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Protein & Cell 2023年第11期14卷 787-806页

作者： Wanglong Gou zelei miao Kui Deng Ju-Sheng Zheng Westlake Intelligent Biomarker Discovery Lab Westlake Laboratory of Life Sciences and BiomedicineHangzhou 310024China Research Center for Industries of the Future Key Laboratory of Growth Regulation and Translational Research of Zhejiang ProvinceSchool of Life SciencesWestlake UniversityHangzhou 310030China Institute of Basic Medical Sciences Westlake Institute for Advanced StudyHangzhou 310024China

Diet and nutrition have a substantial impact on the human microbiome,and interact with the microbiome,especially gut microbiome,to modulate various diseases and health status.Microbiome research has also guided the nutrition field to a more integrative direction,becoming an essential component of the rising area of precision nutrition.In this review,we provide a broad insight into the interplay among diet,nutrition,microbiome,and microbial metabolites for their roles in the human health.Among the microbiome epidemiological studies regarding the associations of diet and nutrition with microbiome and its derived metabolites,we summarize those most reliable findings and highlight evidence for the relationships between diet and disease-associated microbiome and its functional readout.Then,the latest advances of the microbiome-based precision nutrition research and multidisciplinary integration are described.Finally,we discuss several outstanding challenges and opportunities in the field of nutri-microbiome epidemiology.

关键词： microbiome nutrition human health epidemiology

Gut microbiome,cognitive function and brain structure:a multi-omics integration analysis

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Translational Neurodegeneration 2022年第1期11卷 178-191页

作者： Xinxiu Liang Yuanqing Fu Wen-ting Cao Zhihong Wang Ke Zhang Zengliang Jiang Xiaofang Jia Chun-ying Liu Hong-rou Lin Haili Zhong zelei miao Wanglong Gou Menglei Shuai Yujing Huang Shengdi Chen Bing Zhang Yu-ming Chen Ju-Sheng Zheng College of Life Sciences Zhejiang UniversityHangzhou 310058China School of Life Sciences Westlake University18 Shilongshan RdCloud TownHangzhou 310024China Guangdong Provincial Key Laboratory of Food Nutrition and HealthDepartment of Medical Statistics and EpidemiologySchool of Public HealthSun Yat-Sen UniversityGuangzhou 510080China Chinese Center for Disease Control and Prevention National Institute for Nutrition and HealthBeijing 100050China School of Public Health Hainan Medical UniversityHaikou 571199China Westlake Intelligent Biomarker Discovery Lab Westlake Laboratory of Life Sciences and BiomedicineHangzhou 310024China Department of Neurology and Institute of Neurology Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of MedicineShanghai 200025China Key Laboratory of Trace Element Nutrition National Health CommissionBeijing 100050China Institute of Basic Medical Sciences Westlake Institute for Advanced StudyHangzhou 310024China.

Background:Microbiome-gut-brain axis may be involved in the progression of age-related cognitive impairment and relevant brain structure changes,but evidence from large human cohorts is lacking.This study was aimed to investigate the associations of gut microbiome with cognitive impairment and brain structure based on multi-omics from three independent populations.Methods:We included 1430 participants from the Guangzhou Nutrition and Health Study(GNHS)with both gut microbiome and cognitive assessment data available as a discovery cohort,of whom 272 individuals provided fecal samples twice before cognitive assessment.We selected 208 individuals with baseline microbiome data for brain magnetic resonance imaging during the follow-up visit.Fecal 16S rRNA and shotgun metagenomic sequencing,tar-geted serum metabolomics,and cytokine measurements were performed in the GNHS.The validation analyses were conducted in an Alzheimer’s disease case-control study(replication study 1,n=90)and another community-based cohort(replication study 2,n=1300)with cross-sectional dataset.Results:We found protective associations of specific gut microbial genera(Odoribacter,Butyricimonas,and Bac-teroides)with cognitive impairment in both the discovery cohort and the replication study 1.Result of Bacteroides was further validated in the replication study 2.Odoribacter was positively associated with hippocampal volume(β,0.16;95%CI 0.06-0.26,P=0.002),which might be mediated by acetic acids.Increased intra-individual alterations in gut microbial composition were found in participants with cognitive impairment.We also identified several serum metabolites and inflammation-associated metagenomic species and pathways linked to impaired cognition.Conclusions:Our findings reveal that specific gut microbial features are closely associated with cognitive impair-ment and decreased hippocampal volume,which may play an important role in dementia development.

