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Aging hallmarks of the primate ovary revealed by spatiotemporal transcriptomics

Protein & Cell 2024年第5期15卷 364-384页

作者： Huifen Lu Ying Jing chen Zhang Shuai Ma Weiqi Zhang Daoyuan Huang Bin Zhang Yuesheng Zuo Yingying Qin guang-Hui Liu Yang Yu Jing Qu Si Wang Advanced Innovation Center for Human Brain Protection National Clinical Research Center for Geriatric DisordersXuanwu Hospital Capital Medical UniversityBeijing 100053China State Key Laboratory of Stem Cell and Reproductive Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Translational Medicine Center International Center for Aging and CancerBeijing Municipal Geriatric Medical Research CenterXuanwu HospitalCapital Medical UniversityBeijing 100053China State Key Laboratory of Membrane Biology Institute of ZoologyChinese Academy of SciencesBeijing 100101China University of Chinese Academy of Sciences Beijing 100049China Beijing Institute for Stem Cell and Regenerative Medicine Beijing 100101China CAS Key Laboratory of Genomic and Precision Medicine Beijing Institute of GenomicsChinese Academy of SciencesBeijing 100101China Institute for Stem cell and Regeneration CASBeijing 100101China China National Center for Bioinformation Beijing 100101China The Fifth People’s Hospital of Chongqing Chongqing 400062China Sino-Danish College University of Chinese Academy of SciencesBeijing 101408China Sino-Danish Center for Education and Research Beijing 101408China Department of Obstetrics and Gynecology Center for Reproductive MedicinePeking UniversityThird HospitalBeijing 100191China Clinical Stem Cell Research Center Peking UniversityThird HospitalBeijing 100191China Center for Reproductive Medicine Cheeloo College of MedicineShandong UniversityJinan 250012China Key Laboratory of Reproductive Endocrinology of Ministry of Education National Research Center for Assisted Reproductive Technology and Reproductive GeneticsShandong Key Laboratory of Reproductive MedicineShandong Provincial Clinical Research Center for Reproductive HealthJinan 250012China Key Laboratory of Organ Regeneration and Reconstruction Institute of ZoologyChinese Academy of SciencesBeijing 100101China Aging Biomarker Consortium Beijing 100101China

The ovary is indispensable for female reproduction,and its age-dependent functional decline is the primary cause of ***,the molecular basis of ovarian aging in higher vertebrates remains poorly ***,we apply spatiotemporal transcriptomics to benchmark architecture organization as well as cellular and molecular determinants in young primate ovaries and compare these to aged primate *** a global view,somatic cells within the non-follicle region undergo more pronounced transcriptional fluctuation relative to those in the follicle region,likely constituting a hostile microenvironment that facilitates ovarian ***,we uncovered that inflammation,the senescent-associated secretory phenotype,senescence,and fibrosis are the likely primary contributors to ovarian aging(PCOA).Of note,we identified spatial co-localization between a PCOA-featured spot and an unappreciated MT2(Metallothionein 2)highly expressing spot(MT2^(high))characterized by high levels of inflammation,potentially serving as an aging hotspot in the primate ***,with advanced age,a subpopulation of MT2^(high)accumulates,likely disseminating and amplifying the senescent signal *** study establishes the first primate spatiotemporal transcriptomic atlas,advancing our understanding of mechanistic determinants underpinning primate ovarian aging and unraveling potential biomarkers and therapeutic targets for aging and age-associated human ovarian disorders.

