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Sonosensitized Aggregation-Induced Emission Dots with Capacities of Immunogenic Cell Death Induction and Multivalent Blocking of Programmed Cell Death-Ligand 1 for Amplified Antitumor Immunotherapy

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CCS Chemistry 2022年第2期4卷 501-514页

作者： Shaorui Jia Zhiyuan Gao zelin wu Heqi Gao He Wang Hanlin Ou Dan Ding Key Laboratory of Bioactive Materials Ministry of Education College of Life SciencesState Key Laboratory of Medicinal Chemical BiologyNankai UniversityTianjin 300071 Department of Urology First Affiliated Hospital of Soochow UniversitySuzhou 215006

The combination of immunogenic cell death(ICD)induction and immune checkpoint blockade has emerged as a major direction of cancer immunotherapy.Among currently available ICD inducers,sonosensitizers that produce reactive oxygen species(ROS)under an external trigger to evoke ICD of tumor cells have shown great promise.However,a highly efficient sonosensitizer-based ICD inducer with an aggregationinduced emission(AIE)characteristic has yet to be developed.Herein,a novel AIE sonosensitizer with a twisted molecular structure,very small energy gap between the singlet and triplet excited states(ΔE_(ST)),and efficient ROS generation ability,which can serve as an effective ICD inducer,is reported for sonodynamic processes in cancer immunotherapy.Furthermore,an AIE sonosensitizer-based nanosystem with surface modification of anti-PD-L1 peptide is constructed for boosting antitumor immunotherapy.In this system,AIE sonosensitizer-mediated sonodynamic therapy can successfully convert a hypoimmunogenic cold tumor to a hot one and further facilitate the multivalent blocking of programed death ligand(PD-L1)by anti-PD-L1 peptides.Such an advanced nanosystem could effectively initiate the activation of antitumoral immune reactions and modulation of an immunosuppressive microenvironment,contributing to systemic antitumor effects to further inhibit the growth of distant tumors.

关键词： aggregation-induced emission sonodynamic therapy immunogenic cell death PD-L1 antitumor immunotherapy

Efficient degradation of sulfamethoxazole by acetylene black activated peroxydisulfate

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Chinese Chemical Letters 2020年第10期31卷 2657-2660页

作者： Silang Nimai Heng Zhang zelin wu Naiwen Li Bo Lai State Key Laboratory of Hydraulics and Mountain River Engineering College of Architecture and EnvironmentSichuan UniversityChengdu 610065China College of Hydraulic and Hydroelectric Engineering Sichuan UniversityChengdu 610065China Sino-German Centre for Water and Health Research Sichuan UniversityChengdu 610065China

Acetylene black(AB),as a kind of carbon material with large specific surface area,low density,strong electron transferability,is supposed to have great potential for application in advanced oxidation processes(AOPs).In this study,AB was utilized as a peroxydisulfate(PDS)activator for the catalytic degradation of sulfamethoxazole(SMX)in aqueous media.Scanning electron microscopy(SEM),X-ray diffraction(XRD),Brunauer-Emmett-Teller(BET)techniques,zeta potential and Raman spectra were employed to characterize the features of AB.To verify the excellent performance of AB/PDS systems,a series of control experiments were carried out.Compared to graphite/PDS and biochar/PDS system,AB/PDS system could complete degradation of SMX within 15 min.Besides,the effects of key factors including AB dosage,PDS dosage,initial pH and SMX concentration on SMX degradation in AB/PDS system were elucidated systematically.Furthermore,through the radical quenching experiments,it was proved that singlet oxygen(1 O_(2))was dominantly responsible for the degradation of SMX.Finally,based on the experiment results and compre hensive analysis,a probable reaction mechanism of AB/PDS system for SMX degradation was proposed.This work suggests that AB has a good potential for tackling the hazardous pollutants in environmental remediation.

关键词： Sulfamethoxazole(SMX) Acetylene black(AB) Peroxydisulfate(PDS) Reaction mechanism

上颌腭侧微螺钉可摘式腭杆远中移动磨牙的研究

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实用口腔医学杂志 2024年第3期40卷 401-406页

作者：何武成吴泽琳李迎兰鲁光炜焉姝鹤西宁市第一人民医院口腔正畸科 810099

目的:评价上颌腭侧微螺钉可摘式腭杆远中移动上颌磨牙的临床效果。方法:共收集33例采用该装置进行磨牙远中移动治疗上颌轻中度拥挤和前突患者,分别于矫治前(T0期)和磨牙远移到位(T1期)后进行石膏模型的制取和头颅侧位片的拍摄,通过对模... 详细信息

