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高压氧联合丹参酮ⅡA磺酸钠对不稳定型心绞痛患者血脂代谢、血管内皮功能及左心室功能的影响

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中华航海医学与高气压医学杂志 2024年第4期31卷 472-476页

作者：杨聪德林友聪曾清泽林天华刘甲兴解放军联勤保障部队第九一○医院心血管内科泉州362000 解放军联勤保障部队第九一○医院康复医学科泉州362000

目的探讨高压氧联合丹参酮ⅡA磺酸钠对不稳定型心绞痛患者血脂代谢、血管内皮功能及左心室功能的影响。方法便利选取解放军联勤保障部队第九一○医院2020年1月至2022年6月收治的120例不稳定型心绞痛患者,采用随机数字表法分为观察组和对... 详细信息

目的探讨高压氧联合丹参酮ⅡA磺酸钠对不稳定型心绞痛患者血脂代谢、血管内皮功能及左心室功能的影响。方法便利选取解放军联勤保障部队第九一○医院2020年1月至2022年6月收治的120例不稳定型心绞痛患者,采用随机数字表法分为观察组和对照,每组60例。观察组行丹参酮ⅡA磺酸钠联合高压氧治疗,对照组行丹参酮ⅡA磺酸钠治疗,比较2组患者治疗前后的血脂、血管内皮功能、左心室功能指标变化及治疗后的临床症状和心电图表现。结果治疗前,2组患者的血脂指标、血管内皮功能和左心室功能比较差异无统计学意义(P>0.05)。治疗后,观察组患者血清总胆固醇、三酰甘油、和低密度脂蛋白分别为(5.12±0.81)、(1.88±0.31)、(2.45±0.52)mmol/L,血管内皮生长因子和内皮素-1含量分别为(18.20±1.02)、(61.32±4.28)ng/L,左心室收缩末期及舒张末期容积分别为(172.48±5.37)、(202.34±5.64)ml,均低于治疗前及对照组(P<0.05);高密度脂蛋白为(1.48±0.20)mmol/L,一氧化氮含量为(67.96±6.45)mmol/L,左心室射血分数为(41.96±2.79)%,均高于治疗前及对照组(P<0.05)。观察组心绞痛症状缓解总有效率和心电图表现改善总有效率分别为96.67%、85.00%,均优于对照组(P<0.05)。结论高压氧联合丹参酮ⅡA磺酸钠治疗不稳定型心绞痛,有利于调节患者血脂水平,改善血管内皮功能和左心室功能。

关键词：不稳定型心绞痛丹参酮ⅡA磺酸钠高压氧心功能血管内皮

The distribution of 10-year cardiovascular risk in Chinese adults： analysis of the China Health Examination Database （CHED） 2008

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Journal of Geriatric Cardiology 2010年第3期7卷 131-137页

作者： liu-Xin Wu Qiang zen Dong-Chang Qiang Institute of Aviation Medicine Chinese PLA Air Force Beijing 100036 China Chinese PLA General Hospital Beijing 100853 China

Objective Global cardiovascular risk assessment has been incorporated into current Chinese guidelines for the management of hypertension and hypercholesterolemia. The aim of our study is to determine the distribution of 10-year risk for ischemic cardiovascular disease （ICVD） among middle-aged Chinese adults, and to evaluate the usefulness of global risk assessment tools in the primary prevention of ICVD in Chinese *** Simplified prediction tools derived from the USA-PRC Collaborative Study of Cardiovascular Epidemiology cohort were applied to the Chinese Health Examination Database （CHED） 2008. 10-year risk for ICVD was estimated in 461 157 ICVD-free subjects （264 432 male and 196 725 female） aged 35 to 59 years. Results Among the male subjects, 82.4% had a 10-year risk for ICVD of 〈5%, 14.4% of 5% to 12.1% and 3.4 of≥ 12.2%, and in female subjects, 86.7% had a 10-year risk for ICVD of 〈5%, 12.1% of 5% to 12.0% and 1.2% of ≥ 12.1%. All subjects with predicted high level ICVD risk （≥ 12.2% in male or ≥ 12.1% in female） had either remarkably elevated （≥ 160 mmHg） blood pressure, significantly increased （≥ 6.22 mml/L） total serum cholesterol or *** Using the currently recommended prediction tools, only very small proportions of middle-aged Chinese men and women who were free of ICVD would be classified into high level risk group. These prediction tools are unlikely to help for the medical intervention decision making in Chinese adult patients with hypertension and/or hypercholesterolemia

