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Early identification of stroke through deep learning with multi-modal human speech and movement data

Neural Regeneration Research 2025年第1期20卷 234-241页

作者： Zijun Ou Haitao Wang Bin Zhang Haobang Liang Bei Hu Longlong ren Yanjuan Liu Yuhu Zhang Chengbo Dai Hejun Wu Weifeng Li xin Li School of Computer Science and Engineering Sun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Department of Neurology Guangdong Neuroscience InstituteGuangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina Department of Emergency Medicine Guangdong Provincial People’s Hospital(Guangdong Academy of Medical Sciences)Southern Medical UniversityGuangzhouGuangdong ProvinceChina

Early identification and treatment of stroke can greatly improve patient outcomes and quality of *** clinical tests such as the Cincinnati Pre-hospital Stroke Scale(CPSS)and the Face Arm Speech Test(FAST)are commonly used for stroke screening,accurate administration is dependent on specialized *** this study,we proposed a novel multimodal deep learning approach,based on the FAST,for assessing suspected stroke patients exhibiting symptoms such as limb weakness,facial paresis,and speech disorders in acute *** collected a dataset comprising videos and audio recordings of emergency room patients performing designated limb movements,facial expressions,and speech tests based on the *** compared the constructed deep learning model,which was designed to process multi-modal datasets,with six prior models that achieved good action classification performance,including the I3D,SlowFast,X3D,TPN,TimeSformer,and *** found that the findings of our deep learning model had a higher clinical value compared with the other ***,the multi-modal model outperformed its single-module variants,highlighting the benefit of utilizing multiple types of patient data,such as action videos and speech *** results indicate that a multi-modal deep learning model combined with the FAST could greatly improve the accuracy and sensitivity of early stroke identification of stroke,thus providing a practical and powerful tool for assessing stroke patients in an emergency clinical setting.

关键词： artificial intelligence deep learning diagnosis early detection FAST screening stroke

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Testing Cotton gravity as dark matter substitute with weak lensing

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Science China(Physics,Mechanics & Astronomy) 2025年第04期Mechanics & Astronomy) .卷 86-94页

作者： Geyu Mo Qingqing Wang xin ren Weitong Yan Qinxun Li Yen Chin Ong Wentao Luo CAS Key Laboratory for Researches in Galaxies and Cosmology School of Astronomy and Space ScienceUniversity of Science and Technology of China Department of Astronomy School of Physical Sciences University of Science and Technology of China Department of Physics Tokyo Institute of Technology Universita¨ts-Sternwarte Fakulta¨t fu¨r Physik Ludwig-Maximilians Universita¨t Mu¨nchen Center for Gravitation and Cosmology College of Physical Science and Technology Yangzhou University School of Aeronautics and Astronautics Shanghai Jiao Tong University

Harada proposed a modified theory of gravity called Cotton gravity, and argued that it successfully explains the rotation curves of 84 galaxies without the need for dark matter. In this work, we use the galaxy-galaxy lensing technique to test whether the modification effect of Cotton gravity can indeed be a viable substitute for dark matter. Using the spherically symmetric solution of Cotton gravity, we obtain the deflection angle via the Gauss-Bonnet theorem and the weak lensing shear. We use five galaxy catalogs divided into 5 stellar mass bins from the Sloan Digital Sky Survey Data Release 7(SDSS DR7), each further divided into blue star-forming galaxy and red passive galaxy sub-catalogs. We find that Cotton gravity on its own has a significant deviation from the measured galaxy-galaxy lensing signals, thus it cannot replace the role of dark matter. If we consider the combination of dark matter and Cotton gravity, the modification is tightly constrained. Our analysis also applies to other modified gravity theories whose an additional linear term appears in the Schwarzschild solution.

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Iron-handling solute carrier SLC22A17 as a blood-brain barrier target after stroke

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Neural Regeneration Research 2025年第11期20卷 3207-3208页

作者： Xueqi ren Wenlu Li Key Laboratory of Neuropharmacology and Translational Medicine of Zhejiang Province School of Pharmaceutical SciencesZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Neuroprotection Research Laboratories Departments of Radiology and NeurologyMassachusetts General HospitalHarvard Medical SchoolBostonMAUSA

The pathophysiology of ischemic stroke is complex and multifactorial,involving various forms of cell death such as apoptosis,autophagy,and necrosis.A recent study suggests that oxidative and inflammatory stress can induce ferroptosis,a specialized form of cell death characterized by the accumulation of lipid peroxides dependent on intracellular iron overload(Li and Jia,2023).

