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基于虚拟网关的交通基础设施监测点位数据接入方法

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计算机工程 2024年第4期50卷 50-59页

作者：黄亮邹鹏曹菁菁胡健颜泽锌黄小蝶武汉理工大学水路交通控制全国重点实验室湖北武汉430063 武汉理工大学国家水运安全工程技术研究中心湖北武汉430063 武汉理工大学智能交通系统研究中心湖北武汉430063 武汉理工大学交通与物流工程学院湖北武汉430063 北京四维图新科技股份有限公司北京100093

针对交通基础设施点位监测数据来源多样、结构各异、协议不一的特点,分析具体接入需求,提出一种基于Netty架构的交通基础设施监测点位数据接入虚拟网关。阐述网关接入监测点位的配置方法及集群分配策略,定义超文本传输协议(HTTP)、传输... 详细信息

针对交通基础设施点位监测数据来源多样、结构各异、协议不一的特点,分析具体接入需求,提出一种基于Netty架构的交通基础设施监测点位数据接入虚拟网关。阐述网关接入监测点位的配置方法及集群分配策略,定义超文本传输协议(HTTP)、传输控制协议(TCP)、用户数据报协议(UDP)下的数据传输格式,设计一种数据传输消息的编码和校验机制。在真实监测数据样本增强的基础上,利用分布式消息模拟工具对虚拟网关性能进行测试,结果表明,该虚拟网关实现了多点位多协议的交通基础设施监测数据统一接入,每亿条数据接入时间、存储时间分别达到8.14 s和9.75 s,平均数据溯源时间为2.96 s,具有亿级规模点位监测数据的接入能力,可为交通基础设施数字化监测的研究和应用提供理论支撑。

关键词： Netty框架 Kafka消息队列数据接入平台化物联网数据

Molecular rotaxane shuttle-relay accelerates K^(+)/Cl^(-) symport across a lipid membrane

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Science China Chemistry 2023年第8期66卷 2300-2308页

作者： Kai Ye Zekai Zhang zexin yan Shihao Pang Huiting yang Xiaonan Sun Can Liu Linyong Zhu Cheng Lian Chunyan Bao Key Laboratory for Advanced Materials and Joint International Research Laboratory of Precision Chemistry and Molecular Engineering Feringa Nobel Prize Scientist Joint Research CenterFrontiers Science Center for Materiobiology and Dynamic ChemistryInstitute of Fine ChemicalsSchool of Chemistry and Molecular EngineeringEast China University of Science and TechnologyShanghai200237China State Key Laboratory of Bioreactor Engineering Shanghai Frontiers Science Center of Optogenetic Techniques for Cell MetabolismSchool of PharmacyEast China University of Science and TechnologyShanghai200237China

Synthetic molecules that can mediate the coupled transport of Cl^(-) with K^(+) and/or Na+across the lipid bilayers have aroused great interest due to their potential as a novel therapeutic strategy by disrupting cellular ion *** on the structural advantages of molecular rotaxanes,we herein show that two rotaxane-based transporters[2]R and[3]R induce coupled K^(+)/Cl^(-) channel transport by introducing Cl^(-) recognition sites in the thread and K^(+) binding group in the wheel,*** welldesigned molecular structures allow the insertion of unimolecular rotaxanes into the lipid bilayer,thus achieving effective ion transport by means of thermodynamically controlled movement and driven by the difference in ion concentration inside and outside the *** addition,the use of a three-component rotaxane can accelerate ion transport through a cooperative shuttlerelay mechanism in which two wheels move along the thread in the lipid membrane,thereby enabling[3]R to have higher ion transport *** work represents a major advance in the use of rotaxane molecules to accomplish more complex and effective tasks.

关键词： K^(+)/Cl^(-)symport molecular rotaxane artificial ion channel ion-pair recognition

考虑土壤时变性与频变性的接地体冲击特性研究

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电瓷避雷器 2024年第4期 106-113,121页

作者：唐力严泽鑫黄家豪郝良收熊银武蒋益黄保铭李江涛中国南方电网有限责任公司超高压输电公司天生桥局贵州兴义562400 西安交通大学电气工程学院西安710049

发生雷击故障时,接地体起到泄放故障电流的作用。由于雷电流幅值与瞬时频率均随注入时间快速变化,在雷电流作用下注流点附近土壤电气参数同时呈现时变性和频变性,忽略土壤的时变性和频变性会给接地体的冲击阻抗计算带来误差。针对土壤... 详细信息