关键词： spatial transcriptome primate ovary aging senescence inflammation

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Neurosyphilis complicated by anti-γ-aminobutyric acid-B receptor encephalitis: A case report

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World Journal of Clinical Cases 2024年第11期12卷 1960-1966页

作者： Ya-Xiu Fang Xiao-Ming Zhou Dong Zheng guang-Hui Liu Peng-Bo Gao Xiao-Zhen Huang Zhi-cheng chen Hui Zhang Lin chen Ya-Fang Hu Department of Neurology The Affiliated Brain Hospital of Guangzhou Medical UniversityGuangzhou 510000Guangdong ProvinceChina Department of Neurology Nanfang HospitalSouthern Medical UniversityGuangzhou 510000Guangdong ProvinceChina

BACKGROUND Syphilis is an infectious disease caused by Treponema pallidum that can invade the central nervous system,causing *** cases of anti-N-methyl-Daspartate receptor autoimmune encephalitis(AE)secondary to neurosyphilis have been *** report a neurosyphilis patient with anti-γ-aminobutyric acid-B receptor(GABABR)*** SUMMARY A young man in his 30s who presented with acute epileptic status was admitted to a local *** was diagnosed with neurosyphilis,according to serum and cerebrospinal fluid(CSF)tests for *** 14 d of antiepileptic treatment and anti-Treponema pallidum therapy with penicillin,epilepsy was controlled but serious cognitive impairment,behavioral,and serious psychiatric symptoms were *** was then transferred to our *** Mini-Mental State Examination(MMSE)crude test results showed only 2 *** magnetic resonance imaging revealed significant cerebral atrophy and multiple fluidattenuated inversion recovery high signals in the white matter surrounding both lateral ventricles,left amygdala and bilateral ***-GABABR antibodies were discovered in CSF(1:3.2)and serum(1:100).The patient was diagnosed with neurosyphilis complicated by anti-GABABR AE,and received methylprednisolone and *** treatment,his mental symptoms were *** impairment was significantly improved,with a MMSE of 8 *** anti-GABABR antibody titer decreased to 1:*** patient received methylprednisolone and penicillin after *** months later,the patient’s condition was stable,but the serum anti-GABABR antibody titer was 1:*** This patient with neurosyphilis combined with anti-GABABR encephalitis benefited from immunotherapy.

关键词： Anti-γ-aminobutyric acid-B receptor GABABR Neurosyphilis Tissue-based assay Magnetic resonance imaging Mini-mental state examination Case report

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A contradictory phenomenon of thicken pericardium and cardiac compression without inferior vena cava dilation:sign of IVC escape

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Journal of Geriatric Cardiology 2024年第5期21卷 583-587页

作者： Tie-Nan chen Shuang ZHAO Shuai QIAO Yong-Yong HAN Qing LIU Chang-Le LIU guang-Ping LI Tong LIU Hua-Ying FU Department of Cardiovascular Surgery Second Hospital of Tianjin Medical UniversityTianjinChina Department of Cardiology Tianjin Key Laboratory of Ionic-Molecular Function of Cardiovascular DiseaseTianjin Institute of Cardi-ologyThe Second Hospital of Tianjin Medical UniversityTianjinChina Department of Oncology Second Hospital of Tianjin Medical UniversityTianjinPeople's Republic of China

A 77-year-old female presented with shortness of breath and tightness of chest was *** past medical history included hypertension and she has been taking nifedipine *** years before,she was diagnosed with pericardial effusion(Figure 1)and had pericardiocentesis *** physical examination,her blood pressure was 151/100 mm-Hg and her pulse rate was 91 beats/min.

关键词： admitted cardiac thick

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PRaG 3.0 therapy for human epidermal growth factor receptor 2-positive metastatic pancreatic ductal adenocarcinoma:A case report

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World Journal of Gastroenterology 2024年第9期30卷 1237-1249页

作者： Yue-Hong Kong Mei-Ling Xu Jun-Jun Zhang guang-Qiang chen Zhi-Hui Hong Hong Zhang Xiao-Xiao Dai Yi-Fu Ma Xiang-Rong Zhao chen-Yang Zhang Rong-Zheng chen Peng-Fei Xing Li-Yuan Zhang Center for Cancer Diagnosis and Treatment The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Radiotherapy&Oncology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Institution of Radiotherapy&Oncology Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Radiology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Nuclear Medicine The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Clinical Laboratory The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina Department of Pathology The Second Affiliated Hospital of Soochow UniversitySuzhou 215000Jiangsu ProvinceChina

