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Effect of Electroacupuncture on NLRP3 Inflammasome and Morphology of Uterine in Rats with Primary Dysmenorrhea Based on Meridian Acupoint Viscera Correlation Theory

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World Journal of Traditional Chinese Medicine 2023年第2期9卷 123-130页

作者： Shao-Hua Wang Han-Yu Yuan Juan Li Si-An Pan Xiao Xue zeng-hui yue Yu Liu College of Acupuncture-Moxibustion Tui-na and RehabilitationHunan University of Chinese MedicineChangshaChina

Objective:To explore the relationship between acupoints and the uterus in primary dysmenorrhea(PDM)and observe the effects of electroacupuncture(EA)on NLRP3 inflammasome and morphology of uterine tissues in *** and Methods:Rats were divided into four groups:Control,PDM,EA,and nonacupoint EA(sham)*** reactions in the rats were carefully *** E2(PGE2)and prostaglandin F2α(PGF2α)levels in the rat serum were measured using the enzyme-linked immunosorbent *** assess the damage,the histomorphology of the rat uterus was examined using the optical and electron *** blotting was performed to determine the nucleotide-binding oligomerization domain carboxy-terminal leucine-rich repeat domain and amino-terminal pyrin domaincontaining protein 3(NLRP3),apoptosis-associated speck-like protein containing a caspase recruitment domain(ASC),and cysteinyl aspartate specific proteinase-1(caspase-1),interleukin-1β(IL-1β),and ***:Compared with the control group,the PDM group exhibited significant increases in both writhing times and scores,with a high pathological score of the uterine *** PGF2αlevels were significantly elevated,whereas PGE2 levels were significantly *** addition,the expression levels of NLRP3,ASC,caspase-1,IL-1β,and IL-18 significantly increased(P<0.001).The EA group showed opposite effects from the PDM group(all P<0.05).The sham group exhibited significantly higher writhing time,serum PGF2αlevels,and expression levels of NLRP3,ASC,caspase-1,IL-1β,and IL-18 than the EA *** contrast,serum PGE2 levels in the sham group were significantly lower than those in the EA group(all P<0.05).Conclusions:NLRP3 infiammasome activation in PDM triggers pathological ***(SP6)and Guanyuan(CV4)had specific effects on *** of SP6 and CV4 may treat PDM by inhibiting inflammation and protecting the morphological structure of the uterus.

关键词： Electroacupuncture primary dysmenorrhea meridian acupoint-viscera correlation morphology NLRP3 inflammasome

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Discussion on Relationship Between Meridians and Viscera of Decreased Ovarian Reserve from the Perspective of"Preventive Treatment of Disease"by Acupuncture

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World Journal of Traditional Chinese Medicine 2023年第2期9卷 111-122页

作者： Si-An Pan Zhi-Miao Murong Yi-Lin Zhu Jia-Wei Song Xiao-Rong Chang Yu Liu zeng-hui yue Department of Professional Acupuncture and Moxibustion College of AcupunctureMoxibustion and TuinaHunan University of Chinese MedicineChangshaHunanChina

Based on extensive historical data,clinical experience,and modern scientific research,we discuss the relationship between meridians and viscera of decreased ovarian reserve(OR)from the perspective of"preventive treatment of disease"by *** is believed that the endogenous protection mechanism of acupuncture in"preventive treatment of disease"lies in harmonizing Yin and Yang and dredging meridians;stimulating righteousness and rejecting the evil outside;preventing disease;co-cultivating body and spirit,and regulating *** incidence ofOR dysfunction is closely related to the uterus-related meridians and *** mechanism of acupuncture treatment of OR dysfunction may be related to reproductive endocrine hormone levels,ovarian tissue morphology,immune system,granulosa cell apoptosis,and related signal transduction *** clinical effect of acupuncture treatment of diminished OR is reflected in improving menstruation and ovulation;improving OR function,promoting pregnancy;improving local ovarian microenvironment;improving negative emotions,improving quality of life,and thus affecting pregnancy *** article summarizes the mechanism of action and clinical effect of acupuncture in the treatment of decreased OR function based on recent findings,analyzes the advantages and disadvantages of acupuncture in the treatment of disease,and provides the rationale for the clinical application of acupuncture in the treatment of decreased OR function.

