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Surface photodynamic ion sterilization of ITO-Cu_(2)O/ZnO preventing touch infection

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Journal of Materials Science & Technology 2022年第27期122卷 10-19页

作者： zexin liu Xiangmei liu Zhenduo Cui Yufeng Zheng Zhaoyang Li Yanqin Liang Xubo Yuan Shengli Zhu Shuilin Wu School of Materials Science&Engineering the Key Laboratory of Advanced Ceramics and Machining Technology by the Ministry of Education of ChinaTianjin UniversityTianjin 300072China School of Life Science and Health Engineering Hebei University of TechnologyTianjin 300401China School of Materials Science&Engineering Peking UniversityBeijing 100871China

Pathogenic microbial infections are threatening the people’s health and even *** most common channel of infections can be caused by skin contact,especially hand touching facilities such as touching *** this work,Cu_(2)O covered with ZnO nanofilm was prepared on the surface of indium tin oxide conductive glass by electrodeposition and the followed atomic layer deposition *** composite coating had a light transmittance of 71.5%,which met the light transmission needs of touch screen *** spin resonance spectra showed that composite materials can generate more reactive oxygen species(ROS)than a single component under solar light *** was because a p-n junction with a built-in electric field was formed at the interface after Cu_(2)O contacting with *** the process of photocatalysis,photogenerated electrons and holes migrated at the interface driven by the built-in electric field,which promoted the separation of *** antibacterial rate against Staphylococcus aureus reached 92.5%after 3 min of light irradiation with simulated sunlight due to the synergy of ROS and Cu ions,Zn ***,this work may provide a potential method for antibacterial application of preventing hand touch infections.

关键词： Antibacterial Cu_(2)O ZnO Contact infection Photodynamic ion sterilization

Fabrication of super-elastic graphene aerogels by ambient pressure drying and application to adsorption of oils

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Chinese Journal of Chemical Engineering 2022年第7期35卷 89-97页

作者： Xinxin Zhao Wenlong Xu Shuang Chen Huie liu Xiaofei Yan Yan Bao zexin liu Fan Yang Huan Zhang Ping Yu State Key Laboratory of Heavy Oil Processing China University of Petroleum(Huadong)Qingdao 266580China Qingdao Institute of Bioenergy and Bioprocess Technology Chinese Academy of SciencesQingdao 266101China

Three-dimensional graphene-based aerogels have promising applications in oil adsorption and environmental ***,current research of graphene-based aerogels is often hindered by high preparation cost,poor mechanical properties and low recycling ***,superelastic graphene aerogel(SGA)was prepared through one-step freezing and twice hydrothermal reduction followed by drying under ambient *** simple atmospheric drying provides a possibility for large-scale preparation of high performance graphene-based *** prepared SGA not only has the ability of highly repeatable compression rebound,but also exhibits excellent oil adsorption *** the overall performance of SGA is better than most of graphenebased aerogels prepared by freeze *** the SGA was cyclically compressed with 70%strain for 300 times,it can return to the original shape and height *** retained about 90%of the initial adsorption capacity after 50 cycles of adsorption and compression regeneration for cyclohexane.

关键词： Graphene aerogels Super-elastic Ambient pressure drying Adsorption and regeneration of oil

Universal chimeric Fcγreceptor T cells with appropriate affinity for IgG1 antibody exhibit optimal antitumor efficacy

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Acta Pharmaceutica Sinica B 2023年第5期13卷 2071-2085页

作者： Wen Zhu Yang Wang Liangyin Lv Hui Wang Wenqiang Shi zexin liu Mingzhe Zhou Jianwei Zhu Huili Lu Engineering Research Center of Cell and Therapeutic Antibody Ministry of EducationSchool of PharmacyShanghai Jiao Tong UniversityShanghai 200240China State Key Laboratory of Genetic Engineering School of Life ScienceFudan UniversityShanghai 200433China