关键词： Gut microbiome Cognitive impairment Brain structure Metagenomics Microbiome-gut-brain axis Cohort

Gut microbiota,inflammation,and molecular signatures of host response to infection

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Journal of Genetics and Genomics 2021年第9期48卷 792-802页

作者： Wanglong Gou Yuanqing Fu Liang Yue Geng-Dong Chen Xue Cai Menglei Shuai Fengzhe Xu Xiao Yi Hao Chen Yi Zhu Mian-Li Xiao Zengliang Jiang zelei miao Congmei Xiao Bo Shen Xiaomai Wu Haihong Zhao Wenhua Ling Jun Wang Yu-Ming Chen Tiannan Guo Ju-Sheng Zheng College of Life Sciences Zhejiang UniversityHangzhou 310058China Key Laboratory of Growth Regulation and Translational Research of Zhejiang Province School of Life SciencesWestlake UniversityHangzhou 310024China Center for Infectious Disease Research Westlake Laboratory of Life Sciences and BiomedicineHangzhou 310024China Institute of Basic Medical Sciences Westlake Institute for Advanced StudyHangzhou 310024China Key Laboratory of Structural Biology of Zhejiang Province School of Life SciencesWestlake UniversityHangzhou 310024China Guangdong Provincial Key Laboratory of Food Nutrition and HealthDepartment of EpidemiologySchool of Public HealthSun Yat-sen UniversityGuangzhou 510275China Taizhou Hospital Wenzhou Medical UniversityLinhai 325035China CAS Key Laboratory for Pathogenic Microbiology and Immunology Institute of MicrobiologyChinese Academy of SciencesBeijing 100101China

Gut microbial dysbiosis has been linked to many noncommunicable diseases.However,little is known about specific gut microbiota composition and its correlated metabolites associated with molecular signatures underlying host response to infection.Here,we describe the construction of a proteomic risk score based on 20 blood proteomic biomarkers,which have recently been identified as molecular signatures predicting the progression of the COVID-19.We demonstrate that in our cohort of 990 healthy individuals without infection,this proteomic risk score is positively associated with proinflammatory cytokines mainly among older,but not younger,individuals.We further discover that a core set of gut microbiota can accurately predict the above proteomic biomarkers among 301 individuals using a machine learning model and that these gut microbiota features are highly correlated with proinflammatory cytokines in another independent set of 366 individuals.Fecal metabolomics analysis suggests potential amino acid-related pathways linking gut microbiota to host metabolism and inflammation.Overall,our multi-omics analyses suggest that gut microbiota composition and function are closely related to inflammation and molecular signatures of host response to infection among healthy individuals.These results may provide novel insights into the cross-talk between gut microbiota and host immune system.

关键词： Gut microbiota Proinflammatory cytokines Proteomic biomarkers COVID-19 Host infection response

“新华盛顿共识”下美国农业法案发展走向及中国的应对

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世界农业 2024年第2期 17-25页

作者：邢泽蕾李春顶中国农业大学经济管理学院北京100083

美国农业政策经历了价格支持政策、生产灵活性与市场取向政策、风险保障与多元化政策、市场取向政策再度回归四个阶段。“新华盛顿共识”作为自由市场经济政策的替代方案,以国家介入为主旨的产业政策,将对美国农业法案产生重要影响。本... 详细信息

美国农业政策经历了价格支持政策、生产灵活性与市场取向政策、风险保障与多元化政策、市场取向政策再度回归四个阶段。“新华盛顿共识”作为自由市场经济政策的替代方案,以国家介入为主旨的产业政策,将对美国农业法案产生重要影响。本文在整理美国相关建议的基础上,探讨了新一轮美国农业法案对商品、农作物保险、保护、营养和农村发展5项计划的改革方向。在“新华盛顿共识”背景下,美国农业法案也将在本土化、农业保险、国际贸易合作、环境保护、社会经济平等方面做出一系列的政策调整。通过深入分析,本文从四个方面提出中国的应对之策:一是建立与国际规则相适应的补贴制度;二是完善农业保险制度;三是强化农业科技研发;四是拓展国际农业合作。

关键词： “新华盛顿共识” 农业法案国际经济政策

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西安市典型行业VOCs源成分谱及环境影响

环境监测管理与技术 2024年第3期36卷 73-77页

作者：陈妙薛兴钊李顺姬曹泽磊孟小兰党小庆黄宇广西安市环境保护科学研究院陕西西安710061 西安建筑科技大学陕西西安710200

采用苏玛罐采样-GC/MS法分析西安市家具制造、表面涂装、汽车整车制造和印刷行业VOCs成分谱,计算不同工序VOCs对O 3和二次有机气溶胶(SOA)的生成贡献。结果表明:西安市不同行业TVOC排放值为0.332 mg/m^(3)~45.7 mg/m^(3),涂装行业最高,... 详细信息

