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cKBET:assessing goodness of batch effect correction for single-cell RNA-seq

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Frontiers of Computer Science 2024年第1期18卷 215-228页

作者： Yameng ZHAO Yin guo Limin LI School of Mathematics and Statistics Xi’an Jiaotong UniversityXi’an 710049China

Single-cell RNA sequencing reveals the gene structure and gene expression status of a single cell,which can reflect the heterogeneity between ***,batch effects caused by non-biological factors may hinder data integration and downstream *** the batch effect can be evaluated by visualizing the data,which actually is subjective and *** this work,we propose a quantitative method cKBET,which considers the batch and cell type information *** cKBET method accesses batch effects by comparing the global and local fraction of cells of different batches in different cell *** verify the performance of our cKBET method on simulated and real biological data *** experimental results show that our cKBET method is superior to existing methods in most *** general,our cKBET method can detect batch effect with either balanced or unbalanced cell types,and thus evaluate batch correction methods.

关键词： single-cell RNA-seq dataset b batch effect assessment cKBET method

Solid Desiccant Heat Pump Fresh Air Unit using Composite Silica Gel

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Journal of Thermal Science 2024年第4期33卷 1286-1300页

作者： YANG Tianyu guo Defang GE Tianshu Institute of Refrigeration and Cryogenics Shanghai Jiao Tong UniversityKey Laboratory of Power Mechanical EngineeringMOE ChinaShanghai200240China Qingdao Haier A/C Electronic Co. LtdQingdao266101China

The introduction of fresh air into the indoor space leads to a significant increase in cooling or heating *** desiccant heat pump fresh air unit which can handle the latent and sensible load of fresh air efficiently have been proposed *** improve the performance of the solid desiccant heat pump fresh air unit in the fresh air handling process,in this paper,the application of composite silica gel in a heat pump fresh air unit was *** comparison between silica gel coating(SGC)and composite silica gel coating(CSGC)shows that the adsorption rate and water uptake capacity of CSGC are more than two times higher than those of *** experimental setup for the solid desiccant heat pump fresh air unit was *** performance of SGC and CSGC was tested in the setup *** show that under summer conditions,compared with the solid desiccant heat pump fresh air unit using silica gel(SGFU),the average moisture removal and COP of the one using composite silica gel(CSGFU)increased by 15%and 30%,*** winter conditions,compared with SGFU,the average humidification and COP of CSGFU increased by 42%and 17%.With optimal operation conditions of 3 min switchover time and 40 r/s compressor frequency,the COP of CSGFU under summer conditions can reach *** also show that the CSGFU and SGFU have higher COP and dehumidification rate under higher outdoor temperature and humidity ratio.

关键词： fresh air system desiccant coated heat exchanger humidification dehumidification experimental comparison

Reliability-based life-cycle cost seismic design optimization of coastal bridge piers with nonuniform corrosion using different materials

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 209-225页

作者： Wu Xiangtong Yuan Wenting guo Anxin Key Lab of Smart Prevention and Mitigation of Civil Engineering Disasters of the Ministry of Industry and Information Technology Harbin Institute of TechnologyHarbin 150090China Key Lab of Structures Dynamic Behavior and Control of the Ministry of Education Harbin Institute of TechnologyHarbin 150090China Institute of Transportation Inner Mongolia UniversityHohhot 010070China

Reinforcement corrosion is the main cause of performance deterioration of reinforced concrete(RC)*** research has been performed to investigate the life-cycle cost(LCC)of coastal bridge piers with nonuniform corrosion using different *** this study,a reliability-based design optimization(RBDO)procedure is improved for the design of coastal bridge piers using six groups of commonly used materials,i.e.,normal performance concrete(NPC)with black steel(BS)rebar,high strength steel(HSS)rebar,epoxy coated(EC)rebar,and stainless steel(SS)rebar(named NPC-BS,NPC-HSS,NPC-EC,and NPC-SS,respectively),NPC with BS with silane soakage on the pier surface(named NPC-Silane),and high-performance concrete(HPC)with BS rebar(named HPC-BS).First,the RBDO procedure is improved for the design optimization of coastal bridge piers,and a bridge is selected to illustrate the ***,reliability analysis of the pier designed with each group of materials is carried out to obtain the time-dependent reliability in terms of the ultimate and serviceability ***,the repair time of the pier is predicted based on the time-dependent reliability ***,the time-dependent LCCs for the pier are obtained for the selection of the optimal design.

