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Traditional Chinese Medicine in the prevention and treatment of stable angina pectoris in patients with coronary heart disease based on the theory of "phlegm and blood stasis" under guidance of evidence-based medicine:a prospective cohort study

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Journal of Traditional Chinese Medicine 2021年第1期41卷 150-156页

作者： CHEN Ying XIAO Xue XU Xiaolin DENG Yue zhang zepeng Department of Cardiology the Affiliated Hospital to Changchun University of Chinese MedicineChangchunChina Research Center of Traditional Chinese Medicine the Affiliated Hospital to Changchun University of Chinese MedicineChangchunChina Jilin Provincial Key Laboratory of BioMacromolecules of Chinese Medicine Changchun University of Chinese MedicineChangchunChina

OBJECTIVE: To ascertain whether continuous treatment with Traditional Chinese Medicine(TCM) combined with standardized drug therapy from Western Medicine can further reduce the incidence of cardiovascular events in patients with coronary heart disease and angina and reduce the incidence of angina pectoris in patients with coronary heart ***: A multicenter, prospective cohort study of 1042 patients in 22 hospitals was conducted. A total of 423 patients with angina pectoris were treated with standardized Western Medicine alone(control group) and 619 with a combination of Chinese and Western Medicine(exposure group). The two groups underwent follow-up for 1 year to establish whether there was any improvement in the incidence of cardiovascular events or change in the curative ***: The incidence of primary endpoint events in the combined-exposure group decreased by 0.45%(P > 0.05) and the incidence of secondary terminal events decreased by 5.25% in comparison with the control group(P < 0.05). The total angina pectoris score clearly decreased in the Western Medicine group over the first 6 months, but the decline was more apparent in the combined-exposure ***: Compared with treatment using standardized Western Medicine alone, providing TCM combined with Western medical treatment reduced the incidence of cardiovascular events in patients with stable angina pectoris(grade Ⅱ endpoint) and effectively improved the curative effect.

关键词： Coronary disease Angina pectoris cardiovascular events Prospective study Cohort study

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Detecting the single chiral molecule during the reaction

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Science China Materials 2023年第8期66卷 3377-3378页

作者： Juejun Wang zepeng zhang Shurui Ji Yanxi zhang Wenjing Hong College of Chemistry and Chemical Engineering Xiamen UniversityXiamen 361005China The Institute of Flexible Electronics(IFE Future Technologies)Xiamen UniversityXiamen 361005China

Detecting an individual molecule during the chemistry dynamics is essential for capturing accurate information about the chemical process in the time domain,which could be achieved by precisely forming single-molecule junctions between two electrodes and reading out the variation in electrical signals[1–3],but has yet to penetrate the stereochemistry *** is a crucial pursuit of chirality chemistry to develop effective asymmetric synthesis methodologies and reveal the physicochemical mechanisms[4,5].And the key obstacle lies in achieving in situ detection of chiral intermediates in reactions[6].Chirality is a fundamental molecular property arising from the structure asymmetry,with two mirror-image forms known as *** to similar signals of enantiomeric isomers,it is a great challenge to distinguish chiral species and the process of their configurational transformation in single-molecule *** then comes up with a question—how to detect chirality changes in stereochemistry.

关键词： chiral isomers mirror

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High phosphate removal using La(OH)3 loaded chitosan based composites and mechanistic study

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Journal of Environmental Sciences 2021年第8期33卷 105-115页

作者： Shaopeng zhang Yi zhang Jie Ding zepeng zhang Chao Gao Muslim Halimi Hary Demey Zhen Yang Weiben Yang School of Chemistry and Materials Science Jiangsu Provincial Key Laboratory of Materials Cycling and Pollution ControlNanjing Normal UniversityNanjing 210023China Department of Chemical and Environmental Engineering Anyang Institute of TechnologyAnyang 455000China Department of Chemical Engineering Universitat Politècnica de CatalunyaBarcelona 08028Spain

