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Precise Control of Self-assembly in vivo Based on Polymer-Peptide Conjugates

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Chinese Journal of Chemistry 2022年第23期40卷 2815-2824页

作者： Yin-Sheng Xu Hao Wang zeng-ying qiao CAS Key Laboratory for Biomedical Effects of Nanomaterials and Nanosafety CAS Center for Excellence in NanoscienceNational Center for Nanoscience and Technology(NCNST)Center of Materials Science and Optoelectronics EngineeringUniversity of Chinese Academy of SciencesBeijing 100190China

The self-assembled nanomaterials based on peptides,which have not only good biocompatibility and low toxicity but also high stability and performance,are increasingly becoming an important way for cancer treatment.In this review,we highlight the progress of in vivo self-assembled polymer-peptide conjugates(PPCs)and their application,showing the recent advances in the development of“in vivo self-assembly”strategy for cancer treatment.Given the diverse microenvironments of tumor cells,different responsive assembly strategies(enzyme,pH,redox,temperature,etc.)have been developed to precisely control the assembly at different biological levels,realizing enhanced drug delivery and improved anticancer efficacy.

关键词： Polymer-peptide conjugates Drug design In vivo self-assembly Drug delivery Antitumor agents

Integrated Frequency-constrained Scheduling Considering Coordination of Frequency Regulation Capabilities from Multi-source Converters

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Journal of Modern Power Systems and Clean Energy 2024年第1期12卷 261-274页

作者： Jiaming Li ying qiao Zongxiang Lu Wei Ma Xin Cao Rongfu Sun the Department of Electrical Engineering Tsinghua UniversityBeijing 100084China the China Suntien Green Energy Limited Company Shijiazhuang 050011China the State Grid Jibei Electric Power Company Beijing 100054China

As the proportion of renewable energy(RE)increases,the inertia and the primary frequency regulation(FR)capability of the power system decrease.Thus,ensuring frequency security in the scheduling model has become a new technical requirement in power systems with a high share of RE.Due to a shortage of conventional synchronous generators,the frequency support of multi-source converters has become an indispensable part of the system frequency resources,especially variable-speed wind turbine generation(WTG)and battery energy storage(BES).Quantitative expression of the FR capability of multi-source converters is necessary to construct frequency-constrained scheduling model.However,the frequency support performance of these converter-interfaced devices is related to their working states,operation modes,and parameters,and the complex coupling of these factors has not been fully exploited in existing models.In this study,we propose an integrated frequency-constrained scheduling model considering the coordination of FR capabilities from multi-source converters.Switchable FR control strategies and variable FR parameters for WTG with or without reserved power are modeled,and multi-target allocation of BES capacity between tracking dispatch instruction and emergency FR is analyzed.Then,the variable FR capabilities of WTG and BES are embedded into the integrated frequency-constrained scheduling model.The nonlinear constraints for frequency security are precisely linearized through an improved iteration-based strategy.The effectiveness of the proposed model is verified in a modified IEEE 24-bus standard system.The results suggest that the coordinated participation of BES and WTG in FR can effectively reduce the cost of the scheduling model while meeting frequency security constraints.

关键词： Battery energy storage(BES) wind turbine generation(WTG) frequency regulation(FR) frequency security power system scheduling

Modeling of multiphase flow in low permeability porous media:Effect of wettability and pore structure properties

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Journal of Rock Mechanics and Geotechnical Engineering 2024年第4期16卷 1127-1139页

作者： Xiangjie Qin Yuxuan Xia Juncheng qiao Jiaheng Chen Jianhui zeng Jianchao Cai National Key Laboratory of Petroleum Resources and Engineering China University of PetroleumBeijing102249China Research Institute of Petroleum Exploration and Development Beijing10083China

