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Icariin attenuates vascular endothelial dysfunction by inhibiting inflammation through GPER/Sirt1/HMGB1 signaling pathway in type 1 diabetic rats

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Chinese Journal of Natural Medicines 2024年第4期22卷 293-306页

作者： YAO Wenhui TAO Rongpin WANG Kai ding Xuansheng School of Basic Medicine and Clinical Pharmacy China Pharmaceutical UniversityNanjing211198China

Icariin, a flavonoid glycoside, is extracted from Epimedium. This study aimed to investigate the vascular protective effects of icariin in type 1 diabetic rats by inhibiting high-mobility group box 1 (HMGB1)-related inflammation and exploring its potential mechanisms. The impact of icariin on vascular dysfunction was assessed in streptozotocin (STZ)-induced diabetic rats through vascular reactivity studies. Western blotting and immunofluorescence assays were performed to measure the expressions of target proteins. The release of HMGB1 and pro-inflammation cytokines were measured by enzyme-linked immunosorbent assay (ELISA). The results revealed that icariin administration enhanced acetylcholine-induced vasodilation in the aortas of diabetic rats. It also notably reduced the release of pro-inflammatory cytokines, including interleukin-8 (IL-8), IL-6, IL-1β, and tumor necrosis factor-alpha (TNF-α) in diabetic rats and high glucose (HG)-induced human umbilical vein endothelial cells (HUVECs). The results also unveiled that the pro-inflammatory cytokines in the culture medium of HUVECs could be increased by rHMGB1. The increased release of HMGB1 and upregulated expressions of HMGB1-related inflammatory factors, including advanced glycation end products (RAGE), Toll-like receptor 4 (TLR4), and phosphorylated p65 (p-p65) in diabetic rats and HG-induced HUVECs, were remarkably suppressed by icariin. Notably, HMGB1 translocation from the nucleus to the cytoplasm in HUVECs under HG was inhibited by icariin. Meanwhile, icariin could activate G protein-coupled estrogen receptor (GPER) and sirt1. To explore the role of GPER and Sirt1 in the inhibitory effect of icariin on HMGB1 release and HMGB-induced inflammation, GPER inhibitor and Sirt1 inhibitor were used in this study. These inhibitors diminished the effects of icariin on HMGB1 release and HMGB1-induced inflammation. Specifically, the GPER inhibitor also negated the activation of Sirt1 by icariin. These findings suggest t

关键词： Icariin Diabetes Inflammation Vascular endothelial dysfunction GPER HMGB1

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Surface integrity evolution during creep feed profile grinding ofγ-TiAl blade tenon

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Chinese Journal of Aeronautics 2024年第8期37卷 496-512页

作者： Tao CHEN Xiaowei WANG Biao ZHAO Wenfeng ding Jiuhua XU National Key Laboratory of Science and Technology on Helicopter Transmission Nanjing University of Aeronautics and AstronauticsNanjing 210016China

Gamma titanium-aluminum(γ-TiAl)intermetallic compounds are increasingly used in manufacturing key hot-end components(e.g.,blade tenon)in aero engines due to their high specific strength and lightweight *** feed profile grinding(CFPG)as a crucial precision process that is applied to produce the final profile of the blade ***,sudden surface burns and microcracks of machined c-TiAl blade tenon often occur because of its low plasticity and high strength during grinding processes,leading to poor surface *** this work,CFPG experiments based on the profile characteristics ofγ-TiAl blade tenon were performed and an associated undeformed chip thickness model considering grain–workpiece contact condition was established to explore the evolution of the surface ***,the surface integrity was analyzed at different positions of the blade tenon in terms of surface roughness and morphology,metallographic structure,microhardness,and residual *** show that the profile characteristics of blade tenon have a significant influence on machined surface integrity because of the thermomechanical effect at various detecting *** residual stress was established based on the undeformed chip thickness model considering the profile structure,with a prediction error of 10%–15%.The thermomechanical effect is more obvious at the bottom area,where the surface roughness,work hardening degree,and subsurface plastic deformation range are the largest,while the values at the bevel area are the *** on the undeformed chip thickness model,a residual stress finite element simulation was conducted by employing thermomechanical coupled *** addition,the error between the simulation and the experiment was between 10%–15%.Strain and strain rate equations were established through the relationship between material displacement and *** average strain and strain rate of the ground surface when ap is 1.0 mm are 18.8%and 33.2%l

