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基于仪器法的肼类推进剂快速分析技术研究进展

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化学推进剂与高分子材料 2024年第3期22卷 8-13页

作者：李明徐泽龙黄希云于舒婷侯子文酒泉卫星发射中心甘肃酒泉732750

总结了当前应用于肼类推进剂分析的仪器分析技术,包括用于主要组分含量测定的自动电位滴定法、气相色谱分析法和近红外光谱法,以及用于微量组分含量测定的分光光度法和比色法等,讨论了目前在分析仪器、方法、流程以及误差分析等方面的... 详细信息

总结了当前应用于肼类推进剂分析的仪器分析技术,包括用于主要组分含量测定的自动电位滴定法、气相色谱分析法和近红外光谱法,以及用于微量组分含量测定的分光光度法和比色法等,讨论了目前在分析仪器、方法、流程以及误差分析等方面的不足和改良,并展望了未来有望提高快速分析能力的技术方法。

关键词：肼液体推进剂质量检验仪器分析快速化验

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Nano metal-photosensitizer based on Aza-BODIPY-Cu complex for CDT-enhanced dual phototherapy

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Chinese Chemical Letters 2024年第7期35卷 296-300页

作者： Wenjuan Jin zelong Chen Yi Wang Jiaxuan Li Jiahui Li Yuxin Pei Zhichao Pei College of Chemistry&Pharmacy Northwest A&F UniversityYangling 712100China

Chemodynamic therapy(CDT)combined with dual phototherapy(photothermal therapy(PTT)and photodynamic therapy(PDT))is an efficient way to synergistically improve anti-tumor ***,the combination of multiple modes often makes the composition of the system more complex,which is not conducive to clinical *** this study,a dual phototherapy ligand carboxyl-modified Aza-BODIPY(BOD-COOH)and metal active center Cu^(2+)were used to construct multiple-modes metalphotosensitizer nanoparticles(BOD-Cu NPs)via one-step coordination self-assembly for combination therapy of CDT/PDT/*** order to improve delivery efficiency,the targeted hydrophilic molecule pyridinemodified glucose derivative(G-Py)was synthesized and coated onto the BOD-Cu NPs to form a glycosylated nano metal-photosensitizer BOD-Cu@G by electrostatic *** Cu^(2+)in BOD-Cu@G could not only be used as a coordination node for metal-driven self-assembly but also consume intracellular glutathione(GSH),and then catalyze Fenton-like reaction to generate hydroxyl radical(·OH)for *** vitro and in vivo studies revealed that BOD-Cu@G could achieve excellent anti-tumor efficiency by CDTenhanced dual phototherapy.

关键词： Nano metal-photosensitizer Aza-BODIPY-Cu Coordination self-assembly Chemodynamic therapy Dual phototherapy

Integrated circulating tumor DNA and T cell repertoire predict radiotherapeutic response and outcome in non-small cell lung cancer patients with brain metastasis

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Cancer Communications 2023年第5期43卷 625-629页

作者： Ling Peng Yawen Bin Peng Ding Lingjuan Chen Hao Zeng zelong xu Liyan Ji xuan Gao Pian Liu Ye Wang Sheng Zhang Zhongxing Liao xuefeng Xia Ruiguang Zhang Fan Tong Xiaorong Dong Cancer Center Union HospitalTongji Medical CollegeHuazhong University of Science and TechnologyWuhanHubeiP.R.China Geneplus-Beijing BeijingP.R.China State Key Laboratory of Microbial Resources Institute of MicrobiologyChinese Academy of SciencesBeijingP.R.China GenePlus-Shenzhen Clinical Laboratory ShenzhenGuangdongP.R.China Department of Radiation Oncology The University of Texas MD Anderson Cancer CenterHoustonTXUSA

Dear editor,The scarcity of routinemetastatic biopsies or resection limits the finding of biomarkers of diagnosis and prognosis in patients with brain *** from necrosis,apoptosis,and secretion of tumor cells,circulating tumor DNA(ctDNA)is widely distributed in various body fluids,including peripheral blood and cerebrospinal fluid(CSF),as an alternative biomarker for tumor-associated analysis[1].Fortunately,genomic alterations of blood ctDNA and CSF ctDNA have been proven as prognostic markers in non-small cell lung cancer(NSCLC)patients with brain metastasis[2,3].

关键词： metastasis patients routine

Predictive value of T cell receptor repertoire profiling for immunosuppressive therapy in severe aplastic anemia

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Genes & Diseases 2024年第1期11卷 95-98页

作者： Cunte Chen Yuling Zhang Dongpei Lu zelong Zhang Jun Yang Xiaowei Chen Ming Zhou Wenjian Mo Caixia Wang Qinghua Cai Yumiao Li Ruiqing Zhou Shilin xu Wei Zhou Tingfen Deng Shiyi Pan Yanli xu Shunqing Wang Yuping Zhang Department of Hematology Guangzhou First People's HospitalSouth China University of TechnologyGuangzhouGuangdong 510180China Guangzhou Junruikang Biotechnology Co. LtdGuangzhouGuangdong 510700China

Increasing evidence supports the hypothesis of autologous immune attack in severe aplastic anemia(SAA):the predominant role of activated cytotoxic T cells(CTL)expressing-interferon in inhibiting the growth of bone marrow(BM)cells,putative autoantigens,and oligoclonal expansion of CD8+T cells.1 For SAA patients,the definitive therapies are immunosuppressive therapy(IST)or hematopoietic stem transplantation(HSCT).

