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Human-like adrenal features in Chinese tree shrews revealed by multi-omics analysis of adrenal cell populations and steroid synthesis

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Zoological Research 2024年第3期45卷 617-632页

作者： Jing-Hang Jiang Yi-Fu Wang Jie Zheng Yi-Ming Lei Zhong-Yuan Chen Yi Guo Ya-Jie Guo Bing-Qian Guo Yu-Fang Lv Hong-Hong Wang Juan-Juan Xie Yi-Xuan Liu Ting-Wei Jin Bi-Qi Li Xiao-Shu Zhu Yong-Hua Jiang zeng-nan mo Center for Genomic and Personalized Medicine Guangxi Collaborative Innovation Center for Genomic and Personalized MedicineGuangxi Key Laboratory for Genomic and Personalized MedicineGuangxi Medical UniversityNanningGuangxi 530021China Department of Urology First Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530021China Reproductive Medicine Center Jingmen People’s HospitalJingChu University of Technology Affiliated Central HospitalJingmenHubei 448000China School of Computer Science and Engineering Yulin Normal UniversityYulinGuangxi 537000China Collaborative Innovation Centre of Regenerative Medicine and Medical BioResource Development and Application Co-constructed by the Province and Ministry Guangxi Medical UniversityNanningGuangxi 530021China Department of Pathology Second Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530007China Department of Obstetrics and Gynecology Second Affiliated Hospital of Guangxi Medical UniversityNanningGuangxi 530007China

The Chinese tree shrew(Tupaia belangeri chinensis)has emerged as a promising model for investigating adrenal steroid synthesis,but it is unclear whether the same cells produce steroid hormones and whether their production is regulated in the same way as in humans.Here,we comprehensively mapped the cell types and pathways of steroid metabolism in the adrenal gland of Chinese tree shrews using single-cell RNA sequencing,spatial transcriptome analysis,mass spectrometry,and immunohistochemistry.We compared the transcriptomes of various adrenal cell types across tree shrews,humans,macaques,and mice.Results showed that tree shrew adrenal glands expressed many of the same key enzymes for steroid synthesis as humans,including CYP11B2,CYP11B1,CYB5A,and CHGA.Biochemical analysis confirmed the production of aldosterone,cortisol,and dehydroepiandrosterone but not dehydroepiandrosterone sulfate in the tree shrew adrenal glands.Furthermore,genes in adrenal cell types in tree shrews were correlated with genetic risk factors for polycystic ovary syndrome,primary aldosteronism,hypertension,and related disorders in humans based on genome-wide association studies.Overall,this study suggests that the adrenal glands of Chinese tree shrews may consist of closely related cell populations with functional similarity to those of the human adrenal gland.Our comprehensive results(publicly available at http://***:16245/scAGMap/)should facilitate the advancement of this animal model for the investigation of adrenal gland disorders.

关键词： Tree shrew Adrenal gland Dehydroepiandrosterone Genome-wide association studies Disease model

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Research progress in spasmodic torticollis rehabilitation treatment

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World Journal of Clinical Cases 2024年第7期12卷 1205-1214页

作者： Shuang Zhang Ni zeng Shuang Wu Hui-Hui Wu mo-Wei Kong Department of Rehabilitation The Affiliated Hospital of Guizhou Medical UniversityGuiyang 550018Guizhou ProvinceChina Department of Cardiology Guiqian International General HospitalGuiyang 550018Guizhou ProvinceChina

Spasmodic torticollis(ST)is a focal dystonia that affects adults,causing limited muscle control and impacting daily activities and quality of life.The etiology and curative methods for ST remain unclear.Botulinum toxin is widely used as a firstline treatment,but long-term usage can result in reduced tolerance and adverse effects.Rehabilitation therapy,with its minimal side effects and low potential for harm,holds significant clinical value.This article explores the effectiveness of adjunctive therapies,including exercise therapy,transcranial magnetic stimulation,shockwave therapy,neuromuscular electrical stimulation,vibration therapy,electromyographic biofeedback,and acupuncture,in the treatment of ST.The aim is to provide clinicians with additional treatment options and to discuss the efficacy of rehabilitation therapy for ST.

关键词： Spasmodic torticollis Rehabilitation therapy Botulinum toxin Exercise therapy Adjunctive therapy Effectiveness

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Editorial: Welcome Message from Editor-in-Chief, Xuming mo

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Congenital Heart Disease 2024年第1期19卷 1-3页

作者： Xuming mo Department of Cardiothoracic Surgery Children’s Hospital of Nanjing Medical UniversityNanjing210008China

1 Introduction The release of the most recent volume of Congenital Heart Disease(CHD)(Issue 19,Volume 1,2024)coincides with my assumption of the role of Co-Editor-In-Chief for CHD.I would like to express my appreciation to CHD for providing me with the opportunity to use the Editorial page.I took on this responsibility on November 18,2023.I would like to take this opportunity to share reflections and convey my appreciation.Founded in 2006,CHD stands as the pioneering professional periodical exclusively dedicated to the exploration and treatment of congenital cardiac abnormalities across all age groups.Its paramount goal is to elevate the scholarly and educational dimension of CHD,driven by an unwavering commitment to provide optimal,holistic cardiac care to patients spanning infancy to adulthood.This commitment remains steadfast,with a focus on community service,research,and education quality,regardless of the patient’s financial situation.