关键词： Gamma titanium-aluminum intermetallic compounds Blade tenon Creep feed profile grinding Surface integrity Thermomechanical effect

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Design strategy and relevant flow mechanisms of highly loaded 3D compressor tandem cascades

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Chinese Journal of Aeronautics 2024年第7期37卷 220-235页

作者： Xiaochen MAO Yunyu WANG Zhihua ding Hao CHENG Bo LIU School of Power and Energy Northwestern Polytechnical UniversityXi’an 710129China The National Key Laboratory of Science and Technology on Aerodynamic Design and Research Xi’an 710129China Xi’an Thermal Power Research Institute Co.Ltd Xi’an 710072China

To investigate the design strategy of highly loaded tandem cascades at both the midspan and endwall,the overall performance and flow mechanisms of four typical tandem cascades based on the optimization were analyzed from multiple perspectives *** results show that the interference effects on the Front Blade(FB)and Rear Blade(RB)should not be overlooked during the design phase,and the design strategies at the midspan and endwall are completely *** the midspan,the optimization aims to increase the interference effects and the strength of the gap jet while maintaining the same load on the FB and ***,the endwall optimal airfoil exhibits weakening interference effects,advancement of the gap jet location,and load transfer from the FB to *** further analysis of flow characteristics,the midspan optimal airfoil is beneficial for inhibiting the low-energy fluid from interacting with the suction surface of RB under the design condition,but results in earlier occurrence of corner *** endwall optimal airfoil helps suppress the development of the secondary flow and delay the onset of corner ***,by combining the benefits of these two design approaches,additional forward sweep effects are achieved,further enhancing the performance of the tandem cascade.

关键词： Tandem cascade Interference effect Vortex structure Load split Compressor

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OsMYB84,a transcriptional regulator of OsCOPT2 and OsHMA5,modulates copper uptake and transport and yield production in rice

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The Crop Journal 2024年第2期12卷 456-469页

作者： Jingli ding Chenchen Ji Lu Yu Chuang Wang Guangda ding Sheliang Wang Lei Shi Fangsen Xu Hongmei Cai Research Center of Microelement Huazhong Agricultural UniversityWuhan 430070HubeiChina College of Resources and Environment Huazhong Agricultural UniversityWuhan 430070HubeiChina National Key Laboratory of Crop Genetics and Improvement Huazhong Agricultural UniversityWuhan 430070HubeiChina

Transcription factors regulating crop uptake and translocation of the micronutrient Cu have not been *** isolated a novel R2R3-MYB transcription factor,OsMYB84,and showed that it was a positive regulator involved in uptake and transport of Cu via activation of OsCOPT2 and OsHMA ***84 was highly expressed in roots and anthers and induced by *** of OsMYB84 promoted uptake and root-to-shoot translocation of Cu in rice,facilitated Cu distribution into grain and increased grain *** contrast,mutation of OsMYB84 reduced Cu concentration in xylem ***84 bound to the promoter region of OsCOPT2 and OsHMA5 and upregulated their ***2 mutants showed reduced uptake of Cu and OsHMA5 overexpression lines showed increased root-to-shoot translocation of Cu.

关键词： OsMYB84 OsCOPT2 OsHMA5 Copper Rice

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Sound event localization and detection based on deep learning

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Journal of Systems Engineering and Electronics 2024年第2期35卷 294-301页

作者： ZHAO Dada ding Kai QI Xiaogang CHEN Yu FENG Hailin School of Mathematics and Statistics Xidian UniversityXi’an 710071China Science and Technology on Near-Surface Detection Laboratory Wuxi 214035China

Acoustic source localization(ASL)and sound event detection(SED)are two widely pursued independent research *** recent years,in order to achieve a more complete spatial and temporal representation of sound field,sound event localization and detection(SELD)has become a very active research *** paper presents a deep learning-based multioverlapping sound event localization and detection algorithm in three-dimensional ***-Mel spectrum and generalized cross-correlation spectrum are joined together in channel dimension as input *** features are classified and regressed in parallel after training by a neural network to obtain sound recognition and localization results *** channel attention mechanism is also introduced in the network to selectively enhance the features containing essential information and suppress the useless ***,a thourough comparison confirms the efficiency and effectiveness of the proposed SELD *** experiments show that the proposed algorithm is robust to reverberation and environment and can achieve higher recognition and localization accuracy compared with the baseline method.

