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brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

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Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han deyang zeng Wei Tan Xingxing Chen Shuyuan bai Qiong Wu Yushan Chen Zhen Wei Yufei Mei Yan zeng brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to Wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase b signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned.b.ain regions of the corticolimbic ***,bdNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

Liver as a new target organ in Alzheimer's disease:insight from cholesterol metabolism and its role in amyloid.b.ta clearance

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Neural Regeneration Research 2025年第3期20卷 695-714页

作者： beibei Wu Yuqing Liu Hongli Li Lemei Zhu Lingfeng zeng Zhen Zhang Weijun Peng department of Integrated Traditional Chinese&Western Medicine The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina Academician Workstation Changsha Medical UniversityChangshaHunan ProvinceChina Yangsheng College of Traditional Chinese Medicine Guizhou University of Traditional Chinese MedicineGuiyangGuizhou ProvinceChina Qinhuangdao Shanhaiguan Pharmaceutical Co. LtdQinhuangdaoHebei ProvinceChina National Clinical Research Center for Mental disorder The Second Xiangya HospitalCentral South UniversityChangshaHunan ProvinceChina

Alzheimer's disease,the primary cause of dementia,is characterized.b. neuropathologies,such as amyloid plaques,synaptic and neuronal degeneration,and neurofibrillary *** amyloid plaques are the primary characteristic of Alzheimer's disease in the central nervous system and peripheral organs,targeting amyloid.b.ta clearance in the central nervous system has shown limited clinical efficacy in Alzheimer's disease *** abnormalities are commonly observed in patients with Alzheimer's *** liver is the primary peripheral organ involved in amyloid.b.ta metabolism,playing a crucial role in the pathophysiology of Alzheimer's ***,impaired cholesterol metabolism in the liver may exacerbate the development of Alzheimer's *** this review,we explore the underlying causes of Alzheimer's disease and elucidate the role of the liver in amyloid.b.ta clearance and cholesterol ***,we propose that restoring normal cholesterol metabolism in the liver could represent a promising therapeutic strategy for addressing Alzheimer's disease.

关键词： AbCA1 Alzheimer's disease amyloid.b.ta apolipoprotein E cholesterol metabolism liver liver X receptor low-density lipoprotein receptor-related protein 1 peripheral clearance tauroursodeoxycholic acid

Mutual regulation of microglia and astrocytes after Gas6 inhibits spinal cord injury

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Neural Regeneration Research 2025年第2期20卷 557-573页

作者： Jiewen Chen Xiaolin zeng Le Wang Wenwu Zhang Gang Li Xing Cheng Peiqiang Su Yong Wan Xiang Li department of Spine Surgery The First Affiliated HospitalSun Yat-sen UniversityGuangzhouGuangdong ProvinceChina Guangdong Province Key Laboratory of Orthopedics and Traumatology GuangzhouGuangdong ProvinceChina

Invasive inflammation and excessive scar formation are the main reasons for the difficulty in repairing nervous tissue after spinal cord *** and astrocytes play key roles in the spinal cord injury micro-environment and share a close ***,the mechanisms involved remain *** this study,we found that after spinal cord injury,resting microglia(M0)were polarized into pro-inflammatory phenotypes(MG1 and MG3),while resting astrocytes were polarized into reactive and scar-forming *** expression of growth arrest-specific 6(Gas6)and its receptor Axl were significantly down-regulated in microglia and astrocytes after spinal cord *** vitro experiments showed that Gas6 had negative effects on the polarization of reactive astrocytes and pro-inflammatory microglia,and even inhibited the cross-regulation between *** further demonstrated that Gas6 can inhibit the polarization of reactive astrocytes by suppressing the activation of the Yes-associated protein signaling ***,in turn,inhibited the polarization of pro-inflammatory microglia by suppressing the activation of the nuclear factor-κb/p65 and Janus kinase/signal transducer and activator of transcription signaling *** vivo experiments showed that Gas6 inhibited the polarization of pro-inflammatory microglia and reactive astrocytes in the injured spinal cord,thereby promoting tissue repair and motor function ***,Gas6 may play a role in the treatment of spinal cord *** can inhibit the inflammatory pathway of microglia and polarization of astrocytes,attenuate the interaction between microglia and astrocytes in the inflammatory microenvironment,and thereby alleviate local inflammation and reduce scar formation in the spinal cord.

关键词： astrocytes Axl cell polarization Gas6 Hippo signal inflammatory micro-environment intercellular interaction microglia single-cell sequencing spinal cord injury

Glutamatergic CYLd deletion leads to aberrant excitatory activity in the basolateral amygdala:association with enhanced cued fear expression

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Neural Regeneration Research 2025年第11期20卷 3259-3272页

作者： Huidong Li Faqin Li Zhaoyi Chen Erwen Wu Xiaoxi dai danni Li Haojie An Shiyi zeng Chunyan Wang Li Yang Cheng Long School of Life Sciences South China Normal UniversityGuangzhouGuangdong ProvinceChina School of Life Sciences Guangzhou UniversityGuangzhouGuangdong ProvinceChina Guangdong Provincial Key Laboratory of Major Obstetric diseases The Third Affiliated Hospital of Guangzhou Medical UniversityGuangzhouGuangdong ProvinceChina South China Normal University-Panyu Central Hospital Joint Laboratory of Translational Medical Research Panyu Central HospitalGuangzhouGuangdong ProvinceChina