关键词： cardiac education release

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Role of glucose metabolism and signaling pathways at different stages of ovarian folliculogenesis

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生殖与发育医学(英文) 2024年第2期8卷 111-120页

作者： mo Dan zeng Zhong-Hong Sui Xin Li Rong Yang Yi-Hua Guangxi Reproductive Medical Center the First Affiliated Hospital of Guangxi Medical University Nanning China Guangxi Key Laboratory of Immunology and Metabolism for Liver Diseases Nanning China Key Laboratory of Early Prevention and Treatment for Regional High Frequency Tumor (Guangxi Medical University) Ministry of Education Nanning China Center for Reproductive Medicine Department of Obstetrics and Gynecology Peking University Third Hospital Beijing China Key Laboratory of Assisted Reproduction (Peking University) Ministry of Education Beijing Key Laboratory of Reproductive Endocrinology and Assisted Reproductive Technology National Clinical Research Center for Obstetrics and Gynecology (Peking University Third Hospital) Beijing China

The female ovaries are critical for follicle growth and development in the process known as "folliculogenesis" . This complex process is regulated by various factors, among which the microenvironment around follicles appears to be crucial. According to previous studies, folliculogenesis is an energy-demanding process. In fact, well-balanced follicular energy metabolism is associated with ovarian function and female fertility. Consequently, glucose metabolism has been widely described as the main source of energy during folliculogenesis. Generally, the follicular glucose metabolism profiles change dynamically during follicular development. Metabolic abnormalities during folliculogenesis are associated with aging, primary ovarian insufficiency, and polycystic ovary syndrome, thereby leading to subfertility and infertility in females. The signaling pathways in follicles appear to form a link between glucose metabolism and folliculogenesis. Therefore, a better understanding of glucose metabolism dynamics at different stages of folliculogenesis and the associated signaling pathways will provide potential implications for follicle developmental competence. This review aimed to describe variations in glucose metabolism at different stages of folliculogenesis, provide new insights into glucose metabolic disorder-related diseases, and specifically discuss two major signaling pathways that regulate glucose metabolism during folliculogenesis: phosphatidylinositol 3-kinase, protein kinase B (PI3K-PKB/AKT), and AMP-activated protein kinase (AMPK) signaling pathways.

关键词： Folliculogenesis Glucose metabolism Glycolysis Oxidative phosphorylation Signaling pathway

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Imbalance of Circulating Follicular Regulatory and Follicular Helper T Cell Subpopulations Is Associated with Disease Progression and Serum CYFRA 21-1 Levels in Patients with Non-small Cell Lung Cancer

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Current Medical Science 2024年第1期44卷 102-109页

作者： Tian-ci LIU mo-han ZHENG Xing-yue zeng Rui KANG Ayibaota Bahabayi Bulidierxin Tuerhanbayi Song-song LU Chen LIU Department of Clinical Laboratory Peking University People's HospitalBeijing 100044China School of Basic Medical Sciences Peking University Health Science CenterBeijing 100191China

Objective This study aimed to investigate the changes of follicular helper T(TFH)and follicular regulatory T(TFR)cell subpopulations in patients with non-small cell lung cancer(NSCLC)and their significance.Methods Peripheral blood was collected from 58 NSCLC patients at different stages and 38 healthy controls.Flow cytometry was used to detect TFH cell subpopulation based on programmed death 1(PD-1)and inducible co-stimulator(ICOS),and TFR cell subpopulation based on cluster determinant 45RA(CD45RA)and forkhead box protein P3(FoxP3).The levels of interleukin-10(IL-10),interleukin-17a(IL-17a),interleukin-21(IL-21),and transforming growth factor-β(TGF-β)in the plasma were measured,and changes in circulating B cell subsets and plasma IgG levels were also analyzed.The correlation between serum cytokeratin fragment antigen 21-1(CYFRA 21-1)levels and TFH,TFR,or B cell subpopulations was further explored.Results The TFR/TFH ratio increased significantly in NSCLC patients.The CD45RA^(+)FoxP3^(int) TFR subsets were increased,with their proportions increasing in stages Ⅱ to Ⅲ and decreasing in stage IV.PD-1^(+)ICOS+TFH cells showed a downward trend with increasing stages.Plasma IL-21 and TGF-β concentrations were increased in NSCLC patients compared with healthy controls.Plasmablasts,plasma IgG levels,and CD45RA^(+)FoxP3^(int) TFR cells showed similar trends.TFH numbers and plasmablasts were positively correlated with CYFRA 21-1 in stages Ⅰ-Ⅲ and negatively correlated with CYFRA 21-1 in stage IV.Conclusion Circulating TFH and TFR cell subpopulations and plasmablasts dynamically change in different stages of NSCLC,which is associated with serum CYFRA 21-1 levels and reflects disease progression.

