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Visualization of nasal powder distribution using biomimetic human nasal cavity model

Acta Pharmaceutica Sinica B 2024年第1期14卷 392-404页

作者： Jiawen Su Yan liu Hongyu Sun Abid Naeem Huipeng Xu Yue Qu Caifen Wang zeru li Jianhua Lu Lulu Wang Xiaofeng Wang Jie Wu lixin Sun Jiwen Zhang Zhigang Wang Rui Yang li Wu Key Laboratory of Modern Preparation of TCM Ministry of EducationJiangxi University of Chinese MedicineNanchang 330004China Key Laboratory of Molecular Pharmacology and Drug Evaluation School of PharmacyMinistry of EducationYantai UniversityYantai 264005China Shanghai Institute of Materia Medica Chinese Academy of SciencesShanghai 201210China Nantong Haimen People’s Hospital Nantong 226199China Yangtze Delta Drug Advanced Research Institute Nantong 226126China Shenyang Pharmaceutical University Shenyang 110016China National Institutes for Food and Drug Control Beijing 100000China Nanjing University of Chinese Medicine Nanjing 210023China

Nasal drug delivery efficiency is highly dependent on the position in which the drug is deposited in the nasal ***,no reliable method is currently available to assess its impact on delivery *** this study,a biomimetic nasal model based on three-dimensional(3D)reconstruction and three-dimensional printing(3DP)technology was developed for visualizing the deposition of drug powders in the nasal *** results showed significant differences in cavity area and volume and powder distribution in the anterior part of the biomimetic nasal model of Chinese males and *** nasal cavity model was modified with dimethicone and validated to be suitable for the deposition *** experimental device produced the most satisfactory results with five spray ***,particle sizes and spray angles were found to significantly affect the experimental device’s performance and alter drug distribution,***,mometasone furoate(MF)nasal spray(NS)distribution patterns were investigated in a goat nasal cavity model and three male goat noses,confirming the in vitro and in vivo *** conclusion,the developed human nasal structure biomimetic device has the potential to be a valuable tool for assessing nasal drug delivery system deposition and distribution.

关键词： Nasal drug deposition Nasal drug distribution Nasal drug delivery Biomimetic nasal model Nasal powder Three-dimensional reconstruction Three-dimensional printing Nasal drug distribution

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Characteristics and outcomes of patients with autoimmune pancreatitis after pancreatectomy:a retrospective study

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Journal of Pancreatology 2023年第2期6卷 43-47页

作者： Bangbo Zhao Cheng Qin Tianyu li zeru li Yuanyang Wang Weibin Wang Department of General Surgery State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

Objective:Autoimmune pancreatitis(AIP)is a rare and special type of pancreatitis,which is often difficult to distinguish from pancreatic *** aimed to discuss the clinical characteristics,operation characteristics,and therapeutic effects of AIP pa-tients who received surgical treatment based on retrospective ***:The medical records of patients who underwent surgery at Peking Union Medical College Hospital from January 2012 to July 2021 and whose postoperative pathology was AIP were *** symptoms,laboratory examinations,imaging features,surgical information,and prognostic data were ***:Nineteen patients with AIP(median age 60 years old,14 males)underwent surgery,whose main indication for surgery was suspected of a malignant lesion(n=18,94.7%).Ten patients underwent pancreaticoduodenectomy,8 underwent distal pancreatectomy,and 1 underwent total pancreatectomy,the pathological result of whom were all *** main postoperative complication was pancreatic fistula(n=11,57.9%),and one patient(5.3%)underwent a second operation due to gastrointestinal anastomotic *** patient(5.6%)had a recurrence of AIP,3 patients(16.7%)were treated with glucocorticoid after sur-gery,and one patient(5.6%)was treated with ***:Differential diagnosis of AIP from pancreatic cancer is *** difficulty and complication incidence for patients with AIP were similar to pancreatic cancer *** glucocorticoid is the first-line treatment for AIP,surgery may still be necessary for patients who are strongly suspected of a malignant lesion.