Neuronal activity,synaptic transmission,and molecular changes in the basolateral amygdala play critical roles in fear ***(CYLd)is a deubiquitinase that negatively regulates the nuclear factor kappa-b *** is well studied in non-neuronal cells,yet underinvestigated in the brain,where it is highly *** studies have shown involvement of CYLd in the remodeling of glutamatergic synapses,neuroinflammation,fear memory,and anxiety-and autism-like ***,the precise role of CYLd in glutamatergic neurons is largely ***,we first proposed involvement of CYLd in cued fear *** next constructed transgenic model mice with specific deletion of Cyld from glutamatergic *** results show that glutamatergic CYLd deficiency exaggerated the expression of cued fear in only male ***,loss of CYLd in glutamatergic neurons resulted in enhanced neuronal activation,impaired excitatory synaptic transmission,and altered levels of glutamate receptors accompanied.b. over-activation of microglia in the basolateral amygdala of male ***,our study suggests a critical role of glutamatergic CYLd in maintaining normal neuronal,synaptic,and microglial *** may contribute,at least in part,to cued fear expression.

关键词： basolateral amygdala cued fear expression cylindromatosis deubiquitinase glutamate receptor 1 glutamatergic neuron microglial activation N-methyl-d-aspartate receptor 1 neuronal activation synaptic transmission

Microstructure and Mechanical Property of in-situ Al-Cu/TiC Composites

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Journal of Materials Science & Technology 1998年第3期14卷 255-258页

作者： Zhang, EL zeng, SY Yang, b Li, QC Ma, MZ Harbin Inst Technol Sch Mat Sci & Engn Harbin 150001 Peoples R China Jiamusi Univ Jiamusi 154002 Peoples R China

An approach named direct reaction synthesis (dRS) has been developed to fabricate particulate composites with an extremely fine reinforcement size. Id situ Al matrix composites were fabri-cated.b. dRS. Extensive analysis of the composites microstructure using SEM and TEM identify that the reinforcement formed during the dRS process is Ti carbide (TiC) particle, generally less than 1.0 μm. The reacted, semisolid extruded samples exhibit a homogeneous distribution of fine TiC particles in Al-Cu matrix, Mechanical property evaluation of the composites has revealed a very high tensile strength relative to the matrix alloy. Fractographic analysis indicates ductile failure although the ductility and strength are limited.b. the presence of coarse titanium aluminides (Al3Ti).

关键词： TiC Cu Figure Microstructure and Mechanical Property of in-situ Al-Cu/TiC Composites Al

ROCO:Using a Solid State drive Cache to Improve the Performance of a Host-Aware Shingled Magnetic Recording drive

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Journal of Computer Science & Technology 2019年第1期34卷 61-76页

作者： Wen-Guo Liu Ling-Fang zeng dan Feng Kenneth b.Kent School of Computer Science and Technology Huazhong University of Science and TechnologyWuhan 430074China Faculty of Computer Science University of New BrunswickFrederictonE3B 5A3Canada

Shingled magnetic recording (SMR)can effectively increase the capacity of hard disk drives (Hdds).Hostaware SMR (HA-SMR)is expected to be more popular than other SMR models because of its backward compatibility and new SMR-specific ***,an HA-SMR drive often suffers performance degradation under write-intensive workloads because of frequent non-sequential writes buffered in the disk *** non-sequential writes mainly come from update writes,small random writes and out-of-order *** this paper,we propose a hybrid storage system called ROCO which aims to use a solid state drive (SSd)cache to improve the performance of an HA-SMR *** reorders out-of-order writes belonging to the same zone and uses the SSd cache to absorb update writes and small random *** also design a data replacement algorithm called CREA for the SSd *** first conducts zone-oriented hot/cold data identification to identify cold-cached zones and hot-cached zones,and then evicts data blocks belonging to colder zones with higher priorities that can be sequentially written or written through host-side read-modify-write *** gives the lowest priority to data blocks belonging to the hottest-cached zone that have to be non-sequentially *** results show that ROCO can effectively reduce non-sequential writes to the HA-SMR drive and improve the performance of the HA-SMR drive.

关键词： solid state reordering zone-oriented drive (SSd)cache host-aware shingled magnetic recording (HA-SMR)drive zone-oriented block hot/cold data identification data replacement algorithm

THE　STUdY　ON　EFFECT　OF　PARTICLE　SIZE　IN　bOTANICAL　STANdARd　SAMPLE　ANALYSIS　bY　SLURRY　SAMPLING　ANd　FLUORINATION　ELECTROTHERMAL　VAPORIZATION（ETV）－ICP－AES

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Chinese Chemical Letters 1995年第4期6卷 325-326页

作者： Qin, YC Jiang, ZC zeng, YE Hu, b Wuhan Univ Dept Chem Wuhan 430072 Peoples R China

In this paper, the effect of partical size, in fluorination assisted ETV-ICP-AES. The results experimental show that when the pertical size of slurry samples is less than 170μm, the signal intensities of analytes were identical to those obtained with aqueous solutions. Comparing with the data given by slurry nebulization ICP-AES in literature, the tolerable particle size in this method is large by about 17-fold.

