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The switch triggering the invasion process:Lipid metabolism in the metastasis of hepatocellular carcinoma

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Chinese Medical Journal 2024年第11期137卷 1271-1284页

作者： Jiaqian zhang Zhicheng zhang zhangfan Wu Yufei Wang zerui zhang Limin Xia Department of Gastroenterology Institute of Liver and Gastrointestinal DiseasesHubei Key Laboratory of Hepato-Pancreato-Biliary DiseasesTongji Hospital of Tongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubei 430030China State Key Laboratory of Holistic Integrative Management of Gastrointestinal Cancers and National Clinical Research Center for Digestive Diseases Xijing Hospital of Digestive DiseasesFourth Military Medical UniversityXi’anShaanxi 710032China

In humans,the liver is a central metabolic organ with a complex and unique histological *** carcinoma(HCC),which is a highly aggressive disease with a poor prognosis,accounts for most cases of primary liver *** an emerging hallmark of cancers,metabolic reprogramming acts as a runaway mechanism that disrupts homeostasis of the affected organs,including the ***,rewiring of the liver metabolic microenvironment,including lipid metabolism,is driven by HCC cells,propelling the phenotypes of HCC cells,including dissemination,invasion,and even metastasis in *** resulting formation of this vicious loop facilitates various malignant behaviors of HCC ***,few articles have comprehensively summarized lipid reprogramming in HCC ***,we have reviewed the general situation of the liver microenvironment and the physiological lipid metabolism in the liver,and highlighted the effects of different aspects of lipid metabolism on HCC metastasis to explore the underlying *** addition,we have recapitulated promising therapeutic strategies targeting lipid metabolism and the effects of lipid metabolic reprogramming on the efficacy of HCC systematical therapy,aiming to offer new perspectives for targeted therapy.

关键词： Hepatocellular carcinoma Invasion Metastasis Lipid metabolism Tumor microenvironment

聚吡咯微胶囊γ-Fe_(2)O_(3)的合成及在膨胀阻燃环氧树脂中的应用

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高分子材料科学与工程 2024年第5期40卷 47-55页

作者：张泽瑞龙邈天颜龙徐志胜中南大学防灾科学与安全技术研究所湖南长沙410075

以聚吡咯(PPy)微胶囊γ-Fe_(2)O_(3)得到的PPy-Fe_(2)O_(3)为协效剂、二氨基二苯甲烷改性聚磷酸铵(DDP)为阻燃剂制备了膨胀阻燃环氧树脂(EP)复合材料。结合极限氧指数(LOI)、UL94、热重分析、锥形量热仪及扫描电镜探究PPy-Fe_(2)O_(3)对... 详细信息

以聚吡咯(PPy)微胶囊γ-Fe_(2)O_(3)得到的PPy-Fe_(2)O_(3)为协效剂、二氨基二苯甲烷改性聚磷酸铵(DDP)为阻燃剂制备了膨胀阻燃环氧树脂(EP)复合材料。结合极限氧指数(LOI)、UL94、热重分析、锥形量热仪及扫描电镜探究PPy-Fe_(2)O_(3)对EP/DDP体系的阻燃性、热稳定性及成炭性能的影响。结果表明,PPy-Fe_(2)O_(3)的加入可增强EP/DDP体系的阻燃性能、抑烟性能及热稳定性。利用PPy-Fe_(2)O_(3)与DDP复配有助于形成更加致密和稳定的炭层结构以减少热释放和生烟量,其中添加0.2%PPy-Fe_(2)O_(3)与9.8%DDP可使EP复合材料的峰值热释放速率(PHRR)与峰值生烟速率(PSPR)分别下降12.3%与11.0%,并成功通过UL94 V-0级且具有35.5%的LOI值。热重分析表明,PPy-Fe_(2)O_(3)的加入显著提高了EP/DDP体系的热稳定性与成炭性能,其中含0.2%PPy-Fe_(2)O_(3)的EP复合材料在700℃时的残炭量达到32.0%。

关键词： γ-Fe_(2)O_(3) 聚吡咯环氧树脂阻燃性能微胶囊

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大模型时代下的医疗人工智能技术进展与挑战

中国医学装备 2024年第6期21卷 189-194页

作者：张一帆张泽瑞董敬王浩任海萍中国医疗器械有限公司北京100028 中国食品药品检定研究院医疗器械检定所北京102629 重庆大学生物工程学院重庆400044 解放军总医院医学创新研究部北京100853

人工智能(AI)与医疗应用结合已经衍生出大量的应用场景,从诊疗流程、数据融合、赋能医疗设备等多维度参与并改变了医疗行业。AI大模型是基于庞大的参数规模和复杂程度的机器学习模型,具有高度准确和广泛的泛化能力。在面对医疗场景数据... 详细信息

