检索结果-南通市图书馆

Roles of hydroxyl and oxygen vacancy of CeO;·xH;O in Pd-catalyzed ethanol electro-oxidation

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2022年

作者： Zhenyu Li Jiefei Li Zexuan Zheng Kunhong Jiang Tianrun zheng Dongmin Wang Hang Wei Zhiming Shi Xiaotian Li Haibin Chu College of Chemistry and Chemical Engineering Inner Mongolia Engineering and Technology Research Center for Catalytic Conversion and Utilization of Carbon Resource Molecules Inner Mongolia University College of Materials Science and Engineering Jilin University College of Chemistry Jilin University State Key Laboratory of Luminescence and Applications Changchun Institute of Optics Fine Mechanics and Physics Chinese Academy of Sciences

In the field of noble metal-catalyzed alcohol electro-oxidation reaction（AOR）, huge attention is paid on the composition, size,facet, and structure of the metals, while the support engineering should also be emphasized. CeO;has been widely used as an unique support in AOR, primarily due to its abundant oxygen vacancies（Ov）. Herein, we report CeO;·xH;O nanoparticles with both massive hydroxyl groups（OH） and Ovremarkably enhance the catalytic activity and stability of Pd toward ethanol oxidation reaction（EOR）. The CO striping experiments and density functional theory（DFT） calculations suggest that OH and Ov on CeO;·xH;O surface bring about a large downshift of Pd d-band center and a significant weakening of CO absorption on Pd.Moreover, OH and Ovalso play synergic roles in the removal of toxic intermediates. Consequently, the important roles of OH and Ovof CeO;·xH;O are confirmed in Pd-catalyzed EOR. The facile CeO;·xH;O-enhanced strategy can contribute to the catalyst design for other energy conversion reactions.

关键词：

数学课堂多元对话教学模式的实践与探索——以七年级“电话计费问题”教学为例

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

科教文汇 2018年第9期 105-107页

作者：郑择选天台县螺溪中学浙江台州317200

学生是教学的主体,课堂对话是数学教学的重要环节,可以知道学生的思考过程。课堂多元对话的方式是培养学生学习能力的桥梁。该文从开展教学对话的五个途径阐述数学课堂对话的多元性,必须关注学生的问题辨析与思考过程,培养学生的创造性... 详细信息

学生是教学的主体,课堂对话是数学教学的重要环节,可以知道学生的思考过程。课堂多元对话的方式是培养学生学习能力的桥梁。该文从开展教学对话的五个途径阐述数学课堂对话的多元性,必须关注学生的问题辨析与思考过程,培养学生的创造性思维能力。

关键词：数学教学课堂对话教学模式有效性

Identifying intact N-glycopeptides from tandem mass spectrometry data using StrucGP

在线全文

学校读者我要写书评

暂无评论

Biophysics Reports 2022年第Z1期8卷 282-300页

作者： Jiechen Shen zexuan Chen Shisheng Sun College of Life Sciences Northwest University

Protein glycosylation is of great importance in many biological processes. Glycosylation has been increasingly analyzed at the intact glycopeptide level using mass spectrometry to study site-specific glycosylation changes under different physiological and pathological conditions. StrucGP is a glycan database-independent search engine for the structural interpretation of N-glycoproteins at the site-specific level. To ensure the accuracy of results, two collision energies are implemented in instrument settings for each precursor to separate fragments of peptides and glycans. In addition, the false discovery rates(FDR) of peptides and glycans as well as probabilities of detailed structures are estimated. In this protocol, the use of StrucGP is demonstrated, including environment configuration,data preprocessing as well as result inspection and visualization using our in-house software“GlycoVisualTool ”. The described workflow should be able to be performed by anyone with basic proteomic knowledge.

