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Late Jurassic oceanic plateau subduction in the Bangong-Nujiang Tethyan Ocean of northern Tibet

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Geoscience Frontiers 2024年第4期15卷 274-289页

作者： Hao Wu Haiyong Liu Yu Wang Xijun Liu Qinggao zeng Panxi Wang Guangxi Key Laboratory of Hidden Metallic Ore Deposits Exploration&Collaborative Innovation Center for Exploration of Nonferrous Metal Deposits and Efficient Utilization of Resources on Guangxi Guilin University of TechnologyGuilin 541006China Tibet Geological Survey Lhasa 850000China Tibet Bureau of Geological and Mineral Exploration and Development Lhasa 850000China

Oceanic plateau accretion and subsequent flat-slab subduction in modern convergent settings have profoundly influenced the nature of subduction and mantle ***,evaluating similar impacts in ancient convergent settings,where oceanic plateaus have been subducted but geological records are limited,remains *** this study,we present geochronological and geochemical data for a suite of ore-associated plutonic rocks from the Gaobaoyue area of northern *** rocks have zircon U-Pb ages of 152-146 Ma,with high Sr contents and Sr/Y and La/Yb ratios,low MgO,Yb,and Y contents,and depleted Sr-Nd-Hf isotopic compositions,consistent with an adakitic affinity that was generated by the partial melting of subducting oceanic *** compare the Late Jurassic adakitic magmatism with the spatiotemporal evolution of magmatism in northern Tibet to infer oceanic plateau subduction and subsequent flat-slab subduction in the Bangong-Nujiang Tethyan *** tectonic model explains(ⅰ)slab-derived adakitic magmatism,(ⅱ)the observed lull in magmatic activity,(ⅲ)intraplate compression and uplift,and(ⅳ)subduction jump and *** also propose that the subduction of heterogeneous oceanic crust(i.e.,buoyant oceanic plateau subduction)provided favorable conditions for tectonic exhumation,vertical slab tearing,and the formation of Cu-Au *** findings not only have implications for establishing the fundamental process of oceanic plateau accretion in ancient subduction zones but also provide an alternative explanation for Late Jurassic complex tectonomagmatic activity in north-ern Tibet.

关键词： Northern Tibet Adakitic magma Oceanic plateau Flat-slab subduction Vertical slab tearing

High photoluminescence Ag-In-Ga-S quantum dots based on ZnX_(2)-treated surface passivation

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Nano Research 2024年第8期17卷 7533-7541页

作者： Danni Yan Yuhui Dong Naiwei Wei Shuai Yang Hong Zhu Wanzhong Gu Yousheng Zou Haibo zeng MIIT Key Laboratory of Advanced Display Materials and Devices Institute of Optoelectronics&NanomaterialsSchool of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China

Quaternary Ag-In-Ga-S(AIGS)quantum dot(qd)is considered a promising,spectral-tunable,and environmentally friendly luminescent display ***,the more complex surface defect states of AIGS qds resulting from the coexistence of multiple elements lead to a low( qds to dramatically enhance the PLQY and stability without affecting the crystalline structure and *** show that the addition of ZnCl_(2) during the purified process of AIGS qds leads to a 3-fold increase of PLQY(from 28.5% to 87%).Impressively,the highest PLQY is up to a recorded value of 92%,which is comparable to typical heavy metal *** dynamics studies have shown that the rapid annihilation process of excitons in treated qds is *** also confirm that the improvement in PLQY is a result of the effective passivation of the non-coordinating atom on the qd surface by building a new bonding between sulfur dangling and Zn2+.The realization of high PLQY will further promote the application of AIGS qds in luminescent displays.

关键词： I-III-VI quantum dots Ag-In-Ga-S surface defect passivation Z-type ligand photoluminescence quantum yield

Systematic review and network meta-analysis of different nonsteroidal anti-inflammatory drugs for juvenile idiopathic arthritis

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World Journal of Clinical Cases 2024年第12期12卷 2056-2064页

作者： Tao zeng Jian-Zhong Ye Hui Qin Qian-Qian Xu College of Medicine Jingchu University of Technology JingmenJingmen 448000Hubei ProvinceChina