BACKGROUND Pancreatic ductal adenocarcinoma(PDAC)is a highly fatal disease with limited effective treatment especially after first-line *** human epidermal growth factor receptor 2(HER-2)immunohistochemistry(IHC)positive is associated with more aggressive clinical behavior and shorter overall survival in *** SUMMARY We present a case of multiple metastatic PDAC with IHC mismatch repair proficient but HER-2 IHC weakly positive at diagnosis that didn’t have tumor regression after first-line nab-paclitaxel plus gemcitabine and PD-1 inhibitor treatment.A novel combination therapy PRaG 3.0 of RC48(HER2-antibody-drug conjugate),radio-therapy,PD-1 inhibitor,granulocyte-macrophage colony-stimulating factor and interleukin-2 was then applied as second-line therapy and the patient had confirmed good partial response with progress-free-survival of 6.5 months and overall survival of 14.2 *** had not developed any grade 2 or above treatment-related adverse events at any *** of peripheral CD8^(+) Temra and CD4^(+) Temra were increased during first two activation cycles of PRaG 3.0 treatment containing radiotherapy but deceased to the baseline during the maintenance cycles containing no *** PRaG 3.0 might be a novel strategy for HER2-positive metastatic PDAC patients who failed from previous first-line approach and even PD-1 immunotherapy but needs more data in prospective trials.

关键词： Pancreatic ductal adenocarcinoma PRaG 3.0 therapy Human epidermal growth factor receptor 2 Novel combination therapy Case report

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Differential diagnosis of Crohn’s disease and intestinal tuberculosis based on ATR-FTIR spectroscopy combined with machine learning

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World Journal of Gastroenterology 2024年第10期30卷 1377-1392页

作者： Yuan-Peng Li Tian-Yu Lu Fu-Rong Huang Wei-Min Zhang Zhen-Qiang chen Pei-Wen guang Liang-Yu Deng Xin-Hao Yang College of Physical Science and Technology Guangxi Normal UniversityGuilinGuangxi 541004China Department of Gastroenterology The Affiliated Hospital of South University of Science and TechnologyShenzhen 518000Guangdong ProvinceChina Department of Optoelectronic Engineering Jinan UniversityGuangzhou 510632Guangdong ProvinceChina Department of Gastroenterology Integrated Hospital of Traditional Chinese MedicineSouthern Medical UniversityGuangzhou 510632Guangdong ProvinceChina

BACKGROUND Crohn’s disease(CD)is often misdiagnosed as intestinal tuberculosis(ITB).However,the treatment and prognosis of these two diseases are dramatically ***,it is important to develop a method to identify CD and ITB with high accuracy,specificity,and *** To develop a method to identify CD and ITB with high accuracy,specificity,and *** A total of 72 paraffin wax-embedded tissue sections were pathologically and clinically diagnosed as CD or *** wax-embedded tissue sections were attached to a metal coating and measured using attenuated total reflectance fourier transform infrared spectroscopy at mid-infrared wavelengths combined with XGBoost for differential *** The results showed that the paraffin wax-embedded specimens of CD and ITB were significantly different in their spectral signals at 1074 cm^(-1) and 1234 cm^(-1) bands,and the differential diagnosis model based on spectral characteristics combined with machine learning showed accuracy,specificity,and sensitivity of 91.84%,92.59%,and 90.90%,respectively,for the differential diagnosis of CD and *** Information on the mid-infrared region can reveal the different histological components of CD and ITB at the molecular level,and spectral analysis combined with machine learning to establish a diagnostic model is expected to become a new method for the differential diagnosis of CD and ITB.

