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Exploring the potential of olivine-containing copper-nickel slag for carbon dioxide mineralization in cementitious materials

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 562-573页

作者： Qianqian Wang zequn Yao Lijie Guo Xiaodong Shen College of Materials Science and Engineering Nanjing Tech UniversityNanjing 211816China State Key Laboratory of Materials-Oriented Chemical Engineering Nanjing 211816China BGRIMM Technology Group Beijing 100160China

Water-quenched copper-nickel metallurgical slag enriched with olivine minerals exhibits promising potential for the production of CO_(2)-mineralized cementitious *** this work,copper-nickel slag-based cementitious material(CNCM)was synthesized by using different chemical activation methods to enhance its hydration reactivity and CO_(2) mineralization *** water curing ages and carbonation conditions were explored related to their carbonation and mechanical properties ***,thermogravimetry differential scanning calorimetry and X-ray diffraction methods were applied to evaluate the CO_(2) adsorption amount and carbonation products of *** development of carbonated CNCM blocks was examined by backscattered electron imaging(BSE)with energy-dispersive X-ray *** showed that among the studied samples,the CNCM sample that was subjected to water curing for 3 d exhibited the highest CO_(2) sequestration amount of 8.51wt%at 80℃and 72 h while presenting the compressive strength of 39.07 *** result indicated that 1 t of this CNCM can sequester 85.1 kg of CO_(2) and exhibit high compressive *** the addition of citric acid did not improve strength development,it was beneficial to increase the CO_(2) diffusion and adsorption amount under the same carbonation conditions from BSE *** work provides guidance for synthesizing CO_(2)-mineralized cementitious materials using large amounts of metallurgical slags containing olivine minerals.

关键词： copper-nickel slag fayalite CO_(2)sequestration cementitious material admixtures carbonation conditions

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QARF: A Novel Malicious Traffic Detection Approach via Online Active Learning for Evolving Traffic Streams

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Chinese Journal of Electronics 2024年第3期33卷 645-656页

作者： zequn NIU Jingfeng XUE Yong WANG Tianwei LEI Weijie HAN Xianwei GAO School of Computer Science and Technology Beijing Institute of Technology School of Space Information Space Engineering University

In practical abnormal traffic detection scenarios,traffic often appears as drift,imbalanced and rare labeled streams,and how to effectively identify malicious traffic in such complex situations has become a challenge for malicious traffic *** have extensive studies on malicious traffic detection with single challenge,but the detection of complex traffic has not been widely *** adaptive random forests(QARF) is proposed to detect traffic streams with concept drift,imbalance and lack of labeled *** is an online active learning based approach which combines adaptive random forests method and adaptive margin sampling *** achieves querying a small number of instances from unlabeled traffic streams to obtain effective *** conduct experiments using the NSL-KDD dataset to evaluate the performance of *** is compared with other state-of-the-art *** experimental results show that QARF obtains 98.20% accuracy on the NSL-KDD *** performs better than other state-of-the-art methods in comparisons.

关键词： Training Streams Random forests

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An adaptive algorithm of 2-dimension secrete information hiding for remote sensing image

An adaptive algorithm of 2-dimension secrete information hid...

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Photonics Asia 2004:Information Processing and Data Storage

作者： Xianmin Wang*a zequn guana Chenhan Wua aCollege of Remote Sensing Information Engineering Wuhan University No. 129 Luoyu Road Wuhan City Hubei Province P.R.China 430079

Tn order to hide secrete information in remote sensing image, we proposed an algorithm for secrete information hiding which was adaptive to the feature of remote sensing image. Firstly, we segmented a

关键词： Remote Sensing image Information Hiding Human Visual System(HVS) adaptive

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Antitumor effects of a novel photosensitizer-mediated photodynamic therapy and its influence on the cell transcriptome

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Oncology Research 2024年第5期32卷 911-923页

作者： JINGJING CHEN DAN WANG zequn WANG MENGYUAN HAN HOUQING YIN WENTING ZHOU RIBAI YAN YAN PAN Department of Pharmacology School of PharmacyChangzhi Medical CollegeChangzhiChina2 Department of PharmacologySchool of Basic Medical SciencesHealth Science CenterPeking UniversityBeijingChina3 Beijing Key Laboratory of Tumor Systems BiologyPeking UniversityBeijingChina4 Department of PharmacologyXinjiang Medical UniversityUrumqiChina5 School of Pharmaceutical SciencesPeking UniversityBeijingChina

