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虚拟现实技术在微创化乙状窦前入路显露颈静脉结节的解剖研究中的应用

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中华解剖与临床杂志 2017年第3期22卷 197-200页

作者：钱增辉梁径山汤可李一鸣刘爱华首都医科大学附属北京天坛医院神经外科北京市神经外科研究所北京100050 解放军第三0九医院神经外科

目的在虚拟现实系统中探讨合理缩小乙状窦前入路显露颈静脉结节的手术路径操作范围。方法采集15例成人尸头标本CT和MRI影像数据构建岩骨和后颅窝的虚拟现实解剖模型。在颅盖中选取乳突尖部为乙状窦前入路的开颅标志点，在颅底中选择颈... 详细信息

目的在虚拟现实系统中探讨合理缩小乙状窦前入路显露颈静脉结节的手术路径操作范围。方法采集15例成人尸头标本CT和MRI影像数据构建岩骨和后颅窝的虚拟现实解剖模型。在颅盖中选取乳突尖部为乙状窦前入路的开颅标志点，在颅底中选择颈静脉结节前缘为目标显露区的标志点，以开颅和显露标志点连线为轴线作出直径为2em的圆柱状模拟乙状窦前入路手术路径，再缩小圆柱直径至1cm进行微创化设计；观察和测量微创化前后手术路径中解剖结构显露情况，采用配对t检验进行比较分析。结果微创化前路径中包含乙状窦前缘、颈静脉球下端、颈内静脉和岩下窦，经过舌咽神经、迷走神经、副神经和舌下神经，包含部分颈内动脉的体积为（41．57±2．38）mm3和小脑前下动脉的体积为（60．64±2．13）mm3。微创化后手术路径经过部分颈静脉球、颈内静脉和岩下窦，经过副神经。微创化后手术路径体积以及路径中所包含骨性结构、颅神经、静脉结构体积分别为（2168．00±12．90）mm3、（26．43±1．71）mm3和（780．32±18．74）mm3，均小于微创化前的（7083．40±156．24）mm3、（130．24±1．88）mm3和（2411．00±162．86）mm3，差异均有统计学意义（t=114．349、217．286、54．402，P值均〈0．01）。结论模拟手术路径中，操作方向和范围确定，可实现量化比较。乙状窦前入路显露颈静脉结节的微创化手术路径有助于减少术中对骨性结构的磨除和神经血管的损伤。

关键词：乙状窦前入路虚拟现实三维解剖颈静脉结节颅底

Fine mapping of a major QTL on chromosome A05 conferring pod size in peanut

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The Crop Journal 2024年第6期12卷 1745-1753页

作者： Kunkun Zhao Xufa Du Jingjing Zhang Yi Fan qian Ma Yaoyao Li zenghui Cao Di Cao Sasa Hu Ding Qiu Kai Zhao Fangping Gong Zhongfeng Li Rui Ren Lin Zhang Xingli Ma Xingguo Zhang Dongmei Yin College of Agronomy&Peanut Functional Genome and Molecular Breeding Engineering Henan Agricultural UniversityZhengzhou 450000HenanChina

Pod size is a key agronomic trait that influences peanut yield ***,our understanding of the mechanisms underlying pod size is *** this study,we employed a segregating population derived from a cross between the small-pod line ND_S and the large-pod line ND_L to map quantitative trait loci(QTL)associated with pod *** mapping performed using bulk segregant analysis revealed a candidate interval on chromosome A05 referred to as *** refined this interval to a 256.9 kb genomic region using newly developed molecular *** sequence and expression analyses,we identified the candidate gene AhXE45GC,which encodes an AN1 zinc finger *** discovered a 33-bp insertion in the intron of AhXE45GC in ND_*** that lack this insertion,such as ND_L,had significantly larger pods than those with the insertion,including ND_*** facilitate marker-assisted selection for peanut pod size,we developed a molecular marker associated with this *** marker could provide a valuable genetic resource for breeding high-yielding peanut varieties.