Developing universal CARs with improved flexible targeting and controllable activities is urgently *** several studies have suggested the potential of CD16a in tandem with monoclonal antibodies to construct universal CAR-T cells,the weak affinity between them is one of the limiting factors for ***,we systematically investigated the impact of Fcγreceptor(FcγR)affinity on CAR-T cells properties by constructing universal CARs using Fcγreceptors with different affinities for IgG1 antibodies,namely CD16a,CD32a,and *** demonstrated that the activities of these universal CAR-T cells on tumor cells could be redirected and regulated by IgG1 *** xenografted mice,64CAR chimeric Jurkat cells with the highest affinity showed significant antitumor effects in combination with herceptin in the HER2 low expression U251 MG ***,in the CD20 high expression Raji model,64CAR caused excessive activation of CAR-T cells,which resulted in cytokine release syndrome(CRS)and the decline of antitumor activity,and 32CAR with a moderate affinity brought the best *** work extended the knowledge about FcγR-based universal CAR-T cells and suggested that only the FcγRCAR with an appropriate affinity can offer the optimal antitumor advantages of CAR-T cells.

关键词： Universal CAR-T cells Fcγreceptor CD16a CD32a CD64 Affinity IgG1 antibody CRS

Recent advances in two-dimensional photovoltaic devices

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Journal of Semiconductors 2024年第5期45卷 26-40页

作者： Haoyun Wang Xingyu Song zexin Li Dongyan Li Xiang Xu Yunxin Chen Pengbin liu Xing Zhou Tianyou Zhai State Key Laboratory of Materials Processing and Die&Mould Technology School of Materials Science and EngineeringHuazhong University of Science and TechnologyWuhan 430074China Research Institute of Huazhong University of Science and Technology in Shenzhen Shenzhen 518057China Optics Valley Laboratory Wuhan 430074China

Two-dimensional(2D)materials have attracted tremendous interest in view of the outstanding optoelectronic properties,showing new possibilities for future photovoltaic devices toward high performance,high specific power and *** recent years,substantial works have focused on 2D photovoltaic devices,and great progress has been ***,we present the review of recent advances in 2D photovoltaic devices,focusing on 2D-material-based Schottky junctions,homojunctions,2D−2D heterojunctions,2D−3D heterojunctions,and bulk photovoltaic effect ***,advanced strategies for improving the photovoltaic performances are demonstrated in ***,conclusions and outlooks are delivered,providing a guideline for the further development of 2D photovoltaic devices.

关键词： two-dimensional materials photovoltaic devices photodetectors solar cells heterostructures

Optimizing the power conversion processes in diluted donor/acceptor heterojunctions towards 19.4%efficiency all-polymer solar cells

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Journal of Energy Chemistry 2024年第9期96卷 345-350页

作者： Liang Wang Chen Chen Zirui Gan Chenhao liu Chuanhang Guo Weiyi Xia Wei Sun Jingchao Cheng Yuandong Sun Jing Zhou zexin Chen Dan liu Wei Li Tao Wang School of Materials Science1nd Engineering Wuhan University of TechnologyWuhan 430070HubeiChina School of Materials1nd Microelectronics Wuhan University of TechnologyWuhan 430070HubeiChina

All polymer solar cells(all-PSCs)promise mechanically-flexible and morphologically-stable organic photovoltaics and have aroused increased interests very ***,due to their disorderly conformation structures within the photoactive film,inefficient charge generation and carrier transport are observed which lead to inferior photovoltaic performance compared to smaller molecular acceptor-based ***,by diluting PM6 with a cutting-edge polymeric acceptor PY-IT and diluting PY-IT with PM6 or D18,donor-dominating or acceptor-dominating heterojunctions were *** X-ray and multiple spectrometer techniques reveal that the diluted heterojunctions receive increased structural order,translating to enhanced carrier mobility,improved exciton diffusion length,and suppressed non-radiative recombination loss during the power *** the results,the corresponding PM6+1%PY-IT/PY-IT+1%D18 and PM6+1%PY-IT/PY-IT+1%PM6 devices fabricated by layer-by-layer deposition received superior power conversion efficiency(PCE)of 19.4%and 18.8%respectively,along with enhanced operational lifetimes in air,outperforming the PCE of 17.5%in the PM6/PY-IT reference device.