Multiphase flow in low permeability porous media is involved in numerous energy and environmental applications.However,a complete description of this process is challenging due to the limited modeling scale and the effects of complex pore structures and wettability.To address this issue,based on the digital rock of low permeability sandstone,a direct numerical simulation is performed considering the interphase drag and boundary slip to clarify the microscopic water-oil displacement process.In addition,a dual-porosity pore network model(PNM)is constructed to obtain the water-oil relative permeability of the sample.The displacement efficiency as a recovery process is assessed under different wetting and pore structure properties.Results show that microscopic displacement mechanisms explain the corresponding macroscopic relative permeability.The injected water breaks through the outlet earlier with a large mass flow,while thick oil films exist in rough hydrophobic surfaces and poorly connected pores.The variation of water-oil relative permeability is significant,and residual oil saturation is high in the oil-wet system.The flooding is extensive,and the residual oil is trapped in complex pore networks for hydrophilic pore surfaces;thus,water relative permeability is lower in the water-wet system.While the displacement efficiency is the worst in mixed-wetting systems for poor water connectivity.Microporosity negatively correlates with invading oil volume fraction due to strong capillary resistance,and a large microporosity corresponds to low residual oil saturation.This work provides insights into the water-oil flow from different modeling perspectives and helps to optimize the development plan for enhanced recovery.

关键词： Low permeability porous media Water-oil flow Wettability Pore structures Dual porosity pore network model(PNM) Free surface model

A case report of bilateral lateral ventricle calcified pseudoneoplasm of the neuraxins

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Chinese Neurosurgical Journal 2024年第1期10卷 67-72页

作者： Xiaolong qiao Yinan Chen ying Ji Chaoshi Niu Chuandong Cheng Anhui University of Science and Technology HuainanAnhui 232001People’s Republic of China Department of Neurosurgery The First Affiliated Hospital of USTCDivision of Life Sciences and MedicineUniversity of Science and Technology of China1st Tianehu RoadHefeiAnhui 230031People’s Republic of China

Background Calcifying pseudoneoplasm of the neuraxis(CAPNON)is indeed a rare central nervous system lesion that can occur in central nervous system(CNS).Due to its infrequency and limited literature reports,it is challenging to diagnose and manage CAPNON.Case presentation In this intriguing study,we embarked on a quest to uncover the story of a 16-year-old girl who experienced bothersome headaches.Through advanced imaging techniques like computed tomography(CT)and magnetic resonance imaging(MRI),we glimpsed a delicate calcified growth within the lateral ventricles’posterior horn.Motivated by our unwavering commitment to solving mysteries,we embarked on a surgical journey that not only freed the young patient from her ailment but also shed light on the true nature of her puzzling adversary—a remarkable CAPNON.Conclusions For patients with CAPNON who have multiple or non-respectable lesions,the primary goal is to alleviate symptoms.After alleviating the symptoms with partial resection,close monitoring of any residual lesions is essential.If there is no evidence for disease progression,a strategy of continued close observation is appropriate.

关键词： CAPNON Imaging Pathology Operation

A highly sensitive LITES sensor based on a multi-pass cell with dense spot pattern and a novel quartz tuning fork with low frequency

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Opto-Electronic Advances 2024年第3期7卷 26-34页

作者： Yahui Liu Shunda qiao Chao Fang ying He Haiyue Sun Jian Liu Yufei Ma National Key Laboratory of Science and Technology on Tunable Laser Harbin Institute of TechnologyHarbin 150000China Zhengzhou Research Institute Harbin Institute of TechnologyZhengzhou 450000China Advanced Microscopy and Instrumentation Research Center School of Instrumentation Science and EngineeringHarbin Institute of TechnologyHarbin 150080China.

A highly sensitive light-induced thermoelectric spectroscopy(LITES)sensor based on a multi-pass cell(MPC)with dense spot pattern and a novel quartz tuning fork(QTF)with low resonance frequency is reported in this manuscript.An erbi-um-doped fiber amplifier(EDFA)was employed to amplify the output optical power so that the signal level was further enhanced.The optical path length(OPL)and the ratio of optical path length to volume(RLV)of the MPC is 37.7 m and 13.8 cm^(-2),respectively.A commercial QTF and a self-designed trapezoidal-tip QTF with low frequency of 9461.83 Hz were used as the detectors of the sensor,respectively.The target gas selected to test the performance of the system was acetylene(C2H2).When the optical power was constant at 1000 mW,the minimum detection limit(MDL)of the C2H2-LITES sensor can be achieved 48.3 ppb when using the commercial QTF and 24.6 ppb when using the trapezoid-al-tip QTF.An improvement of the detection performance by a factor of 1.96 was achieved after replacing the commer-cial QTF with the trapezoidal-tip QTF.