关键词： Acupuncture ovarian reserve dysfunction preventive treatment of disease theoretical discussion

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Hypercholesterolemia treated with medicinal pad-separated moxibustion:A randomized clinical trial

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World Journal of Acupuncture-Moxibustion 2022年第4期32卷 310-316页

作者： Qian LI Han PENG Hong-hua LIU Yi-fan ZOU Dan LI Jun-yu GE zeng-hui yue Mai-Ian LIU Xiao-rong CHANG School of Acupuncture-Moxibustion and Tuina Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina School of Nursing Hunan University of Chinese MedicineChangsha 410208Hunan ProvinceChina Shenzhen Nanshan Medical Group Hospital Shenzhen 518000Guangdong ProvinceChina Changsha Hospital of Traditional Chinese Medicine Changsha 410000Hunan ProvinceChina

Objective:To assess the effect of medicinal pad-separated moxibustion for reducing low-density lipoprotein cholesterol(LDL-C)in the patients with ***:Clinical randomized controlled trial with blinding for outcome assessors and ***:Department of Acupuncture-Moxibustion and Tuina,Department of Physical examination of the First Affiliated Hospital of Hunan University of Chinese Medicine and three community health centers adjacent to the Hospital and University,from July 2015 to December ***:60 patients with hypercholesterolemia(elevated LDL-C).Interventions:The therapeutic lifestyle change(TLC)was provided in both *** the experiment group,medicinal pad-separated moxibustion was applied using two groups of acupoints(Group No.1:Jùquē[巨阙CV14],Tiānshū[天枢ST25]and Fēnglóng[丰隆ST40]).(Group No.2:Xīnshū[心俞BL15],Gānshū[肝俞BL18]and Píshū[脾俞BL20])alternatively for 3-5 times a *** the control group,Simvastatin tablets were administered orally by the patients in accordance with instructions in the medication guides(10 mg/d).Main outcome measures:Change of LDL-C after 12 weeks of treatment compared with the ***:After 12 weeks of treatment,LDL-C was reduced in both the medicinal pad-separated moxibustion group and the simvastatin group compared with that at baseline(both P0.05).At week 4 of follow-up,LDL-C was reduced compared with that at baseline in the medicinal pad-moxibustion group(P0.05)and between groups(P>0.05).In comparison with values before treatment,the values of triglyceride(TC)and triacylglycerol(TG)were reduced in both groups(all P<0.05),while value of highdensity lipoprotein cholesterol(HDL-C)was increased in

关键词：随机临床试验高胆固醇血症天枢心俞肝俞巨阙

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Predicting colorectal adenomatous polyps in patients with chronic liver disease: A novel nomogram

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World Journal of Gastroenterology 2025年第2期31卷 71-84页

作者： Yu-Qin Li Wen-Tao Kuai Lin Chen Ming-hui zeng Xue-Mei Tao Jia-Xin Han yue-Kui Wang Lian-Xin Xu Li-Ying Ge Yong-Gang Liu Shuang Li Liang Xu Yu-Qiang Mi Clinical School of the Second People’s Hospital Tianjin Medical UniversityTianjin 300192China Department of Hepatology Tianjin Second People’s HospitalTianjin 300192China Department of Pathology Clinical School of the Second People’s HospitalTianjin 300110China Endoscopy Center Tianjin Second People’s HospitalTianjin 300192China

BACKGROUND Colorectal polyps are commonly observed in patients with chronic liver disease(CLD)and pose a significant clinical concern because of their potential for *** To explore the clinical characteristics of colorectal polyps in patients with CLD,a nomogram was established to predict the presence of adenomatous polyps(AP).METHODS Patients with CLD who underwent colonoscopy at Tianjin Second People’s Hospital from January 2020 to May 2023 were *** data including laboratory results,colonoscopy findings,and pathology reports were *** variables for the nomogram were identified through least absolute shrinkage and selection operator regression,followed by multivariate logistic *** performance of the model was evaluated using the area under the receiver area under curve,as well as calibration curves and decision curve *** The study enrolled 870 participants who underwent colonoscopy,and the detection rate of AP in patients with CLD was 28.6%.Compared to individuals without polyps,six risk factors were identified as predictors for AP occurrence:Age,male sex,body mass index,alcohol consumption,overlapping metabolic dysfunction-associated steatotic liver disease,and serum ferritin *** novel nomogram(AP model)demonstrated an area under curve of 0.801(95%confidence interval:0.756-0.845)and 0.785(95%confidence interval:0.712-0.858)in the training and validation *** curves indicated good agreement among predicted and actual probabilities(training:χ^(2)=11.860,P=0.157;validation:χ^(2)=7.055,P=0.530).The decision curve analysis underscored the clinical utility of the nomogram for predicting the risk of *** The AP model showed reasonable accuracy and provided a clinical foundation for predicting the occurrence of AP in patients with CLD,which has a certain predictive value.

