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Study on cook-off characteristics and thermal safety venting area of RBOE charge

Defence Technology(防务技术) 2025年第1期43卷 271-287页

作者： Kebin Zhang Wenbin li Changfang Zhao Zhifang Wei Shuxia Zhang Jin li School of Mechanical and Electrical Engineering North University of ChinaTaiyuan 030000China ZNDY of Ministerial Key Laboratory Nanjing University of Science and TechnologyNanjing 210094China Department of Engineering Mechanics CNMM and AMLTsinghua UniversityBeijing 100084China

RBOE is a new type of DNAN-based high-energy melt-cast mixed explosive,whose safety under thermal stimulation is significantly affected by heating conditions and venting area of the *** on the thermal decomposition reaction characteristics and combustion characteristics of each component of RBOE explosive,the cook-off calculation models of RBOE warhead before and after ignition were *** addition,closed and vented warheads were designed,as well as fast and slow cook-off test *** cook-off characteristics and thermal safety venting area of RBOE warhead were extensively *** results showed that the closed RBOE warhead underwent deflagration reaction under both slow and fast cook-off *** calculation result of the shell wall temperature before slow cookoff ignition response of the warhead was 454.06 K,with an error of+1.75%compared to the test result of462.15 K,and the temperature rise rate calculated was in good agreement with the *** calculated ignition time of RBOE warhead under fast cook-off was 161 s,with an error of+8.8%compared to the test result of 148 s,which verified the accuracy of cook-off model of RBOE warhead before *** to the cook-off calculation model of the warhead after ignition and cook-off test of the vented warhead,it was determined that the thermal safety venting area was 1124.61 mm^(2)for fast cook-off and 530.66 mm~2 for slow cook-off,effectively preventing the reaction of warhead above ***,this study provides a scientific basis for the thermal safety design and evaluation of insensitive warheads.

关键词： RBOE explosive Cook-off model Temperature distribution Pressure growth Venting area

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Glutamatergic CYLD deletion leads to aberrant excitatory activity in the basolateral amygdala:association with enhanced cued fear expression

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Neural Regeneration Research 2025年第11期20卷 3259-3272页

作者： Huidong li Faqin li Zhaoyi Chen Erwen Wu Xiaoxi Dai Danni li Haojie An Shiyi Zeng Chunyan Wang li Yang Cheng Long School of life Sciences South China Normal UniversityGuangzhouGuangdong ProvinceChina School of life Sciences Guangzhou UniversityGuangzhouGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Major Obstetric Diseases The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research Panyu Central HospitalGuangzhouGuangdong ProvinceChina

Neuronal activity,synaptic transmission,and molecular changes in the basolateral amygdala play critical roles in fear ***(CYLD)is a deubiquitinase that negatively regulates the nuclear factor kappa-B *** is well studied in non-neuronal cells,yet underinvestigated in the brain,where it is highly *** studies have shown involvement of CYLD in the remodeling of glutamatergic synapses,neuroinflammation,fear memory,and anxiety-and autism-like ***,the precise role of CYLD in glutamatergic neurons is largely ***,we first proposed involvement of CYLD in cued fear *** next constructed transgenic model mice with specific deletion of Cyld from glutamatergic *** results show that glutamatergic CYLD deficiency exaggerated the expression of cued fear in only male ***,loss of CYLD in glutamatergic neurons resulted in enhanced neuronal activation,impaired excitatory synaptic transmission,and altered levels of glutamate receptors accompanied by over-activation of microglia in the basolateral amygdala of male ***,our study suggests a critical role of glutamatergic CYLD in maintaining normal neuronal,synaptic,and microglial *** may contribute,at least in part,to cued fear expression.

关键词： basolateral amygdala cued fear expression cylindromatosis deubiquitinase glutamate receptor 1 glutamatergic neuron microglial activation N-methyl-D-aspartate receptor 1 neuronal activation synaptic transmission

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Decoding the nexus:branched-chain amino acids and their connection with sleep,circadian rhythms,and cardiometabolic health

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Neural Regeneration Research 2025年第5期20卷 1350-1363页

作者： Hui li Laurent Seugnet Department of Neurology Xijing HospitalXi’anShaanxi ProvinceChina Centre de Recherche en Neurosciences de Lyon Integrated Physiology of the Brain Arousal Systems(WAKING)UniversitéClaude Bernard Lyon 1INSERM U1028CNRS UMR 5292BronFrance