采用苏玛罐采样-GC/MS法分析西安市家具制造、表面涂装、汽车整车制造和印刷行业VOCs成分谱,计算不同工序VOCs对O 3和二次有机气溶胶(SOA)的生成贡献。结果表明:西安市不同行业TVOC排放值为0.332 mg/m^(3)~45.7 mg/m^(3),涂装行业最高,其次是印刷工序和木质家具制造,汽车软装和印刷覆膜工序较低。木质家具VOCs主要为芳香烃、含氧类有机物和烷烃,随着油性漆替换为水性漆,芳香烃占比下降,含氧类有机物占比上升。汽车喷涂VOCs主要为芳香烃和含氧类有机物,印刷行业VOCs中含氧类有机物占比高。表面涂装排放VOCs对生成O 3和SOA贡献最高,印刷行业R OF最小,汽车软装工序R SOA最小。

关键词：挥发性有机物典型工业谱库环境影响西安市

西安市冬季重污染过程VOCs污染特征及来源解析

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环境与发展 2024年第1期36卷 71-78页

作者：薛兴钊陈妙李顺姬曹泽磊杨檬西安市环境保护科学研究院陕西西安710062

基于西安市超级站重污染时段(2018年12月30日—2019年1月15日)在线连续观测数据,分析了两个污染过程(污染过程Ⅰ:2018年12月30日—2019年1月7日;污染过程Ⅱ:2019年1月8日—1月15日)VOCs特征、老化程度及日变化;利用正交矩阵因子分解法(P... 详细信息

基于西安市超级站重污染时段(2018年12月30日—2019年1月15日)在线连续观测数据,分析了两个污染过程(污染过程Ⅰ:2018年12月30日—2019年1月7日;污染过程Ⅱ:2019年1月8日—1月15日)VOCs特征、老化程度及日变化;利用正交矩阵因子分解法(PMF)解析了重污染期间VOCs来源;通过气溶胶生成系数法(FAC)估算了二次有机气溶胶(SOA)生成潜势。结果表明:污染过程Ⅰ和Ⅱ的体积分数分别为(102.87±31.62)×10^(-9)(、103.57±45.46)×10^(-9),含氧有机物和烷烃二者占比60%以上。与清洁天相比,炔烃的增幅最大,含氧有机物和烷烃增长值最大,烷/乙炔比值在1.0左右,受扩散条件不利影响导致气团老化严重,日变化呈夜高昼低,8时左右有个小高峰特征;PMF模型源解析结果显示VOCs主要来工业源(13.05%)、机动车尾气(27.49%)、溶剂使用源(15.64%)、化石燃烧源(21.38%)、餐饮源(22.43%);通过估算SOA生成潜势,得出芳香烃中的苯系物(BTEX)为SOA污染的主要物质。

关键词：重污染挥发性有机物(VOCs) 源解析二次有机气溶胶(SOA)

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碳氢火灾下钢桁-混凝土组合梁耐火试验研究

建筑结构学报 2024年第3期45卷 160-173页

作者：汤陈皓张岗李徐阳陆泽磊宋超杰王世超长安大学公路学院陕西西安710064

为研究钢桁-混凝土组合结构桥梁的耐火性能,开展了三榀简支下承式钢桁-混凝土组合模型梁的碳氢火灾试验。采集测点的时变温度,获得模型梁的温度场和传热模式;分析关键断面挠度变化规律和模型梁的破坏模式,揭示热-力耦合作用下的结构响... 详细信息

为研究钢桁-混凝土组合结构桥梁的耐火性能,开展了三榀简支下承式钢桁-混凝土组合模型梁的碳氢火灾试验。采集测点的时变温度,获得模型梁的温度场和传热模式;分析关键断面挠度变化规律和模型梁的破坏模式,揭示热-力耦合作用下的结构响应和破坏机理。研究结果表明:热-力耦合作用会使混凝土桥面板产生大量裂缝,并从中释放水蒸气,在裂缝较少的区域则会出现由于混凝土内部水蒸气压力过大导致的混凝土爆裂现象;混凝土板的隔火作用会使模型梁的温度场呈现出显著的分层现象,并在主桁斜杆高度方向上引起显著的温度梯度效应;横、纵梁下翼板会阻隔部分火焰,形成热辐射盲区,呈现出干扰式传热效应;模型梁的挠度历程可分为初增、缓增和急增3个阶段,当跨中挠度达到L/28后,难以持荷,可认为模型梁达到极限状态,表现为大挠度破坏;当外荷载水平降低10%、模型梁桁架高度增大25%时,分别可将耐火时间提高44.7%和33.3%。建立了经耐火试验验证的热-力-结构耦合数值分析模型,提出了针对钢桁-混凝土组合梁的四阶段损伤-破坏路径及其特征。