关键词： sound event localization and detection(SELD) deep learning convolutional recursive neural network(CRNN) channel attention mechanism

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Effects of surface energy and substrate on modulus determination of biological films by conical indentation

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Science China(Technological Sciences) 2024年第6期67卷 1757-1764页

作者： ding Yue LI Cheng-Ya NIU XinRui WANG Gang-Feng Department of Engineering Mechanics SVLXi’an Jiaotong UniversityXi’an710049China Department of Mechanical Engineering City University of Hong KongHong Kong SAR999077China

Micro-/nano-indentation has become prevalent in evaluating the mechanical characteristics of biological samples,such as cells and ***,the existing contact models describing conical indentation ignore the joint effects of surface energy and substrate,and consequently cannot accurately extract the Young's modulus of biological samples deposited on *** finite element methods,we examine the conical indentation of biological films on substrates while taking surface energy into *** on the dimensional analysis,the explicit relationship between load and indentation depth is achieved for films with their moduli varying from 0.001 to 100 times that of the *** the classical Sneddon's model was employed to analyze the load-depth data,the measured modulus could reach 18 times the real modulus for films on harder substrates,but only 4%of the real modulus for films on softer ***,in micro-/nano-indentations,neglecting the contribution of surface energy would result in an overestimation of the Young's modulus of films depending on the contact *** analytical expression provided here can be utilized to precisely deduce the mechanical characteristics of biological films deposited on substrate from the load and indentation depth data of a conical indentation.

关键词： biological film surface effect substrate effect indentation

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Planning of DC Electric Spring with Particle Swarm Optimization and Elitist Non-dominated Sorting Genetic Algorithm

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CSEE Journal of Power and Energy Systems 2024年第2期10卷 574-583页

作者： Qingsong Wang Siwei Li Hao ding Ming Cheng Giuseppe Buja School of Electrical Engineering and Jiangsu Provincial Key Laboratory of Smart Grid Technology and Equipment Southeast UniversityNanjing 210096China School of Software Engineering Southeast universitySuzhou 215123China

This paper addresses the planning problem of parallel DC electric springs (DCESs). DCES, a demand-side management method, realizes automatic matching of power consumption and power generation by adjusting non-critical load (NCL) and internal storage. It can offer higher power quality to critical load (CL), reduce power imbalance and relieve pressure on energy storage systems (RESs). In this paper, a planning method for parallel DCESs is proposed to maximize stability gain, economic benefits, and penetration of RESs. The planning model is a master optimization with sub-optimization to highlight the priority of objectives. Master optimization is used to improve stability of the network, and sub-optimization aims to improve economic benefit and allowable penetration of RESs. This issue is a multivariable nonlinear mixed integer problem, requiring huge calculations by using common solvers. Therefore, particle Swarm optimization (PSO) and Elitist non-dominated sorting genetic algorithm (NSGA-II) were used to solve this model. Considering uncertainty of RESs, this paper verifies effectiveness of the proposed planning method on IEEE 33-bus system based on deterministic scenarios obtained by scenario analysis.

关键词： DC distribution network DC electric spring non-dominated sorting genetic algorithm particle swarm optimization renewable energy source

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Optimising multi-vent module-based adaptive ventilation using a novel parameter for improved indoor air quality and health protection

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Building Simulation 2024年第1期17卷 113-130页

作者： Haotian Zhang Xiaoxiao ding Weirong Zhang Weijia Zhang Yingli Xuan Key Laboratory of Green Built Environment and Energy Efficient Technology Beijing University of TechnologyBeijing 100124China Department ofArchitecture TokyoPolytechnic UniversityTokyoJapan

As infectious respiratory diseases are highly transmissible through the air,researchers have improved traditional total volume air distribution systems to reduce infection ***-vent module-based adaptive ventilation(MAV)is a novel ventilation type that facilitates the switching of inlets and outlets to suit different indoor scenarios without changing ductwork ***,little research has evaluated MAV module sizing and air velocity selection,both related to MAV system efficiency in removing contaminants and the corresponding level of protection for occupants in the ventilated ***,the module-source offset ratio(MSOR)is proposed,based on the MAV module size and its distance from an infected occupant,to inform selection of optimal MAV module *** fluid dynamics simulations illustrated contaminant distribution in a two-person MAV equipped *** phase particles modelled respiratory contaminants from the infected occupant,and contaminant concentration distributions were compared under four MAV air distribution layouts,three air velocities,and three module sizes considered using the *** indicate that lower air velocities favour rising contaminant levels,provided the ventilation rate is *** contaminant discharge can be achieved when the line of outlets is located directly above the infected *** this parameter to guide MAV system design,85.7% of contaminants may be rendered harmless to the human body within 120 s using the default air vent layout.A more appropriate supply air velocity and air vent layout increases this value to 91.4%.These results are expected to inform the deployment of MAV systems to reduce airborne infection risk.

