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Partially hydrolyzed guar gum attenuates non-alcoholic fatty liver disease in mice through the gut-liver axis

World Journal of Gastroenterology 2021年第18期27卷 2160-2176页

作者： Shun Takayama Kazuhiro Katada Tomohisa Takagi Takaya Iida Tomohiro Ueda Katsura Mizushima Yasuki Higashimura Mayuko Morita Tetsuya Okayama Kazuhiro Kamada Kazuhiko Uchiyama Osamu Handa Takeshi Ishikawa zenta yasukawa Tsutomu Okubo Yoshito Itoh Yuji Naito Department of Molecular Gastroenterology and Hepatology Graduate School of Medical ScienceKyoto Prefectural University of MedicineKyoto 602-8566Japan Department of Medical Innovation and Translational Medical Science Graduate School of Medical ScienceKyoto Prefectural University of MedicineKyoto 602-8566Japan Department of Food Science Ishikawa Prefectural UniversityNonoichi 921-8836Japan Department of Health Care Nutrition Showa Gakuin Junior CollegeIchikawa 272-0823Japan Division of Gastroenterology Department of Internal MedicineKawasaki Medical SchoolKurashiki 701-0192Japan Department of Nutrition Taiyo Kagaku Co.LtdYokkaichi 510-0844Japan

BACKGROUND The gut-liver axis has attracted much interest in the context of chronic liver disease *** such as dietary fibers were shown to attenuate non-alcoholic fatty liver disease(NAFLD)by modulating gut *** hydrolyzed guar gum(PHGG),a water-soluble dietary fiber,has been reported to alleviate the symptoms of various intestinal diseases and metabolic ***,its effects on NAFLD remain to be fully *** determine whether treatment with PHGG attenuates NAFLD development in mice through the gut-liver *** Seven-week-old male C57BL/6J mice with increased intestinal permeability were fed a control or atherogenic(Ath)diet(a mouse model of NAFLD)for 8 wk,with or without 5%*** intestinal permeability was induced through chronic intermittent administration of low-dose dextran sulfate *** weight,liver weight,macroscopic findings in the liver,blood biochemistry[aspartate aminotransferase(AST)and alanine aminotransferase(ALT),total cholesterol,triglyceride,free fatty acids,and glucose levels],liver histology,myeloperoxidase activity in liver tissue,mRNA expression in the liver and intestine,serum endotoxin levels in the portal vein,intestinal permeability,and microbiota and short-chain fatty acid(SCFA)profiles in the cecal samples were *** Mice with increased intestinal permeability subjected to the Ath diet showed significantly increased serum AST and ALT levels,liver fat accumulation,liver inflammatory(tumor necrosis factor-αand monocyte chemotactic protein-1)and fibrogenic(collagen 1a1 andαsmooth muscle actin)marker levels,and liver myeloperoxidase activity,which were significantly attenuated by PHGG ***,the Ath diet combined with increased intestinal permeability resulted in elevated portal endotoxin levels and activated toll-like receptor(TLR)4 and TLR9 expression,confirming that intestinal permeability was significantly elevated,as observed by evaluatin

关键词： Non-alcoholic fatty liver disease Partially hydrolyzed guar gum Gut-liver axis Intestinal barrier integrity Microbiota Short-chain fatty acids

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