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Regulating the dimensionality of diphosphaperylenediimide-based polymers by coordinating the out-of-plane anisotropic π-framework toward Ag^(+)

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Science China Chemistry 2022年第9期65卷 1741-1748页

作者： zetong ma Yujian Liu Shengdong Wang Jiadong Zhou Zhaohui Wang Wei Jiang Key Laboratory of Organic Optoelectronics and Molecular Engineering Department of ChemistryTsinghua UniversityBeijing 100084China Institute of Polymer Optoelectronic materials and Devices State Key Laboratory of Luminescent Materials and DevicesSouth China University of TechnologyGuangzhou 510640China

The development of hetero-π-conjugated molecules is of significance for constructing diverse assembling superstructures based on heteroatom-related bonded or nonbonded ***,we developed one-pot P-heteroannulation via palladiumcatalyzed dual P-C bonds formation and subsequent sulfidation to construct two isomeric diphosphaperylenediimides(cis-5 and trans-5).The unique out-of-plane anisotropic π-framework induced a cumulative anisotropy with a dipole moment of up to 8.82 D for cis-5,leading to distinct supramolecular packing *** and electrochemical characterizations demonstrated that they showed the largest redshifts extending to 574 nm and rather low-lying LUMO levels of −4.41 ***,the introduced P=S moieties endowed these diphosphaperylenediimides with prominent coordination ability towards Ag^(+),and thus the first example of perylene diimide(PDI)core-involved metal-organic coordination polymers(MOCPs)with tunable dimensionality varying from 1D,2D,to 3D was tactfully *** view of easy accessibility and 2D layered porous structure,thus 2D(trans-5)·(AgOTf)based MOCP showed high crystallinity and good CO_(2) adsorption capacity with surface area of 112 m^(2)/*** result opens a span-new avenue for exploring rylene imide-based MOCPs and related properties by integrating P functionality.

关键词： metal-organic coordination polymers perylene diimides phosphorous heteroannulation dimensionality gas adsorption

A C2-symmetric triple [5]helicene based on N-annulated triperylene hexaimide for chiroptical electronics

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Science China Chemistry 2020年第2期63卷 208-214页

作者： zetong ma Thorsten Winands Ningning Liang Dong Meng Wei Jiang Nikos L.Doltsinis Zhaohui Wang CAS Research/Education Center for Excellence in Molecular Sciences Institute of ChemistryChinese Academy of SciencesBeijing 100190China Key Laboratory of Organic Optoelectronics and Molecular Engineering Department of ChemistryTsinghua UniversityBeijing 100084China Institute fo r Solid State Theory and Center for Multiscale Theory&Computation University of MuensterWilhelm-Klemm-Slrasse 10Muenster 48149Germany University of Chinese Academy of Sciences Beijing 100049China

Two diastereoisomers(NTPH-P and NTPH-T1) as a C2-symmetric triple [5]helicene based on N-annulated triperylene hexaimide were *** by nuclear magnetic resonance spectroscopy(NMR) and theoretical calculations,NTPH-P was assigned to three-blade propeller conformation while NTPH-T1 tended to exhibit twisted conformation with pyrrole ring fusing on a bowl-shaped PDI *** by circular dichroism(CD) and circular polarized luminescence(CPL) measurements,the enantiomerically pure NTPH-P exhibited fairly good chiral activities both in the absorption and emission range with dissymmetry factors |gabs| of 4.1×10^-3 and |glum| of 1.2×10^-*** diastereoisomers were further employed as acceptors for organic solar cells with distinct PCEs of 8.11% and 5.24% for NTPH-P and NTPH-T1 based devices,respectively,signifying the prospects in chiroptical electronics by designing molecularly defined aromatics.

关键词： triple helicenes perylene diimides N-annulation asymmetric decoration chiroptical properties organic solar cells

NeoHunter:Flexible software for systematically detecting neoantigens from sequencing data

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Quantitative Biology 2024年第1期12卷 70-84页

作者： Tianxing ma zetong Zhao Haochen Li Lei Wei Xuegong Zhang MOE Key Lab of Bioinformatics Bioinformatics Division of BNRIST and Department of AutomationTsinghua UniversityBeijingChina School of Medicine Tsinghua UniversityBeijingChina School of Life Sciences Tsinghua UniversityBeijingChina