关键词： Peanut Pod size BSA-seq Zinc finger protein

DGMI alleviates OGD/R-induced cell injury by regulating inflammatory and apoptosis signaling pathways

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Journal of Chinese Pharmaceutical Sciences 2020年第7期29卷 455-469页

作者： qian Hong zenghui Wang Yang Yang Lu Gao Zhao Yan The 71st Group Army Hospital of CPLA Army(Affiliated Huaihai Hospital of Xuzhou Medical University) Xuzhou 221004China

Diterpene ginkgolides meglumine injection(DGMI),a kind of Ginkgo biloba special extract injection,is now used for the treatment of ischemic stroke in *** the present study,we aimed to confirm whether DGMI could suppress inflammatory responses and apoptosis and explore the potential mechanisms underlying these *** viability and lactate dehydrogenase(LDH)release were measured by MTS and LDH assays after the cells were exposed to oxygen-glucose deprivation/reoxygenation(OGD/R).The extent of anti-apoptotic effect of DGMI was detected by flow cytometry using Annexin V-FITC/PI double staining assay ***-inflammatory cytokines,including TNF-α,IL-1β,IL-6 and IL-10,were quantified by a specific Bio-Plex ProTM Reagent ***,activities of TLR2/4,NF-κB p65,MAPK pathway and apoptosis-related proteins as well as cellular localization of NF-κB p65 were determined by Western blotting analysis and immunofluorescence staining,*** at 50μg/mL significantly increased the cell viability and decreased the secretion of IL-1β,IL-6,IL-10 and TNF-αin OGD/R-induced BV2 microglia *** effects were also confirmed by LDH assay and Annexin V-FITC/PI ***,DGMI not only inhibited the protein expressions of TLR2,TLR4,MyD88,p-TAK1,p-IkBα,p-IKKβand Bak,but also decreased the cleaved caspase-3/caspase-3,Bax/Bcl-2 and cleaved PARP-1/PARP-1 ratio in OGD/R-induced BV2 microglia ***,OGD/R-enhanced p-JNK1/2 and p-p38 MAPK expressions and nuclear translocation of NF-κB p65 were also partially inhibited by *** present study showed that inflammatory responses were triggered in BV2 microglia cells activated by OGD/R,leading to the release of pro-inflammatory cytokines and *** suppressed the inflammatory response and apoptosis by regulating the TLR/MyD88/NF-κB signaling pathways and down-regulation of p-JNK1/2 and p-p38 MAPK activation.

关键词： Ginkgolides BV2 microglia cells TLR Cerebral ischemia NF-κB MAPK Inflammation

露天坑回填土石混合体的渗流特性及颗粒元数值分析

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岩石力学与工程学报 2009年第11期28卷 2342-2348页

作者：高谦刘增辉李欣李俊华北京科技大学土木与环境工程学院北京100083 安徽理工大学能源与安全学院安徽淮南232001 河北钢铁集团矿业公司司家营铁矿河北唐山063700

针对土石混合体的渗透性,结合唐钢司家营铁矿III采场露天转井下的回填土石混合体工程,采用室内试验、现场试验和数值模拟的方法对其进行系统地研究,得出土石混合体的渗透系数与其非均匀度近似存在线性关系,渗透系数与混合土的孔隙比成正... 详细信息

针对土石混合体的渗透性,结合唐钢司家营铁矿III采场露天转井下的回填土石混合体工程,采用室内试验、现场试验和数值模拟的方法对其进行系统地研究,得出土石混合体的渗透系数与其非均匀度近似存在线性关系,渗透系数与混合土的孔隙比成正比;合理控制回填废石的粒径级配,降低平均粒径与非均匀度,可有效降低回填土石混合体的渗透性。通过颗粒元数值正交试验确定对土石混合体的渗流量影响顺序,并二次逐步回归出回填层厚度,水头压力,孔隙率,平均粒径对渗流量的关系式,为土石混合体防渗抗渗提供计算工具。

关键词：土力学土石混合体(RSA) 渗流系数正交试验颗粒元

Hydrothermal alteration of dolostones in the Lower Ordovician,Tarim Basin,NW China:Multiple constraints from petrology,isotope geochemistry and fluid inclusion microthermometry

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Hydrothermal alteration of dolostones in the Lower Ordovicia...