关键词： AES ICP ANALYSIS ETV

deciphering the molecular mechanisms of Simiaowan in the treatment of hyperuricemia: in vivo and in silico approaches

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Traditional Medicine Research 2025年第2期10卷 37-54页

作者： Yong-Chang zeng Jun-Hong Wu dan-dan Xu Kang He Chang-Qing Liu Li-Fei Song Zheng-Zhi Wu Qian-Qian Jiang Shao-Yu Liang department of Neurology The First Affiliated Hospital of Shenzhen UniversityShenzhen 518020China Pharmaceutical department The Affiliated TCM Hospital of Guangzhou Medical UniversityGuangzhou 510000China School of Pharmacy Guizhou University of Traditional Chinese MedicineGuiyang 550025China Guangzhou Zeli Medical Technology Co. Ltd.Guangzhou 510700China

background:Simiaowan(SMW),a well-known traditional Chinese medicine,has been employed to treat hyperuricemia(HUA)and gout for ***,the bioactive components and underlying mechanisms have not been *** objective of this study was to identify the active components and potential mechanisms of SMW by integrating pharmacological experimentation,serum pharmacochemistry,network pharmacology and molecular ***:HUA rats modelling by high-fat/high-sugar diet and potassium oxonate/adenine oral administration were used to evaluate the pharmacodynamic effects of ***-Q-Exactive-MS/MS was employed to detect the bioactive components present in SMW-containing *** pharmacology and molecular docking were utilized to elucidate the potential targets and underlying ***:SMW effectively ameliorated HUA rats via the inhibition of uric acid(UA)production,promotion of UA excretion,improvement of lipid and glucose metabolic abnormalities,antioxidant,anti-inflammatory and anti-insulin resistance effects.A total of 73 compounds detected in SMW-containing serum were identified as potential active components,with alkaloids,flavonoids,organic acids,and terpenoids emerging as the primary active *** 203 corresponding targets were obtained as SMW anti-HUA/gout targets,which mainly participated in apoptosis,insulin resistance,TNF,PI3K-Akt,HIF-1,NF-κb,MAPK,IL-17 and TLR signaling *** docking indicated that active compounds(***,phellodendrine,quercetin,formononetin,ferulic acid)had superior binding abilities to the key targets(*** carrier family 22 member 12(URAT1),solute carrier family 22 member 6(OAT1),ATP-binding cassette sub-family G member 2(AbCG2),solute carrier family 2,facilitated glucose transporter member 9(GLUT9),xanthine dehydrogenase/oxidase(XdH),transcription factor p65(RELA),toll-like receptor 4(TLR4),prostaglandin G/H synthase 2(PTGS2),caspase-3(CASP3),insulin(INS)).Conclusion:S

关键词： hyperuricemia network pharmacology serum pharmacochemistry Simiaowan UPLC-Q-Exactive-MS/MS

Influence of graphene nanoplatelets on mechanical properties and adhesive wear performance of epoxy-based composites

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Friction 2021年第4期9卷 856-875页

作者： K.Y.EAYAL AWWAd.b.F.YOUSIF Khosro FALLAHNEZHAd Khalid SALEH Xuesen zeng Faculty of Health Engineering and SciencesUniversity of Southern QueenslandToowoombaQLDAustralia Centre for Future Materials University of Southern QueenslandToowoombaQLDAustralia School of Mechanical and Mining Engineering University of QueenslandBrisbaneQLDAustralia

Epoxy resin is one of the most widely used thermoset polymers in high-performance composite materials for lightweight ***,epoxy has a high coefficient of friction,which limits its tribological *** this study,the effect was investigated of different weight fractions of solid lubricant graphene nanoplatelets(GNPs),ranging from 0 to 4.5 wt%,on mechanical and adhesive wear performance of *** wear tests covered mild and severe wear *** correlation of tribological and mechanical properties was studied as *** electron microscopy(SEM)was used to observe the failure mechanisms for both tribological and mechanical samples after each *** results revealed that the addition of GNPs to the epoxy improved its stiffness and hardness but reduced its fracture strength and *** wear performance exhibited high efficiency with GNP additions and showed reductions in the specific wear rate,the coefficient of friction,and the induced interface temperature by 76%,37%,and 22%,respectively.A fatigue wear mechanism was predominant as the applied load *** importantly,severe wear signs occurred when the interface temperature reached the heat distortion temperature of the *** tribological,and mechanical properties showed only a weak correlation to each *** addition of GNPs to epoxy by less than 4.5 wt%was highly efficient to improve the wear performance while maintaining the fracture strength and *** transform infrared spectroscopy(FTIR)analysis shows no chemical interaction between the epoxy matrix with GNPs,which implies its physical interaction.

关键词： graphene nanoplatelets epoxy adhesive wear solid lubricants