关键词： Autoimmune pancreatitis Complications Outcomes Surgery

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Exosome-mediated cell-cell communication within pancreatic cancer tumor microenvironment: a narrative review

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Journal of Pancreatology 2022年第1期5卷 177-213页

作者： Cheng Qin Bangbo Zhao Yuanyang Wang Tianhao li zeru li Tianyu li Yutong Zhao Weibin Wang Department of General Surgery State Key Laboratory of Complex Severe and Rare DiseasesPeking Union Medical College HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijingChina

The significance of exosomes has emerged in a variety of physiological processes and *** cancer remains one of the most lethal diseases at ***,increasing evidence has suggested that exosomes are vital for mediating the elaborate interaction of highly heterogeneous cell clusters within the pancreatic tumor microenvironment,contributing to activating pancreatic stellate cells and cancer-associated fibroblasts,compromising immune cells,and enhancing *** their natural and intrinsic roles,exosomes may provide a novel potential way for pancreatic cancer management and therapy as ***,exosomes not only mediate cellular communication during pancreatic cancer progression but also serve as a promising player in precise pancreatic cancer management and *** comprehensively summarize the role of exosomes in pancreatic cancer,we searched the PubMed database and reviewed all relevant original studies.

关键词： cancer-associated fibroblasts exosomes extracellular vesicles pancreatic cancer review tumor microenvironment

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Pancreatic cancer with ovarian metastasis: cases report and literature review

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Journal of Pancreatology 2023年第1期6卷 34-39页

作者： zeru li Xingtong Zhou Bangbo Zhao Zhibo Zheng Cheng Qin Xudong liu Huadan Xue Weibin Wang Department of General Surgery Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijingChina Department of Breast Surgery Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijingChina Department of International Medical Services Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijingChina Medical Science Research Center Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijingChina Department of radiology Peking Union Medical College HospitalChinese Academy of Medical SciencesBeijingChina

Background: Pancreatic cancer with ovarian metastases is rare and easily misdiagnosed. Patients with ovarian metastases are first diagnosed with ovarian cancer and may miss the opportunity to receive surgical operation. We report 7 rare cases of ovarian metastases secondary to pancreatic adenocarcinoma and review the literature to analyze clinical characteristics, diagnostic methods, and potential therapeutic strategies for the rare *** Summary: We retrospectively analyzed the clinical data of 7 female patients with ovarian metastases of primary pancreatic cancer who were admitted to our hospital from January 01, 1985, to April 1, 2020. These 7 patients were diagnosed with ovarian metastasis at an average age of 52.28 (38-69) years. The reason for the patient’s visit was generally a mass in the lower abdomen and/or abdominal pain. Six of them had significantly higher serum Carbohydrate antigen19-9 (CA19-9) levels, 6 patients had pancreatic tumors located in the body or tail, and 1 patient had one in the head of the pancreas. All patients underwent excision of ovarian tumors and resection or biopsy of pancreatic tumors. Five patients had pancreatic ductal adenocarcinoma (PDAC), and 2 had pancreatic cystadenocarcinoma (PCC), all of which were revealed by the pathological results. Ovarian tumors were assessed by pathology and were consistent with pancreatic metastasis. Currently, all 7 patients have died (follow-up to January 2, 2021). The median survival time for all patients was 13.7 months (2.9-27 months).Conclusions: For this rare tumor, elevated serum CA19-9 may indicate that the primary lesion is in the pancreas. Enhanced pancreatic Computed Tomography (CT) can facilitate diagnostic localization. In addition, if the pancreatic tumor cannot be removed, the ovarian tumor should still be resected to reduce the tumor load and improve the quality of life.

关键词： Case report Outcome Ovarian metastases Pancreatic cancer Prognosis

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延续进路电路存在问题的分析与改进

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铁道通信信号 2010年第10期46卷 41-42页

作者：李泽如兰州铁路局兰州电务段

1 存在问题及现象宝中线地处西北山区,多数车站均存在超过6‰的坡道,上下行列车进路均设延续进路,彭阳车站就是其中之一.在运用中因延续进路电路存在缺陷,时常发生继电器错误动作情况.彭阳站场示意图如图1所示.车站值班员办理进路时发现... 详细信息

1 存在问题及现象宝中线地处西北山区,多数车站均存在超过6‰的坡道,上下行列车进路均设延续进路,彭阳车站就是其中之一.在运用中因延续进路电路存在缺陷,时常发生继电器错误动作情况.彭阳站场示意图如图1所示.车站值班员办理进路时发现:当排列X行Ⅱ道接车进路时,有时会错误带起X1LAJ、X3LAJ;当排列S行Ⅱ道接车进路时,有时会错误带起S1LAJ、S3LAJ.