关键词： Metabolic dysfunction associated steatotic liver disease Fatty liver Chronic liver disease Colorectal adenomas Hepatitis Risk factors

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Microglia lactylation in relation to central nervous system diseases

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Neural Regeneration Research 2025年第1期20卷 29-40页

作者： hui Yang Nan Mo Le Tong Jianhong Dong Ziwei Fan Mengxian Jia Juanqing yue Ying Wang School of Pharmacy Hangzhou Normal UniversityHangzhouZhejiang ProvinceChina Department of Clinical Laboratory The Fourth Clinical Medical College of Zhejiang University of Traditional Chinese Medicine(Hangzhou First People’s Hospital)HangzhouZhejiang ProvinceChina College of Medical Veterinary and Life SciencesUniversity of GlasgowGlasgowUK Department of Orthopedics(Spine Surgery) the First Affiliated Hospital of Wenzhou Medical UniversityWenzhouZhejiang ProvinceChina Department of Pathology Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina Department of Clinical Research Center Affiliated Hangzhou First People’s HospitalWestlake University School of MedicineHangzhouZhejiang ProvinceChina

The development of neurodegenerative diseases is closely related to the disruption of central nervous system ***,as innate immune cells,play important roles in the maintenance of central nervous system homeostasis,injury response,and neurodegenerative *** has been considered a metabolic waste product,but recent studies are revealing ever more of the physiological functions of *** is an important pathway in lactate function and is involved in glycolysis-related functions,macrophage polarization,neuromodulation,and angiogenesis and has also been implicated in the development of various *** review provides an overview of the lactate metabolic and homeostatic regulatory processes involved in microglia lactylation,histone versus non-histone lactylation,and therapeutic approaches targeting ***,we summarize the current research on microglia lactylation in central nervous system diseases.A deeper understanding of the metabolic regulatory mechanisms of microglia lactylation will provide more options for the treatment of central nervous system diseases.

关键词： brain central nervous system glycolysis immune response inflammation lactate metabolism lactate lactylation microglia neurodegenerative diseases

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足三里梁门胃俞穴区红外辐射与慢性胃痛的相关规律及其应用

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世界华人消化杂志 2009年第5期17卷 516-520页

作者：常小荣严洁易受乡岳增辉林亚平湖南中医药大学针灸推拿学省级重点学科经穴脏腑相关重点研究室针灸生物信息分析重点实验室湖南省长沙市410007

目的:探讨足三里、梁门、胃俞三穴区红外辐射与慢性胃痛的相关规律及临床运用.方法:采用人体热能辐射测试仪检测慢性胃痛患者足三里、梁门、胃俞穴区红外辐射值,并与健康人及以咳嗽为主症的肺病患者进行对照分析.结果:健康人左右两侧经... 详细信息

目的:探讨足三里、梁门、胃俞三穴区红外辐射与慢性胃痛的相关规律及临床运用.方法:采用人体热能辐射测试仪检测慢性胃痛患者足三里、梁门、胃俞穴区红外辐射值,并与健康人及以咳嗽为主症的肺病患者进行对照分析.结果:健康人左右两侧经穴红外辐射基本平衡,而慢性胃痛患者左右两侧经穴及背俞穴红外辐射不对称(P<0.05或0.01).三穴区红外辐射与慢性胃痛密切相关,其表现为三穴区左右两侧红外辐射不对称(P<0.05或0.01),足三里与梁门二穴区红外辐射两侧均低于健康人(P<0.01).结论:穴位区域红外辐射检测可作为研究针刺疗效的一个手段.针刺能够使降低的红外辐射升高,从而调节经气使之趋向正常.