中国科学院地质与地球物理研究所2013年度（第13届）学术年会

作者： Shaofeng Dong Daizhao Chen Hairuo Qing Xiqiang Zhou Dan Wang zenghui Guo Maosheng Jiang Yixiong qian Key Laboratory of Petroleum Resources Research Institute of Geology and GeophysicsChinese Academy of Sciences Graduate University of Chinese Academy of Sciences Department of Geology University of ReginaReginaSKCanada S4S0A2 Research Institute of China National Offshore Oil Corporation

Massive dolostones pervasively occur in the Lower Paleozoic strata in Tarim Basin,NW *** study focuses on the hydrothermally-altered dolostones in the Lower Ordovician at Sancha,Bachu County where the hydrothermally-altered dolostones,marbles and diabase intrusions co-occur within a largescale, NW trending strike-slip fault *** this zone,the intrusive diabases mostly occur along the master border faults to the east and west,*** limestones that got in contact with the intrusions commonly were marbleized and the antecedent dolostones were subject to intense hydrothermal alteration,particularly along fractured *** on field investigations and petrographic examinations on the hydrothermally-altered dolostones,five distinctive fabrics of matrix and cement dolomites are *** episodes of vein-filling calcites postdate the hydrothermallyprecipitated saddle *** isotopic geochemistry(C,O and Sr) and fluid inclusion micro thermometry suggest that dolomite recrystallization and precipitation were associated with the hydrothermal activity induced by fracturing/faulting and intrusive *** SIMS U-Pb isotopic dating of zircon grains from the diabases yields an age of 290.5±2.9 Ma in the Early Permian, which reconciles the relative timing revealed by the paragenetic *** magmatic emplacement was thus linked to the large igneous province(LIP) of Early Permian in Tarim *** this case,the widespread magmatic activities could have caused the thermal anomaly and fracturing in the strata that were penetrated by the intrusions,enhancing the thermal diffusion and hydrothermal fluid migration (although minor volumes of thermal fluids from the basic magmas) through the fracture/fault systems, thereby resulting in contact metamorphism(or marbleization),recrystallization of matrix dolomites and dolomite precipitation commonly in primary dolostone *** study provides a useful analogue to unders

关键词： Tarim Basin Lower Ordovician Tectono-magmatism Isotope geochemistry U-Pb isotope dating Hydrothermally-altered dolostone

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草地的红外纹理建模与真实感绘制方法

红外与激光工程 2013年第4期42卷 1100-1105页

作者：柳倩朱枫郝颖明金增辉付双飞中国科学院沈阳自动化研究所辽宁沈阳110016 中国科学院大学北京100049 中国科学院光电信息处理重点实验室辽宁沈阳110016 辽宁省图像理解与视觉计算重点实验室辽宁沈阳110016 空军驻沈阳地区代表室辽宁沈阳110016

纹理是使图像具有视觉真实感的重要因素,红外纹理生成是场景红外成像仿真的重要组成部分,也是真实感场景仿真的迫切需求。以在图像平面直接生成具有真实感的景物红外纹理图像为目标,提出了一种草地的红外纹理建模与真实感绘制方法,从模... 详细信息

纹理是使图像具有视觉真实感的重要因素,红外纹理生成是场景红外成像仿真的重要组成部分,也是真实感场景仿真的迫切需求。以在图像平面直接生成具有真实感的景物红外纹理图像为目标,提出了一种草地的红外纹理建模与真实感绘制方法,从模拟组分温度分布和空间结构形态两方面开展研究。首先,考虑土壤-植被-大气间的热交换过程,建立红外辐射的耦合求解模型;其次,构建各组分的空间分布模式;最后,将已经求解的红外辐射数据映射到图像空间,生成具有真实感的红外纹理图像。对近距离或"放大"状态下草地红外纹理的视觉效果进行了模拟,理论分析和仿真结果表明:所提出的红外纹理模拟方法具有一定的合理性和有效性。

关键词：纹理建模真实感草地红外辐射耦合模型

实时心肌声学造影评价正常犬心肌血流灌注的实验研究

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中国超声医学杂志 2001年第2期17卷 11-14页

作者：韩增辉钱蕴秋苏海砾第四军医大学西京医院超声诊断科

目的 :应用实时心肌声学造影评价正常犬的心肌血流灌注。方法 :8只开胸犬以微量注射泵静脉滴注全氟显 (速度为 5 ml/ min和 10 ml/ min)进行实时心肌声学造影。乳头肌水平短轴切面观察左室各壁的造影效果和室壁运动。以闪烁显像观察左... 详细信息