关键词： reliability-based design optimization(RBDO) life-cycle cost(LCC) nonuniform corrosion coastal bridge pier repair

Mixed H_(∞)/Passive Exponential Synchronization for Delayed Memristive Neural Networks with Switching Event-Triggered Control

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Journal of Systems Science & Complexity 2024年第1期37卷 294-317页

作者： WU Wenhuang guo Lulu CHEN Hong Shanghai Research Institute for Intelligent Autonomous Systems Tongji UniversityShanghai 200092China Department of Control Science and Engineering Tongji UniversityShanghai 201804China

This paper is devoted to event-triggered synchronization of delayed memristive neural networks with H∞and passivity *** aim is to guarantee the exponential synchronization and mixed H∞and passivity control for memristive neural networks by using event-triggered ***,a switching system is constructed under the event-triggered control ***,by adopting a piece-wise Lyapunov functional,a sufficient condition is established for the exponential synchronization and mixed H_(∞)and passivity ***,an event-triggered controller design scheme is proposed using matrix decoupling ***,the effectiveness of the designed controller is exemplified by a numerical example.

关键词： Event-triggered control exponential synchronization memristive neural networks time delays.

Dynamic characteristics of multi-span spinning beams with elastic constraints under an axial compressive force

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Applied Mathematics and Mechanics(English Edition) 2024年第2期45卷 295-310页

作者： Xiaodong guo Zhu SU Lifeng WANG State Key Laboratory of Mechanics and Control for Aerospace Structures Nanjing University of Aeronautics and AstronauticsNanjing 210016China

A theoretical model for the multi-span spinning beams with elastic constraints under an axial compressive force is *** displacement and bending angle functions are represented through an improved Fourier series,which ensures the continuity of the derivative at the boundary and enhances the *** exact characteristic equations of the multi-span spinning beams with elastic constraints under an axial compressive force are derived by the Lagrange *** efficiency and accuracy of the present method are validated in comparison with the finite element method(FEM)and other *** effects of the boundary spring stiffness,the number of spans,the spinning velocity,and the axial compressive force on the dynamic characteristics of the multi-span spinning beams are *** results show that the present method can freely simulate any boundary constraints without modifying the solution *** elastic range of linear springs is larger than that of torsion springs,and it is not affected by the number of *** an increase in the axial compressive force,the attenuation rate of the natural frequency of a spinning beam with a large number of spans becomes larger,while the attenuation rate with an elastic boundary is lower than that under a classic simply supported boundary.

关键词： multi-span spinning beam elastic constraint improved Fourier series free vibration semi-analytical solution

Molecular classification of small cell lung cancer subtypes:Characteristics,prognostic factors,and clinical translation

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Chinese Medical Journal 2024年第2期137卷 130-139页

作者： Hanfei guo Wenqian Li Ye guo Naifei Chen Jiuwei Cui Cancer Center The First Hospital of Jilin UniversityChangchunJilin 130021China

Small cell lung cancer(SCLC)is a highly malignant tumor with a very poor prognosis;therefore,more effective treatments are urgently needed for patients afflicted with the *** recent years,emerging molecular classifications based on key transcription factors of SCLC have provided more information on the tumor pathophysiology,metastasis,immune microenvironment,and acquired therapeutic resistance and reflected the intertumoral heterogeneity of the various SCLC ***,advances in genomics and single-cell sequencing analysis have further revealed the high intratumoral heterogeneity and plasticity of the ***,we review and summarize these recent lines of evidence and discuss the possible pathogenesis of SCLC.

关键词： Small cell lung carcinoma Molecular classification Tumor heterogeneity Drug resistance Transcription factors Genomics Phenotype Prognosis

Distribution of oxide inclusions in H13 castings under super-gravity field with multi-stage rotation speeds

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Journal of Iron and Steel Research International 2024年第1期31卷 121-133页

作者： Shao-ying Li Xiao-jun Xi Xing-ming Zhao Han-jie guo Jing guo School of Metallurgical and Ecological Engineering University of Science and Technology Beijing(USTB)Beijing100083China Beijing Key Laboratory of Special Melting and Preparation of High-End Metal Materials Beijing100083China Beijing Beiye Functional Materials Corporation Beijing100192China Shandong Tianwu Forming Technology Co. Ltd.Liaocheng252024ShandongChina