关键词：延续进路电路车站值班员西北山区列车进路接车进路宝中线误动作继电器

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不同增钙模式对蛋鸡生产性能、胫骨质量和血清生化指标的影响

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动物营养学报 2016年第4期28卷 1186-1192页

作者：孔路欣臧素敏刘培培李泽茹河北农业大学动物科技学院保定071000

本试验旨在研究不同增钙模式对蛋鸡生产性能、胫骨质量以及血清相关生化指标的影响,以确定蛋鸡生产过程中饲粮钙的增加模式以及钙的添加量。选取18周龄海兰灰商品蛋鸡480只,随机分为4组,每组4个重复,每个重复30只。增钙时间点分别为18... 详细信息

本试验旨在研究不同增钙模式对蛋鸡生产性能、胫骨质量以及血清相关生化指标的影响,以确定蛋鸡生产过程中饲粮钙的增加模式以及钙的添加量。选取18周龄海兰灰商品蛋鸡480只,随机分为4组,每组4个重复,每个重复30只。增钙时间点分别为18周龄以及产蛋率为5%、50%和90%时,各时间点增钙方式分别为:Ⅰ组2.00%、2.20%、2.40%和3.75%;Ⅱ组2.00%、2.50%、3.00%和3.75%;Ⅲ组2.00%、3.00%、3.75%和3.75%;Ⅳ组2.00%、3.75%、3.75%和3.75%。试验期9周。结果表明:1)Ⅲ组蛋鸡产蛋率显著高于Ⅰ组和Ⅳ组(P0.05);2)Ⅲ组胫骨强度、胫骨重、胫骨钙含量显著高于Ⅰ组和Ⅱ组(P0.05);3)蛋鸡产蛋率达50%时,Ⅰ组和Ⅱ组血钙含量显著高于Ⅲ组和Ⅳ组(P0.05)。结果提示:当蛋鸡产蛋率达5%、50%和90%时,饲粮钙水平分别为3.00%、3.75%和3.75%有助于提高蛋鸡产蛋率,改善体况和稳定骨骼质量,同时不造成钙源浪费。

关键词：钙蛋鸡生产性能胫骨质量血清生化指标

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不同增钙方式对初产蛋鸡蛋品质的影响

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中国家禽 2015年第21期37卷 37-42页

作者：孔路欣臧素敏刘培培李泽茹河北农业大学动物科技学院河北保定071000

通过研究不同增钙方式对初产蛋鸡蛋壳钙磷含量、蛋壳质量、蛋品质的影响,以确定初产蛋鸡日粮中钙的增加方式和钙的添加量。选取18周龄海兰灰商品蛋鸡480只,随机分为4组,分别在18周龄、产蛋率5%、50%、90%增加饲粮钙含量,增钙方式:Ⅰ组2... 详细信息

通过研究不同增钙方式对初产蛋鸡蛋壳钙磷含量、蛋壳质量、蛋品质的影响,以确定初产蛋鸡日粮中钙的增加方式和钙的添加量。选取18周龄海兰灰商品蛋鸡480只,随机分为4组,分别在18周龄、产蛋率5%、50%、90%增加饲粮钙含量,增钙方式:Ⅰ组2.0%、2.2%、2.4%、3.75%,Ⅱ组2.0%、2.5%、3.0%、3.75%,Ⅲ组2.0%、3.0%、3.75%、3.75%,Ⅳ组2.0%、3.75%、3.75%、3.75%。结果表明:当产蛋率达50%时,蛋壳钙含量Ⅲ组显著高于Ⅰ组(P0.05);蛋重、蛋壳、蛋黄、蛋白品质各组间差异不显著(P>0.05);蛋壳颜色Ⅲ组最均匀。当产蛋率达90%时,蛋壳钙含量Ⅲ组显著高于Ⅰ、Ⅱ组(P0.05);蛋壳重、蛋壳强度、蛋壳厚度Ⅲ组值最高,显著高于Ⅰ组(P0.05);蛋重、蛋黄颜色、蛋白高度各组间差异不显著(P>0.05);蛋壳亮度Ⅲ组显著高于Ⅰ、Ⅱ、Ⅳ组(P<0.05),且均匀。当蛋鸡5%、50%、90%产蛋率日粮钙水平分别为3.0%、3.75%和3.75%时,可提高蛋品质和蛋壳质量,减少鸡蛋的破损。

关键词：钙水平蛋鸡蛋壳质量蛋黄色泽蛋白品质

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不同针刺疗法治疗胰十二指肠切除术后C级胃排空延迟的临床疗效比较:基于倾向性评分匹配的回顾性队列研究

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协和医学杂志 2023年第5期14卷 1031-1037页

