检索结果-南通市图书馆

Understanding adversarial attacks on observations in deep reinforcement learning

在线全文

学校读者我要写书评

暂无评论

Science China(Information Sciences) 2024年第5期67卷 69-83页

作者： You QIAOBEN Chengyang YING xinning ZHOU Hang SU Jun ZHU Bo ZHANG Department of Computer Science and Technology Beijing National Research Center for Information Science and Technology Tsinghua-Bosch Joint Center for Machine Learning Institute for Artificial Intelligence Tsinghua University Peng Cheng Laboratory

Deep reinforcement learning models are vulnerable to adversarial attacks that can decrease the cumulative expected reward of a victim by manipulating its observations. Despite the efficiency of previous optimization-based methods for generating adversarial noise in supervised learning, such methods might not achieve the lowest cumulative reward since they do not generally explore the environmental ***, a framework is provided to better understand the existing methods by reformulating the problem of adversarial attacks on reinforcement learning in the function space. The reformulation approach adopted herein generates an optimal adversary in the function space of targeted attacks, repelling them via a generic two-stage framework. In the first stage, a deceptive policy is trained by hacking the environment and discovering a set of trajectories routing to the lowest reward or the worst-case performance. Next, the adversary misleads the victim to imitate the deceptive policy by perturbing the observations. Compared to existing approaches, it is theoretically shown that our adversary is strong under an appropriate noise level. Extensive experiments demonstrate the superiority of the proposed method in terms of efficiency and effectiveness, achieving state-of-the-art performance in both Atari and MuJoCo environments.

关键词： deep learning reinforcement learning adversarial robustness adversarial attack

Ultra-conservative noncoding RNA uc.243 confers chemo-resistance by facilitating the efflux of the chemotherapeutic drug in ovarian cancer

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

BIOCELL 2024年第8期48卷 1265-1273页

作者： SHAN JIANG XIUFENG LIN YANFEI CHEN xinning LI JIALI KANG Department of Gynecology and Obstetrics The First Affiliated Hospital of Jinan UniversityGuangzhou510180China Reproductive Medical Center Boai Hospital of Zhongshan Affiliated to Southern Medical UniversityZhongshan528400China Department of Gynecology and Obstetrics Boai Hospital of Zhongshan Affiliated to Southern Medical UniversityZhongshan528400China Department of Gynecology and Obstetrics Guangzhou First People’s HospitalGuangzhou Medical UniversityGuangzhou510180China

Background:Despite improvements in objective response rates to cisplatin-based combination chemotherapy,the majority of advanced ovarian cancer remains suboptimal,resulting in poor *** has been found that non-coding RNAs(ncRNAs)not only participate in the transmission of signals between various cells but also participate in tumor immunity and anti-tumor immune responses,thereby regulating tumor occurrence and ***,the function and detailed mechanism of ultraconserved RNA(ucRNA)in ovarian cancer chemoresistance is still ***:Western blotting assay,Quantitative real-time PCR analysis(qPCR),and Kaplan-Meier Plotter analysis were performed to analyze the expression and prognosis of uc.243 in ovarian *** assay and Annexin V assay were performed to analyze the function of uc.243 in cisplatin resistance in ovarian cancer *** pull-down and qPCR experiments were performed to explore the molecular mechanism of uc.243 enhancing cisplatin resistance in ovarian cancer ***:Herein,we found that uc.243 was remarkably upregulated and correlated with patient survival in chemoresistance ovarian cancer patients compared with chemo-sensitive ovarian *** experiment displayed that uc.243 induced cisplatin resistance on ovarian cancer cells by facilitating the efflux of cisplatin(CDDP);but inhibiting the expression of uc.243 significantly reverses this ***,uc.243 can inhibit the binding of RNA binding protein DGCR8 microprocessor complex subunit to pri-miR-155,thereby inhibiting the cleavage of pri-miR-155 and decrease in mature miR-155,subsequently upregulates the expression of ATP binding cassette subfamily B member(ABCB1,ABCC2).Conclusion:Our research findings indicate that uc.243 can induce chemotherapy resistance in ovarian cancer,suggesting that it may become a new prognostic biomarker for malignant ovarian cancer.