关键词： death specialized barrier

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Strong absorption in ultra-wide band by surface nano engineering of metallic glass

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Fundamental Research 2025年第1期5卷 307-314页

作者： Fu, Jianan Li, xin Li, Zhen Sun, Fei Wen, Wenxin Zhao, Jinlai Ruan, Wenqing ren, Shuai Zhang, Zhenxuan Liang, Xiong Ma, Jiang Shenzhen Key Laboratory of High Performance Nontraditional Manufacturing College of Mechatronics and Control Engineering Shenzhen University Shenzhen 518060 China College of Materials Science and Engineering Shenzhen Key Laboratory of Polymer Science and Technology Guangdong Research Center for Interfacial Engineering of Functional Materials Shenzhen 518060 China

Broadband light absorption is important for applications such as infrared detectors, solar energy collectors, and photothermal conversion. We propose a facile and common strategy to fabricate light absorbers with strong ultra-wideband absorption. Due to their excellent thermoplastic forming ability, metallic glasses could be patterned into finely arranged nanowire arrays, which show extremely low reflectivity (∼0.6%) in the visible and near-infrared regimes, and a low reflectivity (∼15%) in the mid-infrared regime as caused by multiscale nano spacing, multiple reflections, and plasmonic behavior. The strong absorption at surfaces with nanowires provides excellent photothermal conversion properties. The photothermal properties show that a surface with nanowires can be rapidly heated up to ∼160 °C at a rate of 28.75 °C/s, which is 30 times higher than smooth surfaces. Meanwhile, a surface with nanowires shows a high photothermal conversion efficiency (ηPT = 56.36%). The fabricated metallic glass absorbers exhibit adaptability as they can be easily formed into various complex shapes and meet the requirements under harsh conditions. The outcomes of our research open the door to manufacturing high-performance absorbers for applications in photothermal electric power generation, desalination, and photodetectors. © 2022

关键词： Metallic glass Nanoforming Photothermal properties Thermoplastic forming Ultra-wideband absorption

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Molecular dynamics simulations of helium transport through inorganic mineral nanopores

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Science China Earth Sciences 2025年第1期68卷 237-252页

作者： Dandan SONG Ping GUAN Chi ZHANG Jiahao ren School of Earth and Space Sciences Peking UniversityBeijing100871China

Helium transport through nanoscale inorganic mineral pores and pore throats is essential for its overall *** elucidate helium's transport dynamics within nanopores,we employed equilibrium and non-equilibrium molecular dynamics simulations to investigate helium's static self-diffusion and pressure-driven flow in quartz slit-shaped *** also introduced water and various gases,including hydrogen,methane,ethane,nitrogen,and carbon dioxide,into the nanopores to assess their influence on helium *** findings indicate minimal helium adsorption on quartz pore *** conditions where the pore size is less than 5 nm and the pressure under 10 MPa,environmental factors markedly influence helium *** pore sizes,high temperatures,and low gas pressures enhance helium desorption and facilitate faster *** observed a positive correlation between helium flow velocity and factors such as pore size,pressure gradient,and surface smoothness of the ***,the presence of pore water and carrier gases in quartz nanopores,which diffuse more slowly than helium,tends to reduce helium surface adsorption and slow its *** the carrier gases studied,nitrogen showed similar adsorption capacity,diffusivity,and stability to helium,while carbon dioxide displayed the highest adsorption capacity and the slowest diffusion rate,markedly differing from *** on the simulation results,we concluded that water and carrier gases primarily function as transport mediums in helium migration,moving together with ***,which shares similar properties with helium,effectively assists in this co-migration ***,carbon dioxide,due to its high adsorption capacity and slow diffusion,tends to be lost during *** a result,gas reservoirs with high nitrogen levels and low carbon dioxide levels are more likely to have higher helium ***,the smaller pore sizes and higher gas pressures in caproc

关键词： Helium transport Slit nanopores Molecular dynamics simulations Diffusion Flow carriers

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Spatiotemporal variations of tenebrionid beetles(Coleoptera:Tenebrionidae)in the Gobi desert,Northwest China

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Journal of Arid Land 2025年第1期17卷 112-129页

作者： ren Jialong ZHAO Wenzhi HE Zhibin WANG Yongzhen FENG Yilin NIU Yiping xin Weidong PAN Chengchen LIU Jiliang College of Geographic Sciences Shanxi Normal UniversityTaiyuan 030031China Key Laboratory of Ecological Safety and Sustainable Development in Arid Lands Linze Inland River Basin Research StationNorthwest Institute of Eco-Environment and ResourcesChinese Academy of SciencesLanzhou 730000China Chengdu Institute of Biology Chinese Academy of SciencesChengdu 610213China Plant Protection Institute Hebei Academy of Agriculture and Forestry SciencesBaoding 071002China