Photodynamic therapy(PDT)is a promising cancer *** study investigated the antitumor effects and mechanisms of a novel photosensitizer meso-5-[ρ-diethylene triamine pentaacetic acid-aminophenyl]−10,15,20-triphenyl-porphyrin(DTP)mediated PDT(DTP-PDT).Cell viability,reactive oxygen species(ROS),and apoptosis were measured with a Cell Counting Kit-8 assay,DCFH-DA fluorescent probe,and Hoechst staining,*** apoptosis-and autophagy-related proteins were examined using western *** sequencing was used to screen differentially expressed mRNAs(DERs),and bioinformatic analysis was performed to identify the major biological events after *** results show that DTP-PDT inhibited cell growth and induced ROS generation in MCF-7 and SGC7901 *** ROS scavenger N-acetyl-L-cysteine(NAC)and the P38 MAPK inhibitor SB203580 alleviated DTP-PDT-induced ***-PDT induced cell apoptosis together with upregulated Bax and downregulated Bcl-2,which could also be inhibited by NAC or *** level of LC3B-Ⅱ,a marker of autophagy,was increased by DTP-PDT.A total of 3496 DERs were obtained after *** Ontology and Kyoto Encyclopedia of Genes and Genomes analyses indicated that DERs included those involved in cytosolic ribosomes,the nuclear lumen,protein binding,cell cycle,protein targeting to the endoplasmic reticulum,and ribosomal DNA *** Ontology and Reactome enrichment analyses indicated that DERs were associated with a variety of cancers and cell cycle ***-protein interaction results demonstrated that cdk1 and rps27a ranked in the top 10 interacting ***,DTP-PDT could inhibit cell growth and induce cell apoptosis and autophagy,partly through ROS and the P38 MAPK signaling *** associated with the cell cycle,ribosomes,DNA replication,and protein binding may be the key changes in DTP-PDT-mediated cytotoxicity.

关键词： Photodynamic therapy ROS Apoptosis Autophagy Bioinformatic analysis

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Prioritization of risk genes in colorectal cancer by integrative analysis of multi-omics data and gene networks

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Science China(Life Sciences) 2024年第1期67卷 132-148页

作者： Ming Zhang Xiaoyang Wang Nan Yang Xu Zhu zequn Lu Yimin Cai Bin Li Ying Zhu Xiangpan Li Yongchang Wei Shaokai Zhang Jianbo Tian Xiaoping Miao Department of Epidemiology and Biostatistics School of Public HealthDepartment of Gastrointestinal OncologyZhongnan Hospital of Wuhan UniversityDepartment of Radiation OncologyRenmin Hospital of Wuhan UniversityTaiKang Center for Life and Medical SciencesWuhan UniversityWuhan 430071China Research Center of Public Health Renmin hospital of Wuhan UniversityWuhan UniversityWuhan 430060China Department of Cancer Epidemiology The Affiliated Cancer Hospital of Zhengzhou University&Henan Cancer HospitalHenan Engineering Research Center of Cancer Prevention and ControlHenan International Joint Laboratory of Cancer PreventionZhengzhou 450008China Department of Gastrointestinal Surgery Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Radiation Oncology Renmin Hospital of Wuhan UniversityWuhan 430060China Department of Gastrointestinal Oncology Hubei Cancer Clinical Study CenterZhongnan Hospital of Wuhan UniversityWuhan 430062China Department of Epidemiology and Biostatistics School of Public HealthTongji Medical CollegeHuazhong University of Science and TechnologyWuhan 430073China Jiangsu Collaborative Innovation Center for Cancer Personalized Medicine Nanjing Medical UniversityNanjing 211166China

Genome-wide association studies(GWASs)have identified over 140 colorectal cancer(CRC)-associated loci;however,target genes at the majority of loci and underlying molecular mechanisms are poorly ***,we utilized a Bayesian approach,integrative risk gene selector(iRIGS),to prioritize risk genes at CRC GWAS loci by integrating multi-omics *** a result,a total of 105 high-confidence risk genes(HRGs)were identified,which exhibited strong gene dependencies for CRC and enrichment in the biological processes implicated in *** the 105 HRGs,CEBPB,located at the 20q13.13 locus,acted as a transcription factor playing critical roles in *** subsequent assays indicated the tumor promoter function of CEBPB that facilitated CRC cell proliferation by regulating multiple oncogenic pathways such as MAPK,PI3K-Akt,and Ras ***,by integrating a fine-mapping analysis and three independent case-control studies in Chinese populations consisting of 8,039 cases and 12,775 controls,we elucidated that rs1810503,a putative functional variant regulating CEBPB,was associated with CRC risk(OR=0.90,95%CI=0.86–0.93,P=1.07×10^(−7)).The association between rs1810503 and CRC risk was further validated in three additional multi-ancestry populations consisting of 24,254 cases and 58,741 ***,the rs1810503 A to T allele change weakened the enhancer activity in an allele-specific manner to decrease CEBPB expression via longrange promoter-enhancer interactions,mediated by the transcription factor,REST,and thus decreased CRC *** summary,our study provides a genetic resource and a generalizable strategy for CRC etiology investigation,and highlights the biological implications of CEBPB in CRC tumorigenesis,shedding new light on the etiology of CRC.