关键词： cardiovascular disease hypertension hypercholesterolemia prevention Chinese

2D SAXS/WAXD ANALYSIS OF PAN CARBON FIBER MICROSTRUCTURE IN ORGANIC/INORGANIC TRANSFORMATION

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Chinese Journal of Polymer Science 2013年第5期31卷 823-832页

作者： Cai-zhen Zhu Xiao-lan Yu Xiao-fang liu Yun-zen Mao Rui-gang liu 赵宁 Xiao-li Zhang 徐坚 Beijing National Laboratory for Molecular Sciences Laboratory of Polymer Physics and ChemistryInstitute of ChemistryChinese Academy of Sciences shenZhen Key Laboratory of Functional Polymer College of Chemistry and Chemical EngineeringShenzhen University College of Materials Science and Engineering Donghua University

Structure of PAN fibers during pre-oxidation and carbonization was studied using two dimensional small angle X-ray scattering/wide angle X-ray diffraction （2D SAXS/WAXD）. The SAXS results show that during pre-oxidation between 180 ℃ and 275 ℃, the volume content of microvoids increases with the temperature increasing, which may be one of reasons for the decrease of tensile strength ofpre-oxidized fibers. 253 ℃ was the critical transition temperature, the length, diameter, aspect ratio and orientation distribution of microvoids increased with temperature before this temperature and decreased after this temperature. After the high temperature carbonization, lots of spindly microvoids formed. WAXD patterns demonstrate that the crystallite size of PAN fibers first increased before 230 ℃ and then decreased with the increase of temperature during the pre-oxidation. The diffraction peak of PAN fibers at 2θ ≈ 17°almost disappeared at the end of pre- oxidation while the diffraction peak of aromatic structure at 2θ ≈ 25° appeared at 253 ℃. During carbonization, the peak intensity at 2θ ≈ 25° increased apparently due to the formation of graphite structure. The results obtained give a deep understanding of the microstrncture development in the PAN fibers during pre-oxidation and carbonization, which is important for the preparation of high performance carbon fibers.

关键词： Polyacrylonitrile Pre-oxidation Carbonization SAXS/WAXD Microstructure.

Locating Mechanism of Quartz Vein Gold Deposits in Rushan, shandong Province

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Acta Geologica Sinica(English Edition) 1998年第1期72卷 77-86页

作者： XIE Hongyuan shEN Yuanchao WANG Yuejun LI Guangming liu Tiebing ZHANG Qirui zen Qingdong Institute of Geology Chinese Academy of SciencesBeijing 100029

According to the differences in ore-controlling structural systems and the characteristics of host rocks, textures and structures of ores and mineral associations of ores, quartz vein-type gold deposits in the Rushan area can be divided into the Rushan and Tongling styles. Rushan style gold deposits, occurring in the Kunyushan complex, include Rushan, Tangjiagou and Tongxishan gold mines. They are distributed along four NNE-trending and sinistral, compresso-shear faults with a right stepping array. A prominent characteristic of the gold mineralization is that the orebodies in neighbouring gold deposits distributed in a single ore-controlling fault zone take opposite pitches. Study of the locating structures of the quartz vein gold deposits shows that the Rushan-style gold deposits are characterized by NNE and NE zoning. Therefore, the intersections of the NE direction of the known gold deposit and the neighbouring NNE-trending fault zones are favourable for looking for gold deposits, and the ends of the curving segments of sinistral and right-stepping faults are favourable for looking for large gold deposits. Tongling-style gold deposits occur in the Sanfosan porphyritic monzonitic granite. Emplacement of gold deposits is controlled by arcuate and radiate structures formed during the intrusion of the Sanfoshan porphyritic monzonitic granite; the radiate faults controlled the distribution of orebodies and the arcuate faults controlled the pitch of the orebodies.

关键词： vein type gold deposit Muping-Rushan gold mineralized zone conjugate orebodies arcuate and radiate structures

Small non-coding RNAs transfer through mammalian placenta and directly regulate fetal gene expression

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Protein & Cell 2015年第6期6卷 391-396页

作者： Jing Li Yujing Zhang Dameng Li Yuchen liu Danping Chu Xiaohong Jiang Dongxia Hou Ke zen Chen-Yu zhang State Key Laboratory of Pharmaceutical Biotechnology Nanjing Advanced Institute for Life Sciences (NAILS) Nanjing University School of Life Sciences Jiangsu Engineering Research Center for MicroRNA Biology and Biotechnoiogy Nanjing University 22 Hankou Road Nanjing 210093 Jiangsu China