Tenebrionid beetles represent a crucial arthropod taxon in the Gobi desert ecosystems owing to their species richness and high biomass,both of which are essential for maintaining ecosystem health and ***,the spatiotemporal variations of tenebrionid beetle assemblages in the Gobi desert remain poorly *** this study,the monthly dynamics of tenebrionid beetles in the central part of the Hexi Corridor,Northwest China,a representative area of the Gobi desert ecosystems,were monitored using pitfall trapping during *** following results were showed:(1)monthly activity of tenebrionid beetles was observed from March to October,with monthly activity peaking in spring and summer,and monthly activity periods and peak of tenebrionid beetle species exhibited interspecific differences that varied from year to year;(2)spatial distribution of tenebrionid beetle community was influenced by structural ***,at a spatial scale of 24.00 m,tenebrionid beetle community was strongly and positively correlated with the dominant species,with distinct spatial distribution patterns observed for Blaps gobiensis and Microdera kraatzi alashanica;(3)abundance of tenebrionid beetles was positively correlated with monthly mean precipitation and monthly mean temperature,whereas monthly abundance of *** and *** alashanica was positively correlated with monthly mean precipitation;and(4)the cover of Reaumuria soongarica(Pall.)*** Nitraria sphaerocarpa *** a positive influence on the number of tenebrionid beetles *** conclusion,monthly variation in precipitation significantly influences the community dynamic of tenebrionid beetles,with precipitation and shrub cover jointly determining the spatial distribution pattern of these beetles in the Gobi desert ecosystems.

关键词： Gobi desert precipitation change tenebrionid beetles temporal dynamics spatial pattern

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Exploring the diversity of dissolved organic matter(DOM)properties and sources in different functional areas of a typical macrophyte-derived lake combined with optical spectroscopy and FT-ICR MS analysis

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Journal of Environmental Sciences 2025年第1期147卷 462-473页

作者： Kun Wang Haoyu ren Shengwu Yuan Xia Jiang Pengfei Wang College of Water Sciences Beijing Normal UniversityBeijing 100875China National Engineering Laboratory of Lake Pollution Control and Ecological Restoration Chinese Research Academy of Environmental SciencesBeijing 100012China

Lake Baiyangdian is one of China’s largest macrophyte-derived lakes,facing severe challenges related to water quality maintenance and eutrophication *** organic matter(DOM)was a huge carbon pool and its abundance,property,and transformation played important roles in the biogeochemical cycle and energy flow in lake *** this study,Lake Baiyangdian was divided into four distinct areas:Unartificial Area(UA),Village Area(VA),Tourism Area(TA),and Breeding Area(BA).We examined the diversity of DOM properties and sources across these functional *** findings reveal that DOM in this lake is predominantly composed of protein-like substances,as determined by excitation-emission matrix and parallel factor analysis(EEM-PARAFAC).Notably,the exogenous tyrosine-like component C1 showed a stronger presence in VA and BA compared to UA and ***-resolution mass spectrometry(FT-ICR MS)unveiled a similar DOM molecular composition pattern across different functional areas due to the high relative abundances of lignan compounds,suggesting that macrophytes significantly influence the material structure of *** properties exhibited specific associations with water quality indicators in various functional areas,as indicated by the Mantel *** connections between DOM properties and NO_(3)-N andNH3-Nwere more pronounced in VA and BA than in UA and *** results underscore the viability of using DOM as an indicator for more precise and scientific water quality management.

关键词： Dissolved organic matter Fluorescence property Molecular composition Source

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Broad-Learning-System-Based Model-Free Adaptive Predictive Control for Nonlinear MASs Under DoS Attacks

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IEEE/CAA Journal of Automatica Sinica 2025年第2期12卷 381-393页

作者： Hongxing Xiong Guangdeng Chen Hongru ren Hongyi Li the School of Automation Guangdong-Hong Kong Joint Laboratory for Intelligent Decision and Cooperative Control Guangdong University of Technology Guangdong Provincial Key Laboratory for Intelligent Decision and Cooperative Control Guangdong University of Technology the College of Electronic and Information Engineering Southwest University IEEE

In this paper, the containment control problem in nonlinear multi-agent systems(NMASs) under denial-of-service(DoS) attacks is addressed. Firstly, a prediction model is obtained using the broad learning technique to train historical data generated by the system offline without DoS attacks. Secondly, the dynamic linearization method is used to obtain the equivalent linearization model of NMASs. Then, a novel model-free adaptive predictive control(MFAPC) framework based on historical and online data generated by the system is proposed, which combines the trained prediction model with the model-free adaptive control method. The development of the MFAPC method motivates a much simpler robust predictive control solution that is convenient to use in the case of DoS attacks. Meanwhile, the MFAPC algorithm provides a unified predictive framework for solving consensus tracking and containment control problems. The boundedness of the containment error can be proven by using the contraction mapping principle and the mathematical induction method. Finally, the proposed MFAPC is assessed through comparative experiments.