The sleep-wake cycle stands as an integrative process essential for sustaining optimal brain function and,either directly or indirectly,overall body health,encompassing metabolic and cardiovascular *** the heightened metabolic activity of the brain,there exists a considerable demand for nutrients in comparison to other *** these,the branched-chain amino acids,comprising leucine,isoleucine,and valine,display distinctive significance,from their contribution to protein structure to their involvement in overall metabolism,especially in cerebral *** the first amino acids that are released into circulation post-food intake,branched-chain amino acids assume a pivotal role in the regulation of protein synthesis,modulating insulin secretion and the amino acid sensing pathway of target of ***-chain amino acids are key players in influencing the brain's uptake of monoamine precursors,competing for a shared *** their involvement in protein synthesis,these amino acids contribute to the metabolic cycles ofγ-aminobutyric acid and glutamate,as well as energy ***,they impact GABAergic neurons and the excitation/inhibition *** rhythmicity of branchedchain amino acids in plasma concentrations,observed over a 24-hour cycle and conserved in rodent models,is under circadian clock *** mechanisms underlying those rhythms and the physiological consequences of their disruption are not fully *** sleep,obesity,diabetes,and cardiovascular diseases can elevate branched-chain amino acid concentrations or modify their oscillatory *** mechanisms driving these effects are currently the focal point of ongoing research efforts,since normalizing branched-chain amino acid levels has the ability to alleviate the severity of these *** this context,the Drosophila model,though underutilized,holds promise in shedding new light on these *** findings indicate its po

关键词： branched-chain amino acids cardiovascular health circadian clock drosophila insulin metabolism sleep γ-aminobutyric acid

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Platinum oxide redefined: a thermally stable two-dimensional crystallineform

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Science China Materials 2025年第2期68卷 683-684页

作者： Bixuan li Yongji Gong Tianmushan Laboratory Hangzhou 310023China School of Materials Science and Engineering Beihang UniversityBeijing 100191China

Catalysis,as a core technology in the chemical industry,plays a pivotal role in numerous fields,including energy,environmental science,and materials ***(Pt),a ubiquitous and indispensable catalyst,has been extensively employed in diverse applications,including industrial chemical transformations and automotive emission control systems[1].However,it was believed to suffer from deactivation under severe operating conditions,particularly in high-temperature and oxidizing *** concept suggests that platinum oxides,decompose or sublimate at elevated temperatures,typically above 700 K[2].Consequently,researchers frequently employ encapsulation techniques for metal particles,utilizing materials such as mesoporous silica[3],zeolites[4],two-dimensional(2D)layered materials[5],and various other protective *** approach necessitates a delicate balance between activity and stability,often resulting in enhanced stability at the expense of catalytic efficiency.

关键词： stability crystalline utilizing

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Impact of aerosol-radiation interaction and heterogeneous chemistry on the winter decreasing PM_(2.5)and increasing O_(3)in Eastern China 2014–2020

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Journal of Environmental Sciences 2025年第5期151卷 469-483页

作者： Yasong li Tijian Wang Qin’geng Wang Mengmeng li Yawei Qu Hao Wu Min Xie School of the Environment Nanjing UniversityNanjing 210023China School of Atmospheric Sciences Nanjing UniversityNanjing 210023China College of Intelligent Science and Control Engineering Jinling Institute of TechnologyNanjing 211169China Key Laboratory of Transportation Meteorology of China Meteorological Administration Nanjing Joint Institute for Atmospheric SciencesNanjing 210041China School of Environment Nanjing Normal UniversityNanjing 210023China

In the context of the prevalent winter air quality issues in China marked by declining PM_(2.5)and rising O_(3),this study employed amodified WRF-Chem model to examine the aerosol radiation interaction(ARI),heterogeneous chemistry(AHC),and their combined impact(ALL)on the variations in O_(3)and PM_(2.5)during the 2014–2020 in eastern *** analysis confirmed that ARI curtailed O_(3)while elevating PM_(2.5).AHC reduced O_(3)through heterogeneous absorption of NOx and hydroxideswhile notably fostering fine-grained sulfate,resulting in a PM_(2.5)*** reductions mitigated the inhibitory impact of ARI on meteorological fields and photolysis *** reduction individually without aerosol feedback led to a 5.43 ppb O_(3)increase and a 22.89μg/m^(3)PM_(2.5)*** and AHC amplified the emission-reduction-induced(ERI)O_(3)rise by 1.83 and 0.31 ppb,*** response of ARI to emission diminution brought about a modest PM_(2.5)increase of 0.31μg/m^(3).Conversely,AHC,acting as the primary contributor,caused a noteworthy PM_(2.5)decrease of 4.60μg/m^(3).As efforts concentrate on reducing PM_(2.5),the promotion of ARI on PM_(2.5)counterbalanced the efficacy of emission reduction and the AHC-induced strengthening of PM_(2.5)*** ALL magnified the ERI O_(3)increase by 38.9%and PM_(2.5)decrease by 18.7%.Sensitivity experiments with different degrees of emission reduction demonstrated a consistent linear relationship between the ALL-induced enhancement of O_(3)increase and PM_(2.5)decrease to the ERI PM_(2.5)*** investigation revealed the complex connection between emissions and aerosol feedback in influencing air quality.