关键词： susceptibility genes gene screening models multi-omics GWAS CEBPB long-range promoter-enhancer interactions

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Apigenin ameliorates imiquimod-induced psoriasis in C57BL/6J mice by inactivating STAT3 and NF-κB

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Food Science and Human Wellness 2024年第1期13卷 211-224页

作者： Xianshe Meng Shihong Zheng zequn Yin Xuerui Wang Daigang Yang Tingfeng Zou Huaxin Li Yuanli Chen Chenzhong Liao Zhouling Xie Xiaodong Fan Jihong Han Yajun Duan Xiaoxiao Yang Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes College of Food and Biological EngineeringHefei University of TechnologyHefei 230601China Tianjin Key Laboratory of human Development and Reproductive Regulation Department of General GynecologyTianjin Central Hospital of Gynecology and ObstetricsTianjin 300100China Key Laboratory of Medicinal Chemical Biology Key Laboratory of Bioactive Materials of Ministry of EducationCollege of Life SciencesNankai UniversityTianjin 300071China

Psoriasis is a chronic autoimmune disease featured by patches on the *** is caused by malfunction of immune cells and keratinocytes with inflammation as one of its key ***(API)is a natural flavonoid with anti-inflammatory and immunoregulatory ***,we speculated that API can ameliorate psoriasis,and determined its effect on the development of psoriasis by using imiquimod(IMQ)-induced psoriasis mouse *** results showed that API attenuated IMQ-induced phenotypic changes,such as erythema,scaling and epidermal thickening,and improved splenic *** differentiation of immune cells was restored in API-treated ***,we revealed that API is a key regulator of signal transducer activator of transcription 3(STAT3).API regulated immune responses by reducing interleukin-23(IL-23)/STAT3/IL-17A ***,it suppressed IMQ-caused cell hyperproliferation by inactivating STAT3 through regulation of extracellular signal-regulated kinase 1/2 and nuclear factor-κB(NF-κB)***,API reduced expression of inflammatory cytokines through inactivation of NF-κ*** together,our study demonstrates that API can ameliorate psoriasis and may be considered as a strategy for psoriasis treatment.

关键词： Psoriasis Apigenin Imiquimod Inflammation Signal transducer activator of transcription 3 (STAT3) Nuclear factor-κB(NF-κB)

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异形加强冻结管外壁保温对管幕冻结效果影响试验研究

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隧道建设（中英文） 2024年第1期44卷 100-108页

作者：任辉洪泽群张军珠海市轨道交通有限公司广东珠海519060 中国矿业大学江苏徐州221116 中交第二公路勘察设计研究院有限公司湖北武汉430056

新型管幕冻结法冻结系统由充填混凝土的实顶管内布置圆形主力冻结管和限位管、未充填混凝土的空顶管内布置异形加强冻结管组成。为分析该新型管幕冻结系统中空顶管周围的冻结效果,通过拱北隧道管幕冻结现场原型试验,对空顶管中异形加强... 详细信息

新型管幕冻结法冻结系统由充填混凝土的实顶管内布置圆形主力冻结管和限位管、未充填混凝土的空顶管内布置异形加强冻结管组成。为分析该新型管幕冻结系统中空顶管周围的冻结效果,通过拱北隧道管幕冻结现场原型试验,对空顶管中异形加强冻结管是否采取外表面保温措施展开研究,利用冻土帷幕厚度的变化对异形加强冻结管保温措施与不保温状态进行冻结效果对比分析。结果表明:异形加强冻结管保温不利于冻土帷幕的形成,随着冻结时间推移,冻土帷幕的发展会越来越慢;协同冻结模式下60 d后保温与不保温的冻土厚度之差约为冻结20 d的2倍。可以把空顶管作为“大冻结管”来考虑,利用异形加强冻结管对空顶管内部整体降温,更有利于顶管周围冻土帷幕的发展。

关键词：管幕冻结法异形加强冻结管冻结管保温现场试验拱北隧道

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基于规则提示的知识图谱通用推理预训练模型

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计算机研究与发展 2024年第8期61卷 2030-2044页

作者：崔员宁孙泽群胡伟计算机软件新技术全国重点实验室(南京大学) 南京210023

知识图谱是存储真实世界海量知识的图数据库,为大量知识驱动的下游任务提供了数据支持.知识图谱往往具有不完备性,存在大量缺失的事实,因此知识图谱推理任务基于已知事实推理新结论来补全知识图谱.随着知识工程及其商业应用的研究与发展... 详细信息