关键词： Protein glycosylation Glycoproteomics Mass spectrometry StrucGP Glycan structure

A Differential-Difference Hierarchy Related to the Toda Lattice and Its Inverse Scattering Transformation

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Mathematical Research with Applications 2022年第1期42卷 57-72页

作者： zexuan ZHANG Jianbing ZHANG School of Mathematics and Statistics Jiangsu Normal University

By combined power evolution laws of the spectral parameter and the initial constants of integration, a new differential-difference hierarchy is presented from the Toda spectral problem.The hierarchy contains the classic Toda lattice equation, the nonisospectral Toda lattice equation and the mixed Toda lattice equation as reduced cases. The evolution of the scattering data in the inverse scattering transform is analyzed in detail and exact soliton solutions are computed through the corresponding inverse scattering transform.

关键词： Toda lattice inverse scattering transformation soliton solution

Impact of immunization programs on 11 childhood vaccine-preventable diseases in China: 1950–2018

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

The Innovation 2021年第2期2卷 109-116页

作者： Jinhua Pan Yesheng Wang Lingsheng Cao Ying Wang Qi Zhao Shenglan Tang Wenfeng Gong Lei Guo Zhixi Liu zexuan Wen Bo zheng Weibing Wang Department of Epidemiology School of Public HealthFudan UniversityShanghai 200032China School of Public Health Key Laboratory of Public Health Safety of Ministry of EducationFudan UniversityShanghai 200032China National Immunization Program Chinese Center for Disease Control and PreventionBeijing 102206China Department of Social Medicine School of Public HealthFudan UniversityShanghai 200032China Duke Global Health Institute Duke UniversityDurhamNC 27708USA Bill and Melinda Gates Foundation SeattleWA 98109USA These authors contributed equally

To evaluate the achievements of China’s immunization program between 1950 and 2018,we chose 11 vaccine-preventable diseases(VPDs)as representative notifiable diseases and used annual surveillance data obtained between 1950 and 2018 to derive disease incidence and mortality trends.Quasi-Poisson and polynomial regression models were used to estimate the impacts of specific vaccine programs,and life-table methods were used to calculate the loss of life expectancy,years of life lost,and loss of working years.The total notification number for the 11 VPDs was 211,866,000 from 1950 to 2018.The greatest number occurred in 1959,with a total incidence of 1,723 per million persons.From 1978 to 2018,a substantial decline was observed in the incidence of major infectious diseases.The incidence of pertussis fell 98%from 126.35 to 1.58 per million,and the incidences of measles,meningococcal meningitis,and Japanese encephalitis fell 99%,99%,and 98%,respectively.The regression models showed that most of the 11 diseases exhibited dramatic declines in morbidity after their integration into the Expanded Program on Immunization(EPI),while varicella and paratyphoid fever,which were not integrated into the EPI,showed increased morbidity.From 1978 to 2018,the total life expectancy for the 11 VPDs increased by 0.79 years,and similar results were obtained for different age groups.China has had great success in controlling VPDs in recent decades,and improving vaccination coverage is a key aspect of controlling VPDs in China.

关键词： China vaccine-preventable diseases morbidity mortality immunization

早发型原发性干燥综合征患者疾病严重程度与血清炎症因子表达水平的相关性研究

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

中外医学研究 2023年第14期21卷 67-71页

作者：郑可弟周泽绚王育凯汕头大学医学院广东汕头515000 汕头市中心医院

目的:探讨早发型原发性干燥综合征患者疾病严重程度与血清炎症因子表达水平的相关性。方法:选择2019年9月—2022年9月汕头市中心医院收治的60例早发型原发性干燥综合征患者纳入观察组,根据患者疾病严重程度,将稳定期的早发型原发性干燥... 详细信息