BACKGROUND Various non-steroidal anti-inflammatory drugs(NSAIDs)have been used for juvenile idiopathic arthritis(JIA).However,the optimal method for JIA has not yet been *** To perform a systematic review and network meta-analysis to determine the optimal *** We searched for randomized controlled trials(RCTs)from PubMed,EMBASE,Google Scholar,CNKI,and Wanfang without restriction for publication date or language at August,*** RCTs that comparing the effectiveness of NSAIDs with each other or placebo for JIA were included in this network *** surface under the cumulative ranking curve(SUCRA)analysis was used to rank the treatments.P value less than 0.05 was identified as statistically *** We included 8 RCTs(1127 patients)comparing 8 different instructions including meloxicam(0.125 qd and 0.250 qd),Celecoxib(3 mg/kg bid and 6 mg/kg bid),piroxicam,Naproxen(5.0 mg/kg/d,7.5 mg/kg/d and 12.5 mg/kg/d),inuprofen(30-40 mg/kg/d),Aspirin(60-80 mg/kg/d,75 mg/kg/d,and 55 mg/kg/d),Tolmetin(15 mg/kg/d),Rofecoxib,and *** were no significant differences between any two NSAIDs regarding ACR Pedi 30 *** SUCRA shows that celecoxib(6 mg/kg bid)ranked first(SUCRA,88.9%),rofecoxib ranked second(SUCRA,68.1%),Celecoxib(3 mg/kg bid)ranked third(SUCRA,51.0%).There were no significant differences between any two NSAIDs regarding adverse *** SUCRA shows that placebo ranked first(SUCRA,88.2%),piroxicam ranked second(SUCRA,60.5%),rofecoxib(0.6 mg/kg qd)ranked third(SUCRA,56.1%),meloxicam(0.125 mg/kg qd)ranked fourth(SUCRA,56.1%),and rofecoxib(0.3 mg/kg qd)ranked fifth(SUCRA,56.1%).CONCLUSION In summary,celecoxib(6 mg/kg bid)was found to be the most effective NSAID for treating ***,piroxicam,and meloxicam may be safer options,but further research is needed to confirm these findings in larger trials with higher quality studies.

关键词： Non-steroidal anti-inflammatory drugs Juvenile idiopathic arthritis Network meta-analysis Systematic review

Overview of epigenetic degraders based on PROTAC, molecular glue, and hydrophobic tagging technologies

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Acta Pharmaceutica Sinica B 2024年第2期14卷 533-578页

作者： Xiaopeng Peng Zhihao Hu Limei zeng Meizhu Zhang Congcong Xu Benyan Lu Chengpeng Tao Weiming Chen Wen Hou Kui Cheng Huichang Bi Wanyi Pan Jianjun Chen College of Pharmacy Key Laboratory of Prevention and Treatment of Cardiovascular and Cerebrovascular Diseases of Ministry of EducationGannan Medical UniversityGanzhou 314000China College of Basic Medicine Gannan Medical UniversityGanzhou 314000China Guangdong Provincial Key Laboratory of New Drug Screening NMPA Key Laboratory for Research and Evaluation of Drug MetabolismSchool of Pharmaceutical SciencesSouthern Medical UniversityGuangzhou 510515China

Epigenetic pathways play a critical role in the initiation, progression, and metastasis of cancer. Over the past few decades, significant progress has been made in the development of targeted epigenetic modulators(e.g., inhibitors). However, epigenetic inhibitors have faced multiple challenges,including limited clinical efficacy, toxicities, lack of subtype selectivity, and drug resistance. As a result,the design of new epigenetic modulators(e.g., degraders) such as PROTACs, molecular glue, and hydrophobic tagging(Hy T) degraders has garnered significant attention from both academia and pharmaceutical industry, and numerous epigenetic degraders have been discovered in the past decade. In this review,we aim to provide an in-depth illustration of new degrading strategies(2017-2023) targeting epigenetic proteins for cancer therapy, focusing on the rational design, pharmacodynamics, pharmacokinetics, clinical status, and crystal structure information of these degraders. Importantly, we also provide deep insights into the potential challenges and corresponding remedies of this approach to drug design and development. Overall, we hope this review will offer a better mechanistic understanding and serve as a useful guide for the development of emerging epigenetic-targeting degraders.