作者：李天宇张亚敏米沁东李泽儒包飞王维斌中国医学科学院北京协和医院基本外科北京100730 中国医学科学院北京协和医院中医科北京100730

目的探究不同针刺疗法治疗胰十二指肠切除术后C级胃排空延迟(delayed gastric emptying, DGE)的疗效差异。方法本研究为回顾性队列研究,研究对象为2015年1月—2021年9月北京协和医院基本外科行胰十二指肠切除术后接受中医针刺疗法治疗... 详细信息

目的探究不同针刺疗法治疗胰十二指肠切除术后C级胃排空延迟(delayed gastric emptying, DGE)的疗效差异。方法本研究为回顾性队列研究,研究对象为2015年1月—2021年9月北京协和医院基本外科行胰十二指肠切除术后接受中医针刺疗法治疗的C级DGE患者。根据针刺疗法的不同,将其分为体针组(单纯体针疗法)和耳体针组(耳针联合体针疗法),并根据基线胃液引流量,采用倾向性评分法对两组患者进行1∶1匹配。比较两组主要结局指标[短期(3 d内)疗效、长期(10 d内)疗效]及次要结局指标(术后住院时间、带胃管出院患者的比例、治疗期间不良事件发生率)差异。结果共入选符合纳入与排除标准的C级DGE患者65例,其中耳体针组34例(52.3%)、体针组31例(47.7%)。(1)短期疗效:经倾向性评分法匹配后共纳入耳体针组患者23例、体针组患者23例。耳体针组短期胃液引流量下降率高于体针组[42.7%(19.6%,65.1%)比6.5%(-14.7%,50.6%),P=0.034]。(2)长期疗效及次要结局指标:由于体针组、耳体针组分别存在4例、6例于治疗3 d内成功拔除胃管的患者,其无法计算治疗长期疗效,故将其排除。采用倾向性评分法再次对两组患者进行匹配后,共纳入耳体针组患者16例、体针组患者16例。两组治疗期间均无不良事件发生,耳体针组长期胃液引流量下降率高于体针组[49.6%(15.7%,56.9%)比8.8%(-9.3%,33.1%),P=0.024],术后住院时间[30.0(26.0,38.5)d比31.0(24.3,43.8)d,P=0.748]及带胃管出院患者的比例(18.8%比25.0%,P>0.999)与体针组均无显著差异。结论相较于单纯体针疗法,耳针联合体针疗法减少胰十二指肠切除术后C级DGE患者胃液引流量的疗效更显著,可能更有利于患者术后康复。

关键词：胰十二指肠切除术胃排空延迟针刺疗法倾向性评分

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粒子群算法中惯性权重参数

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长春工业大学学报 2017年第4期38卷 354-360页

作者：王泽儒李芬田王红梅长春工业大学计算机科学与工程学院吉林长春130012

研究粒子群算法惯性权重与种群规模大小、空间维度以及惯性权重递减率的关系,对多个具有代表性的函数进行实验研究。结果表明,适当改变惯性权重可以快速收敛、提高搜索效率以及避免陷入局部最优。

关键词：粒子群种群空间维度惯性权重递减率

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三叉神半月节射频热凝术+甘油封闭术治疗老年三叉神经痛的临床研究

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现代医院 2024年第4期24卷 648-650页

作者：谢昭太李泽如黄桂鸿揭阳市慈云医院广东揭阳522000

目的研究C臂引导下三叉神半月节射频热凝术联合甘油治疗老年三叉神经痛的价值。方法选取我院在2022年1月—2023年6月收治的180例三叉神经痛患者纳入研究,按照随机数字表法分为观察组和对照组,各90例。对照组采取射频热凝术治疗,观察组... 详细信息

目的研究C臂引导下三叉神半月节射频热凝术联合甘油治疗老年三叉神经痛的价值。方法选取我院在2022年1月—2023年6月收治的180例三叉神经痛患者纳入研究,按照随机数字表法分为观察组和对照组,各90例。对照组采取射频热凝术治疗,观察组行射频热凝联合甘油封闭术治疗。观察两组治疗效果,比较两组患者治疗前后疼痛视觉模拟评分(VAS)、睡眠质量评分,检测两组患者治疗前后血清炎症因子水平,记录两组患者并发症发生率。结果观察组治疗效果显著优于对照组(P0.05)。结论C臂引导下射频热凝术联合甘油封闭术疗效显著,能够减轻患者的疼痛程度,改善患者睡眠质量,且并发症发生率低,适用于临床治疗。

关键词：射频热凝术甘油老年三叉神经痛疼痛视觉模拟评分并发症

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