Complicated molecular alterations in tumors generate various mutant *** of these mutant peptides can be presented to the cell surface and then elicit immune responses,and such mutant peptides are called *** detection of neoantigens could help to design personalized cancer *** some computational frameworks for neoantigen detection have been proposed,most of them can only detect SNV-and indel-derived *** addition,current frameworks adopt oversimplified neoantigen prioritization *** factors hinder the comprehensive and effective detection of *** developed NeoHunter,flexible software to systematically detect and prioritize neoantigens from sequencing data in different *** can detect not only SNV-and indel-derived neoantigens but also gene fusion-and aberrant splicing-derived *** supports both direct and indirect immunogenicity evaluation strategies to prioritize candidate *** strategies utilize binding characteristics,existing biological big data,and T-cell receptor specificity to ensure accurate detection and *** applied NeoHunter to the TESLA dataset,cohorts of melanoma and non-small cell lung cancer *** achieved high performance across the TESLA cancer patients and detected 79%(27 out of 34)of validated neoantigens in ***-and indel-derived neoantigens accounted for 90%of the top 100 candidate neoantigens while neoantigens from aberrant splicing accounted for 9%.Gene fusion-derived neoantigens were detected in one *** is a powerful tool to‘catch all’neoantigens and is available for free academic use on Github(XuegongLab/NeoHunter).

关键词： cancer vaccine molecular alteration neoantigen neoantigen prioritization

数字与智能化技术在皖南地区现代农业机械中的应用

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南方农业 2023年第20期17卷 46-48页

作者：马泽同池州学院大数据与人工智能学院安徽池州247000

作为安徽省农业生产的主要区域之一,皖南地区的农业一直是当地重要的经济支柱。随着数字与机智能化技术的快速发展,其在现代农业机械中的应用也日益广泛,但仍不可避免存在一些问题。为了能为皖南地区农牧业的现代化和绿色发展提供新的... 详细信息

作为安徽省农业生产的主要区域之一,皖南地区的农业一直是当地重要的经济支柱。随着数字与机智能化技术的快速发展,其在现代农业机械中的应用也日益广泛,但仍不可避免存在一些问题。为了能为皖南地区农牧业的现代化和绿色发展提供新的思路和途径,主要介绍了数字与智能化技术在皖南地区现代农业机械方面的发展现状和应用场景,分析其发展过程中存在的主要问题,详细论述了皖南地区农业机械智能化的应用路径。

关键词：数字与智能化技术农业机械皖南地区

Syntheses of phenyl benzoate compounds and their bioactivity investigation

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Journal of Chinese Pharmaceutical Sciences 2021年第11期30卷 874-882页

作者： Beidou Zhou Jiali Li Baocheng Huang Zihan Yu zetong ma Zhipeng Ruan Qihong Cai Dongbao Hu School of Pharmacy and Medical Technology Putian UniversityKey Laboratory of Pharmaceutical Analysis and Laboratory Medicine(Putian University)Fujian Province UniversityKey Laboratory of Medical Microecology(Putian University)Fujian Province UniversityPutian UniversityPutian 351100China School of Chemical Biology and Environment Yuxi Normal UniversityYuxi 653100China

Eight phenyl benzoate compounds were synthesized in one step, and then their antioxidant, anti-tyrosinase, and anti-pancreatic lipase activities were evaluated in the present study. The total yields ranged from 31% to 85%. Compound 4 c exhibited a stronger antioxidant activity compared with Trolox, with half maximal inhibitory concentrations(IC50) of approximately 13.06 μM, and the antioxidant mechanism was further studied using computational chemistry. Compounds 1 c–5 c exhibited minimal anti-tyrosinase activity. Compounds 4 c, 5 d, 6 c and 6 d exhibited weak anti-pancreatic lipase activity, with an inhibition rate of 33.52%, 15.76%, 18.37% and 20.77%, respectively. These results demonstrated that all compounds had reference significance, especially compound 4 c.

关键词： Phenyl benzoate Synthesis Antioxidant Anti-tyrosinase Anti-pancreatic lipase

Synthesis and antitumor, antityrosinase, and antiplatelet aggregation activities of xanthone

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Journal of Chinese Pharmaceutical Sciences 2019年第4期28卷 247-256页

作者：周北斗王欣翁智敏黄堡城马泽通于博阮丽琴胡栋宝莆田学院药学与医学技术学院药物分析与检验医学福建省高校重点实验室福建莆田351100 玉溪师范学院化学生物与环境学院云南玉溪653100

In the present study, five fluorine substituted and three chlorine substituted 1,3-dihydroxyxanthones were synthesized in one *** yields ranged from 48% to 72%.Among them, compounds 12 and 15–18 were reported for the first *** antitumor, antityrosinase and antiplatelet aggregation activities of all or part of compounds 1–19 were *** 1, 2, 4, 6–7, 10–15 and 19 exhibited enhanced cytotoxicity against certain cancer *** 10, containing 2,4-difluorophenyl at the C7 position, particularly exhibited superior antitumor *** inhibition rate of compound 18 against tyrosinase was approximately 22%.Compounds 1–3, 6, 9, 12 and 18, 19 exhibited obvious inhibitory platelet aggregation induced by ADP in ***, the effects of compounds 2 and 3 were more *** results demonstrated that compounds 1–4, 6–7, 9–15 and 19 were promising leads for further structural modification.