Our present study was to prepare a biomass-supported adsorbents with high adsorptive capacity and high selectivity to prevent the accelerated eutrophication in water *** this end,different metal hydroxide(La,Zr and Fe)first was successfully loaded on chitosan *** the quaternary ammonium group with different content was introduced into the adsorbent by *** comparison of adsorption properties,chitosanLa(OH)3-quaternary ammonium-20%(CS-La-N-20%)has strong adsorption to phosphate(160 mg/g)by immobilizing nano-sized La(OH)3 within a quaternary-aminated chitosan and it maintain high adsorption in the presence of salt *** pH results indicated that the CS-La-N-20%would effectively sequestrate phosphate over a wide pH range between 3 and 7 without significant La3+***’s more,adsorption capacity on the introduce of positively charged quanternary-aminated groups was significantly higher than that of the unmodified adsorbents at alkaline *** column adsorption capacity reached 1300 bed volumes(BV)when phosphate concentration decreased until 0.5 mg/L at 6 BV/*** column adsorption/desorption reveals that no significant capacity loss is observed,indicating excellent stability and repeated use *** revealed that phosphate adsorption on CS-La-N-20%through ligand exchange(impregnated nano-La(OH)3)and electrostatic attraction(positively charged quanternary-aminated groups).All the results suggested that CS-La-N-20%can serve as a promising adsorbent for preferable phosphate removal in realistic application.

关键词： Phosphate Chitosan-nanocomposite Metal hydroxide Quaternary ammonium

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Spatial correlation-based characterization of acoustic emission signal-cloud in a granite sample by a cube clustering approach

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International Journal of Mining Science and Technology 2021年第4期31卷 535-551页

作者： Dongjie Xue zepeng zhang Cheng Chen Jie Zhou Lan Lu Xiaotong Sun Yintong Liu School of Mechanics and Civil Engineering China University of Mining and Technology-BeijingBeijing 100083China State Key Laboratory of Coal Mine Disaster Dynamics and Control Chongqing UniversityChongqing 400030China State Key Laboratory of Coal Resource and Safe Mining China University of Mining and Technology-BeijingBeijing 100083China

To extract more in-depth information of acoustic emission(AE)signal-cloud in rock failure under triaxial compression,the spatial correlation of scattering AE events in a granite sample is effectively described by the cube-cluster ***,the complete connection of the fracture network is regarded as a critical ***,according to the Hoshen-Kopelman(HK)algorithm,the real-time estimation of fracture con-nection is effectively made and a dichotomy between cube size and pore fraction is suggested to solve such a challenge of the one-to-one match between complete connection and cluster ***,the 3D cube clusters are decomposed into orthogonal layer clusters,which are then transformed into the ellip-soid ***,the anisotropy evolution of fracture network could be visualized by three orthogonal ellipsoids and quantitatively described by aspect ***,the other three quantities of centroid axis length,porosity,and fracture angle are analyzed to evaluate the evolution of cube *** result shows the sample dilatancy is strongly correlated to four quantities of aspect ratio,centroid axis length,and porosity as well as fracture ***,the cube cluster model shows a potential pos-sibility to predict the evolution of fracture ***,the cube cluster model provides an in-depth view of spatial correlation to describe the AE signal-cloud.

关键词： Acoustic emission Triaxial compression Fracture connection Spatial correlation Cube cluster model Dilatancy

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MIL-101(Cr)-decorated Ti/TiO_(2) anode for electrochemical oxidation of aromatic pollutants from water

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Chinese Chemical Letters 2023年第2期34卷 301-305页

作者： zepeng zhang Yunyun Li Longzhang Dong Zhonglong Yin Ziqi Tian Weiben Yang Zhen Yang School of Chemistry and Materials Science Jiangsu Provincial Key Laboratory of Material Cycling and Pollution ControlJiangsu Collaborative Innovation Center of Biomedical Functional MaterialsNanjing Normal UniversityNanjing 210046China Ningbo Institute of Materials Technology&Engineering Chinese Academy of SciencesNingbo 315000China

Hydroxyl radicals(·OH) generated on anode play a vital role in electrochemical oxidation(EO) of organic pollutants for water treatment. Inspired by the four-electron oxygen evolution reaction(OER), we supposed an anode-selection strategy to stabilize deeply oxidized states(*O and*OOH) which are beneficial to generating·OH. To verify the hypothesis, a candidate anode component(MIL-101(Cr), a well-known metal-organic framework with active variable-valence transition metal centers) was used to coat Ti/TiO_(2)plate to fabricate anodes. Compared to TiO_(2)(101) plane on undecorated anode surface, fast and complete removal of aniline and phenol, and improved energy utilization were achieved on MIL-101(Cr)-coatedTi/TiO_(2)anode. Mechanism investigation, including pollutant degradation pathways, showed the predominate contribution(69.60%–75.13%) of·OH in pollutant mineralization. Density functional theory(DFT)computations indicated Cr site in MIL-101(Cr) was more conducive to stabilizing*O and*OOH, leading to thermodynamical spontaneous generation of·OH. This work opens up an exciting avenue to explore·OH production, and supplies a useful guidance to the development of anode materials for EO process.