关键词： Ultra-conserved non-coding RNA uc.243 Drug efflux Drug transporters Chemoresistance Ovarian cancer

Latest assessment methods for mitochondrial homeostasis in cognitive diseases

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Neural Regeneration Research 2024年第4期19卷 754-768页

作者： Wei You Yue Li Kaixi Liu xinning Mi Yitong Li Xiangyang Guo Zhengqian Li Department of Anesthesiology Peking University Third Hospital Peking University Third Clinical Medical College Beijing Center of Quality Control and Improvement on Clinical Anesthesia Anesthesia and Perioperative Medicine Branch of China International Exchange and Promotive Association for Medical and Health Care(CPAM)

Mitochondria play an essential role in neural function,such as supporting normal energy metabolism,regulating reactive oxygen species,buffering physiological calcium loads,and maintaining the balance of morphology,subcellular distribution,and overall health through mitochondrial *** the recent technological advances in the assessment of mitochondrial structure and functions,mitochondrial dysfunction has been regarded as the early and key pathophysiological mechanism of cognitive disorders such as Alzheimer’s disease,Parkinson’s disease,Huntington’s disease,mild cognitive impairment,and postoperative cognitive *** review will focus on the recent advances in mitochondrial medicine and research methodology in the field of cognitive sciences,from the perspectives of energy metabolism,oxidative stress,calcium homeostasis,and mitochondrial dynamics(including fission-fusion,transport,and mitophagy).

关键词： cognitive disorders mitochondrial dysfunction mitochondrial energy metabolism mitochondrial dynamics mitochondrial transport mitophagy mitochondrial biogenesis oxidative stress calcium homeostasis

Comparative Study on Different Methods for Prediction of Thermal Insulation Performance of Thermal Barrier Coating Used on Turbine Blades

在线全文

学校读者我要写书评

暂无评论

Journal of Thermal Science 2024年第1期33卷 172-189页

作者： ZHANG Zhixin zeng Wu ZHANG Xiaodong zeng Yuntao Advanced Gas Turbine Laboratory Institute of Engineering ThermophysicsChinese Academy of SciencesBeijing 100190China Key Laboratory of Advanced Energy and Power Institute of Engineering ThermophysicsChinese Academy of SciencesBeijing 100190China Innovation Academy for Light-duty Gas Turbine Chinese Academy of SciencesBeijing 100190China University of Chinese Academy of Sciences Beijing 100049China

As turbine inlet temperature gets higher and higher,thermal barrier coating(TBC) is more and more widely used in turbine *** turbine blades with TBC,it is of great significance to evaluate the temperature distribution of its substrate metal quickly and accurately,especially during the design *** different degrees of simplification such as whether to consider the change of the geometric size of the fluid domain by TBC and whether to consider the planar heat conduction in TBC,three different methods used in conjugate heat transfer(CHT) simulation to model the TBC of the turbine blades have been developed and widely used by ***,little research has been conducted to investigate the influence of the three methods on the temperature distribution of turbine *** fill this gap,three geometric models were *** are a solid conduction model with a substrate metal layer and a TBC layer,a transonic turbine vane with internal cooling and TBC,and a plate cylindrical film hole cooling model with *** methods were used in these geometric models and their differences were carefully analyzed and *** result shows that for the conduction model used in this paper,with the same TBC surface temperature distribution,the difference between the three methods is very small and can be *** a transonic turbine vane with internal cooling,regarding the local maximum temperature of the substrate-TBC interface,the largest difference between the method in which TBC is considered as a thermal resistance or a virtual layer of cells and the method in which three-dimensional heat conduction equation of TBC is solved occurs at the trailing *** difference near the leading edge is below *** employed to the film cooling model,the difference of the laterally averaged temperature of the substrate-TBC interface can be 8 K which is mainly due to the change of the length to diameter ratio of the film cooling hole by *** the substrate

关键词： turbine blade thermal barrier coating conjugate heat transfer film cooling hole

Measurement of solar pp neutrino flux using electron recoil data from PandaX-4T commissioning run