关键词： All-polymer solar cells Power conversion efficiency Structural order Charge generation

Andrographolide and Its Derivative Potassium Dehydrographolide Succinate Suppress PRRSV Replication in Primary and Established Cells via Differential Mechanisms of Action

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Virologica Sinica 2021年第6期36卷 1626-1643页

作者： Lizhan Su Yarou Gao Mingxin Zhang zexin liu Qisheng Lin Lang Gong Jianying Guo Lixia Chen Tongqing An Jianxin Chen Guangdong Provincial Key Laboratory of Veterinary Pharmaceutics Development and Safety Evaluation College of Veterinary MedicineSouth China Agricultural UniversityGuangzhou 510642China Guangdong Laboratory for Lingnan Modern Agriculture College of Veterinary MedicineSouth China Agricultural UniversityGuangzhou 510642China Department of Natural Products Chemistry School of Traditional Chinese Materia MedicaKey Laboratory of Structure-Based Drug Design&DiscoveryMinistry of EducationShenyang Pharmaceutical UniversityShenyang 110016China State Key Laboratory of Veterinary Biotechnology Harbin Veterinary Research InstituteChinese Academy of Agricultural SciencesHarbin 150001China

Porcine reproductive and respiratory syndrome virus(PRRSV) continues to cause significant economic loss worldwide and remains a serious threat to the pork industry. Currently, vaccination strategies provide limited protection against PRRSV infection, and consequently, new antiviral strategies are urgently required. Andrographolide(Andro) and its derivative potassium dehydrographolide succinate(PDS) have been used clinically in China and other Asian countries as therapies for inflammation-related diseases, including bacterial and viral infections, for decades. Here, we demonstrate that Andro and PDS exhibit robust activity against PRRSV replication in Marc-145 cells and primary porcine alveolar macrophages(PAMs). The two compounds exhibited broad-spectrum inhibitory activities in vitro against clinically circulating type 2 PRRSV GD-HD, XH-GD, and NADC30-like HNhx strains in China. The EC_(50)values of Andro against three tested PRRSV strain infections in Marc-145 cells ranged from 11.7 to 15.3 lmol/L, with selectivity indexes ranging from 8.3 to10.8, while the EC_(50)values of PDS ranged from 57.1 to 85.4 lmol/L, with selectivity indexes ranging from 344 to ***, the anti-PRRSV activity of the two compounds is closely associated with their potent suppression on NFj B activation and enhanced oxidative stress induced by PRRSV infection. Further mechanistic investigations revealed that PDS, but not Andro, is able to directly interact with PRRSV particles. Taken together, our findings suggest that Andro and PDS are promising PRRSV inhibitors in vitro and deserves further in vivo studies in swine.

关键词： Porcine reproductive and respiratory syndrome virus(PRRSV) Andrographolide(Andro) Potassium dehydrographolide succinate(PDS) Inhibit NF-kB signaling pathway Oxidative stress

Cold-Induced Reprogramming of Subcutaneous White Adipose Tissue Assessed by Single-Cell and Single-Nucleus RNA Sequencing

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Research 2024年第1期2023卷 763-778页

作者： Qing liu Qiaoyun Long Jiayu Zhao Wenjie Wu zexin Lin Wei Sun Ping Gu Tuo Deng Kerry Martin Loomes Donghai Wu Alice P.S.Kong Jingying Zhou Alfred S.Cheng Hannah Xiaoyan Hui School of Biomedical Sciences The Chinese University of Hong KongHong KongChina Department of Pharmacology and Pharmacy The University of Hong KongHong KongChina Guangzhou Institute of Biomedicine and Health Chinese Academy of SciencesGuangzhouChina China-New Zealand Joint Laboratory on Biomedicine and Health Chinese Academy of SciencesGuangzhouChina Department of Endocrinology Jinling HospitalNanjing UniversitySchool of MedicineNanjingChina National Clinical Research Center for Metabolic Diseases and Department of Metabolism and EndocrinologyThe Second Xiangya Hospital of Central South UniversityChangshaChina Key Laboratory of Diabetes Immunology Ministry of Educationand Metabolic Syndrome Research CenterThe Second Xiangya Hospital of Central South UniversityChangshaChina Clinical Immunology Center The Second Xiangya Hospital of Central South UniversityChangshaChina School of Biological Sciences and Maurice Wilkins Centre University of AucklandAucklandNew Zealand Department of Medicine and Therapeutics The Chinese University of Hong KongHong KongChina Hong Kong Institute of Diabetes and Obesity The Chinese University of Hong KongPrince of Wales HospitalShatinHong KongChina Li Ka Shing Institute of Health Sciences The Chinese University of Hong KongPrince of Wales HospitalShatinHong KongChina