关键词： multi-vent module-based adaptive ventilation computational fluid dynamics indoor air quality infection control

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CXCL13 shapes tumor immune microenvironment in ovarian cancer with homologous recombination deficiency

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Genes & Diseases 2024年第5期11卷 48-50页

作者： Yue ding Zheng Ye Bo ding Songwei Feng Furong Du Xuejiao Ma Xiaoxuan Wang Yang Shen Department of Obstetrics and Gynaecology Zhongda HospitalSchool of MedicineSoutheast UniversityNanjingJiangsu 210008China State Key Laboratory of Bioelectronics School of Biological Science and Medical EngineeringSoutheast UniversityNanjingJiangsu 210096China State Key Laboratory of Translational Medicine and Innovative Drug Development Jiangsu Simcere Diagnostics Co.Ltd.NanjingJiangsu 210042China

Recently,immune checkpoint inhibitors(ICIs)and poly(ADP-ribose)polymerase inhibitors(PARPi)have played a pivotal role in prolonging the recurrence-free survival of patients with ovarian cancer(OC).1,2 Although PARPi have revolutionized the treatment of OC,the absence of reliable predictive biomarkers limits the broad application of ICIs for patients with homologous recombination(HR)deficiency(HRD).3 CXC-chemokine ligand 13(CXCL13)is a cytokine constitutively secreted in the stromal cells of the B-cell region of secondary lymphoid tissue.4 It exclusively binds to the chemokine receptor CXCR5,which is abundantly expressed in subsets of mature circulating B lymphocytes,follicular helper T cells,and skin-derived dendritic cells,and governs the migration of these cells into secondary lymphoid organs in response to the CXCL13 gradient.5 In this study,we aimed to elucidate the role of CXCL13 in shaping the tumor immune microenvironment(TIME)in HR-deficient OC and to explore its relationship with the cGAS-STING signaling pathway.

关键词： CXCL13 cancer organs

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Bioinformatics analysis and experimental validation of cystathionine-gamma-lyase as a potential prognosis biomarker in hepatocellular carcinoma

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BIOCELL 2024年第3期48卷 463-471页

作者： YANAN MA SHANSHAN WANG HUIGUO ding Department of Gastroenterology and Hepatology Beijing You’an Hospital Affiliated with Capital Medical UniversityBeijing100069China Beijing Institute of Hepatology Beijing You’an Hospital Affiliated with Capital Medical UniversityBeijing100069China

Background:Hepatocellular carcinoma(HCC)is a common malignant tumor with poor prognosis and high mortality *** cystathionine-gamma-lyase(CSE)plays an important role in the development of multiple tumors,the clinical implication and potential mechanisms of CSE in HCC development remain ***:In our study,the CSE expression in HCC was analyzed in Gene Expression Omnibus(GEO)and The Cancer Genome Atlas(TCGA)datasets and further conﬁrmed by RT-qPCR and immunohistochemistry assays in HCC ***,the associations between CSE expression and HCC malignancy as well as survival were analyzed in GSE14520 and validated in HCC ***,the biological functions of CSE in HCC cells was assessed by CCK-8,ﬂow cytometry and Western ***:Lower transcriptional and proteomic CSE expressions were found in HCC tissues in contrast to adjacent normal *** CSE mRNA expression was signiﬁcantly associated with advanced clinicopathological features and poor outcomes in HCC patients from public database and our *** univariate and multivariate analyses of GSE14520 data showed that CSE expression was an independent prognostic indicator for the overall survival(OS)and recurrence-free survival(RFS)of HCC *** vitro experiments further explained that CSE might trigger HCC cell apoptosis by ***:In summary,the present study identiﬁed the relationship between CSE expression and HCC malignancy as well as OS and RFS,indicating that CSE might be a potential prognostic biomarker and a novel therapeutic target for HCC.

关键词： Hepatocellular carcinoma Cystathionine-gamma-lyase Hydrogen sulfide Prognosis Apoptosis

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