关键词： Infrared spectroscopy Machine learning Intestinal tuberculosis Crohn’s disease Differential diagnosis Inflammatory bowel disease

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MCSTransWnet:A new deep learning process for postoperative corneal topography prediction based on raw multimodal data from the Pentacam HR system

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Medicine in Novel Technology and Devices 2024年第1期21卷 53-63页

作者： Nan cheng Zhe Zhang Jing Pan Xiao-Na Li Wei-Yi chen guang-Hua Zhang Wei-Hua Yang College of Biomedical Engineering Taiyuan University of TechnologyTaiyuan 030600ShanxiChina Shenzhen Eye Hospital Jinan UniversityShenzhen Eye InstituteShenzhen 518040GuangdongChina Department of Intelligence and Automation Taiyuan UniversityTaiyuan 030032ShanxiChina Graphics and Imaging Laboratory University of GironaGirona 17004Spain

This work provides a new multimodal fusion generative adversarial net(GAN)model,Multiple Conditions Transform W-net(MCSTransWnet),which primarily uses femtosecond laser arcuate keratotomy surgical parameters and preoperative corneal topography to predict postoperative corneal topography in astigmatism-corrected *** MCSTransWnet model comprises a generator and a discriminator,and the generator is composed of two *** first sub-generator extracts features using the U-net model,vision transform(ViT)and a multi-parameter conditional module branch.The second sub-generator uses a U-net network for further image *** discriminator uses the pixel discriminator in ***,most GAN models are convolutional neural networks;however,due to their feature extraction locality,it is difficult to comprehend the relationships among global ***,we added a vision Transform network as the model branch to extract the global *** is normally difficult to train the transformer,and image noise and geometric information loss are ***,we adopted the standard U-net fusion scheme and transform network as the generator,so that global features,local features,and rich image details could be obtained *** experimental results clearly demonstrate that MCSTransWnet successfully predicts postoperative corneal topographies(structural similarity=0.765,peak signal-to-noise ratio=16.012,and Fréchet inception distance=9.264).Using this technique to obtain the rough shape of the postoperative corneal topography in advance gives clinicians more references and guides changes to surgical planning and improves the success rate of surgery.

关键词： Deep learning Generative adversarial networks Corneal topography Transformer W-net U-net Medical imaging Multimodal fusion

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Lipid-lowering effects of gefarnate in statin-treated patients with residual hypertriglyceridemia:a randomized controlled study

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Journal of Geriatric Cardiology 2024年第8期21卷 791-798页

作者： Jing SHI Ming-Lu XU Mei-Jiao HE Wan-Lan BO Hai-Yu ZHANG Dang-Hui SUN Ding-Yu WANG Xiao-Yu WANG Qun SHAO Yu-Jiao PAN Yu ZHANG chen-guang DAI Jing-Ying WANG Lin-Wei ZHANG guang-Zhong LIU Yue LI for the GPROT Study Group Department of Cardiology the First Affiliated HospitalHarbin Medical UniversityHarbinChina Department of Gastroenterology the Fourth Affiliated HospitalHarbin Medical UniversityHarbinChina Department of Cardiology Harbin Medical University Cancer HospitalHarbinChina Department of Cardiology Shenzhen People’s HospitalShenzhenChina National Key Laboratory of Frigid Zone Cardiovascular Diseases Harbin Medical UniversityHarbinChina NHC Key Laboratory of Cell Transplantation Key Laboratory of Cardiovascular Disease Acousto-Optic Electromagnetic Diagnosis and Treatment in Heilongjiang ProvinceHeilongjiang Province Clinical Medical Research Center for Hypertensionthe First Affiliated HospitalHarbin Medical UniversityHarbinChina Institute of Metabolic Disease Heilongjiang Academy of Medical ScienceHarbinChina 不详