关键词： Xanthone Synthesis Antitumor Antityrosinase Antiplatelet aggregation

头孢哌酮钠舒巴坦钠诱发严重中毒性表皮坏死松解症致死亡

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药物不良反应杂志 2017年第2期19卷 127-129页

作者：马泽通龚睿付南思高华宁夏医科大学总医院药剂科银川750004 四川省科学城医院药剂科绵阳621002 深圳市第二人民医院药剂科 518035

1例68岁女性患者因左膝关节置换术后感染静脉滴注头孢哌酮钠舒巴坦钠2.0 g、2次/d.第2次给药快结束时患者出现气促、呼吸困难、大汗淋漓伴高热,立即停止静脉滴注.停药第3天,患者躯干部出现密集的粟粒到黄豆大小红色斑疹,边界清楚,压之褪... 详细信息

1例68岁女性患者因左膝关节置换术后感染静脉滴注头孢哌酮钠舒巴坦钠2.0 g、2次/d.第2次给药快结束时患者出现气促、呼吸困难、大汗淋漓伴高热,立即停止静脉滴注.停药第3天,患者躯干部出现密集的粟粒到黄豆大小红色斑疹,边界清楚,压之褪色,皮肤科会诊拟诊为麻疹样红斑原因待查,给予氯雷他定颗粒10 mg口服、1次/d,炉甘石洗剂局部涂抹.停药第8天,患者腰背部、右肩胛处及脊柱旁出现皮肤破溃,左肘尺侧散在水泡,右侧腰背处多处皮肤剥脱缺损,皮肤科会诊后考虑为头孢哌酮钠舒巴坦钠所致中毒性表皮坏死松解症.给予葡萄糖酸钙20 ml、甲泼尼龙琥珀酸钠80 mg、人免疫球蛋白2.5 g静脉滴注,1次/d;盐酸苯海拉明注射液20 mg静脉注射,1次/12 h;纳米银抗菌凝胶破溃处外敷.但患者皮肤剥脱、缺损等情况未见好转,并出现肺部感染.停药第14天,患者家属因经济原因放弃治疗.此后电话随访得知,患者于出院后第3天死亡.

关键词：头孢哌酮表皮坏死松解症,中毒性

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血必净注射液不良反应及事件的Meta分析

宁夏医科大学学报 2015年第11期37卷 1296-1299页

作者：孙维红马泽通陈倩田龙宁夏医科大学总医院药剂科银川750004

目的根据临床研究文献,采用Meta分析法评价血必净注射液临床应用的安全性。方法以'血必净注射液'为关键词,检索《中国期刊全文数据库》自2016年1月建网开始至2014年6月期间发表的有关血必净注射液临床随机对照研究,采用Rev man 5.2软件... 详细信息

目的根据临床研究文献,采用Meta分析法评价血必净注射液临床应用的安全性。方法以'血必净注射液'为关键词,检索《中国期刊全文数据库》自2016年1月建网开始至2014年6月期间发表的有关血必净注射液临床随机对照研究,采用Rev man 5.2软件,对血必净注射液的不良反应发生率进行Meta分析。结果共纳入24篇随机对照研究,不良反应发生率血必净组(4.36%)低于对照组(8.57%),经异质性检验(P=0.03,I2=40%)采用固定模型计算合并RR=0.55,95%可信区间为0.39~0.78。结论血必净注射液治疗组的不良反应低于对照组,血必净注射液安全性较好。

关键词：血必净注射液不良反应 Meta分析

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相位细分高分辨率激光回波模拟方法研究

长春理工大学学报（自然科学版） 2022年第2期45卷 13-18页

作者：马泽同王劲松陈雅鑫张丽芳张奇长春理工大学光电工程学院长春130022

为了提高激光回波模拟距离分辨率,设计了基于FPGA主控芯片的回波模拟延时系统。采用粗细延时相结合的方式实现高分辨率采样,粗延时利用计数器实现大范围延时,细延时采用最小相移量相位调整次数的方法实现精细采样延时。外围电路包括串... 详细信息

为了提高激光回波模拟距离分辨率,设计了基于FPGA主控芯片的回波模拟延时系统。采用粗细延时相结合的方式实现高分辨率采样,粗延时利用计数器实现大范围延时,细延时采用最小相移量相位调整次数的方法实现精细采样延时。外围电路包括串口通信模块、边缘检测模块和寄存器模块等共同组成回波模拟的延时系统。搭建实验平台并对15~6 000 m进行仿真和实验,仿真结果表明系统延时模块延时仿真误差≤100 ps,即0.015 6 m,实验结果数据表明18~6 000 m延时模块延时误差≤800 ps,即0.12 m。

关键词：回波模拟延时系统相位细分相位调整高分辨率