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Metabolome and RNA-seq reveal discrepant metabolism and secretory metabolism profile in skeletal muscle between obese and lean pigs at different ages

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Science China Life Sciences 2025年

作者： Liu Guo Junfei Xu Wenyue Zhou Sisi Chen Hanjing Shi Mengmeng Han zekun yang Yehui Duan Weijun Pang Yulong Yin Fengna Li Laboratory of Animal Nutritional Physiology and Metabolic Process Key Laboratory of Agro-ecological Processes in Subtropical Region Institute of Subtropical Agriculture Chinese Academy of Sciences University of Chinese Academy of Sciences Laboratory of Animal Fat Deposition and Muscle Development College of Animal Science and Technology Northwest A&F University College of Advanced Agricultural Sciences University of Chinese Academy of Sciences

Metabolites and metabolism-related gene expression profiles in skeletal muscle change dramatically under obesity, aging and metabolic disease. Since obese and lean pigs are ideal models for metabolic research. Here, we compared metabolome and transcriptome of Longissimus dorsi(LD) muscle between Taoyuan black(TB, obese) and Duroc(lean) pigs at different ages. We defined the “window phase” of intramuscular fat(IMF) deposition in TB pig, which has significantly higher IMF than Duroc pig. Our results displayed discrepant lipid composition and different expression genes(DEGs) enriched in lipid metabolism, and both metabolome and transcriptome analyses revealed stronger energy expenditure and more active amino acid and protein metabolism in Duroc pig. 10 up-and 51 down-regulated biomarker metabolites with age-and breed-specificity were identified. Potential secretory metabolites, including organic acid(fumaric acid, succinate,malic acid, and gamma-aminobutyric acid), amino acid(L-lysine, and L-glutamic acid), lipid(2-hydroxyisovaleric acid, and L-carnitine) were demonstrated a significant correlation with IMF deposition. Our research highlights the huge difference of metabolic spectrum in skeletal muscle between obese and lean model and muscle-derived secretory metabolites might act as an ambassador of intercellular communication to regulate systematic metabolism.

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Energy partitioning and evapotranspiration in a black locust plantation on the Yellow River Delta,China

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Journal of Forestry Research 2022年第4期33卷 1219-1232页

作者： Xiang Gao Zhenyu Du Qingshan yang Jinsong Zhang Yongtao Li Xiaojie Wang Fengxue Gu Weiping Hao zekun yang Dexi Liu Jianmin Chu Key Laboratory of Tree Breeding and Cultivation of National Forestry and Grassland Administration Research Institute of ForestryChinese Academy of ForestryBeijing 100091People’s Republic of China Research Center for Coastal Forestry of National Forestry and Grassland Administration Beijing 100091People’s Republic of China Shandong Academy of Forestry Sciences Ji’nan 250014People’s Republic of China Forest Ecosystem Research Station of the Yellow River Delta in Shandong Dongying 257000People’s Republic of China Yellow River Delta Ecological Research Station of Coastal Wetland Yantai Institute of Coastal Zone ResearchChinese Academy of SciencesYantai 264003People’s Republic of China Key Laboratory of Dryland Agriculture of Ministry of Agriculture and Rural Aff airs Institute of Environment and Sustainable Development in AgricultureChinese Academy of Agricultural SciencesBeijing 100081People’s Republic of China

Plantations of woody tree species play a crucial role in ecological security along coastal *** energy partitioning and evapotranspiration can reveal land–atmosphere interaction *** investigated energy fluxes,evapotranspiration,and their related biophysical factors using eddy covariance techniques in a black locust(Robinia pseudoacacia L.)plantation in 2016,2018,and 2019 on the Yellow River *** longwave radiation offsets 84–85%of upward longwave radiation;upward shortwave radiation accounted for 12–13%of downward shortwave *** ratio of net radiation to downward radiation was 18–19%over the three *** the growing season,latent heat flux was the largest component of net radiation;during the dormant season,the sensible heat flux was the dominant component of net *** seasonal variation in daily evapotranspiration was mainly controlled by net radiation,air temperature,vapor pressure deficit,and leaf area *** locust phenology influenced daily evapotranspiration variations,and evapotranspiration was greater under sea winds than under land winds because soil water content at 10-cm depth was greater under sea winds during the *** patterns of daily evaporative fraction,Bowen ratio,crop coefficient,Priestley–Taylor coefficient,surface conductance,and decoupling coefficient were mainly controlled by leaf area *** threshold value of daily surface conductance was approximately 8 mm sover the plantation.