关键词： Active oxidation species Electrocatalytic oxidation DFT computation MOF Hydroxyl radical Composite anode

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Correction to:Inhibition of p53 and/or AKT as a new therapeutic approach specifically targeting ALT cancers

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Protein & Cell 2019年第11期10卷 927-928页

作者： Yuanlong Ge Shu Wu zepeng zhang Xiaocui Li Feng Li Siyu Yan Haiying Liu Junjiu Huang Yong Zhao MOE Key Laboratory of Gene Function and Regulation State Key Laboratory of BiocontrolSchool of Life SciencesSun Yat-sen UniversityGuangzhou 510006China Collaborative Innovation Center of High Performance Computing National University of Defense TechnologyChangsha 410073China

Figure *** is phosphorylated in p53>dependent manner in ALT cells.(A)Western blot determination of total and phosphorylated AKT(S473)in p53-positive(VA13,U20S)and p53-defective(SAOS2,SKLU-1)ALT cells.(B)Knockdown of p53 in U20S or moderate expression of p53 in SAOS2 induces down or up-regulation of p-AKT,respectively.(C)Knockdown of ATM or ATR by siRNA decreases abundance of p53,phosphorylated p53 and p-AKT.(D)Quantitative-PCR determination of the level of ATR or ATM in U20S cells transfected with siRNA to ATR or ATM,*** siRNA(Si-Ctl)was used as *** represent the mean±SEM,n=3-4.(E)ATM(KU60019)or ATR(VE-821)inhibitor decreases abundance of p-AKT in U20S cells.U20S cells were treated with indicated concentration of KU60019 or VE-821 for 24 h.(F)The expression of wt-p53,but not mutant p53(p53-s269e)defective of transcription activity,increases the level of p-AKT.(G)*** inhibitor of p53 transcription activity,suppresses the phosphorylation of AKT.U20S cells were treated with indicated concentration of PFTa for 24 h.

关键词： AKT ALT DNA damage apoptosis p53 telomeres

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APOE interacts with ACE2 inhibitingg SARS-CoV-2 cellular entry and inflammation in COVID-19 patients

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Signal Transduction and Targeted Therapy 2022年第9期7卷 3459-3467页

作者： Hongsheng zhang Lin Shao Zhihao Lin Quan-Xin Long Huilong Yuan Lujian Cai Guangtong Jiang Xiaoyi Guo Renzhi Yang zepeng zhang Bingchang zhang Fan Liu Zhiyong Li Qilin Ma Yun-Wu zhang Ai-Long Huang Zhanxiang Wang Yingjun Zhao Huaxi Xu Center for Brain Sciences the First Aliated Hospital of Xiamen UniversityInstitute of NeuroscienceFujian Provincial Key Laboratory of Neurodegenerative Disease and Aging ResearchXiamen UniversityXiamenChina Institute for Brain Science and Disease Chongqing Medical UniversityChongqingChina school of Medicine Xiamen UniversityXiamenChina Key Laboratory of Molecular Biology for Infectius Diseases(Minstry of Educatio) Chongqing Medical UniversityChongqingChina

Apolipoprotein E(APOE)plays a pivotal role in lipid including cholesterol *** APOE 4(APOE4)allele is a major genetic risk factor for Alzheimer's and cardiovascular *** APOE has recently been associated with increased susceptibility to infections of several viruses,whether and how APOEand its isoforms affect SARS-CoV-2 infection remains ***,we show that serum concentrations of APOE correlate inversely with levels of cytokine/chemokine in 73 COVID-19 *** multiple protein interaction assays,we demonstrate that APOE3 and APOE4 interact with the SARS-CoV-2 receptor ACE2;and APOE/ACE2 interactions require zinc metallopeptidase domain of ACE2,a key docking site for SARS-CoV-2 Spike *** addition,immuno-imaging assays using confocal,super-resolution,and transmission electron microscopies reveal that both APOE3 and APOE4 reduce ACE2/Spikemediated viral entry into ***,while having a comparable binding affinity to ACE2,APOE4 inhibits viral entry to a lesser extent compared to APOE3,which is likely due to APOE4's more compact structure and smaller spatial obstacle to compete against Spike binding to ***,APOE e4 carriers clinically correlate with increased SARS-CoV-2 infection and elevated serum inflammatory factors in 142 COVID-19 patients *** study suggests a regulatory mechanism underlying SARS-CoV-2 infection through APOE interactions with ACE2,which may explain in part increased COVID-19 infection and disease severity in APOE e4 carriers.

