemistry 2025年第1期68卷 226-232页

作者： Rongrong Du Senmiao xu State Key Laboratory for Oxo Synthesis and Selective Oxidation Lanzhou Institute of Chemical PhysicsChinese Academy of SciencesLanzhou 730000China College of Material Chemistry and Chemical Engineering Key Laboratory of Organosilicon Chemistry and Material TechnologyMinistry of EducationHangzhou Normal UniversityHangzhou 311121China University of Chinese Academy of Sciences Beijing 100049China

Reported here is an iridium-catalyzed enantio-divergent C(sp^(3))–H borylation ofα-gem-dimethyl groups of trifluoromethyl ketone-derived hydrazones to construct a series of acyclic all-carbon quaternary stereocenters with a high level of chiral *** different chiral bidentate boryl ligands from a common chiral source not only can switch the enantioselectivity but also are complementary in terms of the substrate scope.

关键词： asymmetric catalysis C–H borylation all-carbon quaternary stereocenters synthetic methods

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Aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders:progress of experimental models based on disease pathogenesis

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Neural Regeneration Research 2025年第2期20卷 354-365页

作者： Li xu Huiming xu Changyong Tang Department of Neurology The Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina

Neuromyelitis optica spectrum disorders are neuroinflammatory demyelinating disorders that lead to permanent visual loss and motor *** date,no effective treatment exists as the exact causative mechanism remains ***,experimental models of neuromyelitis optica spectrum disorders are essential for exploring its pathogenesis and in screening for therapeutic *** most patients with neuromyelitis optica spectrum disorders are seropositive for IgG autoantibodies against aquaporin-4,which is highly expressed on the membrane of astrocyte endfeet,most current experimental models are based on aquaporin-4-IgG that initially targets *** experimental models have successfully simulated many pathological features of neuromyelitis optica spectrum disorders,such as aquaporin-4 loss,astrocytopathy,granulocyte and macrophage infiltration,complement activation,demyelination,and neuronal loss;however,they do not fully capture the pathological process of human neuromyelitis optica spectrum *** this review,we summarize the currently known pathogenic mechanisms and the development of associated experimental models in vitro,ex vivo,and in vivo for neuromyelitis optica spectrum disorders,suggest potential pathogenic mechanisms for further investigation,and provide guidance on experimental model *** addition,this review summarizes the latest information on pathologies and therapies for neuromyelitis optica spectrum disorders based on experimental models of aquaporin-4-IgG-seropositive neuromyelitis optica spectrum disorders,offering further therapeutic targets and a theoretical basis for clinical trials.

关键词： aquaporin-4 experimental model neuromyelitis optica spectrum disorder pathogenesis

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Cu gradient design to attain high efficient solution-processed CuIn（S,Se）2 solar cells

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Journal of Energy Chemistry 2025年第2期101卷 213-222页

作者： xuejun xu Rutao Meng Yue Liu Han xu Jianpeng Li Yi Zhang Institute of Photoelectronic Thin Film Devices and Technology State Key Laboratory of Photovoltaic Materials and Cells and Engineering Research Center of Thin Film Optoelectronics Technology Ministry of Education Nankai University

Solution-processed chalcopyrite solar cells are widely regarded as a promising alternative method in reducing the cost compared with vacuum-based *** is noted that the absorber layer usually needs to be prepared under a high insert pressure（～1.6 atm） to suppress element loss or under a mild pressure but additional surface etching is needed for fabricating high efficient solar ***,a copper gradient structured precursor is proposed to prepare CuIn（S,Se）2（CISSe） film under a mild pressure（1.1 atm）.The designed gradient Cu not only promotes crystal grain growth and tailors the defects,but also avoids the surface etching of the formed CISSe film for the fabrication of high efficient solar ***,Cu gradient design decreases the conduction band offset of heterojunction,boosting the carriers transport across the p-n ***,a 13,35% efficient CISSe solar cell,comparable to the high efficient CISSe solar cell prepared by this method under high pressure or with film surface etching,is *** work provides a facile pathway to fabricate high efficient solution-processed chalcopyrite solar cell,avoiding high selenization pressure and film etching,and shows huge potential for solutionprocessed copper-based solar cells.

关键词： Band alignment Carrier transport CISSe Crystal grain growth Cu gradient Defect passivation

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Mitophagy in acute central nervous system injuries:regulatory mechanisms and therapeutic potentials

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Neural Regeneration Research 2025年第9期20卷 2437-2453页

作者： Siyi xu Junqiu Jia Rui Mao Xiang Cao Yun xu Department of Neurology Nanjing Drum Tower HospitalClinical College of Jiangsu UniversityNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalChinese Academy of Medical Science&Peking Union Medical CollegeNanjingJiangsu ProvinceChina Department of Neurology Nanjing Drum Tower HospitalAffiliated Hospital of Medical SchoolNanjing UniversityNanjingJiangsu ProvinceChina State Key Laboratory of Pharmaceutical Biotechnology and Institute of Translational Medicine for Brain Critical Diseases Nanjing UniversityNanjingJiangsu ProvinceChina Jiangsu Key Laboratory for Molecular Medicine Medical School of Nanjing UniversityNanjingJiangsu ProvinceChina Nanjing Neurology Medical Center NanjingJiangsu ProvinceChina

Acute central nervous system injuries,including ischemic stro ke,intracerebral hemorrhage,subarachnoid hemorrhage,traumatic brain injury,and spinal co rd injury,are a major global health *** optimal therapies and improving the long-term neurological functions of patients with acute central nervous system injuries are urgent *** are susceptible to damage after acute central nervous system injury,and this leads to the release of toxic levels of reactive oxygen species,which induce cell ***,a selective form of autophagy,is crucial in eliminating redundant or damaged mitochondria during these *** evidence has highlighted the significant role of mitophagy in acute central nervous system *** this review,we provide a comprehensive overview of the process,classification,and related mechanisms of *** also highlight the recent developments in research into the role of mitophagy in various acute central nervous system injuries and drug therapies that regulate *** the final section of this review,we emphasize the potential for treating these disorders by focusing on mitophagy and suggest future research paths in this area.

关键词： autophagy intracerebral hemorrhage ischemic stroke mitochondria mitochondrial biogenesis mitochondrial quality control mitophagy spinal cord injury subarachnoid hemorrhage traumatic brain injury

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