关键词：钢桁-混凝土组合梁碳氢火灾耐火试验数值模拟耐火性能

日本车用塑料回收再利用经验及其对我国的启示

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中国汽车 2024年第1期 17-22页

作者：金浩姜泽磊中国汽车技术研究中心有限公司天津300300

本文着眼于日本报废汽车塑料零部件回收再利用体系在政策推广的背景下的发展,围绕现状介绍对回收利用相关企业和终端消费者进行了阐述,并通过生命周期评价方法分析现状问题,最后结合中国的实际情况,对中国有效推动报废汽车回收提出建议。

关键词：回收再利用报废汽车塑料

多维度视角下社会组织政策的量化分析与优化研究

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郑州轻工业大学学报（社会科学版） 2024年第1期25卷 78-87页

作者：肖泽磊王烨罗来燕华中师范大学政治与国际关系学院湖北武汉430079 河北省人民代表大会常务委员会研究室河北石家庄050000

透过历史制度主义的视角对社会组织政策变迁的过程进行回顾和分析,有利于理顺社会组织的发展脉络与历史规律。基于此,本文从政策工具的研究视角,对改革开放以来国家层面的465份社会组织政策文本进行编码和量化分析,并结合政策要素与时... 详细信息

透过历史制度主义的视角对社会组织政策变迁的过程进行回顾和分析,有利于理顺社会组织的发展脉络与历史规律。基于此,本文从政策工具的研究视角,对改革开放以来国家层面的465份社会组织政策文本进行编码和量化分析,并结合政策要素与时间序列对社会组织政策变迁过程及各阶段的特征进行描述性统计,考察社会组织政策“反治理”现象,即规范性政策文种缺位、政策工具使用结构失衡、专门性和配套性政策不完善,以及新旧政策并行等,并在此基础上从协调政策结构、优化政策工具、均衡政策布局、加强顶层设计与基层指导四个方面提出相对应的针对性对策建议,以期为我国社会组织发展提供理论参考。

关键词：社会组织政策变迁政策工具政策文本

Annealing,solvation,and mirror-plating effects in phosphonium chloroaluminate ionic liquids

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Nano Research 2023年第2期16卷 3348-3357页

作者： zelei Zhang Atsushi Kitada Kazuhiro Fukami Kuniaki Murase Department of Materials Science and Engineering Kyoto UniversityKyoto 606-8501Japan Department of Chemical System Engineering The University of TokyoTokyo 113-8656Japan

The physicochemical properties of a specific ionic liquid(IL)are naturally considered to be constant at a given temperature.However,a series of eutectic melts of trihexyl(tetradecyl)phosphonium chloride([P6,6,6,14]Cl)with aluminum chloride(AlCl3)is an exception.The viscosity of Al_(2)Cl_(7)−-dominated[P6,6,6,14]Cl–AlCl_(3)ILs(i.e.,AlCl_(3)mole fraction x=0.60–0.67)gradually increased as a function of annealing.Annealing also influenced the ultraviolet–visible spectra,nuclear magnetic resonance spectra,and the glass transition temperature of the ILs.Such annealing-induced variations in physicochemical properties were not observed in the AlCl4−-and Cl−-dominated ILs.In particular,the ionic conductivities of the ILs(x=0.60–0.67)were strongly decoupled from their viscosities during annealing.Ab initio calculations revealed the bending of the long tetradecyl chains in[P6,6,6,14]+coupled with Al_(2)Cl_(7)−,while neither Cl−nor AlCl_(4)−caused bending.In general,[P6,6,6,14]+-based ILs are recognized as sponge-like structures that consist of nano-scale polar and non-polar domains.We propose a gradual structurization process in Al_(2)Cl_(7)−-dominated ILs to account for their unusual physicochemical properties.Moreover,the addition of tetradecane,solvated in the non-polar domains of the ILs,substantially reduced the viscosity of the structured IL with x=0.67.Mirror Al electroplating is possible without a brightener,using the x=0.67 ILs,regardless of annealing or the admixture of tetradecane.

关键词： ionic liquid physicochemical property ab initio calculation electrodeposition