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课程思政融入眼科学教学的设计与实践

中国继续医学教育 2024年第3期16卷 6-10页

作者：李芳许玮陆琳娜毕晓萍李瑾傅瑶上海交通大学医学院附属第九人民医院眼科上海200010

目的探讨课程思政融入眼科学教学的设计方法及实践效果。方法选取2022年6—12月参加眼科学课程的上海交通大学医学院临床医学专业本科生、眼科学专业研究生合计54名,授课教师9名,通过问卷进行教学成效及改进方向调查,分析课程思政融入... 详细信息

目的探讨课程思政融入眼科学教学的设计方法及实践效果。方法选取2022年6—12月参加眼科学课程的上海交通大学医学院临床医学专业本科生、眼科学专业研究生合计54名,授课教师9名,通过问卷进行教学成效及改进方向调查,分析课程思政融入眼科学教学设计的应用效果。结果79.36%的学生对此门课程满意度为非常满意及满意,79.63%的学生和88.89%的教师均认同及完全认同思政元素融入教学有助于提升学生职业责任感,81.48%的学生及100%的教师认为思政教学可以开拓国际视野和加强科研信念。但对于感兴趣的思政元素以及思政启示,教师认为学生最感兴趣的思政元素为眼科大家事迹[(3.22±1.86)分],但学生角度该项是最不感兴趣的思政元素,得分仅为(1.93±1.65)分。结论课程思政融入眼科学教学可以获得良好效果,但需注重及时反馈,切实发现学生所需,思政教育才会有的放矢。

关键词：课程思政眼科学教学改革思政元素教学设计教学实践

On-Surface Synthesis of Na-Porphyrins Using NaCl as a Convenient Na Source

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Precision Chemistry

Precision Chemistry 2023年第4期1卷 226-232页

作者： Zewei Yi Chi Zhang Zhaoyu Zhang Rujia Hou Yuan Guo wei xu Interdisciplinary Materials Research Center School of Materials Science and EngineeringTongji UniversityShanghai 201804P.R.China

Metallo-porphyrins with different metal centers display unique properties and are essential in various biological and chemical processes.Enormous efforts have been devoted to enriching the family of metallo-porphyrins on surfaces mainly through metalation processes within porphyrins and exogenous pure metals or intrinsic surface adatoms,which have focused on transition elements.However,less attention has been paid to the synthesis of alkali-metal-based porphyrins on a surface.Herein,by a combination of scanning tunneling microscopy(STM)imaging/manipulations and density functional theory(DFT)calculations,we report the fabrication of Na-porphyrins on Au(111)by introducing NaCl,i.e.,two double-layered Na-centered porphyrins.Moreover,the interconversion between them was realized by precise STM manipulations.Our results demonstrate the feasibility of metalation by applying inorganic salt,which would serve as a promising strategy to embed intramolecular metal components into porphyrins for further functionalization and modification.

关键词： metallo-porphyrin alkali metal on-surface chemistry scanning tunneling microscopy density functional theory

β_(2)-肾上腺素能受体与神经丝在山羊脾中的分布和共定位研究

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动物医学进展 2024年第2期45卷 48-53页

作者：李晓萌窦体馨李志伟叶守冲杨松桦徐永平武永杰西北农林科技大学动物医学院陕西杨凌712100

为探讨肾上腺素能神经与脾功能联系,用免疫组织化学SP法和免疫荧光双标记法观察β_(2)-肾上腺素能受体(β_(2)-AR)和羊脾神经丝(NFs)在山羊脾中的表达分布特点。结果显示,β_(2)-AR免疫反应阳性产物在山羊脾中分布广泛,白髓、红髓、中... 详细信息