关键词： Aerosol-radiation interaction Heterogeneous chemistry O_(3)increase PM_(2.5)decrease Emission reduction

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Cooperative output regulation of heterogeneous directed multi-agent systems:a fully distributed model-free reinforcement learning framework

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Science China(Information Sciences) 2025年第2期68卷 170-185页

作者： Xiongtao SHI Yanjie li Chenglong DU Huiping li Chaoyang CHEN Weihua GUI Guangdong Key Laboratory of Intelligent Morphing Mechanisms and Adaptive Robotics School of Mechanical Engineering and AutomationHarbin Institute of Technology (Shenzhen) School of Automation Central South University School of Marine Science and Technology Northwestern Polytechnical University School of Information and Electrical Engineering Hunan University of Science and Technology

In this paper, the cooperative output regulation(COR) problem of a class of unknown heterogeneous multi-agent systems(MASs) with directed graphs is studied via a model-free reinforcement learning(RL) based fully distributed eventtriggered control(ETC) strategy. First, we consider the scenario that the exosystem is accessible globally to all agents, an internal model-based augmented algebraic Riccati equation(AARE) is constructed, and its solution is learned by the proposed model-free RL algorithm via online input-output data. Further, for the scenario that the exosystem is accessible only to its adjacent followers, the distributed observers are designed for each agent to get the state of the exosystem, and an internal modelbased fully distributed adaptive ETC protocol is then synthesized to construct the corresponding AARE, and the feedback gain matrix is learned in a model-free fashion. The model-free RL-based control protocol proposed in this paper can not only remove the prior knowledge of agents' dynamics, but also release the dependence on global information by the adaptive event-triggered mechanism(ETM) and the new graph-based Lyapunov function. Finally, simulation results are illustrated to show the feasibility and effectiveness of the proposed control scheme.

关键词： model-free reinforcement learning unknown heterogeneous multi-agent systems fully distributed event-triggered control directed graph

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Bidirectional regulation of the cyclic guanosine monophosphateadenosine monophosphate synthase-stimulator of interferon gene pathway and its impact on hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第2期17卷 246-261页

作者： Ai-Yu Nie Zhong-Hui Xiao Jia-li Deng Na li li-Yuan Hao Sheng-Hao li Xiao-Yu Hu College of Clinical Medicine Chengdu University of Traditional Chinese MedicineChengdu 610075Sichuan ProvinceChina Department of Infection Affiliated Hospital of Chengdu University of Traditional Chinese MedicineChengdu 610072Sichuan ProvinceChina

BACKGROUND Hepatocellular carcinoma(HCC)ranks as the fourth leading cause of cancerrelated deaths in China,and the treatment options are *** cyclic guanosine monophosphate-adenosine monophosphate synthase(cGAS)activates the stimulator of interferon gene(STING)signaling pathway as a crucial immune response pathway in the cytoplasm,which detects cytoplasmic DNA to regulate innate and adaptive immune *** a potential therapeutic target,cGASSTING pathway markedly inhibits tumor cell proliferation and metastasis,with its activation being particularly relevant in ***,prolonged pathway activation may lead to an immunosuppressive tumor microenvironment,which fostering the invasion or metastasis of liver tumor *** To investigate the dual-regulation mechanism of cGAS-STING in *** This review was conducted according to the PRISMA *** study conducted a comprehensive search for articles related to HCC on PubMed and Web of Science *** rigorous screening and meticulous analysis of the retrieved literature,the research aimed to summarize and elucidate the impact of the cGAS-STING pathway on HCC *** All authors collaboratively selected studies for inclusion,extracted data,and the initial search of online databases yielded 1445 *** removing duplicates,remaining 964 records were ***,55 articles met the inclusion criteria and were included in this *** Acute inflammation can have a few inhibitory effects on cancer,while chronic inflammation generally promotes its *** cGAS-STING pathway activation will result in a suppressive tumor microenvironment.

关键词： Hepatocellular carcinoma Cyclic guanosine monophosphate-adenosine monophosphate synthase-stimulator of interferon gene Interferon genes The metastasis of a tumor Immunology

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Statistical Research on Megahertz-peaked Spectra Pulsars

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Research in Astronomy and Astrophysics 2025年第1期25卷 116-134页

作者： Hong-Bing Cai li Chen Shi-Dang li Kai Wang Hang liu JSNU SPBPU Institute of Engineering & SINO RUSSIAN Institute Jiangsu Normal University School of Physics and Electronic Engineering Jiangsu Normal University

Megahertz-peaked spectra(MPS) pulsars are referred as cases whose radio spectra turn over around 100 MHz. We identified 53 MPS pulsars based on the spectral data from the literature, and statistically analyzed the spatial location distribution, the magnetic field-period distribution, peak frequencies, spectral indices, and dispersion measures of these MPS pulsars. We found that there is a strong positive correlation between the dispersion measures and the peak frequencies of MPS pulsars, and negative correlations of the dispersion measures with spectral indices and the ages are also found. Such correlations suggest that the interstellar medium is an important factor that affects observational properties of MPS pulsars.