关键词： Epigenetic Degrader PROTAC Molecularglue Hydrophobic tagging

Highly ordered inkjet-printed quantum-dot thin films enable efficient and stable QLEDs with EQE exceeding 23%

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eScience 2024年第3期4卷 152-162页

作者： Changting Wei Bo Xu Meng Zhang Zhenhuang Su Jiawei Gu Wenrui Guo Xingyu Gao Wenming Su Zheng Cui Seokwoo Jeon Zhiyong Fan Haibo zeng MIIT Key Laboratory of Advanced Display Materials and Devices Institute of Optoelectronics&NanomaterialsSchool of Materials Science and EngineeringNanjing University of Science and TechnologyNanjing 210094China Ningbo Nato New Material Technology Co. LtdNingbo 315600China Shanghai Synchrotron Radiation Facility(SSRF) Zhangjiang LaboratoryShanghai Advanced Research InstituteChinese Academy of SciencesShanghai 201204China School of Mechanical Engineering Jiangsu UniversityZhenjiang 212013China Printable Electronics Research Center Nano Devices and Materials DivisionSuzhou Institute of Nano-Tech and Nano-BionicsChinese Academy of SciencesSuzhou 215123China Department of Materials Science and Engineering Korea UniversitySeoul 02841South Korea Department of Electronic and Computer Engineering The Hong Kong University of Science and TechnologyHong Kong 999077China

Inkjet-printed quantum dot light-emitting diodes(QLEDs)are emerging as a promising technology for next-generation ***,the progress in fabricating QLEDs using inkjet printing technique has been slower compared to spin-coated devices,particularly in terms of efficiency and *** key to achieving high performance QLEDs lies in creating a highly ordered and uniform inkjet-printed quantum dot(qd)thin *** this study,we present a highly effective strategy to significantly improve the quality of inkjet-printed CdZnSe/CdZnS/ZnS qd thin films through a pressure-assisted thermal annealing(PTA)*** from this PTA process,a high quality qd thin film with ordered packing,low surface roughness,high photoluminescence and excellent electrical property is *** mechanism behind the PTA process and its profound impact on device performance have been thoroughly investigated and ***,a record high external quantum efficiency(EQE)of 23.08%with an impressive operational lifetime(T50)of up to 343,342h@100cdm−2,and a record EQE of 22.43%with T50 exceeding to 1,500,463h@100cdm−2 are achieved in inkjet-printed red and green CdZnSe-based QLEDs,*** work highlights the PTA process as an important approach to realize highly efficient and stable inkjet-printed QLEDs,thus advancing QLED technology to practical applications.

关键词： Inkjet printing Quantum dot light-emitting diode High efficiency Thermal annealing Highly ordered

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AI时代著作权独创性标准适用问题研究

经贸法律评论 2024年第4期 140-158页

作者：曾田对外经济贸易大学法学院

面对AI时代的著作权法系统挑战,须立足文学艺术作品的符号本质,客观区分人类符号创作与机器信号转译的本质区别。在著作权独创性认定上,考虑本土化的视角,独创性认定与其他版权制度及知识产权制度之间的协作和协调。应适当提升独创性门... 详细信息

面对AI时代的著作权法系统挑战,须立足文学艺术作品的符号本质,客观区分人类符号创作与机器信号转译的本质区别。在著作权独创性认定上,考虑本土化的视角,独创性认定与其他版权制度及知识产权制度之间的协作和协调。应适当提升独创性门槛,强调创作过程中超出功能或实用目的限制的个性化选择,同时确保创作结果与现有成果存在一定的差异性。此方法有利于版权法实现促进符号创新、个性发展与社会文化进步的功能。

关键词：人工智能作者身份独创性标准差异性符号学

Unloading and successful treatment with bioresorbable stents during percutaneous coronary intervention:A case report

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World Journal of Cardiology 2024年第8期16卷 484-490页

作者： Tao Sun Ming-Xue Zhang Yan zeng Li-Hua Ruan Yi Zhang Cheng-Long Yang Zhang Qin Jing Wang Hai-Mei Zhu Yun Long Department of Cardiology The First Hospital of Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina Teaching and Research Section of Chinese Internal Medicine The First Hospital of Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina Department of Pain The First Hospital of Hunan University of Chinese MedicineChangsha 410007Hunan ProvinceChina