关键词：足三里梁门胃俞慢性胃痛红外辐射

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Hypidone hydrochloride(YL-0919)ameliorates functional deficits after traumatic brain injury in mice by activating the sigma-1 receptor for antioxidation

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Neural Regeneration Research 2025年第8期20卷 2325-2336页

作者： Yafan Bai hui Ma yue Zhang Jinfeng Li Xiaojuan Hou Yixin Yang Guyan Wang Yunfeng Li Department of Anesthesiology Beijing Tongren HospitalCapital Medical UniversityBeijingChina Beijing Institute of Basic Medical Sciences BeijingChina Hebei North University ZhangjiakouHebei ProvinceChina Beijing Institute of Pharmacology and Toxicology State Key Laboratory of Toxicology and Medical CountermeasuresBeijing Key Laboratory of NeuropsychopharmacologyBeijingChina

Traumatic brain injury involves complex pathophysiological mechanisms,among which oxidative stress significantly contributes to the occurrence of secondary *** this study,we evaluated hypidone hydrochloride(YL-0919),a self-developed antidepressant with selective sigma-1 receptor agonist properties,and its associated mechanisms and targets in traumatic brain *** experiments to assess functional deficits were followed by assessment of neuronal damage through histological analyses and examination of blood-brain barrier permeability and brain ***,we investigated the antioxidative effects of YL-0919 by assessing the levels of traditional markers of oxidative stress in vivo in mice and in vitro in HT22 ***,the targeted action of YL-0919 was verified by employing a sigma-1 receptor antagonist(BD-1047).Our findings demonstrated that YL-0919 markedly improved deficits in motor function and spatial cognition on day 3 post traumatic brain injury,while also decreasing neuronal mortality and reversing blood-brain barrier disruption and brain ***,YL-0919 effectively combated oxidative stress both in vivo and in *** protective effects of YL-0919 were partially inhibited by *** results indicated that YL-0919 relieved impairments in motor and spatial cognition by restraining oxidative stress,a neuroprotective effect that was partially reversed by the sigma-1 receptor antagonist ***-0919 may have potential as a new treatment for traumatic brain injury.

关键词： antidepressant drug blood-brain barrier cognitive function hypidone hydrochloride(YL-0919) neurological function nuclear factor-erythroid 2 related factor 2 oxidative stress sigma-1 receptor superoxide dismutase traumatic brain injury

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Antiviral therapy for hepatitis B virus infection is beneficial for the prognosis hepatocellular carcinoma

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World Journal of Gastrointestinal Oncology 2025年第1期17卷 1-9页

作者： hui Wan Yu-Xin Zhang Guan-yue Shan Jun-Ya Cheng Duan-Rui Qiao Yi-Ying Liu Wen-Na Shi Hai-Jun Li Institute of Translational Medicine The First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina Department of Bioengineering Pharmacy School of Jilin UniversityChangchun 130061Jilin ProvinceChina Institute of Liver Diseases Institute of Translational MedicineThe First Hospital of Jilin UniversityChangchun 130061Jilin ProvinceChina

In this editorial,we comment on the article by Mu et al,published in the recent issue of the World Journal of Gastrointestinal *** pay special attention to the immune tolerance mechanism caused by hepatitis B virus(HBV)infection,the pathogenesis of hepatocellular carcinoma(HCC),and the role of antiviral therapy in treating HCC related to HBV *** infection leads to systemic innate immune tolerance by directly inhibiting pattern recognition receptor recognition and antiviral signaling pathways,as well as by inhibiting the immune functions of macrophages,natural killer cells and dendritic *** addition,HBV leads to an immunosuppressive cascade by expressing inhibitory molecules to induce exhaustion of HBV-specific cluster of differentiation 8+T cells,ultimately leading to long-term viral *** loss of immune cell function caused by HBV infection ultimately leads to ***-term antiviral therapy can improve the prognosis of patients with HCC and prevent tumor recurrence and metastasis.