关键词： (stars:) pulsars: general ISM: general radio continuum: general

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Carbon Dots-Modified Hollow Mesoporous Photonic Crystal Materials for Sensitivityand Selectivity-Enhanced Sensing of Chloroform Vapor

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Nano-Micro Letters 2025年第4期17卷 381-398页

作者： Junchen liu Ji liu Zhipeng li liupeng Zhao Tianshuang Wang Xu Yan Fangmeng liu Xiaomin li Qin li Peng Sun Geyu Lu Dongyuan Zhao State Laboratory On Integrated Optoelectronics College of Electronic Science and EngineeringJilin UniversityChangchun 130012People’s Republic of China Department of Chemistry and Laboratory of Advanced Materials Shanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsState Key Laboratory of Molecular Engineering of PolymersCollaborative Innovation Center of Chemistry for Energy Materials(2011-iChEM)College of Chemistry and MaterialsFudan UniversityShanghaiPeople’s Republic of China School of Engineering and Built Environment Griffith UniversityNathanQLD 4111Australia

Chloroform and other volatile organic pollutants have garnered widespread attention from the public and researchers,because of their potential harm to the respiratory system,nervous system,skin,and ***,research on chloroform vapor sensing is still in its early stages,primarily due to the lack of specific recognition *** we report a mesoporous photonic crystal sensor incorporating carbon dots-based nanoreceptor(HMSS@CDs-PCs)for enhanced chloroform *** colloidal PC packed with hollow mesoporous silica spheres provides an interconnected ordered macro-meso-hierarchical porous structure,ideal for rapid gas sensing utilizing the photonic bandgap shift as the readout *** as-synthesized CDs with pyridinic-N-oxide functional groups adsorbed in the hollow mesoporous silica spheres are found to not only serve as the chloroform adsorption sites,but also a molecular glue that prevents crack formation in the colloidal *** sensitivity of HMSS@CDs-PCs sensor is 0.79 nm ppm^(-1)and an impressively low limit of detection is 3.22 ppm,which are the best reported values in fast-response chloroform vapor sensor without multi-signal *** positive response time is 7.5 s and the negative response time 9 ***,relatively stable sensing can be maintained within a relative humidity of 20%-85%RH and temperature of 25-55℃.This study demonstrates that HMSS@CDs-PCs sensors have practical application potential in indoor and outdoor chloroform vapor detection.

关键词： Carbon dots Photonic crystal sensors Sensitivity-enhanced sensing Selectivity-enhanced sensing Chloroform vapor sensing

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Subsection cooling system of hot rolling silicon steel and its industrial application

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Journal of Iron and Steel Research International 2025年第1期32卷 159-170页

作者： Qiu-na Wang Ji-quan Sun li-po Yang Hai-shen Wang li-jie Dong Jie-ming li Zhen-yang Zhi Yan-wen Bi National Engineering Research Center of Flat Rolling Equipment University of Science and Technology BeijingBeijing100083China Hot Rolling Department of Qian’an Iron and Steel Corporation Shougang Company LimitedTangshan064404HebeiChina National Engineering Research Center for Equipment and Technology of Cold Strip Rolling Yanshan UniversityQinhuangdao066004HebeiChina

An online subsection cooling method for hot rolling silicon steel was designed to achieve local adjustment of transverse roll ***,it was able to meet the requirements of edge drop of the strip by using the features of online thermal ***,after the new subsection spray beam was installed at the exit of mill,the special local cooling rules were analyzed for altering the thermal crown of roll according to rolling process ***,the dynamic impact of subsection cooling on the local thermal crown could just be obtained according to the measured ***,the heat transfer coefficient was determined by different subsection cooling curves under varied rolling ***,the rolling rhythm and variable conditions were important dynamic factors of transient roll temperature in practical rolling ***,real-time calculation and presetting of the thermal crown were carried out to maximize special requirements of load roll gap on local strip *** this new method,the transient temperature and the thermal crown of roll could be quantitatively controlled *** the practical results showed that the predicted temperature was able to match the measured value by more than 95%.Meanwhile,the adjustable range of thermal crown increased by more than 2.5 ***,the qualification rate of strip edge crown has increased from the original 30%to over 70%.

关键词： Subsection cooling Thermal roll crown Multi-parameter coupling Hot rolling Silicon steel

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