关键词： Black locust plantation Yellow River Delta Eddy covariance Energy partitioning Evapotranspiration

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Wearable multichannel-active pressurized pulse sensing platform Yunlong

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Microsystems & Nanoengineering 2024年第3期10卷 283-292页

作者： Zhao Qingxia Sun Shixuan Mei Libo Gao Xikuan Zhang zekun yang Xueli Nan Haiyan Zhang Chenyang Xue Junyang Li Pen-Tung Sah Institute of Micro-Nano Science and Technology Xiamen University361102 XiamenChina Discipline of Intelligent Instrument and Equipment Xiamen University361102 XiamenChina Department of Electronic Engineering Ocean University of China266000 QingdaoChina School of Automation and Software Engineering Shanxi University030006 TaiyuanChina Innovation Laboratory for Sciences and Technologies of Energy Materials of Fujian Province(IKKEM) 361005 XiamenChina Key Laboratory of Instrumentation Science and Dynamic Measurement Ministry of Education North University of China030051 TaiyuanChina Science and Technology on Vacuum Technology and Physics Laboratory Lanzhou Institute of PhysicsChinese Academy of Space Technology730000 LanzhouChina

With the modernization of traditional Chinese medicine(TCM),creating devices to digitalize aspects of pulse diagnosis has proved to be *** currently available pulse detection devices usually rely on external pressure devices,which are either bulky or poorly integrated,hindering their practical *** this work,we propose an innovative wearable active pressure three-channel pulse monitoring device based on TCM pulse diagnosis *** combines a flexible pressure sensor array,flexible airbag array,active pressure control unit,advanced machine learning approach,and a companion mobile application for human–computer *** to the high sensitivity(460.1 kPa^(−1)),high linearity(R^(2)>0.999)and flexibility of the flexible pressure sensors,the device can accurately simulate finger pressure to collect pulse waves(Cun,Guan,and Chi)at different external pressures on the *** addition,by measuring the change in pulse wave amplitude at different pressures,an individual’s blood pressure status can be successfully *** enables truly wearable,actively pressurized,continuous wireless dynamic monitoring of wrist pulse *** innovative and integrated design of this pulse monitoring platform could provide a new paradigm for digitizing aspects of TCM and other smart healthcare systems.

关键词： pulse diagnosis enable

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Nation always Upholds People-centered Rights

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International Understanding 2022年第3期 39-40页

作者： yang zekun China Daily

China has always upheld the people-centered perspective on human rights and takes the path to effectively meet the people’s ever-growing need for a better life,experts said at an online meeting on *** online meeting ... 详细信息

关键词： holds centered Rights

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Boron nitride-enabled printing of a highly sensitive and flexible iontronic pressure sensing system for spatial mapping

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Microsystems & Nanoengineering 2023年第3期9卷 209-219页

作者： zekun yang Qikai Duan Junbin Zang Yunlong Zhao Weihao Zheng Ran Xiao Zhidong Zhang Liangwei Hu Guirong Wu Xueli Nan Zengxing Zhang Chenyang Xue Libo Gao Key Laboratory of Instrumentation Science and Dynamic Measurement Ministry of Education North University of China030051 TaiyuanChina School of Automation and Software Engineering Shanxi University030006 TaiyuanChina Department of Mechanical and Electrical Engineering Xiamen University361102 XiamenChina School of Mechano-Electronic Engineering Xidian University710071 Xi’anChina Department of Mechanical Engineering City University of Hong Kong999077 KowloonHong Kong SAR

Recently,flexible iontronic pressure sensors(FIPSs)with higher sensitivities and wider sensing ranges than conventional capacitive sensors have been widely *** to the difficulty of fabricating the nanostructures that are commonly used on electrodes and ionic layers by screen printing techniques,strategies for fabricating such devices using these techniques to drive their mass production have rarely been ***,for the first time,we employed a 2-dimensional(2D)hexagonal boron nitride(h-BN)as both an additive and an ionic liquid reservoir in an ionic film,making the sensor printable and significantly improving its sensitivity and sensing range through screen *** engineered sensor exhibited high sensitivity(S_(min)>261.4 kPa^(−1))and a broad sensing range(0.05-450 kPa),and it was capable of stable operation at a high pressure(400 kPa)for more than 5000 *** addition,the integrated sensor array system allowed accurate monitoring of wrist pressure and showed great potential for health care *** believe that using h-BN as an additive in an ionic material for screen-printed FIPS could greatly inspire research on 2D materials for similar systems and other types of sensors.