关键词： non-small cell lung cancer follicular helper T cells follicular regulatory T cells progression

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RARRES2 regulates lipid metabolic reprogramming to mediate the development of brain metastasis in triple negative breast cancer

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Military Medical Research 2024年第1期11卷 34-49页

作者： Yi-Qun Li Fang-Zhou Sun Chun-Xiao Li Hong-nan mo Yan-Tong Zhou Dan Lv Jing-Tong Zhai Hai-Li Qian Fei Ma Department of Medical Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China State Key Laboratory of molecular Oncology National Cancer Center/National Clinical Research Center for Cancer/Cancer HospitalChinese Academy of Medical Sciences and Peking Union Medical CollegeBeijing 100021China

Background Triple negative breast cancer(TNBC),the most aggressive subtype of breast cancer,is characterized by a high incidence of brain metastasis(BrM)and a poor prognosis.As the most lethal form of breast cancer,BrM remains a major clinical challenge due to its rising incidence and lack of effective treatment strategies.Recent evidence suggested a potential role of lipid metabolic reprogramming in breast cancer brain metastasis(BCBrM),but the underlying mechanisms are far from being fully elucidated.Methods Through analysis of BCBrM transcriptome data from mice and patients,and immunohistochemical validation on patient tissues,we identified and verified the specific down-regulation of retinoic acid receptor responder 2(RARRES2),a multifunctional adipokine and chemokine,in BrM of TNBC.We investigated the effect of aberrant RARRES2 expression of BrM in both in vitro and in vivo studies.Key signaling pathway components were evaluated using multi-omics approaches.Lipidomics were performed to elucidate the regulation of lipid metabolic reprogramming of RARRES2.Results We found that downregulation of RARRES2 is specifically associated with BCBrM,and that RARRES2 deficiency promoted BCBrM through lipid metabolic reprogramming.Mechanistically,reduced expression of RARRES2 in brain metastatic potential TNBC cells resulted in increased levels of glycerophospholipid and decreased levels of triacylglycerols by regulating phosphatase and tensin homologue(PTEN)-mammalian target of rapamycin(mTOR)-sterol regulatory element-binding protein 1(SREBP1)signaling pathway to facilitate the survival of breast cancer cells in the unique brain microenvironment.Conclusions Our work uncovers an essential role of RARRES2 in linking lipid metabolic reprogramming and the development of BrM.RARRES2-dependent metabolic functions may serve as potential biomarkers or therapeutic targets for BCBrM.

关键词： RARRES2 Lipid metabolic reprogramming Brain metastasis(BrM) Breast cancer

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Insights into the mechanism of multiple Cu-doped Co Fe_(2)O_(4)nanocatalyst activated peroxymonosulfate for efficient degradation of Rhodamine B

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Journal of Environmental Sciences 2024年第3期137卷 382-394页

作者： Yuanmin mo Xiaoping Zhang School of Environment&Energy South China University of TechnologyGuangzhou Higher Education Mega CentreGuangzhou 510006China The Key Laboratory of Pollution Control and Ecosystem Restoration in Industry Clusters of Ministry of Education Guangzhou 510006China Guangdong Provincial Key Laboratory of Solid Wastes Pollution Control and Recycling Guangzhou 510006China Guangdong Provincial Engineering and Technology Research Center for Environmental Risk Prevention and Emergency Disposal Guangzhou 510006China

The multiple metal catalyst as a promising nanomaterial has shown excellent activity in the peroxymonosulfate(PMS)activation for pollutant degradation.However,the role of special sites and in-depth understanding of the PMS activation mechanism are not fully studied.In this study,a Cu-doped CoFe_(2)O_(4)nanocatalyst(0.5CCF)was synthesized by a sol-gel and calcination method,and used for PMS activation to remove Rhodamine B(RhB).The results showed that the Cu doping obviously enhanced the catalytic performance of CoFe_(2)O_(4),with 99.70%of RhB removed by 0.5CCF while 74.91%in the CoFe_(2)O_(4)within 15 min.Based on the X-ray photoelectron spectroscopy and electrochemical analysis,this could be ascribed to the more low valence of Co and Fe species generated on the 0.5CCF and faster electron transfers occurred in the 0.5CCF due to the Cu doping.In addition,Cu doping could provide more reaction sites for the 0.5CCF to activate PMS for RhB removal.The metal species and the surface hydroxyl were the reaction sites of PMS activation,and the surface hydroxyl played an important role in surface-bound reactive species generation.During the PMS activation,the Cu not only activated PMS to produce reactive oxygen species(ROS),but also regenerated Co^(2+)and Fe^(2+)to accelerate the PMS activation.The non-radical of ^(1)O_(2)was the main ROS with a 99.35%of contribution rate,and the SO_(5)^(·–)self-reaction was its major source.This study provides a new insight to enhance the PMS activation performance of multiple metal catalysts by Cu doping in wastewater treatment.

