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The 2018 Nobel Prize in Chemistry: Engineering proteins(enzymes/peptide/antibodies) towards desired properties via the construction of random libraries

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Science China(Life Sciences) 2019年第5期62卷 713-724页

作者： zengyi chang School of Life Sciences State Key Laboratory of Protein and Plant Engineering Research Center for Protein Science Center of History and Philosophy of Science Peking University

The 2018 Nobel Prize in Chemistry was awarded one half to Dr. Frances Arnold (of California Institute of Technology,USA) for her work on 'directed evolution of enzymes', the other half to Dr. George Smith (of the University of Missouri, USA) and Sir Gregory Winter (of MRC Laboratory of Molecular Biology, UK) for their work on 'phage display of peptides and antibodies'.

关键词： The 2018 Nobel Prize in Chemistry towards desired properties via the construction of random libraries Engineering proteins

90 years of perseverance and achievements in biological education and research

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Science China(Life Sciences) 2015年第11期58卷 1053-1054页

作者： chang zengyi School of Life Sciences Center for Protein Science Center for the History and Philosophy of Science Peking University

This special issue commemorates the 90th anniversary （1925-2015） of Peking University＇s School of Life Scienc- es. As one of China＇s centers for education and research in biological sciences, the school＇s past 90 years have been eventful, ranging from times of prosperity to periods of war and chaos, with numerous outstanding students launching distinguished careers as educators and researchers in biolo- gy and other disciplines, both within China and worldwide.

关键词：生物教育科研成果北京大学生命科学生物科学研究人员生物技术职业生涯

A reciprocating motion-driven rotation mechanism for the ATP synthase

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Science China(Life Sciences) 2016年第1期59卷 44-48页

作者： Jiafeng Liu Xinmiao Fu zengyi chang State Key Laboratory of Protein and Plant Gene Research School of Life Sciences Peking University Center for Protein Science Peking University

The ATP synthase （having a typical subunit composition of α3β3γeab2c8-15） employs an intriguing rotary mechanism for the generation of ATP from ADP and Pi, using energy stored in a transmembrane proton gradient. The conventional rotary model, although being generally accepted, remains difficult to explain certain experimental observations. Here we propose an alterna- tive rotary model for the ATP synthase such that what rotates is the catalytic α3β3 cylinder rather than the central stalk and the membrane-embedded c-ring. Specifically, the membrane translocation of protons would induce a cycled conformational change in the c-ring, leading to a reciprocating motion of the attached central stalk, which in turn drives the unidirectional rotation of the α3β3 cylinder. Such a reciprocating motion-driven rotation mechanism is somehow analogous to the working mechanism of a retractable click ballpoint pen. Our new model not only explains the experimental observations that have been difficult to reconcile with the conventional model but also avoids its theoretical illogicality.

关键词： ATP synthase rotational catalysis rotary model

Is the mission to identify all the human proteins achievable? —Commenting on the human proteome draft maps

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Science China(Life Sciences) 2014年第10期57卷 1039-1040页

作者： chang zengyi GU LiangCai Center for Protein Science State Key Laboratory of Protein and Plant Gene Studies School of Life Sciences Center for History and Philosophy of Science Peking University Department of Genetics Harvard Medical School

Unveiling the structure and function of all the proteins a human body produces is undoubtedly a key task for us to better understand ourselves. Although a mission difficult to achieve, this apparently becomes more feasible upon the determination of the DNA sequence of the whole human genome, which was predicted to encode a total of 20,000-25,000 proteins [1]. Recent efforts of direct （de novo） protein isolation and peptide sequencing, mainly using liquid chromatography-tandem mass spectrometry （LC-MS/ MS） and in-depth bioinformatics analyses, led to the apparent identification of over 17,000 proteins from large sets of human tissues, cell lines and body fluids [2,3].

关键词：人类蛋白质组 DNA序列 LC-MS 地图人类基因组串联质谱法蛋白分离液相色谱

Chinese protein scientists met in Hefei for the 4th Chinese Protein Society Symposium

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Science China(Life Sciences) 2013年第12期56卷 1154-1155页

作者： LI GenXi chang zengyi Department of Biochemistry and State Key Laboratory of Pharmaceutical Biotechnology Nanjing University School of Life Sciences and Center of Protein Science Peking University

Some 600 scholars and students in protein science from around 40 institutions across China gathered at the 4th Symposium of the Chinese Protein Society held during October 12-14, 2013, in the city of Hefei, Anhui Province, China, with the theme ＂Protein and Human Health＂. This symposium was organized by the Chinese Protein Society, and locally sponsored by the University of Science and Technology of China and Anhui University. The topics of this symposium covered almost all areas in protein science, from structure to function, from mechanism to regulation, from single molecule to computer simulation, from in vitro （in the test tube） to in vivo （in living cells）, from qualitative to quantitative studies, from basic research to medical application, and from protein engineering to agriculture.

关键词：中国科学家蛋白质工程合肥市协会安徽大学专题讨论会计算机模拟人类健康

The discovery of Qinghaosu(artemisinin) as an effective anti-malaria drug:A unique China story

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Science China(Life Sciences) 2016年第2期59卷 81-88页

作者： zengyi chang Center of History and Philosophy of Science School of Life Sciences Center for Protein Science State Key Laboratory of Protein and Plant Gene Research Peking University

In a collective effort to find new drugs for killing the ma- laria parasites （plasmodium） that became resistant to the conventional drugs such as chloroquine, scientists in China not only rediscovered the anti-malaria effect of the Chinese herb Qinghao （Artemesia annua L.）, but also isolated the single active ingredient Qinghaosu （artemisinin in English） in crystal form. They subsequently conducted very system- atic studies on the pharmacological properties of qinghaosu and its derivatives, and determined the unusual chemical structure of Qinghaosu. These anti-malaria drugs have saved countless lives, especially in the developing coun- tries. Due to her key role in achieving these remarkable discoveries, Prof. Youyou Tu was awarded the 2015 Nobel Prize in Physiology or Medicine ＂for her discoveries con- cerning a novel therapy against Malaria＂. Here I will try to tell this fascinating China story based on what have been recorded in the peer-reviewed papers that were published in Chinese or English and largely in journals published in China.

关键词：青蒿素中国疟疾故事诺贝尔生理学或医学奖治疗药物晶体形态有效成分

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Homo-oligomerization as a common way for Proteins to modulate their activities

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生物物理学报 2009年第S1期25卷 88-89页

作者： zengyi chang Center for Protein Science, School of Life Sciences Peking University 100871

Although many proteins have been found to exist as homooligomers in nature, the biological significance and mechanism for its occurring is far from clear. We have examined a variety

关键词： Li Zhang Homo-oligomerization as a common way for Proteins to modulate their activities

SPECIAL TOPICS: Research frontiers highlighted in Science China Life Sciences in 2009

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Science Bulletin 2010年第36期55卷 4209-4211页

作者： chang zengyi School of Life Sciences, Peking University, Beijing 100871, China

The Science China series celebrated their 60th anniversary of publication in 2010. In this context, Science in China Series C-Life Sciences

关键词： Li SPECIAL TOPICS Research frontiers highlighted in Science China Life Sciences in 2009

Regrowth-delay Body as a Bacterial Subcellular Structure Marking Multidrug Tolerant Persisters

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Regrowth-delay Body as a Bacterial Subcellular Structure Mar...