发生雷击故障时,接地体起到泄放故障电流的作用。由于雷电流幅值与瞬时频率均随注入时间快速变化,在雷电流作用下注流点附近土壤电气参数同时呈现时变性和频变性,忽略土壤的时变性和频变性会给接地体的冲击阻抗计算带来误差。针对土壤的频变性,通过希尔伯特黄变换对雷电流作时频域分解,用Viascro-Alipio土壤频变公式对土壤电阻率、介电常数等频变参数进行修正;针对土壤的时变性,将接地体分段,计算各段随时间变化的火花放电区域等效半径,建立了考虑土壤时变性和频变性的接地体暂态模型,并与文献真型试验结果对比验证其有效性。通过模型分析土壤频变性的影响,发现土壤电气参数的频变性会使接地体的冲击阻抗有所下降,在土壤电阻率高与冲击电流陡度大的情况下,其影响更加明显。

关键词：接地体土壤时变性土壤频变性希尔伯特黄变换冲击阻抗

Pharmacokinetic enhancement of oncolytic virus M1 by inhibiting JAK-STAT pathway

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Acta Pharmaceutica Sinica B 2024年第6期14卷 2554-2566页

作者： Jingyi Tan Jiayu Zhang Cheng Hu Gongwei Wang Qianyao Ren Chaoqun Wang Jia Dan zexin Zeng Jun Hu Wenbo Zhu Jiankai Liang Jing Cai Ying Liu Guangmei yan Yuan Lin Department of Pharmacology Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China The Sixth Affiliated Hospital Sun Yat-sen UniversityGuangzhou 510655China Department of Urology the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China Advanced Medical Technology Center the First Affiliated Hospital-Zhongshan School of MedicineSun Yat-sen UniversityGuangzhou 510080China Key Laboratory of Human Microbiome and Elderly Chronic Diseases Ministry of EducationGuangzhou 510655China Department of Infectious Diseases the Third Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510630China

Oncolytic viruses(OVs),a group of replication-competent viruses that can selectively infect and kill cancer cells while leaving healthy cells intact,are emerging as promising living anticancer *** traditional drugs composed of non-replicating compounds or biomolecules,the replicative nature of viruses confer unique pharmacokinetic properties that require further *** some pharmacokinetics studies of OVs,mechanistic insights into the connection between OV pharmacokinetics and antitumor efficacy remain ***,we characterized the pharmacokinetic profile of oncolytic virus M1(OVM)in immunocompetent mouse tumor models and identified the JAK-STAT pathway as a key modulator of OVM *** suppressing the JAK-STAT pathway,early OVM pharmacokinetics are ameliorated,leading to enhanced tumor-specific viral accumulation,increased AUC and Cmax,and improved antitumor *** than compromising antitumor immunity after JAK-STAT inhibition,the improved pharmacokinetics of OVM promotes T cell recruitment and activation in the tumor microenvironment,providing an optimal opportunity for the therapeutic outcome of immune checkpoint blockade,such as *** together,this study advances our understanding of the pharmacokinetic-pharmacodynamic relationship in OV therapy.

关键词： Pharmacokinetics Oncolytic virus JAK-STAT Anticancer

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多孔硅质岩的试验研究

武汉城市建设学院学报 1997年第4期14卷 28-31页

作者： yan zexin(Dept.of Urban Construction & Management) 武汉城市建设学院城市建设与管理系

通过试验分析了多孔硅质岩的化学成分，微区结构状态，火山灰性检验以及不同细度、不同掺量的多孔硅质岩掺入到水泥中对水泥试件各龄期强度的影响．认为多孔硅质岩矿粉是一种天然活性混合材料，掺入水泥中可提高水泥的强度，在此基础上... 详细信息

通过试验分析了多孔硅质岩的化学成分，微区结构状态，火山灰性检验以及不同细度、不同掺量的多孔硅质岩掺入到水泥中对水泥试件各龄期强度的影响．认为多孔硅质岩矿粉是一种天然活性混合材料，掺入水泥中可提高水泥的强度，在此基础上可作进一步研究开发．

关键词：多孔硅质岩硅酸盐水泥活性混合材料硅质岩

Virtual reality-based cognitive-behavioural therapy for the treatment of anxiety in patients with acute myocardial infarction:a randomised clinical trial

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General Psychiatry 2024年第2期37卷 189-196页

作者： Yuanyuan Li Juan Peng Pingyuan yang Jiajun Weng yan'e Lu Jiajia Liu Shikun Xu Lihua Guan Dong Huang Qibing Wang Juying Qian zexin Zhao Yabin Wei Junbo Ge Xiao Huang Department of Psychological Medicine Zhongshan Hospital Fudan UniversityShanghaiChina Department of Cardiology Zhongshan HospitalFudan UniversityShanghai Institute of Cardiovascular DiseasesNational Clinical Research Center for Interventional MedicineShanghaiChina Department of Psychological Medicine Shanghai Geriatric Medical CenterShanghaiChina School of Nursing Peking UniversityBeijingChina Beijing Key Laboratory of Drug Dependence Research National Institute on Drug DependencePeking UniversityBeijingChina