关键词： anemia aplastic interferon

Tailoring the Microstructure and Mechanical Property of Mg-Zn Matrix Composite via the Addition of Al Element

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Acta Metallurgica Sinica(English Letters) 2024年第3期37卷 438-452页

作者： Chong Wang Fuyuan Liu xuejian Wang Enyu Guo zelong Du Kunkun Deng Zongning Chen Huijun Kang Guohao Du Tongmin Wang Key Laboratory of Solidification Control and Digital Preparation Technology(Liaoning Province) School of Materials Science and EngineeringDalian University of TechnologyDalian 116024China School of Mechanical Engineering Guizhou UniversityGuiyang 550025China Ningbo Institute of Dalian University of Technology Ningbo 315000China Shanxi Key Laboratory of Advanced Magnesium-Based Materials College of Materials Science and EngineeringTaiyuan University of TechnologyTaiyuan 030024China Shanghai Synchrotron Radiation Facility Shanghai Advanced Research Institute CASShanghai 201204China

The semi-solid stir casting method is adopted to prepare 10 wt%SiC_(p)/Mg-6Zn-0.5Ca-xAl(x=0,1,3 and 5 wt%)composites,and the microstructure evolution and mechanical property of composites with various Al content are *** results show that the addition of 3 wt%Al improves the distribution of SiC_(p),whereas the SiC_(p) cluster occurs again with Al content greater than 3%.An abnormal phenomenon of twinning is observed in the cast composites in this *** SiC_(p)/Mg-6Zn-0.5Ca composite possesses the highest twin content of~23%,for which tension twins(TTW)and compression twins(CTW)account for~19%and~3%,*** CTW is only observed in ZXA600 *** addition of Al has an inhibiting effect for the generation and growth of *** content of twin decreases firstly and then increases with increase of Al *** lowest twin content is obtained as Al increases to 3 wt%.It is found the existence of twin is detrimental to the mechanical property of ***-cast SiC_(p)/Mg-6Zn-0.5Ca-3Al composite with the lowest twin content exhibits the optimal mechanical property of yield strength,ultimate tensile strength and elongation for 100 MPa,188 MPa and 4.4%,*** outstanding mechanical property is attributed to the uniform distribution of SiC_(p),the low twin content and the well-distributed fine second phases.

关键词： Mg matrix composite Synchrotron tomography Twinning Liquid melt processing Mechanical property

The Ca^(2+)/CaN/ACC and cAMP/PKA/HK signal pathways are required for PBAN-mediated sex pheromone biosynthesis in Conogethes punctiferalis

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Journal of Integrative Agriculture 2024年第8期23卷 2735-2751页

作者： Yao Zhang zelong She Ruolan He Shuangyan Yao Xiang Li Xiaoguang Liu Xinming Yin Jizhen Wei Mengfang Du Shiheng An State Key Laboratory of Wheat and Maize Crop Science/Henan International Laboratory for Green Pest Control/College of Plant Protection Henan Agricultural UniversityZhengzhou 450046China

Conogethes punctiferalis is a crop and fruit pest that has caused serious economic losses to agricultural *** pest relies heavily on its sex pheromone to ensure sexual encounters and subsequent mating ***,the molecular mechanism underlying sex pheromone biosynthesis in this species remains *** present study investigated the detailed mechanism underlying PBAN-regulated sex pheromone biosynthesis in *** by transcriptome sequencing of the *** pheromone glands(PGs)and subsequent functional identification of the target *** results showed that female mating started from the first scotophase,and peaked at the second to fifth scotophases in accordance with the release of sex *** regulated sex pheromone biosynthesis by employing Ca^(2+)and cAMP as secondary messengers,as demonstrated by RNA interference(RNAi),pharmacological inhibitors,and behavioral *** investigation revealed that calcineurin(CaN)and acetyl-CoA carboxylase(ACC)were activated by PBAN/Ca^(2+)signaling,and the RNAimediated knockdown of CaN and ACC transcripts significantly reduced sex pheromone production,ultimately leading to a significantly reduced ability of females to attract ***,hexokinase(HK)was found to regulate sex pheromone biosynthesis in response to the PBAN/cAMP/PKA signaling pathway,as demonstrated by RNAi,enzyme activity,and pharmacological inhibitor ***,Far2 and Desaturase1 were found to participate in PBAN-regulated sex pheromone ***,our findings revealed that PBAN regulates sex pheromone biosynthesis through the PBANR/Ca^(2+)/CaN/ACC and PBANR/cAMP/PKA/HK pathways in ***,which enriches our comprehension of the details of sex pheromone biosynthesis in moths.