BACKGROUND The prevention of coronary artery disease(CAD)faces dual challenges:the aspirin-induced gastrointestinal injury,and the residual cardiovascular risk after statin *** acetate(Gefarnate)is an anti-ulcer *** was reported that geraniol might participate in lipid metabolism through a variety of *** aim of this study was to assess the lipid-lowering effects of gefarnate in statin-treated CAD patients with residual *** In this prospective,open-label,randomized,controlled trial,69 statin-treated CAD patients with residual hypertriglyceridemia were randomly assigned to gefarnate group and control group,received gefarnate(100 mg/3 times a day)combined with statin and statin alone,*** baseline and after one-month treatment,the levels of plasma triglyceride,high-density lipoprotein cholesterol(HDL-C),low-density lipoprotein cholesterol(LDL-C)and total cholesterol were *** After one-month gefarnate treatment,triglyceride level was significantly lowered from 2.64 mmol/L to 2.12 mmol/L(P=0.0018),LDL-C level lowered from 2.7 mmol/L to 2.37 mmol/L(P=0.0004),HDL-C level increased from 0.97 mmol/L to 1.17mmol/L(P=0.0228).Based on statin therapy,gefarnate could significantly reduce the plasma triglyceride level(P=0.0148)and increase the plasma HDL-C level(P=0.0307).Although the LDL-C and total cholesterol levels tended to decrease,there was no statistically significant *** The addition of gefarnate to statin reduced triglyceride level and increased HDL-C level to a significant extent compared to statin alone in CAD patients with residual *** suggested that gefarnate might provide the dual benefits of preventing gastrointestinal injury and lipid lowering in CAD patients.

关键词： nat alone Lipid

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Liver histological changes in untreated chronic hepatitis B patients in indeterminate phase

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World Journal of Hepatology 2024年第6期16卷 920-931页

作者： De-Liang Huang Qin-Xian Cai guang-De Zhou Hong Yu Zhi-Bin Zhu Jing-Han Peng Jun chen Department of Liver Diseases The Third People’s Hospital of ShenzhenShenzhen 510000Guangdong ProvinceChina Department of Pathology Beijing Youan HospitalCapital Medical UniversityBeijing 100000China Department of Pathology National Clinical Research Centre for Infectious DiseaseThe Third People's Hospital of Shenzhen and the Second Hospital Affiliated with the Southern University of Science and TechnologyShenzhen 518112Guangdong ProvinceChina

BACKGROUND Studies with large size samples on the liver histological changes of indeterminate phase chronic hepatitis B(CHB)patients were not previously *** To assess the liver histological changes in the indeterminate phase CHB patients using liver *** The clinical and laboratory data of 1532 untreated CHB patients were collected,and all patients had least once liver biopsy from January 2015 to December *** significant differences among different phases of CHB infection were compared with t-test,and the risk factors of significant liver histological changes were analyzed by the multivariate logistic regression *** Among 1532 untreated CHB patients,814(53.13%)patients were in the indeterminate *** liver histological changes(defined as biopsy score≥G2 and/or≥S2)were found in 488/814(59.95%)CHB patients in the indete-rminate *** liver histological changes were significant differences among different age,platelets(PLTs),and alanine aminotransferase(ALT)subgroup in indeterminate *** logistic regression analysis indicated that age≥40 years old[adjust odd risk(aOR),1.44;95%confidence interval(CI):1.06-1.97;P=0.02],PLTs≤150×10^(9)/L(aOR,2.99;95%CI:1.85-4.83;P<0.0001),and ALT≥upper limits of normal(aOR,1.48;95%CI:1.08,2.05,P=0.0163)were independent risk factors for significant liver histological changes in CHB patients in the indeterminate *** Our results suggested that significant liver histological changes were not rare among the untreated CHB patients in indeterminate phase,and additional strategies are urgently required for the management of these patients.