在线全文

学校读者我要写书评

暂无评论

CHINESE PHYSICS C 2024年第9期48卷 1-7,300页

作者： Lu, Xiaoying Abdukerim, Abdusalam Bo, Zihao Chen, Wei Chen, Xun Chen, Yunhua Cheng, Chen Cheng, Zhaokan Cui, Xiangyi Fan, Yingjie Fang, Deqing Geng, Lisheng Giboni, Karl Guo, Xuyuan Han, Chencheng Han, Ke He, Changda He, Jinrong Huang, Di Huang, Junting Huang, Zhou Hou, Ruquan Hou, Yu Ji, Xiangdong Ju, Yonglin Li, Chenxiang Li, Jiafu Li, Mingchuan Li, Shuaijie Li, Tao Lin, Qing Liu, Jianglai Lu, Congcong Luo, Lingyin Luo, Yunyang Ma, Wenbo Ma, Yugang Mao, Yajun Meng, Yue Ning, Xuyang Pang, Binyu Qi, Ningchun Qian, Zhicheng Ren, Xiangxiang Shaheed, Nasir Shang, Xiaofeng Shao, Xiyuan Shen, Guofang Shen, Manbin Si, Lin Tao, Yi Wang, Anqing Wang, Meng Wang, Qiuhong Wang, Shaobo Wang, Siguang Wang, Wei Wang, Xiuli Wang, Xu Wang, Zhou Wei, Yuehuan Wu, Mengmeng Wu, Weihao Wu, Yuan Xiao, Mengjiao Xiao, Xiang Xiong, Kaizhi Yan, Binbin Yan, Xiyu Yang, Yong Yuan, Ying Yuan, Zhe Yun, Youhui zeng, xinning Zhang, Minzhen Zhang, Peng Zhang, Shibo Zhang, Shu Zhang, Tao Zhang, Wei Zhang, Yang Zhang, Yingxin Zhang, Yuanyuan Zhao, Li Zhou, Jifang Zhou, Ning Zhou, Xiaopeng Zhou, Yubo Zhou, Zhizhen Shandong Univ Inst Frontier & Interdisciplinary Sci Res Ctr Particle Sci & Technol Qingdao 266237 Peoples R China Shandong Univ Key Lab Particle Phys & Particle Irradiat Minist Educ Qingdao 266237 Peoples R China Shanghai Jiao Tong Univ Sch Phys & Astron Shanghai Key Lab Particle Phys & Cosmol Key Lab Particle Astrophys & Cosmol MOE Shanghai 200240 Peoples R China Shanghai Jiao Tong Univ Tsung Dao Lee Inst New Cornerstone Sci Lab Shanghai 200240 Peoples R China Shanghai Jiao Tong Univ Sichuan Res Inst Chengdu 610213 Peoples R China Jinping Deep Underground Frontier Sci & Dark Matt Liangshan 615000 Peoples R China Yalong River Hydropower Dev Co Ltd 288 Shuanglin Rd Chengdu 610051 Peoples R China Shanghai Jiao Tong Univ SJTU Paris Elite Inst Technol Shanghai 200240 Peoples R China Shanghai Jiao Tong Univ Sch Mech Engn Shanghai 200240 Peoples R China Sun Yat Sen Univ Sch Phys Guangzhou 510275 Peoples R China Sun Yat Sen Univ Sino French Inst Nucl Engn & Technol Zhuhai 519082 Peoples R China Yantai Univ Dept Phys Yantai 264005 Peoples R China Fudan Univ Inst Modern Phys Key Lab Nucl Phys & Ion Beam Applicat MoE Shanghai 200433 Peoples R China Beihang Univ Sch Phys Beijing 102206 Peoples R China Beihang Univ Beijing Key Lab Adv Nucl Mat & Phys Beijing 102206 Peoples R China Beihang Univ Peng Huanwu Collaborat Ctr Res & Educ Beijing 100191 Peoples R China Chinese Acad Sci Inst Modern Phys Southern Ctr Nucl Sci Theory SCNT Huizhou 516000 Peoples R China Univ Maryland Dept Phys College Pk MD 20742 USA Univ Sci & Technol China State Key Lab Particle Detect & Elect Hefei 230026 Peoples R China Univ Sci & Technol China Dept Modern Phys Hefei 230026 Peoples R China Peking Univ Sch Phys Beijing 100871 Peoples R China Nankai Univ Sch Phys Tianjin 300071 Peoples R China Sun Yat Sen Univ Sch Phys & Astron Zhuhai 519082 Peoples R China

The proton-proton (pp) fusion chain dominates the neutrino production in the Sun. The uncertainty of the predicted pp neutrino flux is at the sub-percent level, whereas that of the best measurement is O(10%). In this study, for the first time, we measure solar pp neutrinos in the electron recoil energy range from 24 to 144 keV using the PandaX-4T commissioning data with 0.63 tonne x year exposure. The pp neutrino flux is determined as, (8.0 +/- 3.9 (stat) +/- 10.0 (syst) x 10(10) s(-1) cm(-2) which is consistent with the Standard Solar Model and existing measurements, corresponding to an upper flux limit of 23.3 x 10(10) at 90% C.L..