为探讨肾上腺素能神经与脾功能联系,用免疫组织化学SP法和免疫荧光双标记法观察β_(2)-肾上腺素能受体(β_(2)-AR)和羊脾神经丝(NFs)在山羊脾中的表达分布特点。结果显示,β_(2)-AR免疫反应阳性产物在山羊脾中分布广泛,白髓、红髓、中央动脉、被膜、小梁、边缘区均有不同程度的着色,白髓中免疫组化染色阳性相对表达量极显著高于红髓(P<0.01),极极显著高于边缘区和被膜(P<0.001);红髓中免疫组化染色阳性相对表达量极显著高于边缘区和被膜(P<0.01);NFs免疫反应阳性产物在山羊脾中红髓、被膜、小梁、小血管、白髓和边缘区均有不同程度的着色,红髓中免疫组化染色阳性相对表达量显著高于白髓(P<0.05),极显著高于边缘区(P<0.01);被膜中免疫组化染色阳性相对表达量极显著高于边缘区和白髓(P<0.01)。共定位研究表明β_(2)-AR和NFs在3个区域存在共定位关系,在平滑肌细胞构成的被膜和小梁中存在,在富含平滑肌细胞的小血管(如中央动脉)中存在,在T、B淋巴细胞丰富区域(如白髓、红髓和边缘区)存在。表明交感-肾上腺素能神经系统对机体免疫具有调控作用。β_(2)-AR和NFs共定位结构证明脾受到交感-肾上腺素能神经的调控,交感神经纤维通过释放神经递质-去甲肾上腺素,作用于脾上的肾上腺素能受体实现功能调控。

关键词： β_(2)-肾上腺素能受体神经丝蛋白脾山羊

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Signal Transduction and Targeted Therapy 2022年第7期7卷 2533-2544页

作者： Xi Shi Zihao Wang wei Ren Long Chen Cong xu Menghua Li Shiyong Fan Yuru xu Mengbing Chen Fanjun Zheng Wenyuan Zhang Xinbo Zhou Yue Zhang Shiwei Qiu Liyuan Wu Peng Zhou Xinze Lv Tianyu Cui Yuehua Qiao Hui Zhao weiwei Guo wei Chen Song Li Wu Zhong Jian Lin Shiming Yang Department of Pharmacy Peking University Third HospitalBeijingChina Artificial Auditory Laboratory of Jiangsu Province Xuzhou Medical UniversityXuzhouChina National Engineering Research Center for the Emergency Drug Beijing Institute of Pharmacology and ToxicologyBeijingChina College of Otolaryngology Head and Neck Surgery Chinese PLA General HospitalBeijingChina National Clinical Research Center for Otolaryngologic Diseases BeijingChina Key Lab of Hearing Science Ministry of EducationBeijingChina Beijing Key Lab of Hearing Impairment for Prevention and Treatment BeijingChina Synthetic and Functional Biomolecules Center Beijing National Laboratory for Molecular SciencesKey Laboratory of Bioorganic Chemistry and Molecular Engineering of Ministry of EducationCollege of Chemistry and Molecular EngineeringInnovation Center for GenomicsPeking UniversityBeijingChina

Inner ear disorders are a cluster of diseases that cause hearing loss in more than 1.5 billion people worldwide.However,the presence of the blood-labyrinth barrier(BLB)on the surface of the inner ear capillaries greatly hinders the effectiveness of systemic drugs for prevention and intervention due to the low permeability,which restricts the entry of most drug compounds from the bloodstream into the inner ear tissue.Here,we report the finding of a novel receptor,low-density lipoprotein receptor-related protein 1(LRP1),that is expressed on the BLB,as a potential target for shuttling therapeutics across this barrier.As a proof-ofconcept,we developed an LRP1-binding peptide,IETP2,and covalently conjugated a series of model small-molecule compounds to it,including potential drugs and imaging agents.All compounds were successfully delivered into the inner ear and inner ear lymph,indicating that targeting the receptor LRP1 is a promising strategy to enhance the permeability of the BLB.The discovery of the receptor LRP1 will illuminate developing strategies for crossing the BLB and for improving systemic drug delivery for inner ear disorders.