关键词： Broad learning technique denial-of-service (DoS) model-free adaptive predictive control (MFAPC) nonlinear multi-agent systems (NMASs)

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Causal Associations between Particulate Matter 2.5(PM_(2.5)),PM_(2.5)Absorbance,and Inflammatory Bowel Disease Risk:Evidence from a Two-Sample Mendelian Randomization Study

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Biomedical and Environmental Sciences 2025年第2期38卷 167-177页

作者： Xu Zhang Zhimeng Wu Lu Zhang Binglong xin Xiangrui Wang xinlan Lu Guifang Lu Mudan ren Shuixiang He Yarui Li Department of Gastroenterology the First Affiliated Hospital of Xi’an Jiaotong UniversityXi’an 710061ShaanxiChina Shannxi clinical research center of digestive disease(cancer division) Xi’an 710061ShaanxiChina Health Science Center Xi’an Jiaotong UniversityXi’an 710061ShaanxiChina Department of Urology Ren Ji HospitalShanghai Jiao Tong University School of MedicineShanghai 200001China State Key Laboratory of Systems Medicine for Cancer Shanghai Cancer InstituteShanghai 200001China Shanxi Institute of Science and Technology Jincheng 048011ShanxiChina

Objective Several epidemiological observational studies have related particulate matter(PM)exposure to Inflammatory bowel disease(IBD),but many confounding factors make it difficult to draw causal links from observational *** objective of this study was to explore the causal association between PM_(2.5)exposure,its absorbance,and *** We assessed the association of PM_(2.5)and PM_(2.5)absorbance with the two primary forms of IBD(Crohn’s disease[CD]and ulcerative colitis[UC])using Mendelian randomization(MR)to explore the causal *** conducted two-sample MR analyses with aggregated data from the UK Biobank genome-wide association ***-nucleotide polymorphisms linked with PM_(2.5)concentrations or their absorbance were used as instrumental variables(IVs).We used inverse variance weighting(IVW)as the primary analytical approach and four other standard methods as supplementary analyses for quality *** The results of MR demonstrated that PM_(2.5)had an adverse influence on UC risk(odds ratio[OR]=1.010;95%confidence interval[CI]=1.001–1.019,P=0.020).Meanwhile,the results of IVW showed that PM_(2.5)absorbance was also causally associated with UC(OR=1.012;95%CI=1.004–1.019,P=0.002).We observed no causal relationship between PM_(2.5),PM_(2.5)absorbance,and *** results of sensitivity analysis indicated the absence of heterogeneity or pleiotropy,ensuring the reliability of MR *** Based on two-sample MR analyses,there are potential positive causal relationships between PM_(2.5),PM_(2.5)absorbance,and UC.

关键词： Particulate matter 2.5 Inflammatory bowel disease Mendelian randomization

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Statistical analysis on the validity of the cold plasma approximation for chorus waves based on Van Allen Probe observations and their effects on radiation belt electrons

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Earth and Planetary Physics 2025年第1期9卷 159-170页

作者： AoJun ren Jiang Yu Jing Wang ZuZheng Chen XiaoMan Liu Planetary Environmental and Astrobiological Research Laboratory(PEARL) School of Atmospheric SciencesSun Yat-sen UniversityZhuhai Guangdong 519000China

Theoretical analysis has demonstrated that the dispersion relation of chorus waves plays an essential role in the resonant interaction and energy transformation between the waves and magnetospheric *** quantitative analyses often simplified the chorus dispersion relation by using the cold plasma ***,the applicability of the cold plasma assumption is doubtful,especially during geomagnetic *** here present a systematic statistical analysis on the validity of the cold plasma dispersion relation of chorus waves based on observations from the Van Allen Probes over the period from 2012 to *** statistical results show that the observed magnetic field intensities deviate substantially from those calculated from the cold plasma dispersion relation and that they become more pronounced with an increase in geomagnetic activity or a decrease in background plasma *** region with large deviations is mainly concentrated in the nightside and expands in both the radial and azimuthal directions as the geomagnetic activity increases or the background plasma density *** addition,the bounce-averaged electron scattering rates are computed by using the observed and cold plasma dispersion relation of chorus *** with usage of the cold plasma dispersion relation,usage of the observed dispersion relation considerably lowers the minimum resonant energy of electrons and lowers the scattering rates of electrons above tens of kiloelectronvolts but enhances those ***,these differences are more pronounced with the enhancement of geomagnetic activity or the decrease in background plasma density.

关键词： chorus waves cold plasma approximation dispersion relations scattering rates

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