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Crohn's disease of esophagus,stomach and duodenum

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2019年第2期10卷 35-49页

作者： Andréa Maia Pimentel Raquel Rocha Genoile Oliveira santana Programa de Pós gradua??o em Medicina e Saúde Universidade Federal da Bahia Departamento de Ciências da Nutri??o Universidade Federal da Bahia

Crohn's disease with involvement of the esophagus, stomach and duodenum has a prevalence of 0.5% to 4% in symptomatic adult patients, but some studies have shown that these results may be underestimated, since upper gastrointestinal endoscopy is not performed routinely in the initial evaluation of the disease in adult patients, as it is in the pediatric population. In general, involvement of the upper gastrointestinal tract in Crohn's disease occurs concomitantly with involvement of the lower gastrointestinal tract. The diagnosis depends on clinical,endoscopic, histological and radiological evaluation. The presence of aphthoid ulcers, longitudinal ulcers, bamboo-joint-like appearance, stenoses and fistulas are endoscopic findings suggestive of the disease, and it is important to exclude the presence of Helicobacter pylori infection. The primary histological findings,which facilitate the diagnosis, are the presence of a chronic inflammatory process with a predominance of lymphoplasmacytic cells and active focal gastritis. The presence of epithelioid granuloma, although less frequent, is highly suggestive of the disease in the absence of chronic granulomatous disease. Treatment should include the use of proton pump inhibitors associated with corticosteroids,immunomodulators and biological therapy according to the severity of the disease.

关键词： Crohn’s disease Upper gastrointestinal tract Upper digestive endoscopy Esophagus Stomach Duodenum Chronic gastritis Focal gastritis Epithelioid granuloma

Microbiological Quality, Transmission of Resistant Bacteria, and Genetic Characterization in Fish Sold in Town Fairs in the Recôncavo da Bahia Region, Brazil

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Food and Nutrition Sciences 2019年第9期10卷 1072-1084页

作者： Sanmily Santos Damacena Ludmilla santana Soares e Barros Center of Environmental and Biological Agrarian Sciences UFRB Cruz das Almas Brazil

Informal fish marketing is an important source of food and income for many families. However, it is also a public health issue, since the quality of fish can be compromised during marketing. The microbiological quality of fish sold in town fairs in the municipalities of the Bahia Reconcavo region, Brazil, was assessed to characterize isolates based on antimicrobial susceptibility and to investigate gene virulence. Samples of mullets (Mugil sp.), mussels (Mytella sp.), and mollusks (Anomalocardia brasiliana) were collected in town fairs in the municipalities of Cachoeira, Cruz das Almas, and Santo Ant ?nio de Jesus. The presence of mesophylls, molds and yeasts, total coliforms, Escherichia coli, and Staphylococcus aureus was evaluated. E. coli and S. aureus isolates were subjected to antimicrobial susceptibility tests and the presence of the gene stx in E. coli isolates was investigated. Total coliforms and S. aureus ranged between 0 and 9.50 log CFU/g, while high counts of mesophylls, molds, and yeasts were detected. E. coli had greater resistance (76.8%) to amoxicillin and S. aureus had greater sensitivity to gentamicin. The stx gene was not identified in any of the samples studied. Results showed that some fish sold in the town fairs of the three municipalities possessed unsatisfactory microbiological quality, which may pose risks to consumer health, and may be vectors for the dissemination of bacteria resistant to different antimicrobial agents.

关键词： Mugil brasiliensis Mytella spp. Anomalocardia brasiliana Resistance Virulence

Smart Grid Cyber Security： An Overview of Threats and Countermeasures

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Journal of Energy and Power Engineering 2015年第7期9卷 632-647页

作者： Carlos Lopez Arman Sargolzaei Hugo santana Carlos Huerta PLC (Power Line Carrier) International Inc. Smart Communication Systems Miami FL 33155 USA Department of Electrical and Computer Engineering Florida International University Miami FL 33174 USA US Naval Research Laboratory Corrosion Science and Engineering Washington DC 20375 USA

The smart grid is the next generation of power and distribution systems. The integration of advanced network, communications, and computing techniques allows for the enhancement of efficiency and reliability. The smart grid interconnects the flow of information via the power line, intelligent metering, renewable and distributed energy systems, and a monitoring and controlling infrastructure. For all the advantages that these components come with, they remain at risk to a spectrum of physical and digital attacks. This paper will focus on digital vulnerabilities within the smart grid and how they may be exploited to form full fledged attacks on the system. A number of countermeasures and solutions from the literature will also be reported, to give an overview of the options for dealing with such problems. This paper serves as a triggering point for future research into smart grid cyber security.

关键词： Smart grid power line communications smart metering threats vulnerabilities countermeasures solutions.