关键词： ACE2 patients inflammation

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Two-dimensional gel analysis of The Formation and Dynamics of T-loop Structure at Chromosome Ends

Two-dimensional gel analysis of The Formation and Dynamics o...

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细胞—生命的基础——中国细胞生物学学会2013年全国学术大会·武汉

作者： zhang zepeng zhang Tianpeng Liu Haiying Zhao Yong Key Laboratory of Gene Engineering of the Ministry of Education School of Life SciencesSun Yat-sen University

Linear chromosome ends are capped by telomeric loop(T-loop) formed by an invasion of the 3 ’single-stranded overhang of telomere into the double stranded telomeric *** ev idences supporting the presence of T-loop in vivo come from EM observation that requires large amounts of purified telomeres and is technically ***,we reported a novel a nd simple method for

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New Organic Montmorillonite Preparation: Anion-Nonionic Surfactants Modified Montmorillonites

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矿物学报 2013年第S1期33卷 140-140页

作者： zhang zepeng WAN Fang zhang Chaoqin LIAO Libing School of Materials Sciences and Technology China University of Geosciences KaiPuQi Science and Technology Development Co. LTD

Montmorillonites (MMT) was modified with nonionic surfactant Trion X-100 (OP-10) and anionic surfactants sodium stearate (SSTA) and sodium dodecyl benzene sulfonate (SDBS) respectively. In this study, the effects of anionic surfactant types and MMT types on modification montmorillonite were investigated. XRD analysis results showed that SSTA/OP-10/MMT and SDBS/OP-10/MMT were successfully obtained. The basal spacing of SSTA/OP-10/MMT reached 5.07nm and the SSTA intercalation reaction was relatively stable. Different types of MMT (Xinjiang natural sodium montmorillonite(MMT-1), Jianping sodium montmorillonite (MMT-2) and artificial sodium montmorillonite(MMT-3)) were modified with SSTA/OP-10. XRD test results showed that MMT-1, MMT-2 and MMT-3 can be modified by SSTA/OP-10. Anion-nonionic organic montmorillonite (SSTA/OP-10/MMT-1, SSTA/OP-10/MMT-2 and SSTA/OP-10/MMT-3 were successfully obtained respectively. The higher expansion capacity was found to be beneficial to organic modification.

关键词： intercalation reaction sodium stearate sodium dodecyl benzene sulfonate Trion x-100

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截断式脉冲水射流冲蚀煤岩特性数值模拟

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振动与冲击 2021年第6期40卷 283-288页

作者：潘越杨帆张泽鹏马浩河北工程大学机械与装备工程学院河北邯郸056038

基于光滑粒子动力学和有限元法(smoothed particle hydrodynamics-finite element method,SPH-FEM)耦合算法,建立了截断式脉冲水射流冲蚀煤岩的数值计算模型。通过对比数值模拟结果与相同工况下的实验结果,验证了该模型的有效性。在此... 详细信息

基于光滑粒子动力学和有限元法(smoothed particle hydrodynamics-finite element method,SPH-FEM)耦合算法,建立了截断式脉冲水射流冲蚀煤岩的数值计算模型。通过对比数值模拟结果与相同工况下的实验结果,验证了该模型的有效性。在此基础上,探究了在截断式脉冲水射流冲击作用下,煤岩沿射流轴向的损伤演化过程,分析了煤岩围压、脉冲长度、脉冲间距及射流速度对煤岩冲蚀深度及速度的影响规律。结果表明:煤岩的冲蚀深度随着围压增大而减小;随着脉冲长度的增加,煤岩的冲蚀深度逐渐减小,冲蚀速度经历了先增大后减小的过程;脉冲间距对冲蚀深度的影响较小,煤岩的冲蚀速度随脉冲间距的增大呈现出线性减小的变化趋势;脉冲速度对冲蚀深度及速度影响较为显著,且随着脉冲速度的增加,冲蚀深度及速度整体呈增长趋势。

关键词：截断式脉冲水射流脉冲长度脉冲间距脉冲速度煤岩冲蚀特性

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