关键词： drugs prevention barrier

Targeting a cryptic allosteric site of SIRT6 with small-molecule inhibitors that inhibit the migration of pancreatic cancer cells

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Acta Pharmaceutica Sinica B 2022年第2期12卷 876-889页

作者： Qiufen Zhang Yingyi Chen Duan Ni Zhimin Huang Jiacheng wei Li Feng Jun-Cheng Su Yingqing wei Shaobo Ning Xiuyan Yang Mingzhu Zhao Yuran Qiu Kun Song Zhengtian Yu Jianrong xu Xinyi Li Houwen Lin Shaoyong Lu Jian Zhang State Key Laboratory of Oncogenes and Related Genes Department of PharmacyRenji HospitalShanghai Jiao Tong University School of MedicineShanghai 200127China Medicinal Chemistry and Bioinformatics Center Shanghai Jiao Tong University School of MedicineShanghai 200025China Nutshell Therapeutics Shanghai 201203China Academy of Integrative Medicine Shanghai University of Traditional Chinese MedicineShanghai 201203China School of Pharmaceutical Sciences Zhengzhou UniversityZhengzhou 450001China

SIRT6 belongs to the conserved NAD^(+)-dependent deacetylase superfamily and mediates multiple biological and pathological processes.Targeting SIRT6 by allosteric modulators represents a novel direction for therapeutics,which can overcome the selectivity problem caused by the structural similarity of orthosteric sites among deacetylases.Here,developing a reversed allosteric strategy Allo Reverse,we identified a cryptic allosteric site,Pocket Z,which was only induced by the bi-directional allosteric signal triggered upon orthosteric binding of NAD^(+).Based on Pocket Z,we discovered an SIRT6 allosteric inhibitor named JYQ-42.JYQ-42 selectively targets SIRT6 among other histone deacetylases and effectively inhibits SIRT6 deacetylation,with an IC50 of 2.33μmol/L.JYQ-42 significantly suppresses SIRT6-mediated cancer cell migration and pro-inflammatory cytokine production.JYQ-42,to our knowledge,is the most potent and selective allosteric SIRT6 inhibitor.This study provides a novel strategy for allosteric drug design and will help in the challenging development of therapeutic agents that can selectively bind SIRT6.

关键词： SIRT6 Molecular dynamics simulations Reversed allostery Allosteric inhibitor Pancreatic cancer Cell migration Cytokine production

Pollution characteristics of the recent sediments in the Hangzhou section of the Grand Canal,China

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Journal of Environmental Sciences 2004年第1期16卷 34-39页

作者： CHENYing-xu LIUHe ZHUGuang-wei CHENHua-lin TIANGuang-min DepartmentofEnvironmentalEngineering ZhejiangUniversityHangzhou310029China NanjingInstituteofGeographyandLimnology ChineseAcademyofSciencesNanjing210008China

Spatial distribution of heavy metals, arsenic and organic matter in recent sediments in the Hangzhou section of the Grand Canal and their relationships were analyzed. The results showed that the concentrations of heavy metals and organic matters varied widely along the canal, and the average geological accumulation factors decreased in the following orders: organic carbon(2.6), zinc(2.1), cadmium(2.0), copper(1.5), lead(1.1), nitrogen(0.9), mercury (0.8), phosphorus(0.4), arsenic(0.2) and chromium(0). Content of heavy metals and organic carbon in the top 10 cm layer were lower than that of lower layers, except for mercury and organic carbon in the S9 section. Contents of organic carbon in the top 50 cm layer of the mud sediments are significantly higher than those underneath. In the bottom mud layer, there is a concentration peak of the pollutants. In the mud sediments of the canal, cadmium mainly occurred in the Fe and Mn oxide fraction, copper in the organic fraction, lead in the Fe and Mn oxide fraction, and zinc in the carbonate and the Fe and Mn oxide fraction.