Analysis of in vivo absorption of didanosine tablets in male adult dogs by HPLC

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Journal of Pharmaceutical Analysis 2012年第1期2卷 29-34页

作者： Patrfícia Severino Heloisa Silva Eliana B. Souto Maria Helena A. santana Teresa Cristina T. Dalla Costa Biotechnological Processes Development Laboratory School of Chemical Engineering State University of Campinas-UNICAMP Campinas School of Pharmacy University of Rio Grande do Sul-UFRGS School of Agrarian Science and Veterinary S o Paulo State University-UNESP Jaboticabal Faculty of Health Sciences Fernando Pessoa University (FCS-UFP) Institute of Biotechnology and Bioengineering Centre of Genomics and Biotechnology University of Trás-os-Montes and Alto Douro (CGB-UTAD/IBB)

Didanosine is an effective antiviral drug in untreated and antiretroviral therapy-experienced patients with Human Immunodeficiency Virus (HIV). An automated system using on-line solid extraction and High Performance Liquid Chromatography (HPLC) with ultraviolet (UV) detection was developed and validated for pharmacokinetic analysis of didanosine in dog plasma. Modifications were introduced on a previous methodology for simultaneous analysis of antiretroviral drugs in human plasma. Extraction was carried out on C18 cartridges, with high extraction yield as stationary phase, whereas mobile phase consisted of a mixture of 0.02 M potassium phosphate buffer, acetonitrile (KH2PO4: acetonitrile: 96:4, v/v) and 0.5% (w/v) of heptane sulphonic acid. The pH was adjusted to 6.5 with triethylamine. All samples and standard solutions were chromatographed at 28 1C. For an isocratic run, the fiux was 1.0 mL/min, detection was at 250 nm and injected volume was 20 mL. The method was selective and linear for concentrations between 50 and 5000 ng/mL. Drug stability data ranged from 96% to 98%, and limit of quantification was 25 ng/mL. Extraction yield was up to 95%. Drug stability in dog plasma was kept frozen at 20 1C for one month after three freeze–thaw cycles, and for 24 h after processing in the auto sampler. Assay was successfully applied to measure didanosine concentrations in plasma dogs.

关键词： Didanosine On-line solid phase extraction HPLC Male dogs

Adjunctive acupuncture for pain and symptom management in the inpatient setting: protocol for a pilot hybrid effectiveness-implementation study

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Journal of Integrative Medicine 2016年第3期14卷 228-238页

作者： Maria T.Chao Alexandra Chang Sanjay Reddy James D.Harrison Joseph Acquah Miria Toveg Trilce santana Frederick M.Hecht Osher Center for Integrative Medicine University of California San Francisco Division of General Internal Medicine Zuckerberg San Francisco General HospitalUniversity of California San Francisco Departments of Anesthesiology and Internal Medicine Loma Linda University Division of Hospital Medicine University of California San Francisco

BACKGROUND： Effective pain management among hospitalized patients is an important aspect of providing quality care and achieving optimal clinical outcomes and patient satisfaction. Common pharmacologic approaches for pain, though effective, have serious side effects and are not appropriate for all inpatients. Findings from randomized controlled trials（RCTs） support the efficacy of acupuncture for many symptoms relevant to inpatients including postoperative pain, cancer-related pain, nausea and vomiting, and withdrawal from narcotic use. However, the extent to which findings from RCTs translate to real-world implementation of acupuncture in typical hospital settings is unknown. METHODS/DESIGN： In partnership with the launch of a clinical program offering acupuncture services to inpatients at the University of California San Francisco’s Mount Zion Hospital, we are conducting a pilot study using a hybrid effectiveness-implementation design to：（1） assess the effectiveness of acupuncture to manage pain and other symptoms and improve patient satisfaction; and（2） evaluate the barriers and facilitators to implementing an on-going acupuncture service for inpatients. During a twomonth pre-randomization phase, we evaluated and adapted clinical scheduling and treatment protocols with acupuncturists and hospital providers and pretested study procedures including enrollment, consent, and data collection. During a six-month randomization phase, we used a two-tiered consent process in which inpatients were first consented into a study of symptom management, randomized to be offered acupuncture, and consented for acupuncture if they accepted. We are also conducting in-depth interviews and focus groups to assess evidence, context, and facilitators of key provider and hospital administration ***： Effectiveness research in ＂real-world＂ practice settings is needed to inform clinical decision-making and guide implementation of evidence-based acupuncture practices. To

关键词： acupuncture therapy medicine,traditional inpatients randomized controlled trials hybrid trials clinicalprotocols

Vapor-Liquid Equilibrium of Ethyl Acetate+C_nH_(2n+1)OH(n=1,2,3) Binary Systems at 0.3 MPa

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Chinese Journal of Chemical Engineering 2012年第4期20卷 723-730页

作者： SUSIAL P. RODRIGUEZ-HENRIQUEZ J.J. SOSA-ROSARIO A. RIOS-santana R. School of Industrial and Civil Engineering University of Las Palmas de Gran CanariaCanary IslandsSpain

Vapor-liquid equilibrium data for the binary systems of ethyl acetate + methanol,ethyl acetate + ethanol and ethyl acetate + 1-propanol at 0.3 MPa were *** experimental data were verified with the point-to-point test of van Ness(1973).All these systems present an azeotropic point at 0.3 MPa that increases in ester composition for longer alcohol *** UNIFAC in different versions and ASOG prediction models were applied.