The 42 kg industrial H13 castings were prepared by different super-gravity fields with multi-rotation speeds,and the distribution of oxide inclusions in the castings was *** addition,the inward movement Reynolds number and inward movement time of oxide inclusions as well as the solidification time of molten steel at different positions in the castings were calculated to clarify the removal mechanism of oxide inclusions in super-gravity *** results show that the large size(i.e.,greater than 10μm)oxide inclusions are mainly concentrated in the inner and outer parts of the super-gravity castings with constant rotation speed(500 r min^(-1))and five-stage rotation speeds(500,600,750,850,and 950 r min^(-1)),respectively,while there are no large oxide inclusions in the super-gravity castings with three-stage rotation speeds(500,600,and 750 r min^(-1)).Although an increase in the particle size of inclusion and the rotation speed in super-gravity field is conducive to the increase in the inward movement Reynolds number of oxide inclusions and reduction in the inward movement time of oxide inclusions,it will reduce the local solidification time of molten *** the range of the rotation speed studied,the super-gravity field with three-stage rotation speeds has the best effect on the removal of inclusions in H13 molten steel.

关键词： Distribution Oxide inclusion H13 casting Super-gravity field Rotation speed

Discovery potential of the Glashow resonance in an air shower neutrino telescope

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Chinese Physics C 2024年第8期48卷 266-275页

作者： guo-Yuan Huang School of Mathematics and Physics China University of GeosciencesWuhan 430074China Max-Planck-Institut für Kernphysik Saupfercheckweg 169117 HeidelbergGermany

The in-ice or in-water Cherenkov neutrino telescope,such as IceCube,has already proved its power in measuring the Glashow resonance by searching for the bump around E_(ν)=6.3PeV arising from the W-boson *** are many proposals for the next few decades for observations of cosmic tau neutrinos with extensive air showers,also known as tau neutrino *** air shower telescope is,in principle,sensitive to the Glashow resonance via the channel W→τν_(τ)followed by the tau decay in the air(e.g.,TAMBO,which has a geometric area of approximately 500km^(2)).Using a thorough numerical analysis,we find that the discovery significance can be up to 90%with a TAMBO-like setup if PeV neutrinos primarily originate from neutron decays,considering the flux parameters measured by IceCube as the *** presence of new physics affecting the neutrino flavor composition can also increase the ***,if ultrahigh-energy neutrinos are dominantly produced from meson decays,it will be statistically difficult for an advanced proposal such as TAMBO to discriminate the Glashow resonance induced byν¯e from the intrinsicντ/ν¯_(τ)*** have identified several limitations for such advanced telescopes,in comparison with the in-ice or in-water telescope,when measuring resonances:(i)a suppressed branching ratio of 11%for the decay W→τν_(τ);(ii)the smearing effect and reduced acceptance because the daughter neutrino takes away(y)∼75%of the energy from the W decay;and(iii)a large attenuation effect for Earth-skimming neutrinos with the resonance.

关键词： Ultrahigh-energy neutrinos Neutrino telescopes Glashow resonance

Optimal regularity of positive solutions of the Hénon-Hardy equation and related equations

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Science China Mathematics 2024年第10期67卷 2283-2302页

作者： Zongming guo Fangshu Wan College of Mathematics and Information Science Henan Normal University School of Mathematical Sciences University of Science and Technology of China School of Mathematical Sciences Anhui University

We present a new method to determine the optimal regularity of positive solutions u∈C4（Ω{0}）∩C0■ of the Hénon-Hardy equation,i.e.,■ where Ω■RN（N≥4） is a bounded smooth domain with 0∈Ω,α>-4,and p∈*** is clear that 0 is an isolated singular point of solutions of（0.1） and the optimal regularity of u in Ω relies on the parameter α.It is also important to see that the regularity of u at x=0 determines the regularity of u in Ω.We first establish asymptotic expansions up to arbitrary orders at x=0 of prescribed positive solutions u ∈C4（Ω{0}） ∩ C0（Ω）of（0.1）.Then we show that the regularity at x=0 of each positive solution u of（0.1） can be determined by some terms in asymptotic expansions of the related positive radial solution of the equation（0.1） with Ω=B,where B is the unit ball of *** main idea works for more general equations with singular weights.

关键词： Hénon-Hardy equation positive solutions optimal regularity singular point asymptotic expansions