关键词： Hepatitis B virus Hepatocellular carcinoma Hepatitis B virus-DNA Immune tolerance Antiviral therapy

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40年来宁乡市稻田土壤肥力时空变异分析

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中国土壤与肥料 2020年第6期 41-49页

作者：孙耿孙梅周峻宇黄晶曾跃辉罗尊长湖南土壤肥料研究所湖南长沙410125 中国农业科学院农业资源与农业区划研究所/耕地培育技术国家工程实验室北京100081 湖南省农业科学院湖南长沙410125

土壤养分具有较强的时空变异性,明确40年来县域稻田土壤肥力时空变异特征,能为稻田土壤培肥管理提供科学指导。通过收集整理宁乡市第二次土壤普查及2018年稻田土壤肥力数据,以地统计学为基础,借助GS+7.0、ArcGIS和R等软件进行分析。结... 详细信息

土壤养分具有较强的时空变异性,明确40年来县域稻田土壤肥力时空变异特征,能为稻田土壤培肥管理提供科学指导。通过收集整理宁乡市第二次土壤普查及2018年稻田土壤肥力数据,以地统计学为基础,借助GS+7.0、ArcGIS和R等软件进行分析。结果表明,40年来稻田土壤有机质、全氮、碱解氮、有效磷、速效钾及综合肥力指数分别增加13.1%、98.5%、20.1%、98.2%、13.7%和47.9%,但pH降低0.58,土壤呈酸化趋势;土壤有效磷空间相关性较弱,受随机因素影响较大;有机质、全氮、碱解氮、速效钾、pH和综合肥力指数空间相关性较强,受地形和人为因素的共同作用;有机质、全氮和碱解氮是土壤综合肥力指数的重要因素,全氮的大幅增加是土壤综合肥力指数提升的关键驱动原因;当前水稻产量与土壤综合肥力指数呈极显著正相关。

关键词：稻田土壤肥力时空变异

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按部选穴针刺治疗对糖尿病胃轻瘫大鼠延髓内c-fos和神经胶质酸性蛋白表达的影响

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世界华人消化杂志 2016年第11期24卷 1701-1707页

作者：刘丽陈小丽文琪琦李萍魏歆然王艳岳增辉湖南中医药大学针灸推拿学院湖南省长沙市410007

目的:观察按部选穴针刺治疗对糖尿病胃轻瘫(diabetic gastroparesis,DGP)模型大鼠延髓内c-fos和神经胶质酸性蛋白(glial fibrillary acidic protein,GFAP)表达的影响,探讨按部选穴是腧穴配伍效应的影响因素.方法:60只SD大鼠随机分为空... 详细信息

目的:观察按部选穴针刺治疗对糖尿病胃轻瘫(diabetic gastroparesis,DGP)模型大鼠延髓内c-fos和神经胶质酸性蛋白(glial fibrillary acidic protein,GFAP)表达的影响,探讨按部选穴是腧穴配伍效应的影响因素.方法:60只SD大鼠随机分为空白对照组、模型组、针刺足三里+中脘组、针刺足三里+内关组、针刺足三里+非经非穴组,每组12只.采用单次腹腔注射2%链脲佐菌素配合普通饲料饮食建立DGP模型大鼠,造模成功后,连续治疗4 wk.治疗结束后,用黑墨水灌胃测小肠推进率,用免疫组织化学法检测大鼠延髓内c-fos和GFAP的灰度值.结果:与空白对照组比较,模型组小肠推进率显著降低,c-fos和GFAP的灰度值降低,有统计学意义(P<0.05).与模型组比较,针刺足三里+中脘组、针刺足三里+内关组、针刺足三里+非经非穴组小肠推进率显著升高,针刺足三里+中脘组c-fos和GFAP的灰度值显著升高,有统计学意义(P<0.05).与针刺足三里+中脘组比较,针刺足三里+内关组、针刺足三里+非经非穴组c-fos和GFAP的灰度值显著降低,有统计学意义(P<0.05).结论:针刺可改善DGP模型大鼠胃排空迟缓症状,调节延髓内c-fos和GFAP的表达,配伍局部腧穴显著优于配伍远端腧穴及非经非穴点,表明不同按部选穴是影响腧穴配伍效应的关键因素.

关键词：腧穴配伍按部选穴糖尿病胃轻瘫 c-fos 神经胶质酸性蛋白

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