关键词： solar pp neutrino flux PandaX-4T electron recoil spectrum GENERATION

Nested Saturated Control of Uncertain Complex Cascade Systems Using Mixed Saturation Levels

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2024年第5期11卷 1163-1174页

作者： Meng Li Zhigang zeng Wuhan National Laboratory for Optoelectronics Wuhan 430074 School of Artificial Intelligence and Automation Huazhong University of Science and TechnologyWuhan 430074China School of Artificial Intelligence and Automation Huazhong University of Science and TechnologyWuhan 430074 Key Laboratory of Image Processing and Intelligent Control of Education Ministry of China Wuhan 430074China

This study addresses the problem of global asymptotic stability for uncertain complex cascade systems composed of multiple integrator systems and non-strict feedforward nonlinear systems. To tackle the complexity inherent in such structures, a novel nested saturated control design is proposed that incorporates both constant saturation levels and state-dependent saturation levels. Specifically, a modified differentiable saturation function is proposed to facilitate the saturation reduction analysis of the uncertain complex cascade systems under the presence of mixed saturation levels. In addition, the design of modified differentiable saturation function will help to construct a hierarchical global convergence strategy to improve the robustness of control design scheme. Through calculation of relevant inequalities, time derivative of boundary surface and simple Lyapunov function,saturation reduction analysis and convergence analysis are carried out, and then a set of explicit parameter conditions are provided to ensure global asymptotic stability in the closed-loop systems. Finally, a simplified system of the mechanical model is presented to validate the effectiveness of the proposed method.

关键词： method saturation differentiable

Aggregation-regulated bioreduction process of graphene oxide by Shewanella bacteria

在线全文

学校读者我要写书评

暂无评论

Chinese Journal of Chemical Engineering 2024年第5期69卷 56-62页

作者： Kaixin Han Yibo zeng Yinghua Lu Ping zeng Liang Shen Department of Chemical and Biochemical Engineering College of Chemistry and Chemical EngineeringXiamen UniversityXiamen 361005China Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen UniversityXiamen 361005China Chinese Research Academy of Environmental Sciences Beijing 100012China

The bioreduction of graphene oxide(GO)using environmentally functional bacteria such as Shewanella represents a green approach to produce reduced graphene oxide(rGO).This process differs from the chemical reduction that involves instantaneous molecular *** bioreduction,the contact of bacterial cells and GO is considered the rate-limiting *** reveal how the bacteria-GO integration regulates rGO production,the comparative experiments of GO and three Shewanella strains were carried ***-transform infrared spectroscopy,X-ray photoelectron spectroscopy,Raman spectroscopy,and atomic force microscopy were used to characterize the reduction degree and the aggregation *** results showed that a spontaneous aggregation of GO and Shewanella into the condensed entity occurred within 36 h.A positive linear correlation was established,linking three indexes of the aggregation potential,the bacterial reduction ability,and the reduction degree(ID/IG)comprehensively.

关键词： Graphene oxide Reduced graphene oxide Bioreduction Aggregation Shewanella

Eigenvalues for the Clamped Plate Problem of L_(ν)^(2) Operator on Complete Riemannian Manifolds

在线全文

学校读者我要写书评

暂无评论

Acta Mathematica Sinica,English Series 2024年第9期40卷 2223-2243页

作者： Ling Zhong zeng Jiangxi Provincial Center for Applied Mathematics&School of Mathematics and Statistics Jiangxi Normal UniversityNanchang 330022P.R.China

L_(ν) operator is an important extrinsic differential operator of divergence type and has profound geometric *** this paper,we consider the clamped plate problem of L_(ν)^(2)operator on a bounded domain of the complete Riemannian manifolds.A general formula of eigenvalues of L_(ν)^(2) operator is *** this general formula,we obtain some estimates for the eigenvalues with higher order on the complete Riemannian *** several fascinating applications,we discuss this eigenvalue problem on the complete translating solitons,minimal submanifolds on the Euclidean space,submanifolds on the unit sphere and projective *** particular,we get a universal inequality with respect to the L_(II) operator on the translating ***,it is very difficult to get universal inequalities for weighted Laplacian and even Laplacian on the complete Riemannian ***,this work can be viewed as a new contribution to universal estimate.

关键词： Mean curvature flows L_(ν)^(2)operator clamped plate problem eigenvalues Riemannian manifolds translating solitons

Electrochemical conversion of organic compounds and inorganic small molecules

在线全文

学校读者我要写书评

暂无评论

Science China Chemistry 2024年第10期67卷 3223-3246页

作者： Weimei zeng Youai Qiu Department of Chemistry Nankai University

Electrochemical synthesis presents a facile and sustainable strategy to produce valuable molecules. This review summarizes the most recent advances in electrosynthesizing value-added compounds with inorganic small molecules. While “small molecules”refers to a broad spectrum of chemicals, we mainly focus on the electrochemical conversion of CO2, H2O/D2O, NH3and SO2until March 2024. This review intends to compare the results and display general trends throughout the field, with an emphasis on the substrate scope and mechanical aspect. Furthermore, we propose several techniques and protocols that can enable a more fundamental understanding of the electrochemical reaction involving inorganic small molecules and help drive this methodology toward commercialization.

关键词： electrochemical synthesis inorganic small molecule organic synthesis carbon dioxide water