SMALL NON-CODING RNA CAN TRANSFER THROUGH THE PLACENTA AND REGULATE FETAL DEVELOPMENT Increasing evidence demonstrated that exogenous plant miRNAs in the diet can be absorbed and are found in mammalian tissues. These miRNAs influence the physio- logical and pathological progression of the recipient. In this issue, Jing Li and colleagues further reveal that exogenous/ endogenous small non-coding RNA in the maternal system can transfer through the placenta to the fetal side and influ- ence fetal development and health. These surprising finding demonstrate that maternal miRNAs profiling are very impor- tant to fetal development, which means maternal diet and the healthy status may influence fetal development and the postnatal morbidity via transplacental small non-coding RNAs. Furthermore, this finding also proposes a brand new potential strategy to treat fetal diseases in utero. Combining with gene therapy, maternal administrating represents a new trend for treating fetal diseases.

关键词： Amniotic Fluid Fetal Liver Fetal Development Maternal Plasma Rubella Virus

Genome and population evolution and environmental adaptation of Glyptosternon maculatum on the Qinghai-Tibet Plateau

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Zoological Research 2021年第4期42卷 502-513页

作者： shi-Jun Xiao zen-Bo Mou Rui-Bin Yang Ding-Ding Fan Jia-Qi liu Yu Zou shi-Lin Zhu Ming Zou Chao-Wei Zhou Hai-Ping liu Institute of Fisheries Science Tibet Academy of Agricultural and Animal Husbandry SciencesLhasaTibet 810000China Department of Computer Science Wuhan University of TechnologyWuhanHubei 430070China College of Fisheries Huazhong Agricultural UniversityWuhanHubei 430070China Key Laboratory of Freshwater Fish Reproduction and Development(Ministry of Education) College of FisheriesSouthwest UniversityChongqing 402400China College of Plant Protection Jilin Agriculture UniversityChangchunJilin 130118China Jiaxing Key Laboratory for New Germplasm Breeding of Economic Mycology JiaxingZhejiang 314000China

Persistent uplift means the Qinghai-Tibet Plateau(QTP)is an ideal natural laboratory to investigate genome evolution and adaptation within highland ***,how paleogeographic and paleoclimatic events influence the genome and population of endemic fish species remains *** maculatum is an ancient endemic fish found on the QTP and the only critically endangered species in the Sisoridae ***,we found that major transposons in the *** genome showed episodic bursts,consistent with contemporaneous geological and climatic events during the QTP ***,histone genes showed significant expansion in the *** genome,which may be mediated by long interspersed nuclear elements(LINE)repetitive element *** analysis showed that ancestral *** populations experienced two significant depressions 2.6 million years ago(Mya)and 10000 years ago,exhibiting excellent synchronization with Quaternary glaciation and the Younger Dryas,***,we propose that paleogeography and paleoclimate were dominating driving forces for population dynamics in endemic fish on the *** movements and temperature fluctuation likely destroyed the habitat and disrupted the drainage connectivity among *** factors may have caused severe bottlenecks and limited migration among ancestral *** populations,resulting in the low genetic diversity and endangered status of the species today.

关键词： Qinghai-Tibet Plateau(QTP) Glyptosternon maculatum Genome evolution Population High-altitude adaptation

Detection of the Pandemic H1N1/2009 Influenza A Virus by a Highly Sensitive Quantitative Real-time Reverse-transcription Polymerase Chain Reaction Assay

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Virologica Sinica 2013年第1期28卷 24-35页

作者： Zhu Yang Guoliang Mao Yujun Yuan-Chuan Chen Chengjing liu Jun Luo Xihan Li Ke zen Yanjun Pang Jianguo Wu Fenyong liu Institute of Virology School of Life Sciences Nanjing University Taizhou Institute of Virology Jiangsu Affynigen Biotechnologies Inc. State Key Laboratory of Virology College of Life Sciences Wuhan University College of Letters and Sciences University of Chicago Division of Infectious Diseases and Vaccinology School of Public Health University of California

A quantitative real time reverse-transcription polymerase chain reaction （qRT-PCR） assay with specific primers recommended by the World Health Organization （WHO） has been widely used successfully for detection and monitoring of the pandemic H1N1/2009 influenza A virus. In this study, we report the design and characterization of a novel set of primers to be used in a qRT-PCR assay for detecting the pandemic H1N1/2009 virus. The newly designed primers target three regions that are highly conserved among the hemagglutinin （HA） genes of the pandemic HlN1/2009 viruses and are different from those targeted by the WHO-recommended primers. The qRT-PCR assays with the newly designed primers are highly specific, and as specific as the WHO-recommended primers for detecting pandemic H1N1/2009 viruses and other influenza viruses including influenza B viruses and influenza A viruses of human, swine, and raccoon dog origin. Furthermore, the qRT-PCR assays with the newly designed primers appeared to be at least 10-fold more sensitive than those with the WHO-recommended primers as the detection limits of the assays with our primers and the WHO-recommended primers were 2.5 and 25 copies of target RNA per reaction, respectively. When tested with 83 clinical samples, 32 were detected to be positive using the qRT-PCR assays with our designed primers, while only 25 were positive by the assays with the WHO-recommended primers. These results suggest that the qRT-PCR system with the newly designed primers represent a highly sensitive assay for diagnosis of the pandemic HIN1/2009 virus infection.