关键词： Conogethes punctiferalis sex pheromone cAMP/PKA calcineurin acetyl-CoA carboxylase hexokinase

系统性金融风险的联合网络关联度测量及频率研究——基于局部平稳的非参数时变VHAR模型

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中国管理科学 2024年第2期32卷 1-10页

作者：傅强石泽龙重庆大学经济与工商管理学院重庆400030

准确度量系统性金融风险并分析其来源是研究系统性金融风险的重要问题,也是制定风险防范措施的必要保证。本文以金融类股票的高频数据为对象,通过假设向量异质自回归模型(VHAR模型)的参数为时间t/T的函数,建立了高维度局部平稳的非参数... 详细信息

准确度量系统性金融风险并分析其来源是研究系统性金融风险的重要问题,也是制定风险防范措施的必要保证。本文以金融类股票的高频数据为对象,通过假设向量异质自回归模型(VHAR模型)的参数为时间t/T的函数,建立了高维度局部平稳的非参数时变VHAR模型(即tv-VHAR model),并利用拟贝叶斯局部似然(QBLL)估计方法,解决了“维数灾难”下的估计问题。进一步,为更准确度量系统性金融风险,对Baruník和K?ehlík(2018)模型存在的缺陷进行修正,提出了联合网络关联度的频率成分指标,结合2015年股灾和新冠疫情这两次危机事件分析了我国系统性金融风险。结果表明:(1)我国金融系统风险的联合网络关联度比较高且持续性波动。(2)从频率角度来看,正常时期短期成分在风险网络中占据主导地位,其次为中期,最后为长期。(3)危机时期,短期成分迅速下降,而中、长期成分迅速上升,甚至超过了短期成分。(4)相比新冠疫情危机事件,股灾危机对投资者信心影响更大,导致危机持续时间更长。(5)各金融机构在风险网络中的作用差异较大:大型证券公司、股份制银行主要表现为风险净传播者,而大型国有商业银行及其他金融机构主要表现为风险净接受者。

关键词： tv-VHAR模型联合网络关联度的频率分解系统性金融风险已实现波动率

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甲状腺乳头状癌流行病学及诊疗焦点探讨

西安交通大学学报（医学版） 2024年第1期45卷 44-48页

作者：田文阳泽龙解放军总医院普通外科医学部甲状腺(疝)外科北京100853

甲状腺癌发病率全球范围内呈快速上升趋势,学术界对其原因观点不一,有部分学者认为其为“过度诊断”导致,但从大样本流行病学研究来看,其发病率为真实上升。国外最新文献报告,美国甲状腺癌死亡率呈上升趋势,其原因可能与美国甲状腺学会(... 详细信息

甲状腺癌发病率全球范围内呈快速上升趋势,学术界对其原因观点不一,有部分学者认为其为“过度诊断”导致,但从大样本流行病学研究来看,其发病率为真实上升。国外最新文献报告,美国甲状腺癌死亡率呈上升趋势,其原因可能与美国甲状腺学会(ATA)指南对于甲状腺乳头状癌诊疗降级相关;而持更积极诊疗态度的韩国等亚洲国家死亡率呈逐年下降趋势,这需要我们注意与深思。因此本文对甲状腺乳头状癌流行病学及国内外诊疗焦点再次探讨。我国甲状腺癌5年生存率从2003-2005年的67.5%增长至2012-2015年的84.3%,出现显著提升,然而仍远低于美国的98.3%。针对如今我国甲状腺癌同质化诊断、治疗水平低的现状,直接照搬国外指南,诊疗降级,存在引起我国甲状腺癌死亡率上升的风险。

关键词：甲状腺微小乳头状癌流行病学积极监测射频消融

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中国现代诗歌史观反思与历史重释路径

文学评论 2024年第2期 169-177页

作者：王泽龙华中师范大学文学院

20世纪以来,中国现代诗歌历史书写的基本格局没有大的改变。现代诗歌史观直接影响了现代诗歌历史的书写,现代诗史的革命论、阶级论、现代性的观念化和一元论,从不同角度揭示了现代诗歌历史本质的某些特征,却不同程度地偏离了现代诗歌的... 详细信息

20世纪以来,中国现代诗歌历史书写的基本格局没有大的改变。现代诗歌史观直接影响了现代诗歌历史的书写,现代诗史的革命论、阶级论、现代性的观念化和一元论,从不同角度揭示了现代诗歌历史本质的某些特征,却不同程度地偏离了现代诗歌的丰富历史生态。按照社团、流派建构诗歌历史的观念与方法,把规律性、共同性的总结作为历史阐释的路径,却大大遮蔽了流派群体中个体的差异性、独特性,也造成了对社团流派之外大量优秀诗人的疏漏。政治性与文学性的纠葛形成了现代诗史书写中固化的意识形态论与“纯文学论”的对立倾向;在历史品格、思想内涵、审美属性的复杂性关联中,应该看到左翼诗歌中另一种“政治化的审美”,探究革命诗学的另类文学史意义。体现史诗性特质的长篇叙事诗书写的单薄,是现代文学史经典意识的一种缺位。应改变抒情短诗的单向格局,推动新诗走向宏阔与深远。

关键词：现代文学史诗史观念诗歌流派诗歌品格长篇叙事诗