目的:评价上颌腭侧微螺钉可摘式腭杆远中移动上颌磨牙的临床效果。方法:共收集33例采用该装置进行磨牙远中移动治疗上颌轻中度拥挤和前突患者,分别于矫治前(T0期)和磨牙远移到位(T1期)后进行石膏模型的制取和头颅侧位片的拍摄,通过对模型和侧位片上相关变量的测量和统计学分析明确该装置下上颌磨牙的远中移动量和移动方式。结果:头影侧位片上第一磨牙远中平均移动3.6 mm(P0.05)。左右第一磨牙宽度增加3.1 mm(P0.05),左侧夹角增大4.8°(P<0.05)。结论:上颌腭侧微螺钉可摘式腭杆能有效的进行磨牙的远中移动从而不拔牙解决上颌轻中度拥挤和前突患者的矫治需求。

关键词：微螺钉可摘式腭杆磨牙远中移动上颌拥挤上颌前突

The Logic of the United States to Reshape the Semiconductor Industry Chain

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和平与发展 2022年第6期 159-160页

作者： wu zelin Shang Xiucheng 上海社会科学院国际问题研究所

Under the combined influence of the comprehensive competition launched by the United States against China,the worldwide COVID-19 pandemic and the Ukraine crisis,the global semiconductor industry chain has suffered a major shock,resulting in prolonged logistics obstruction and"lack of chips",which has greatly affected many industries around the world.In response,the United States,the European Union,Japan,South Korea and other major semiconductor manufacturing countries or regions have introduced strategic measures one after another to enhance technology research and development and supply chain resilience.

关键词： measures Chain strategic

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电刺激治疗骨骼肌肉疾病的应用研究进展

中华解剖与临床杂志 2024年第6期29卷 421-426页

作者：吴泽霖陈紫航艾斯玛尔古丽·艾斯克尔郑小飞 Kin Chiu 王华军暨南大学附属第一医院运动医学科/广州市精准骨科与再生医学重点实验室/广东省速度能力研究重点实验室广州510630 香港大学李嘉诚医学院心理系/脑与认知科学国家重点实验室(香港大学) 中国香港999077

目的总结电刺激(EStim)技术治疗骨骼肌肉系统疾病的临床效果及其作用机制方面的研究进展。方法在中国知网、万方数据、Springer Link、PubMed等中、英文数据库中,检索自2000年1月以后公开发表的有关EStim与骨骼肌肉系统的文章共2778篇,... 详细信息

目的总结电刺激(EStim)技术治疗骨骼肌肉系统疾病的临床效果及其作用机制方面的研究进展。方法在中国知网、万方数据、Springer Link、PubMed等中、英文数据库中,检索自2000年1月以后公开发表的有关EStim与骨骼肌肉系统的文章共2778篇,最终纳入57篇文献进行系统复习及归纳总结。结果EStim技术对骨骼、肌肉、肌腱、韧带、关节软骨等骨骼肌肉系统各组成部分的疾病,如骨折、骨质疏松、肌肉萎缩,以及肌腱、韧带、关节软骨和周围神经损伤等,均有积极的治疗效果,且具备经济性、安全性、便捷性与有效性等优势。EStim对骨骼肌肉系统疾病的作用机制是通过物理、分子生物学等途径,对骨骼肌肉系统的血液循环、细胞分化、机械运动、蛋白质代谢等产生影响,甚至有可能促进软骨细胞增殖、加速神经轴突再生。结论采用EStim技术治疗骨骼肌肉系统疾病,其方法可行、疗效肯定;其作用机制是通过物理和生化两个方面的途径来实现的。

关键词：骨骼肌肉系统电刺激骨骼肌肉肌腱韧带软骨

Electrode particulate materials for advanced rechargeable batteries:A review

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Particuology 2024年第3期86卷 160-181页

作者： Mingyang Ma Miao Du Yan Liu Hongyan Lü Jialin Yang zelin Hao Jinzhi Guo Xinglong wu MOE Key Laboratory for UV Light-Emitting Materials and Technology Northeast Normal UniversityChangchunJilin130024China Department of Chemistry Northeast Normal UniversityChangchunJilin130024China

The demand for large-scale energy storage is increasing due to the decreasing non-renewable resources and deteriorating environmental pollution.Developing rechargeable batteries with high energy density and long cycle performance is an ideal choice to meet the demand of energy storage system.The development of excellent electrode particles is of great significance in the commercialization of nextgeneration batteries.The ideal electrode particles should balance raw material reserves,electrochemical performance,price and environmental protection.Among them,the development of electrode particulate materials with excellent electrochemical properties is the top priority at present.In this review,the typical researches of electrode materials are summarized in terms of crystal structure,morphology,pore structure,surface and interface regulation.Firstly,the structural characteristics and improvement methods of transition metal oxides,polyanionic compounds,Prussian blue and their analogues are introduced.Then,the different effects of particulate morphology,pore,surface and interface structure on the performance of electrode materials are discussed.For designing high-performance electrode materials,preparation route should be set according to the particle properties of the materials and the synergistic effect of various optimization methods should be adopted.At the same time,in addition to the electrode materials,other components of the rechargeable batteries,such as current collector,separator and electrolytes,should be optimized to improve the overall performance of the batteries.This review would provide important guiding principle for designing high-performance electrode particulate materials.