人工智能(AI)与医疗应用结合已经衍生出大量的应用场景,从诊疗流程、数据融合、赋能医疗设备等多维度参与并改变了医疗行业。AI大模型是基于庞大的参数规模和复杂程度的机器学习模型,具有高度准确和广泛的泛化能力。在面对医疗场景数据增长快、数据多模态、知识图谱庞大且复杂等问题时,AI大模型将诊断、决策、治疗、管理等医疗过程串联,进一步拓宽并延长了人工智能的医疗应用空间,将医疗数据高度利用。综述传统AI及大模型在医疗领域应用中的典型应用场景,并探讨大模型在数据治理、模态融合及可信性方面的问题,以期推动大模型与医疗的结合的落地应用。

关键词：人工智能(AI) 医疗器械医学数据大模型

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结合注意力机制的卫星遥感影像立体匹配

时空信息学报 2024年第1期31卷 41-49页

作者：张泽瑞范大昭纪松董杨李东子刘杰信息工程大学地理空间信息学院郑州450002 中国电建集团北京勘测设计研究院有限公司北京100024

采用立体匹配技术对多视卫星遥感影像进行三维场景重建一直是摄影测量与遥感领域的核心问题。基于卷积神经网络的深度学习方法极大地促进了立体匹配技术的发展,然而其中涉及匹配困难和误匹配问题的相关研究仍然不足。为了提升卫星遥感... 详细信息

采用立体匹配技术对多视卫星遥感影像进行三维场景重建一直是摄影测量与遥感领域的核心问题。基于卷积神经网络的深度学习方法极大地促进了立体匹配技术的发展,然而其中涉及匹配困难和误匹配问题的相关研究仍然不足。为了提升卫星遥感影像不适定区域中视差估计的精度,本研究提出了一种结合注意力机制的立体匹配深度学习网络,在特征提取模块中加入注意力机制,分别从通道和空间两个维度捕获全局信息,对特征进行优化;在代价体的构建模块中构建新的代价体积,并重新设置视差的回归范围。为了验证本文方法的有效性,在US3D、WHU-Stereo两个数据集上分别与已有方法Stereo-Net、PSM-Net进行了比较分析。结果表明,本文方法在EPE(endpointerror)和D_1两个指标上均能达到最优,取得了较好的性能,提高了立体匹配的精度,尤其在无纹理、重复纹理、遮挡及视差不连续区域表现出良好的鲁棒性。

关键词：立体匹配卷积神经网络卫星遥感影像注意力机制深度学习视差估计

Unsteady aerodynamic noise prediction of contra-rotating open rotor using meshless method

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Chinese Journal of Aeronautics 2024年第8期37卷 144-165页

作者： Zhiliang HONG Meng SU Haitao zhang zerui XU Lin DU Lingfeng CHEN College of Safety Science and Engineering Civil Aviation University of ChinaTianjin 300300China Civil Aviation Administration of China Beijing 100710China Research Institute of Aero-Engine Beihang UniversityBeijing 100191China

The Contra-Rotating Open Rotor(CROR)design confronts significant noise challenges despite being one of the possible options for future green *** efficiently estimate the noise emitted from a CROR,a three-dimensional unsteady prediction model based on the meshless method is *** unsteady wake flow and the aerodynamic load fluctuations on the blade are solved through the viscous vortex particle method,the blade element momentum theory and vortex lattice ***,the acoustic field is obtained through the Farassat’s formulation *** of this method is conducted on a CROR,and a mesh-based method,e.g.,Nonlinear Harmonic(NLH)method,is also employed for *** is found that the presented method is three times faster than NLH method while maintaining a comparable precision.A thorough parametric analysis is also carried out to illustrate the effects of rotational speed,rotor-rotor spacing and rear rotor diameter on the noise *** rotor speed is found to be the most influencing factor,and by optimizing the speed difference between the front and rear rotors,a notable noise reduction can be *** current findings not only contribute to a deeper comprehension of the CROR’s aeroacoustic properties but also offer an effective tool for engineering applications.

关键词： Contra-Rotating Open Rotor(CROR) Aerodynamic noise Blade element momentum theory Viscosity vortex particle method Farassat’s formulation 1A

On Formulas and Some Combinatorial Properties of Schubert Polynomials

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Algebra Colloquium 2017年第4期24卷 647-672页

作者： zerui zhang Yuqun Chen School of Mathematical Sciences South China Normal University Guangzhou 510631 China

By applying a Grobner-Shirshov basis of the symmetric group Sn, we give two formulas for Schubert polynomials, either of which involves only nonnegative monomials. We also prove some combinatorial properties of Schubert polynomials. As applications, we give two algorithms to calculate the structure constants for Schubert polynomials, one of which depends on Monk＇s formula.