目的:探讨早发型原发性干燥综合征患者疾病严重程度与血清炎症因子表达水平的相关性。方法:选择2019年9月—2022年9月汕头市中心医院收治的60例早发型原发性干燥综合征患者纳入观察组,根据患者疾病严重程度,将稳定期的早发型原发性干燥综合征患者纳入观察A组(n=30),活动期的早发型原发性干燥综合征患者纳入观察B组(n=30);另将同期于本院进行身体健康检查的60例健康人员纳入对照组。比较观察组与对照组血清炎症因子水平;比较观察A组与观察组B组血清炎症因子水平;分析血清炎症因子水平与患者疾病严重程度的相关性。结果:观察组肿瘤坏死因子-α(TNF-α)、白细胞介素-6(IL-6)及白细胞介素-17(IL-17)水平均高于对照组,白细胞介素-10(IL-10)水平低于对照组,差异有统计学意义(P<0.05)。观察B组TNF-α、IL-6、IL-17水平及干燥综合征疾病损伤评分(SSDDI)评分均高于观察A组,IL-10水平低于观察A组,差异有统计学意义(P<0.05)。血清炎症指标中的TNF-α、IL-6及IL-17均与早发型原发性干燥综合征患者疾病严重程度呈正相关(P<0.05);IL-10与患者疾病严重程度呈负相关(P<0.05)。结论:血清炎症因子中的TNF-α、IL-6、IL-10及IL-17均与早发型原发性干燥综合征患者的疾病严重程度相关,临床针对上述炎症因子水平检测可评估患者疾病严重程度和治疗效果,为后续相关治疗方案的制定及评估预后提供数据参考。

关键词：早发型原发性干燥综合征疾病严重程度血清炎症因子相关性研究

On the spring stratospheric final warming in CMIP5 and CMIP6 models

在线全文

学校读者我要写书评

暂无评论

Science China Earth Sciences 2023年第1期66卷 129-145页

作者： Jinggao HU zexuan LIU Haiming XU Rongcai REN Dachao JIN Key Laboratory of Meteorological Disaster Ministry of Education(KLME)Joint International Research Laboratory of Climate and Environment Change(ILCEC)Collaborative Innovation Center on Forecast and Evaluation of Meteorological Disasters(CIC-FEMD)Nanjing University of Information Science and TechnologyNanjing 210044China State Key Laboratory of Numerical Modeling for Atmospheric Sciences and Geophysical Fluid Dynamics(LASG) Institute of Atmospheric PhysicsChinese Academy of SciencesBeijing 100029China

This study evaluates the performance in simulating the stratospheric final warming events(SFWs)that lead to the final collapse of the stratospheric polar vortex in spring in both Southern and Northern Hemispheres(SH and NH,respectively)based on the historical simulations provided by the Coupled Model Intercomparison Project Phases 5 and 6(CMIP5 and CMIP6,respectively).Overall,CMIP5 and CMIP6 models can reproduce the main characteristics of the occurrence of SFWs.However,the SFW onset date(SFWOD)is 7 and 9 days later than in observations in the SH and NH,respectively.Moreover,the intensity of SFWs in models is 50%to 70%of that in observations.Compared with CMIP5 models,CMIP6 models have an ameliorated capability to simulate NH SFWs.However,this improvement does not manifest as significantly earlier SFW onset,but as more intense stratospheric planetary wave activities before the SFWand as a larger interannual variability of the SFWOD.By contrast,in the SH,the capability of CMIP6 models is roughly unchanged,even deteriorated in the simulation of SFWOD and stratospheric planetary wave activities before the SFW onset.The performance of CMIP6 high-top models is better than that of lowtop models.Specifically,in the NH,high-top models are considerably improved in terms of intensity of circumpolar zonal wind around the SFWOD and stratospheric planetary wave activities before the SFW onset.In the SH,high-top models show fairly earlier SFWOD by 11 days,which is closer to observations.