关键词： Quantitative real time reverse-transcription polymerase chain reaction (qRT-PCR) Influenza A virus Detection

3DPhenoFish:Application for two-and three-dimensional fish morphological phenotype extraction from point cloud analysis

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Zoological Research 2021年第4期42卷 492-501页

作者： Yu-Hang Liao Chao-Wei Zhou Wei-Zhen liu Jing-Yi Jin Dong-Ye Li Fei liu Ding-Ding Fan Yu Zou zen-Bo Mu Jian shen Chun-Na liu shi-Jun Xiao Xiao-Hui Yuan Hai-Ping liu Department of Computer Science Wuhan University of TechnologyWuhanHubei 430070China Institute of Fisheries Science Tibet Academy of Agricultural and Animal Husbandry SciencesLhasaTibet 850000China Key Laboratory of Freshwater Fish Reproduction and Development(Ministry of Education) College of FisheriesSouthwest UniversityChongqing 402460China Jiaxing Key Laboratory for New Germplasm Breeding of Economic Mycology JiaxingZhejiang 314000China Huadian Tibet Energy Co. LtdLhasaTibet 851415China China Institute of Water Resources and Hydropower Research Beijing 100038China

Fish morphological phenotypes are important resources in artificial breeding,functional gene mapping,and population-based studies in aquaculture and *** morphological measurement of phenotypes is rather expensive in terms of time and *** importantly,manual measurement is highly dependent on operational experience,which can lead to subjective phenotyping ***,we developed 3DPhenoFish software to extract fish morphological phenotypes from three-dimensional(3D)point cloud *** for background elimination,coordinate normalization,image segmentation,key point recognition,and phenotype extraction were developed and integrated into an intuitive user ***,18 key points and traditional 2D morphological traits,along with 3D phenotypes,including area and volume,can be automatically obtained in a visualized *** fine-tuning of key points and customized definitions of phenotypes are also allowed in the *** 3DPhenoFish,we performed high-throughput phenotyping for four endemic Schizothoracinae species,including Schizopygopsis younghusbandi,Oxygymnocypris stewartii,Ptychobarbus dipogon,and Schizothorax *** indicated that the morphological phenotypes from 3DPhenoFish exhibited high linear correlation(>0.94)with manual measurements and offered informative traits to discriminate samples of different species and even for different populations of the same *** summary,we developed an efficient,accurate,and customizable tool,3DPhenoFish,to extract morphological phenotypes from point cloud data,which should help overcome traditional challenges in manual measurements.3DPhenoFish can be used for research on morphological phenotypes in fish,including functional gene mapping,artificial selection,and conservation studies.3DPhenoFish is an open-source software and can be downloaded for free at https://***/lyh24k/3DPhenoFish/tree/master.

关键词： Fish Phenomics Morphology Point cloud 3D scanning

Nonlinear Stability of Thin Elastic Circular shallow Spherical shell under the Action of Uniform Edge Moment

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Applied Mathematics and Mechanics(English Edition) 1980年第1期1卷 71-90页

作者： Yeh, Kai-yuan, liu, zen-huai, Chang, Chuan-dzi, shue, Ih-fan ( Lanchou University, Gansu.) Lanchou University Gansu

In this paper,nonlinear stability of thin elastic circular shallow spherical shell under the actionof uniform edge moment is considered by the modified iteration method to obtain second and thirdapproximations to decide the upper and lower critical *** are plotted in curves for theengineering use and are compared with results of Hu Hai-Chang’*** also investigate the neighboursituation of the critical point,*** double points of the upper and lower critical loads and denotethe range of validity of the second *** the end,we obtain the special case,the designformulas of rigidity and stress as well as the corresponding curves as v=0.3 of large deflection of cir-cular plate under the same *** results are also compared with Huang Tse-yen’s.

关键词： St Nonlinear Stability of Thin Elastic Circular shallow Spherical shell under the Action of Uniform Edge Moment Edge Thin