关键词： sediment pollution characteristics Grand Canal geological accumulation factor fraction of heavy metals

Mercury removals by existing pollutants control devices of four coal-fired power plants in China

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Journal of Environmental Sciences 2011年第11期23卷 1839-1844页

作者： Juan Wang WenhuaWang wei xu Xiaohao Wang Song Zhao School of Environmental Science ＆ Engineering Shanghai Jiao Tong University Shanghai 200240 China Shanghai Environmental Monitoring Center Shanghai 200030 China

The mercury removals by existing pollution control devices and the mass balances of mercury in four coal-fired power plants of China were carried out based on a measurement method with the aluminum matrix sorbent.All the plants are equipped with a cold-side electrostatic precipitator （ESP） and a wet flue gas desulfurization （FGD） in series.During the course of coal stream,the samples,such as coal,bottom ash,fly ash,gypsum and flue gas,were collected.The Hg concentrations in coals were measured by CVAAS after appropriate preparation and acid digestion.Other solid samples were measured by the RA-915 ＋ Zeeman Mercury Spectrometer.The vapor phase Hg was collected by a sorbent trap from flue gas and then measured using CVAAS followed by acid leaching.The mercury mass balances were estimated in this study were 91.6%,77.1%,118% and 85.8% for the four power plants,respectively.The total Hg concentrations in the stack gas were ranged from 1.56–5.95 μg/m 3.The relative distribution of Hg in bottom ash,ESP,WFGD and stack discharged were ranged between 0.110%–2.50%,2.17%–23.4%,2.21%–87.1%,and 21.8%–72.7%,respectively.The distribution profiles were varied with the coal type and the operation conditions.The Hg in flue gas could be removed by ESP and FGD systems with an average removal efficiency of 51.8%.The calculated average emission factor was 0.066 g/ton and much lower than the results obtained ten years ago.

关键词： mercury power plant mass balance distribution removal efficiency emission factor

国产新型冠状病毒(2019-nCoV)抗原检测试剂盒的性能比较

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标记免疫分析与临床 2024年第3期31卷 554-557页

作者：孙莉孙雪晴陈微朱晋升彭絮王会如北京市医疗器械检验研究院(北京市医用生物防护装备检验研究中心) 北京101111

目的探讨不同国产新型冠状病毒(2019-nCoV)抗原检测试剂盒的阳性符合率、阴性符合率及最低检测限的差异。方法为准确衡量产品的性能,选择具有代表性的16个国产新型冠状病毒(2019-nCoV)抗原检测试剂盒,分别检测国家参考品中的阳性参考品... 详细信息

目的探讨不同国产新型冠状病毒(2019-nCoV)抗原检测试剂盒的阳性符合率、阴性符合率及最低检测限的差异。方法为准确衡量产品的性能,选择具有代表性的16个国产新型冠状病毒(2019-nCoV)抗原检测试剂盒,分别检测国家参考品中的阳性参考品、阴性参考品和最低检测限参考品,得出阳性符合率、阴性符合率和最低检测限并分析结果。结果16个新冠抗原检测试剂盒的阳性符合率和阴性符合率均为100%;16个新冠抗原检测试剂盒的最低检测限结果呈梯度分布。结论新型冠状病毒(2019-nCoV)抗原检测试剂盒的检测方法学及原材料不同影响试剂盒最低检测限检测结果。

关键词：新型冠状病毒(2019-nCoV)抗原检测阳性符合率阴性符合率最低检测限原材料

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基于虚拟样机的某多轴车辆制动轴荷特性分析

车辆与动力技术 2024年第2期 7-11页

作者：范婧周伟徐晓曦杨立煜王师凯陈新波中国北方车辆研究所北京100072

文中对某多轴单纵臂车辆的行动部分进行了虚拟样机建模,依据总体任务指标及相关法规对其进行了不同制动强度工况下的制动过程仿真.通过对仿真结果的综合比较,分析得到了各轴在不同制动强度下轴荷动态分布特性,为车辆行动部件及车体的结... 详细信息

文中对某多轴单纵臂车辆的行动部分进行了虚拟样机建模,依据总体任务指标及相关法规对其进行了不同制动强度工况下的制动过程仿真.通过对仿真结果的综合比较,分析得到了各轴在不同制动强度下轴荷动态分布特性,为车辆行动部件及车体的结构强度校核设计,以及各轴制动力的匹配优化设计提供了参考依据.

关键词：多轴车辆单纵臂制动仿真轴荷分布