知识图谱是存储真实世界海量知识的图数据库,为大量知识驱动的下游任务提供了数据支持.知识图谱往往具有不完备性,存在大量缺失的事实,因此知识图谱推理任务基于已知事实推理新结论来补全知识图谱.随着知识工程及其商业应用的研究与发展,大量通用和领域知识图谱被构建.现有知识图谱推理方法大多面向单一知识图谱的补全,不具备通用推理能力.近年来,受预训练大语言模型通用能力的启发,一些通用的知识图谱推理预训练模型被提出.针对现有预训练模型无法识别高质量推理模式的问题,提出一个基于规则提示的知识图谱通用推理预训练模型——RulePreM,该模型筛选与利用高质量推理规则来提高知识图谱上的推理能力.首先基于推理规则构建关系IO图和一个编码器RuleGNN对关系进行编码,然后将关系编码作为提示来编码知识图谱中的实体,最后对候选实体进行打分预测.还提出一种结合规则置信度的注意力机制,来进一步减少低质量推理模式的影响.实验结果表明,所提出的模型在43个不同设定下的知识图谱上具有良好的通用推理能力,平均性能指标均优于现有的有监督模型和预训练模型.

关键词：知识图谱规则通用推理预训练提示学习关系IO图

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L-Ergothioneine ameliorates MPTP-induced Parkinson's disease in C57BL/6J mice by activating DJ-1

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Food Science and Human Wellness 2024年

作者： Xianshe Meng# Huawen Meng# Shuzeng Hou zequn Yin Xuerui Wang Ke Gong Feng Zhang Qingshan Li Shuang Zhang Yuanli Chen Xiaoxiao Yang Zhiwei Zhao Chenzhong Liao Yajun Duan Department of Cardiology， the First Affiliated Hospital of USTC， Division of Life Sciences and Medicine， University of Science and Technology of China Key Laboratory of Metabolism and Regulation for Major Diseases of Anhui Higher Education Institutes， Hefei University of Technology

Parkinson’s disease (PD) is one of the most common neurodegenerative diseases. The loss of dopaminergic (DAergic) neurons in the substantia nigra and the decrease of dopamine (DA) levels accelerate the process of PD. L-Ergothioneine (EGT) is a natural antioxidant derived from microorganisms， especially in edible mushrooms. EGT can penetrate blood-brain barrier and its levels are significantly decreased in the plasma of PD patients. Therefore， we speculated that EGT could ameliorate PD， and determined its effect on PD development by using 1-methyl-4-phenyl-1，2，3，6-tetrahydropyridine (MPTP)-induced PD mouse models and neurotoxin 1-methyl-4-phenylpyridinium (MPP+)-induced cell models. Our results show that EGT alleviated MPTP-induced behavioral dysfunction in mice. Mechanistically， we innovatively revealed that EGT is a key regulator of DJ-1. EGT restored DA levels by activating the DJ-1-Nuclear receptor-related factor 1(Nurr1) axis. Furthermore， it reduced reactive oxygen species (ROS) levels by regulating the DJ-1-Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway， which inhibited oxidative stress-induced DAergic neuronal apoptosis. Combined treatment with DJ-1-siRNA transfection revealed that blocking DJ-1 reversed EGT upregulated Nurr1 and Nrf2 expression in the nucleus， which significantly decreased the benefits of EGT. Taken together， our study suggests that EGT can ameliorate PD and be considered as a strategy for PD treatment.

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主要国际大通道形成模式、运维经验及对中国的启示

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国际贸易 2024年第2期 37-46页

作者：宋琍琍耿泽群祁欣商务部国际贸易经济合作研究院

国际大通道内涵丰富,形成模式多样,融合性强,目前学界、业界尚无统一定义;但其在全球化持续深入背景下,对国家、地区乃至全球发展的基础性、战略性作用日益突出。马六甲海峡、苏伊士运河等主要国际大通道的稳定发展,得益于相关政府的科... 详细信息

国际大通道内涵丰富,形成模式多样,融合性强,目前学界、业界尚无统一定义;但其在全球化持续深入背景下,对国家、地区乃至全球发展的基础性、战略性作用日益突出。马六甲海峡、苏伊士运河等主要国际大通道的稳定发展,得益于相关政府的科学规划、协同联动,以及企业主体的国际化运作和绿色、数字实践等。我国对现代国际大通道的建设、研究等起步晚、基础弱,应深入研究国际大通道发展情况,借鉴相关国家政府、企业的经验做法,提升国际大通道建设、维护和把控能力,充分利用国际大通道促进高水平对外开放,推动共建“一带一路”高质量发展,保障我国全球利益和发展安全,推动构建国内国际双循环新发展格局。

关键词：国际大通道形成模式运维经验 “一带一路”

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