关键词： Chronic hepatitis B Indeterminate phase Gray-zone Liver biopsy Pathological histology Risk factors

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Designing Symmetric Gradient Honeycomb Structures with Carbon‑Coated Iron‑Based Composites for High‑Efficiency Microwave Absorption

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Nano-Micro Letters 2024年第11期16卷 224-241页

作者： Yu Zhang Shu‑Hao Yang Yue Xin Bo Cai Peng‑Fei Hu Hai‑Yang Dai chen‑Ming Liang Yun‑Tong Meng Ji‑Hao Su Xiao‑Juan Zhang Min Lu guang‑Sheng Wang School of Chemistry Beihang UniversityBeijing 100191People’s Republic of China School of Electronics and Information Zhengzhou University of Light IndustryZhengzhou 450002People’s Republic of China School of Chemical Engineering Northeast Electric Power UniversityJilin 132000People’s Republic of China College of Chemistry and Materials Engineering Beijing Technology and Business UniversityBeijing 100048People’s Republic of China

The impedance matching of absorbers is a vital factor affecting their microwave absorption(MA)*** this work,we controllably synthesized Material of Institute Lavoisier 88C(MIL-88C)with varying aspect ratios(AR)as a precursor by regulating oil bath conditions,followed by one-step thermal decomposition to obtain carbon-coated iron-based *** the precursor MIL-88C(Fe)preparation conditions,such as the molar ratio between metal ions and organic ligands(M/O),oil bath temperature,and oil bath time,influenced the phases,graphitization degree,and AR of the derivatives,enabling low filler loading,achieving well-matched impedance,and ensuring outstanding MA *** MOF-derivatives 2(MD_(2))/polyvinylidene Difluoride(PVDF),MD_(3)/PVDF,and MD4/PVDF absorbers all exhibited excellent MA properties with optimal filler loadings below 20 wt%and as low as 5 wt%.The MD_(2)/PVDF(5 wt%)achieved a maximum effective absorption bandwidth(EAB)of 5.52 GHz(1.90 mm).The MD_(3)/PVDF(10 wt%)possessed a minimum reflection loss(RL_(min))value of−67.4 at 12.56 GHz(2.13 mm).A symmetric gradient honeycomb structure(SGHS)was constructed utilizing the high-frequency structure simulator(HFSS)to further extend the EAB,achieving an EAB of 14.6 GHz and a RL_(min) of−59.0 *** research offers a viable inspiration to creating structures or materials with high-efficiency MA properties.

关键词： MIL-88C(Fe) Fe/Fe_(3)O_(4)/Fe_(3)C@C Controllable preparation Symmetric gradient honeycomb structure Microwave absorbing

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Variable Stars in the 50BiN Open Cluster Survey.Ⅲ.NGC 884

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Research in Astronomy and Astrophysics 2024年第2期24卷 36-45页

作者： Lin-Hong Wang Qian-Heng Nie Kun Wang Xiao-Dian chen Chun-guang Zhang Li-Cai Deng Xiao-Bin Zhang Tian-Lu chen Department of Physics College of ScienceTibet UniversityLhasa 850000China Key Laboratory of Cosmic Rays Tibet UniversityMinistry of EducationLhasa 850000China Key Laboratory of Optical Astronomy National Astronomical ObservatoriesChinese Academy of SciencesBeijing 100101China School of Astronomy and Space Science University of Chinese Academy of SciencesBeijing 100049China Middlesex School ConcordMassachusettsUnited States of America School of Physics and Astronomy China West Normal UniversityNanchong 637002China

Open clusters are the basic building blocks that serve as a laboratory for the study of young stellar populations in the Milky *** stars in open clusters provide a unique way to accurately probe the internal structure,temporal and dynamical evolutionary stages of individual stars and the host *** most powerful tool for such studies is time-domain photometric *** paper follows the route of our previous work,concentrating on a photometric search for variable stars in NGC *** target cluster is the companion of NGC869,forming the well-known double cluster system that is gravitationally *** the observation run in 2016 November,a total of 9247 B-band CCD images and 8218Ⅴ-band CCD images were *** detected a total of 15 stars with variability in visual brightness,including five Be stars,three eclipsing binaries,and seven of unknown *** new variable stars were discovered in this *** also compared the variable star content of NGC 884 with its companion NGC 869.

关键词： stars variables general-(Galaxy:)open clusters and associations individual(…,…)-(stars:)binaries general

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