关键词： divided difference Schubert polynomial Grobner-Shirshov basis

Numerical Study on the Effect of Vortex Generators on the Aerodynamic Drag of a High-Speed Train

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Fluid Dynamics & Materials Processing 2024年第2期20卷 463-473页

作者： Tian Li Hao Liang zerui Xiang Jiye zhang State Key Laboratory of Rail Transit Vehicle System Southwest Jiaotong UniversityChengdu610031China School of Design Southwest Jiaotong UniversityChengdu610031China

A relatively high aerodynamic drag is an important factor that hinders the further acceleration of high-speed *** the shear stress transport(SST)k-ωturbulence model,the effect of various vortex generator types on the aerodynamic characteristics of an ICE2(Inter-city Electricity)train has been *** results indi-cate that the vortex generators with wider triangle,trapezoid,and micro-ramp arranged on the surface of the tail car can signiﬁcantly change the distribution of surface pressure and affect the vorticity intensity in the *** alteration effectively reduces the resistance of the tail ***,the micro-ramp vortex generator with its convergent structure at the rear exhibits enhancedﬂow-guiding capabilities,resulting in a 15.4%reduction in the drag of the tail car.

关键词： Vortex generator aerodynamic drag reduction numerical simulation

Large-scale interplant exchange of macromolecules between soybean and dodder under nutrient stresses

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Plant Diversity 2024年第1期46卷 116-125页

作者： Jingxiong zhang Shalan Li Wenxing Li zerui Feng Shuhan zhang Xijie Zheng Yuxing Xu Guojing Shen Man Zhao Guoyan Cao Xuna Wu Jianqiang Wu Department of Economic Plants and Biotechnology Yunnan Key Laboratory for Wild Plant ResourcesKunming Institute of BotanyChinese Academy of SciencesKunming 650201China CAS Center for Excellence in Biotic Interactions University of Chinese Academy of SciencesBeijing 100049China State Key Laboratory of Conservation and Utilization of Bio-Resources in Yunnan and Center for Life Science School of Life SciencesYunnan UniversityKunming 650500China

Parasitic plants and their hosts communicate through haustorial *** deficiency is a common stress for plants,yet little is known about whether and how host plants and parasites communicate during adaptation to such nutrient *** this study,we used transcriptomics and proteomics to analyze how soybean(Glycine max)and its parasitizing dodder(Cuscuta australis)respond to nitrate and phosphate deficiency(-N and-P).After-N and-P treatment,the soybean and dodder plants exhibited substantial changes of transcriptome and proteome,although soybean plants showed very few transcriptional responses to-P and dodder did not show any transcriptional changes to either-N ***,large-scale interplant transport of mRNAs and proteins was *** the mobile mRNAs only comprised at most 0.2%of the transcriptomes,the foreign mobile proteins could reach 6.8%of the total proteins,suggesting that proteins may be the major forms of interplant ***,the interplant mobility of macromolecules was specifically affected by the nutrient regimes and the transport of these macromolecules was very likely independently *** study provides new insight into the communication between host plants and parasites under stress conditions.

关键词： Cuscuta Mobile molecules Nutrient deficiency Host plant-parasitic plant interaction Interplant transport Systemic signaling

沿空留巷高强让压巷旁支护体“承-让”机理研究

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矿业研究与开发 2022年第5期42卷 108-113页

作者：张钰凯张小强张泽瑞太原理工大学矿业工程学院山西太原030024

针对深井高应力条件下沿空留巷过程中现有充填体材料不能适应顶板活动的问题,在C40基准混凝土的基础上使用不同掺量聚合物(EVA)和钢纤维进行正交试验,得到了应变系数为2%~10%的改性混凝土。以麦地掌煤矿21213工作面回风顺槽留巷为研究对... 详细信息

针对深井高应力条件下沿空留巷过程中现有充填体材料不能适应顶板活动的问题,在C40基准混凝土的基础上使用不同掺量聚合物(EVA)和钢纤维进行正交试验,得到了应变系数为2%~10%的改性混凝土。以麦地掌煤矿21213工作面回风顺槽留巷为研究对象,运用理论分析与数值模拟相结合的方法,研究不同应变系数的改性混凝土充填体的支护效果。研究表明:(1)基于弹性地基基础理论和砌体梁理论,得到在该地质条件下应变系数为5.6%的改性混凝土可以使关键块回转触矸达到稳定状态,充填体所需的最大支撑力为20.46 MPa;(2)数值分析结果表明,随着充填体的应变系数逐渐增大,充填体侧与实体煤侧最大垂直应力比由1.26减小到0.33,应力集中位置逐渐从充填体侧转移至实体煤侧,充填体起到让压承载的作用。但应变系数过大的充填体支撑力不足,顶板下沉速度过大,不利于留巷围岩控制。综合分析得出:在21213工作面回风顺槽留巷时应采用应变系数为6%的混凝土为充填墙体,在适应顶板给定变形的同时,有足够高的强度使基本顶平稳回转下沉。

关键词：沿空留巷改性混凝土数值模拟让压承载