Adipose browning has demonstrated therapeutic potentials in several ***,by conducting transcriptomic profiling at the single-cell and single-nucleus resolution,we reconstituted the cellular atlas in mouse inguinal subcutaneous white adipose tissue(iWAT)at thermoneutrality or chronic cold *** major nonimmune cells within the iWAT,including adipose stem and progenitor cells(ASPCs),mature adipocytes,endothelial cells,Schwann cells,and smooth muscle cells,were recovered,allowing us to uncover an overall and detailed blueprint for transcriptomes and intercellular cross-talks and the dynamics during white adipose tissue brown *** findings also unravel the existence of subpopulations in mature adipocytes,ASPCs,and endothelial cells,as well as new insights on their interconversion and reprogramming in response to *** adipocyte subpopulation competent of major histocompatibility complex class Ⅱ(MHCⅡ)antigen presentation is ***,a subcluster of ASPC with CD74 expression was identified as the precursor of this MHCⅡ^(+)*** adipocytes are transdifferented from preexisting lipid generating adipocytes,which exhibit developmental trajectory from de novo differentiation of amphiregulin cells(Aregs).Two distinct immune-like endothelial subpopulations are present in iWAT and are responsive to *** data reveal fundamental changes during cold-evoked adipose browning.

关键词： evoked programming generating

Pharmacokinetic enhancement of oncolytic virus M1 by inhibiting JAK-STAT pathway

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2554-2566页

作者： Jingyi Tan Jiayu Zhang Cheng Hu Gongwei Wang Qianyao Ren Chaoqun Wang Jia Dan zexin Zeng Jun Hu Wenbo Zhu Jiankai Liang Jing Cai Ying liu Guangmei Yan Yuan Lin Department of Pharmacology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhou 510655China Department of Urology the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Advanced Medical Technology Center the First Affiliated Hospital-Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Key Laboratory of Human Microbiome and Elderly Chronic Diseases Ministry of EducationGuangzhou 510655China Department of Infectious Diseases the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China

Oncolytic viruses(OVs),a group of replication-competent viruses that can selectively infect and kill cancer cells while leaving healthy cells intact,are emerging as promising living anticancer *** traditional drugs composed of non-replicating compounds or biomolecules,the replicative nature of viruses confer unique pharmacokinetic properties that require further *** some pharmacokinetics studies of OVs,mechanistic insights into the connection between OV pharmacokinetics and antitumor efficacy remain ***,we characterized the pharmacokinetic profile of oncolytic virus M1(OVM)in immunocompetent mouse tumor models and identified the JAK-STAT pathway as a key modulator of OVM *** suppressing the JAK-STAT pathway,early OVM pharmacokinetics are ameliorated,leading to enhanced tumor-specific viral accumulation,increased AUC and Cmax,and improved antitumor *** than compromising antitumor immunity after JAK-STAT inhibition,the improved pharmacokinetics of OVM promotes T cell recruitment and activation in the tumor microenvironment,providing an optimal opportunity for the therapeutic outcome of immune checkpoint blockade,such as *** together,this study advances our understanding of the pharmacokinetic-pharmacodynamic relationship in OV therapy.

关键词： Pharmacokinetics Oncolytic virus JAK-STAT Anticancer

物流效率、技术创新与现代服务业发展的门槛效应研究——来自省级面板数据的分析

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宏观经济研究 2022年第7期 149-162页

作者：苏永伟刘泽鑫山西财经大学国际贸易学院

物流业是现代产业体系的重要组成部分。本文基于获取的2010—2019年31个省份的面板数据,将物流效率、技术创新作为解释变量,构建多元线性回归模型,分析两者对现代服务业发展的影响,运用门槛效应模型检验技术创新是否作为门槛变量提升物... 详细信息

物流业是现代产业体系的重要组成部分。本文基于获取的2010—2019年31个省份的面板数据,将物流效率、技术创新作为解释变量,构建多元线性回归模型,分析两者对现代服务业发展的影响,运用门槛效应模型检验技术创新是否作为门槛变量提升物流效率,进而促进现代服务业发展。结果表明,物流效率和技术创新均能显著促进现代服务业发展,且技术创新在物流效率促进现代服务业发展中存在显著的双门槛效应。为此,应在物流基础设施建设、创新驱动等方面持续发力,促进现代服务业水平提升。

关键词：物流效率技术创新现代服务业门槛效应