关键词： light-induced thermoelectric spectroscopy quartz tuning fork multi-pass cell gas sensing

Effect of lens surgery on health-related quality of life in preschool children with congenital ectopia lentis

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International Journal of Ophthalmology(English edition) 2024年第1期17卷 66-72页

作者： Yan-qiao Huang Qian-Zhong Cao Yi-Yao Wang Yi-Jing Zhou Dan-ying Zheng State Key Laboratory of Ophthalmology Zhongshan Ophthalmic CenterSun Yat-sen UniversityGuangdong Provincial Key Laboratory of Ophthalmology and Visual ScienceGuangdong Provincial Clinical Research Center for Ocular DiseasesGuangzhou 510060Guangdong ProvinceChina

AIM:To evaluate the effect of lens surgery on health-related quality of life(HRQoL)of preschool children with congenital ectopia lentis(CEL).METHODS:A prospective self-controlled study was conducted in Zhongshan Ophthalmic Center.Children aged from 5 to 7y whom were diagnosed with CEL and underwent phacoemulsification with scleral-fixated posterior chamber intraocular lens implantation and their parents were enrolled in this study.All of them completed the child and proxy(parental)PedsQL™4.0 before and after the surgery.Their preoperative scores were compared to their postoperative ones.Subgroup analyses were performed based on gender and preoperative bilateral presenting visual acuity of the children.RESULTS:Thirty-two children with CEL successfully underwent surgery without any complications,among whom 8 had monocular surgery and 24 had binocular surgery.Preoperative and postoperative questionnaires were completed by 32 child-parent pairs.Surgical intervention could significantly improve the vision of affected children(P<0.001).The medians of physical,psychosocial and total health scores self-reported by the children were 68.75(62.50,81.25),65.00(60.00,80.00)and 67.39(60.87,78.26)preoperatively and were 93.75(87.50,100.00),90.00(83.33,96.67)and 89.13(85.32,95.65)postoperatively.The preoperative scores of the affected children were significantly lower in all scales than age-matched healthy children(P<0.001).All the postoperative scores were significantly higher than the preoperative scores in affected children and their parents(P<0.001).In the physical functioning evaluation,the preoperative score reported by parents of girls was higher than parents of boys(P=0.041),and the postoperative score of girls was higher than that of boys(P=0.036).CONCLUSION:CEL is associated with significantly worse quality of life in preschool children.Surgical intervention can significantly improve the HRQoL in affected children from both personal and family perspective.

关键词： congenital ectopia lentis surgical intervention health-related quality of life preschool children

Clinicopathological analysis of EWSR1/FUS::NFATC2 rearranged sarcoma in the left forearm:A case report

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World Journal of Clinical Cases 2024年第16期12卷 2887-2893页

作者： qiao-Ling Hu Chao zeng Department of Pathology The Eighth Affiliated Hospital of Sun Yatsen UniversityShenzhen 518000Guangdong ProvinceChina

BACKGROUND We present a case of an EWSR1/FUS::NFATC2 rearranged sarcoma in the left forearm and analyze its clinicopathological and molecular features.CASE SUMMARY The patient is a 23-year-old woman.Microscopically,the tumor cells were medium-sized round cells arranged in small nests.The cytoplasm was clear,nuclei were relatively uniform,chromatin was dense,nucleoli were visible,and mitotic figures were rare.Immunohistochemically,the tumor cells were positive for Vimentin,INI-1,CD99,NKX2.2,CyclinD1,friend leukaemia virus integration 1,and NKX3.1.Next-generation sequencing revealed the presence of the EWSR1-NFATC2 fusion gene.EWSR1/FUS::NFATC2 rearranged sarcomas are rare and can easily be misdiagnosed.CONCLUSION Clinical imaging,immunohistochemistry,and molecular pathology should be considered to confirm the diagnosis.