BACKGROUND With the development of percutaneous coronary intervention(PCI),the number of interventional procedures without implantation,such as bioresorbable stents(BRS)and drug-coated balloons,has increased *** drug-eluting stent unloading is one of the most common clinical ***,BRS detachment is more concealed and harmful,but has yet to be reported in clinical *** this study,we report a case of BRS unloading and successful *** is a case of a 59-year-old male with the following medical history:“Type 2 diabetes mellitus”for 2 years,maintained with metformin extended-release tablets,1 g PO BID;“hypertension”for 20 years,with long-term use of metoprolol sustained-release tablets,47.5 mg PO qd;“hyperlipidemia”for 20 years,without regular *** was admitted to the emergency department of our hospital due to intermittent chest pain lasting 18 hours,on February 20,2022 at 15:*** results showed sinus rhythm,ST-segment elevation in leads I and avL,and poor R-wave progression in leads V1–***-sensitivity troponin I level was 4.59 ng/mL,indicating an acute high lateral wall myocardial *** patient’s family requested treatment with BRS,without *** PCI,the BRS became unloaded but was successfully *** patient was followed up for 2 years;he had no episodes of angina pectoris and was in generally good *** We describe a case of a 59-year-old male experienced BRS unloading and successful *** analyzing images,the causes of BRS unloading and the treatment plan are discussed to provide insights for BRS release *** discuss preventive measures for BRS unloading.

关键词： Coronary artery diseases Percutaneous coronary intervention Bioresorbable stents Stent unloading Stent release Intravascular ultrasound Case report

QLED goes to be both bright and efficient

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Science Bulletin 2019年第7期64卷 464-465页

作者： Haibo zeng School of Materials Science and Engineering Nanjing University of Science and Technology

Quantum dots (qds) and qd-based light-emitting diodes(QLEDs) have been widely recognized as the key materials and devices for the next generation display due to their flexible and ultra-high definition characteristics, and for color-controllable and healthy solid state lighting [1,2].The external quantum efficiency (EQE), brightness.

关键词： qds RGB QLED goes to be both bright and efficient

干旱和遮荫对马尾松幼苗瞬时水分利用效率及δ^(13)C的影响

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生态学杂志 2024年第1期43卷 140-145页

作者：邓秀秀施征曾立雄雷蕾裴顺祥吴莎肖文发中国林业科学研究院华北林业实验中心北京九龙山暖温带森林国家长期科研基地北京102300 中国林业科学研究院森林生态环境与自然保护研究所国家林业和草原局森林生态环境重点实验室北京100091

水分利用是植物光合固碳的关键过程,其效率反映植物对胁迫环境的适应能力,δ^(13)C作为反映植物长期水分利用效率的关键指标,对于揭示植物与环境长期作用的关系具有重要意义。本研究以马尾松幼苗为对象,通过土壤水分和光照条件控制,设... 详细信息

水分利用是植物光合固碳的关键过程,其效率反映植物对胁迫环境的适应能力,δ^(13)C作为反映植物长期水分利用效率的关键指标,对于揭示植物与环境长期作用的关系具有重要意义。本研究以马尾松幼苗为对象,通过土壤水分和光照条件控制,设置干旱(土壤水分为30%饱和含水量)、遮荫(光照强度为全光照的30%)及干旱+遮荫(土壤水分为30%饱和含水量和光照强度为全光照的30%)3种胁迫方式和对照(CK,土壤水分为70%饱和含水量和全光照),研究干旱和遮荫对马尾松瞬时水分利用效率和δ^(13)C的影响。结果表明:干旱和干旱+遮荫处理分别使马尾松当年生叶的瞬时水分利用效率显著增加了67.96%和60.78%,遮荫对瞬时水分利用效率的影响不显著;当年生叶的δ^(13)C在干旱处理下显著增加了14.35%,但在遮荫和干旱+遮荫处理下未发生明显改变;各处理对1年生叶δ^(13)C的影响均不显著;表明瞬时和长期水分利用效率的变化不同步,且马尾松的水分利用效率对干旱的响应较早;在各处理下,各库器官中的δ^(13)C均大于源叶,茎干和根中的δ^(13)C与源叶δ^(13)C的相关系数较大,且与1年生叶呈极显著正相关,各库器官的δ^(13)C主要受源叶δ^(13)C供应的影响。表明环境变化导致水分利用效率的变化将引起各库器官δ^(13)C发生改变。研究结果可为揭示马尾松幼苗对气候变化的响应机制提供参考。

关键词：干旱遮荫水分利用效率 δ^(13)C 马尾松幼苗