关键词： Cu-doped CoFe_(2)O_(4)nanocatalyst PMS activation Mechanism Rhodamine B removal

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Microglia lactylation in relation to central nervous system diseases

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Neural Regeneration Research 2025年第1期20卷 29-40页

作者： Hui Yang nan mo Le Tong Jianhong Dong Ziwei Fan Mengxian Jia Juanqing Yue Ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system homeostasis.Microglia,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative diseases.Lactate has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of lactate.Lactylation is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various diseases.This review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting lactate.Finally,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

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Martensite decomposition under thermal-mechanical coupling conditions to fabricate an ultrafine-grained Ti6Al4mo4Zr1W0.2Si alloy

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Journal of Materials Science & Technology 2024年第1期168卷 157-168页

作者： Taoyu Zhou Jiuxu Yang nan Li Hao Sun Bohua Zhang Zibo Zhao Qingjiang Wang Shi-changxu Innovation Center for Advanced Materials Institute of Metal ResearchChinese Academy of SciencesShenyang 110016China School of Materials Science and Engineering University of Science and Technology of ChinaShenyang 110016China

The fabrication of ultrafine-grained microstructures(grain size below 1μm)in titanium alloys is beneficial for improving their mechanical properties at room temperature and medium tempera-tures(400-550°C).However,a long-standing challenge involves the low-cost manufacturing of bulk ultrafine-grained titanium alloys.In this work,we developed a facile strategy through martensite de-composition at thermal-mechanical coupling conditions,to fabricate an equiaxed microstructure in a Ti6Al4mo4Zr1W0.2Si model alloy with an averageαgrain size of 315±62 nm.The formation of the ultrafine-grained microstructure was because the lattice strain stored in the martensitic initial mi-crostructure enhanced the nucleation rate of dynamic recrystallization,meanwhile,the pinning role of martensite decomposition productsβand(Ti,Zr)_(5)Si_(3)phases suppressed grain coarsening at high tem-peratures.Compared to conventional(α+β)alloys,the tensile strength of this alloy improved by 20%-30%at both room temperature and 550°C,without decreasing its ductility.In situ SEM observations revealed that the ultrafine-grained microstructure would not only suppress dislocation motions but also contribute to the homogenous deformation in the matrix of the material,therefore,it resulted in higher mechanical performance.The research results may be of great significance to the development of next-generation aviation titanium alloys.

关键词： Ultrafine-grained Titanium alloy In situ observation Deformation mechanism Thermostability

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Coupling interface constructions of hollow Co-mo mixed multiple oxidation states heterostructure for high-performance aprotic Li-O_(2) battery

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nano Research 2024年第5期17卷 4100-4107页

作者： Xingzi Zheng Mengwei Yuan Jingshen Xu Zihan Li Caiyun nan Genban Sun Beijing Key Laboratory of Energy Conversion and Storage Materials College of ChemistryBeijing Normal UniversityBeijing 100875China Center for Advanced Materials Research Beijing Normal UniversityZhuhai 519087China

Constructing interfaces in heterostructures is effective for modulating the electronic properties of electrocatalysts.The hollow ComoO_(4)-Co_(3)O_(4) heterostructure(HCMCH)was prepared as a bifunctional electrocatalyst for Li-O_(2) battery.The different components in ComoO_(4)-Co_(3)O_(4) heterostructure presented the efficient coupling and enhanced the electrocatalytic activity for aprotic oxygen reduction reaction(ORR)and oxygen evolution reaction(OER),in which it improved the obviously reduced overpotential of 300 mV(compared with the pure Ketjen black(KB)electrode),enhanced reversibility of 80%capacity retention after 6 full cycles and the superior cyclability of more than 200 cycles with an optimized strategy.The battery performance of the HCMCH was not only associated with the unique hollow structure and rich active sites but also with coupling interface constructions synergetic effects attaching to the improving conductivity and optimized the discharge conversion.These results suggested that this HCMCH electrocatalyst was a promising candidate for the Li-O_(2) battery and it gave a novel insight for high performance electrocatalyst designing.

关键词： Li-oxygen battery heterostructure electrocatalyst coupling interface

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