目的 :应用实时心肌声学造影评价正常犬的心肌血流灌注。方法 :8只开胸犬以微量注射泵静脉滴注全氟显 (速度为 5 ml/ min和 10 ml/ min)进行实时心肌声学造影。乳头肌水平短轴切面观察左室各壁的造影效果和室壁运动。以闪烁显像观察左室各壁的再灌注情况。结果 :实时心肌声学造影良好地显示了犬正常心肌的血流灌注特点 ,包括色彩、亮度与灌注时间 ,同时各室壁节段运动显示良好 ,回放测量与 M型测值无明显差异。闪烁显像准确反映了心肌血流灌注的速度。结论 :实时心肌声学造影可同时观察心肌灌注和室壁运动 ,“闪烁”显像具有定量评价心肌血流灌注的潜在价值 ,具有良好的应用前景。

关键词：心肌声学造影心肌灌注

Monitoring and evaluation of disaster risk caused by linkage failure and instability of residual coal pillar and rock strata in multi-coal seam mining

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Geohazard Mechanics 2023年第4期1卷 297-307页

作者： Qing Ma Xiaoli Liu Yunliang Tan Yurui Wang Ruosong Wang Enzhi Wang Xuesheng Liu zenghui Zhao Darui Ren Weiqiang Xie Ruipeng qian Nan Hu State Key Laboratory of Hydroscience and Engineering Tsinghua UniversityBeijing100084China College of Energy and Mining Engineering Shandong University of Science and TechnologyQingdaoShandong266590China Shandong Energy Xinwen Group Xinjulong CO.LTD Shandong294718China

Comprehensive research methods such as literature research,theoretical analysis,numerical simulations and field monitoring have been used to analyze the disasters and characteristics caused by the linkage failure and instability of the residual coal pillars-rock strata in multi-seam *** effective monitoring area and monitoring design method of linkage instability of residual coal pillar-rock strata in multi-seam mining have been *** evaluation index and the risk assessment method of disaster risk have been established and the project cases have been applied and *** results show that:①The coal pillar will not only cause disaster in singleseam mining,but also more easily cause disaster in multi-seam *** instability of coal pillars can cause not only dynamical disasters such as rock falls and mine earthquakes,but also cause surface subsidence and other disasters.②When monitoring the linkage instability of residual coal pillar-rock strata,it is not only necessary to consider the monitoring of the apply load body(key block),the transition body(residual coal pillar)and the carrier body(interlayer rock and working face),but also to strengthen the monitoring of the fracture development height(linkage body).③According to the principles of objectivity,easy access and quantification,combined with investigation,analysis,and production and geological characteristics of this mining area,the main evaluation indexes of the degree of disaster caused by linkage instability of residual coal pillar-rock strata are determined as:microseismic energy,residual coal pillar damage degree,fracture development *** the evaluation index classification table was also given.④According to the measured value of the evaluation index,the fuzzy comprehensive evaluation method was used to calculate the disaster risk degree in the studied mine belongs to class III,that is,medium risk *** corresponding pressure relief technology was adopted on site,which ach

关键词： Multi-seam mining Residual coal pillar Linkage instability Rock burst Monitor and evaluation

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端苝基功能化聚乙烯的制备及其应用

石油化工 2020年第10期49卷 953-959页

作者：赵增辉李英李倩李化毅中国石油石油化工研究院大庆化工研究中心黑龙江大庆163714 中国科学院化学研究所北京100190

以端双键聚乙烯、β-巯基乙胺为原料,通过点击化学反应得到端氨基功能化聚乙烯,然后与苝-3,4,9,10-四羧酸二酐(PD)进行酰胺化反应制备了端基为苝酰亚胺的功能化聚乙烯(PD-PE)。利用1H NMR、13C NMR、FTIR、UV-Vis和荧光光谱等方法研究了... 详细信息

以端双键聚乙烯、β-巯基乙胺为原料,通过点击化学反应得到端氨基功能化聚乙烯,然后与苝-3,4,9,10-四羧酸二酐(PD)进行酰胺化反应制备了端基为苝酰亚胺的功能化聚乙烯(PD-PE)。利用1H NMR、13C NMR、FTIR、UV-Vis和荧光光谱等方法研究了PD-PE的结构、光吸收性能、着色性能及共混性等。实验结果表明,改性后的PD-PE不会改变PD的紫外吸收峰的位置,但吸收峰强度有所增强。PD-PE不易从基体中析出,上染率高,染色效果稳定。改性后的PD-PE荧光效果得到明显改善,即使以10-6级的量添加时仍有较为明显的荧光效果。该类端基功能化聚乙烯在提高聚乙烯印染性等方面有良好的前景。

关键词：端基功能化聚乙烯共混改性荧光性