关键词： Particulate properties Electrode materials Rechargeable batteries

Reconfigurable logic and in-sensor encryption operations in an asymmetrically tunable van der Waals heterostructure

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Nano Research 2024年第4期17卷 3113-3119页

作者： Fan Gong Wenjie Deng Yi wu Fengming Liu Yihao Guo zelin Che Jingjie Li Jingzhen Li Yang Chai Yongzhe Zhang Key Laboratory of Optoelectronics Technology of Education Ministry of China Faculty of Information TechnologyBeijing University of TechnologyBeijing 100124China Key Laboratory of Advanced Functional Materials Ministry of EducationFaculty of Materials and ManufacturingBeijing University of TechnologyBeijing 100124China Department of Applied Physics Hong Kong Polytechnic UniversityKowloonHong KongChina

Reconfigurable devices can be used to achieve multiple logic operation and intelligent optical sensing with low power consumption,which is promising candidates for new generation electronic and optoelectronic integrated circuits.However,the versatility is still limited and need to be extended by the device architectures design.Here,we report an asymmetrically gate two-dimensional(2D)van der Waals heterostructure with hybrid dielectric layer SiO_(2)/hexagonal boron nitride(h-BN),which enable rich function including reconfigurable logic operation and in-sensor information encryption enabled by both volatile and non-volatile optoelectrical modulation.When the partial gate is grounded,the non-volatile light assisted electrostatic doping endowed partially reconfigurable doping between n-type and p-type,which allow the switching of logic XOR and not implication(NIMP).When the global gate is grounded,additionally taking the optical signal as another input signal,logic AND and OR is realized by combined regulation of the light and localized gate voltage.Depending on the high on/off current ratio approaching 105 and reliable&switchable logic gate,in-sensor information encryption and decryption is demonstrated by manipulating the logic output.Hence,these results provide strong extension for current reconfigurable electronic and optoelectronic devices.

关键词： in-sensor encryption reconfigurable logic van der Waals heterostructure asymmetrical tunable architecture

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数字化和能源转型下大国供应链竞争及其影响

国际关系研究 2022年第6期 3-22,M0003页

作者：吴泽林上海社会科学院国际问题研究所

在新一轮科技革命和产业变革背景下,数字化和能源转型成为经济增长的重要引擎和大国竞争的关键领域。美国、欧盟和中国为争夺竞争优势和确保供应稳定,在数字和绿色领域展开了激烈的供应链竞争,包括供应链本地化竞争、全球重要供应链节... 详细信息

在新一轮科技革命和产业变革背景下,数字化和能源转型成为经济增长的重要引擎和大国竞争的关键领域。美国、欧盟和中国为争夺竞争优势和确保供应稳定,在数字和绿色领域展开了激烈的供应链竞争,包括供应链本地化竞争、全球重要供应链节点竞争和基础设施竞争,对国家间关系和跨国公司的全球布局带来了深刻影响。第一,中美两国可能借助产业优势分别在绿色和数字领域形成产业并立,并以此塑造全球供应链。第二,美欧修复和加强了跨大西洋关系,处在技术弱势地位的欧盟将进一步增强对美国的依赖。第三,数字和绿色行业的跨国公司将在美欧中三大市场分别布局,谋求市场份额和利益的最大化。大国供应链竞争也将使经济全球化向本地化和区域化方向发展,并呈现出更深的价值观意涵。

关键词：数字化转型能源转型供应链竞争

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美欧全球基础设施投资计划及其对中国的影响

现代国际关系 2022年第3期 9-16,61页

作者：吴泽林王健上海社会科学院国际问题研究所

近年来,美国、英国和欧盟相继提出“重建更美好世界”、“清洁绿色倡议”和“全球门户”计划。这些全球基础设施投资计划具有全球性,注重软性基础设施,以发展融资机构带动私人资本,由西方价值观驱动等共同特点,并且已进入了项目甄选阶... 详细信息

近年来,美国、英国和欧盟相继提出“重建更美好世界”、“清洁绿色倡议”和“全球门户”计划。这些全球基础设施投资计划具有全球性,注重软性基础设施,以发展融资机构带动私人资本,由西方价值观驱动等共同特点,并且已进入了项目甄选阶段。由于美欧履行承诺能力不足,内部对华政策不一致,政府调动私人资本难度较大及西方价值观悖论等原因,其发展成效具有较大的不确定性,并且难以对“一带一路”建设带来根本影响。不过,中国仍需关注这些计划捆绑整合后的整体影响,并须注重股权投资的影响和周边形势复杂化的趋势。为此,中国应强化开发性和政策性金融机构的职能和作用,提升配套政策支持力度,提高新经济领域合作,改善基础设施建设方式,加强理念宣传,缓解舆论压力。

关键词：一带一路全球门户重建更美好世界