Background The presence of mental health conditions is pervasive in patients who experienced acute myocardial infarction(AMI),significantly disrupting their *** timely and easily accessible psychological interventions using virtual reality-based cognitive-behavioural therapy(VR-CBT)could potentially improve both acute and long-term symptoms affecting their mental *** We aim to examine the effectiveness of VR-CBT on anxiety symptoms in patients with AMI who were admitted to the intensive care unit(ICU)during the acute stage of their *** In this single-blind randomised clinical trial,participants with anxiety symptoms who were admitted to the ICU due to AMI were continuously recruited from December 2022 to February *** who were Han Chinese aged 18-75 years were randomly assigned(1:1)via block randomisation to either the VR-CBT group to receive VR-CBT in addition to standard mental health support,or the control group to receive standard mental health support ***-CBT consisted of four modules and was delivered at the bedside over a 1-week *** were done at baseline,immediately after treatment and at 3-month *** intention-to-treat analysis began in June *** primary outcome measure was the changes in anxiety symptoms as assessed by the Hamilton Anxiety Rating Scale(HAM-A).Results Among 148 randomised participants,70 were assigned to the VR-CBT group and 78 to the control *** 1-week VR-CBT intervention plus standard mental health support significantly reduced the anxiety symptoms compared with standard mental health support alone in terms of HAM-A scores at both post intervention(Cohen’s d=−1.27(95%confidence interval(CI):−1.64 to−0.90,p<0.001)and 3-month follow-up(Cohen’s d=−0.37(95%CI:−0.72 to−0.01,p=0.024).Of the 70 participants who received VR-CBT,62(88.6%)completed the entire *** was the main reported adverse event(n=5).Conclusions Our results indicate that VR-CB

关键词： admitted behaviour treatment

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基于多帧信息的多传感器融合三维目标检测

北京理工大学学报 2023年第12期43卷 1282-1289页

作者：吴绍斌耿家琳吴超闫泽新陈恺宇北京理工大学机械与车辆学院北京100081

为提高三维目标检测中多传感器融合的效果,并利用前后帧之间的特征关联,提高目标检测的准确率,提出了一种基于多帧信息的多传感器特征融合三维目标检测网络.首先通过基于指导点的特征映射模块,将图像相机视角特征转换为鸟瞰图特征,并通... 详细信息

为提高三维目标检测中多传感器融合的效果,并利用前后帧之间的特征关联,提高目标检测的准确率,提出了一种基于多帧信息的多传感器特征融合三维目标检测网络.首先通过基于指导点的特征映射模块,将图像相机视角特征转换为鸟瞰图特征,并通过自适应融合模块对点云特征和图像特征进行融合;之后利用历史帧跟踪信息,融合多帧特征;最后采用基于CenterPoint检测头进行目标检测.在nuScenes数据集和实车上对三维目标检测网络进行了测试,试验结果表明该网络具有更高的精度和实时性.

关键词：目标检测多传感器融合多帧特征

湖南省农村垃圾问题治理状况调查研究——以长沙县和平江县为例

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环境与可持续发展 2017年第4期42卷 187-189页

作者：严泽心卫劭华中南大学公共管理学院湖南长沙410012

为了解湖南省农村垃圾治理的状况,本文选取了长沙县与平江县"两镇六村"作为典型代表,从资金、制度、人员、设施、宣传五个维度入手,总结两县垃圾治理典型模式,分析其优势与不足,并提出针对性政策建议。

关键词：垃圾治理农村环境新农村建设处理模式

船舶电力永磁同步推进电机空间电压矢量DTC

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中国航海 2017年第4期40卷 25-29页

作者：秦俊峰白洪芬颜泽锌齐运永钦州学院海运学院广西钦州535000 大连海事大学船船电气工程学院辽宁大连116026

为能更好地控制船舶推进电机的动态和静态性能,在传统直接转矩控制的基础上提出基于空间矢量调制的直接转矩控制算法。通过空间矢量控制、磁链控制和转矩控制,介绍空间矢量调制直接转矩控制算法的基本原理;结合船舶永磁同步推进电机的... 详细信息

为能更好地控制船舶推进电机的动态和静态性能,在传统直接转矩控制的基础上提出基于空间矢量调制的直接转矩控制算法。通过空间矢量控制、磁链控制和转矩控制,介绍空间矢量调制直接转矩控制算法的基本原理;结合船舶永磁同步推进电机的数学模型,在MATLAB/Simulink中建立船舶电力推进系统的仿真模型;结合试验电机参数,对船舶的额定负载起动性能、转速转矩突变及低速性能进行仿真分析。仿真结果表明,基于空间矢量调制的直接转矩控制技术在船舶电力推进系统中具有良好的调速、调矩和低速性能,能很好地满足船舶电力推进系统的需求。通过搭建基于DSP的永磁同步电机直接转矩控制硬件试验平台,进一步验证基于空间电压矢量的直接转矩控制策略的正确性和可行性。

关键词：永磁同步推进电机船舶电力推进系统空间电压矢量调制直接转矩控制试验平台