关键词： vapor-liquid equilibrium vapor-liquid equilibrium isobaric data ethyl ester alcohol

Unusual presentation of glomus tympanicum tumour: New bone formation in the middle ear

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World Journal of Clinical Cases 2014年第9期2卷 463-465页

作者： Gaurav Kumar zenon Andreou Jagdeep Singh Virk Anthony Owa ENT Department Queen’s Hospital Romford Essex RM7 0AG United Kingdom

The objective of this study is to increase awareness of the rare presentation, diagnostic difficulties and management of glomus tympanicum of the middle ear. A 49 years old male, with a background of hypertension and epilepsy, presented with a two month history of left sided conductive hearing loss, pulsatile tinnitus and headache. Clinically and radiologically a diagnosis of glomus tympanicum was made. Intraoperatively, extensive osteogenesis of the middle ear resulting in ossicular fixation and erosion was found. This patient required a two stage operation for full clearance of disease. A stapedectomy drill was used to drill off the bony overgrowth surrounding the ossicles resulting in improved hearing thresholds and full clearance of the disease at two year follow up. Glomus tympanicum can result in new bone formation in the middle ear with resultant ossicular fixation and conductive hearing loss. This can be effectively treated surgically with restoration of hearing.

关键词： Glomus Tympanicum Osteogenesis conductive hearing loss

“Acute postoperative open abdominal wall”: Nosological concept and treatment implications

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World Journal of Gastrointestinal Surgery 2013年第12期5卷 314-320页

作者： Manuel López-cano José A Pereira Manuel Armengol-Carrasco Abdominal Wall Surgery Unit Department of General Surgery Hospital Universitari Vall d’Hebrón Universitat Autònoma de Barcelona Department of General and Digestive Surgery Parc de Salut Mar Universitat Autònoma de Barcelona Department of Health and Experimental Sciences Universitat Pompeu Fabra

The so-called 'burst abdomen' has been described for many years and is a well-known clinical condition, whereas the concept of the 'open abdomen' is relatively new. In clinical practice, both nosological entities are characterized by a complex spectrum of symptoms apparently disconnected, which in many cases poses a great challenge for surgical repair. In order to assess the management of these disorders in a more comprehensive and integral fashion, the concept of 'acute postoperative open abdominal wall'(acute POAW) is presented, which in turn can be divided into 'intentional' or planned acute POAW and 'unintentional' or unplanned POAW. The understanding of the acute POAW as a single clinical process not only allows a better optimization of the ther-apeutic approach in the surgical repair of abdominal wallrelated disorders, but also the stratification and collection of data in different patient subsets, favoring a better knowledge of the wide spectrum of conditions involved in the surgical reconstruction of the abdominal wall.

关键词： Burst abdomen Open abdomen Evisceration Abdominal wall Mesh Negative pressure wound therapy Incisional hernia Enteroatmospheric fistula

Impact of Environment Conditions on Grapevine (<i>Vitis vinifera</i>L.): To Optimal Production and Sustainability, Achieving Food Security and Increasing the Palestinian Economy

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Journal of Geoscience and Environment Protection 2018年第2期6卷 62-73页

作者： Jehad M. H. Ighbareyeh Eusebio cano Carmona Department of Animal and Plant Biology and Ecology Faculty of Experimental Sciences University of Jaen Jaen Spain Department of Plant Production and Protection Faculty of Agriculture Al-Quds Open University Abu ktellah Street Hebron Palestine

Grapevine (Vitis vinifera L.) is one of important economic fruit crops found in Hebron of Palestine. Climate is one of the key controlling factors in grape and wine production. Materials & Method: We analyzed grape production in Hebron region, and studied the correlation analyses between productions and climatic, bioclimatic factors. The bioclimate, climatic factors were obtained according to Rivas-Martinez to classification of the earth. However, the independent variables were examined: the bioclimate factors as compensated thermicity index, annual ombrothermic index, water deficit and simple continentality index;and following climate factors: mean monthly temperature, precipitation and soil water reserve. The data used were from one meteorological station of the Palestinian Meteorological Department for the years 1993 to 2009 (16 years), and to the same years of grape production (rain-fed) from the Palestinian Central Bureau of Statistics (PCBS).?Result & Discussion: When we applied a Principal Component Analysis (PCA), and observed that the Hebron type plots are located at the left of axis 1 during 1999-2004 negatively affected by the bioclimate factors as compensated thermicity index, with a large proportion of the variance explained by axes 1 (76.66%), but precipitation was positive influenced on grape yield for the years (2004-2009), with a proportion of the variance explained by axes 2 (23.34%);Hebron type plots are located at the right of axis1during 1993-1999 positive affected by the bioclimate factor as a simple continentality index and annual ombrothermic index, and climate factors as water deficit, soil water reserve and mean monthly temperature, with a large proportion of the variance explained by axes 1 & 2 (100%). Conclusions: Grapes are sensitive climate and the surrounding environment factors, and in order to get a high production and high-quality grapes, mean monthly temperature must be between 15°C - 20°C, and 20°C - 30°C (27&#

关键词： Palestine Hebron Grapes Food Security Economy Climate