关键词： EWSR1 NFATC2 Sarcoma Forearm Case report

Verteporfin fluorescence in antineoplastic-treated pancreatic cancer cells found concentrated in mitochondria

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World Journal of Gastrointestinal Oncology 2024年第3期16卷 968-978页

作者： ying-qiao Zhang Qing-Hao Liu Lu Liu Peng-Yu Guo Run-Ze Wang Zhi-Chang Ba Department of Radiology Harbin Medical University Cancer HospitalHarbin 150010Heilongjiang ProvinceChina Department of Digestive Internal Medicine Harbin Medical University Cancer HospitalHarbin 150010Heilongjiang ProvinceChina

BACKGROUND Traditional treatments for pancreatic cancer(PC)are inadequate.Photodynamic therapy(PDT)is non-invasive,and proven safe to kill cancer cells,including PC.However,the mitochondrial concentration of the photosensitizer,such as verteporfin,is key.AIM To investigate the distribution of fluorescence of verteporfin in PC cells treated with antitumor drugs,post-PDT.METHODS Workable survival rates of PC cells(AsPC-1,BxPC-3)were determined with chemotherapy[doxorubicin(DOX)and gemcitabine(GEM)]and non-chemotherapy[sirolimus(SRL)and cetuximab(CTX)]drugs in vitro,with or without verteporfin,as measured via MTT,flow cytometry,and laser confocal microscopy.Reduced cell proliferation was associated with GEM that was more enduring compared with DOX.Confocal laser microscopy allowed observation of GEM-and verteporfin-treated PC cells co-stained with 4’,6-diamidino-2-phenylindole and MitoTracker Green to differentiate living and dead cells and subcellular localization of verteporfin,respectively.RESULTS Cell survival significantly dropped upon exposure to either chemotherapy drug,but not to SRL or CTX.Both cell lines responded similarly to GEM.The intensity of fluorescence was associated with the concentration of verteporfin.Additional experiments using GEM showed that survival rates of the PC cells treated with 10μmol/L verteporfin(but not less)were significantly lower relative to nil verte-porfin.Living and dead stained cells treated with GEM were distinguishable.After GEM treatment,verteporfin was observed primarily in the mitochondria.CONCLUSION Verteporfin was observed in living cells.In GEM-treated human PC cells,verteporfin was particularly prevalent in the mitochondria.This study supports further study of PDT for the treatment of PC after neoadjuvant chemotherapy.

关键词： Photodynamic therapy Pancreatic cancer Verteporfin Mitochondria Chemotherapy Gemcitabine

Peptide-Based AIEgens:From Molecular Design,Stimuli Responsiveness to Biomedical Application

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CCS Chemistry 2022年第2期4卷 437-455页

作者： Ben-Li Song Xue-Hao Zhang zeng-ying qiao Hao Wang School of Pharmaceutical Sciences Henan Institute of Advanced TechnologyZhengzhou UniversityHenan 450001 CAS Center for Excellence in Nanoscience CAS Key Laboratory for Biomedical Effects of Nanomaterials and NanosafetyNational Center for Nanoscience and Technology(NCNST)Beijing 100190

Luminogens with aggregation-induced emission(AIEgens)have a wide range of biomedical applications in bioimaging,photodynamic anticancer,antibacterial therapy,and other fields,owing to their unique photophysical properties.The precise structural design and modification of AIE molecules have aroused great interest in the past years.As peptides-AIE hybrid materials,peptide-based AIEgens generally have better solubility,biocompatibility,and lower systemic toxicity.The functional diversity,modularity,and portability of peptides provide more possibilities for the intelligent structure and functional design of AIEgens.This review summarizes the recent research progress of peptide-based AIEgens nanomaterials,from molecular design,stimuli responsiveness to biomedical application,focusing on the advantages of peptides and AIE molecules as conjugates.Finally,a summary of the challenges and opportunities of peptide-based AIEgens nanomaterials for future clinical biomedical applications is presented.

关键词： peptide AIEgens nanomaterials responsive bioimaging anticancer