关键词： Stratospheric final warming events CMIP5 and CMIP6 models Historical simulation Southern and Northern Hemispheres

Epigenetic combined with transcriptomic analysis of the m6A methylome after spared nerve injury-induced neuropathic pain in mice

在线全文

学校读者我要写书评

暂无评论

Neural Regeneration Research 2023年第11期18卷 2545-2552页

作者： Fanning Zeng Jun Cao zexuan Hong Yitian Lu Zaisheng Qin Tao Tao Department of Anesthesiology Nanfang HospitalSouthern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Anesthesiology Central People’s Hospital of ZhanjiangZhanjiangGuangdong ProvinceChina Department of Anesthesiology Shenzhen Maternity&Child Healthcare HospitalSouthern Medical UniversityShenzhenGuangdong ProvinceChina

Epigenetic changes in the spinal cord play a key role in the initiation and maintenance of nerve injury-induced neuro pathic pain.N6-methyladenosine(m6A)is one of the most abundant internal RNA modifications and plays an essential function in gene regulation in many diseases.However,the global m6A modification status of mRNA in the spinal cord at different stages after neuropathic pain is unknown.In this study,we established a neuropathic pain model in mice by preserving the complete sural nerve and only damaging the common peroneal nerve.High-throughput methylated RNA immunoprecipitation sequencing res ults showed that after spared nerve injury,there were 55 m6A methylated and diffe rentially expressed genes in the spinal cord.Gene Ontology and Kyoto Encyclopedia of Genes and Genomes pathway results showed that m6A modification triggered inflammatory responses and apoptotic processes in the early stages after spared nerve injury.Over time,the diffe rential gene function at postoperative day 7 was enriched in "positive regulation of neurogenesis" and "positive regulation of neural precursor cell prolife ration." These functions suggested that altered synaptic morphological plasticity was a turning point in neuropathic pain formation and maintenance.Results at postoperative day 14 suggested that the persistence of neuropathic pain might be from lipid metabolic processes,such as "very-low-density lipoprotein particle clearance," "negative regulation of choleste rol transport" and "membrane lipid catabolic process." We detected the expression of m6A enzymes and found elevated mRNA expression of Ythdf2 and Ythdf3 after spared nerve injury modeling.We speculate that m6A reader enzymes also have an important role in neuropathic pain.These results provide a global landscape of mRNA m6A modifications in the spinal cord in the spared nerve injury model at diffe rent stages after injury.

关键词： epigenetic m6A reader m6A MeRIP-Seq Nlrp1b neuropathic pain RNA methylation spared nerve injury Ythdf2

在线全文

学校读者我要写书评

暂无评论

双路离心式喷嘴液膜形态的实验研究

北京工业大学学报 2020年第5期46卷 431-439页

作者：刘赵淼郑会龙林家源李泽轩北京工业大学机械工程与应用电子技术学院北京100124

借助高速运动分析系统对不同工况条件下双路离心式喷嘴液膜形态进行深入研究,重点分析了主、副油路单独供油与同时供油时液膜的形成与破碎机理.结果表明,副油路液膜形成过程分为射流、成膜、展开3个阶段,主油路液膜形成过程为聚集、成... 详细信息

借助高速运动分析系统对不同工况条件下双路离心式喷嘴液膜形态进行深入研究,重点分析了主、副油路单独供油与同时供油时液膜的形成与破碎机理.结果表明,副油路液膜形成过程分为射流、成膜、展开3个阶段,主油路液膜形成过程为聚集、成膜、展开3个阶段.副油路介质流动会提升主油路开启时主油路介质的雾化效果.主、副油路液膜的破碎分为初级破碎与二级破碎2个过程,其中主油路的液膜的初级破碎可按是否有孔洞形成分为2类.副油路液膜存在周期性摆动现象,摆动过程会使得液膜破碎长度减小,雾化效果提升.随着背压差的增加,液膜摆动时长占振动周期的百分比增加,雾化效果提升.研究结果有助于揭示双路离心式喷嘴的流动机理并提供设计指导.

关键词：双路离心式喷嘴液膜形态液膜形成液膜破碎破碎过程雾化机理