关键词： printing system additive

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基于二阶相位补偿器的LCL型并网逆变器电容电流反馈有源阻尼策略

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太阳能学报 2024年第8期45卷 229-239页

作者：孙标广杨泽昆河南理工大学电气工程与自动化学院焦作454003 河南省煤矿装备智能检测与控制重点实验室焦作454003

在控制延时环节的影响下,并网逆变器系统出现了有效阻尼区域过窄的问题。鉴于此,提出在电容电流反馈支路中加入新型二阶相位超前补偿环节,补偿后电容电流反馈有源阻尼(CCFAD)的有效阻尼边界频率从f_(s)/6提高至0.34f_(s)。优化电容电流... 详细信息

在控制延时环节的影响下,并网逆变器系统出现了有效阻尼区域过窄的问题。鉴于此,提出在电容电流反馈支路中加入新型二阶相位超前补偿环节,补偿后电容电流反馈有源阻尼(CCFAD)的有效阻尼边界频率从f_(s)/6提高至0.34f_(s)。优化电容电流反馈系数的参数设计方法,并在离散域下分析所提控制策略的闭环极点轨迹。通过与已有策略仿真和实验结果的对比分析,结果表明在电网阻抗增加、滤波器参数宽范围波动的工况下,所提策略具有更高的鲁棒性。

关键词：延时并网逆变器补偿参数设计鲁棒性

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Model Predictive Control of Current with Fixed Switching Frequency on VEINNA Rectifier

Model Predictive Control of Current with Fixed Switching Fre...

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第32届中国控制与决策会议

作者： Xiping Huang zekun yang Guitao Chen Chen Xi School of Automation and Information Engineering Xi’an University of Technology

The model predictive control of current on finite control set（FCS-MPCC） on VIENNA rectifier can only output a single discrete voltage vector in one control *** switching frequency is variable,and the quality of the input current depends on the higher sampling *** solve these problems,a model predictive control of current with fixed switching frequency（FSF-MPCC） is ***,the reference voltage vector and its sector are calculated by the prediction *** the optimal voltage vector is predicted by the objective function and the finite set *** then,three voltage vectors are determined by combining the optimal voltage vector and the two basic vectors of the ***,the SVPWM algorithm is used to convert the three voltage vectors into the corresponding switching signals to realize the fixed switching frequency *** it can reduce the switching frequency and make the filter parameter design ***,the FSF-MPCC method can track the reference voltage vector more accurately and reduce the THD of the input *** simulation results has showed that the proposed method is feasible and effective.

关键词： VIENNA Rectifier Fixed Switching Frequency Model Predictive Control of Current SVPWM

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基于自适应变参数MPC的分布式驱动智能车轨迹跟踪控制

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机械工程学报 2024年第6期60卷 363-377页

作者：杨泽坤李韶华王振峰湖南大学机械与运载工程学院长沙410082 石家庄铁道大学省部共建交通工程结构力学行为与系统安全国家重点实验室石家庄050043 中汽研(天津)汽车工程研究院有限公司天津300300

为了协调分布式驱动智能驾驶车辆的轨迹跟踪精确性和稳定性,提高控制算法对车速扰动和路面附着系数变化等不确定性因素的自适应能力,基于平方根容积卡尔曼滤波(Square rooting cubature Kalman filter,SRCKF)估计轮胎侧向力以在线修正... 详细信息

为了协调分布式驱动智能驾驶车辆的轨迹跟踪精确性和稳定性,提高控制算法对车速扰动和路面附着系数变化等不确定性因素的自适应能力,基于平方根容积卡尔曼滤波(Square rooting cubature Kalman filter,SRCKF)估计轮胎侧向力以在线修正轮胎侧偏刚度,并基于T-S模糊变权重的MPC控制策略以实现轨迹跟踪控制。针对分布式驱动智能车全轮独立可控的特点,以前轮转角和各轮纵向驱动力为控制变量,以实时横向误差和横摆角误差为模糊输入,通过T-S模糊控制在线优化MPC目标函数权重,协调权重矩阵对轨迹跟踪精确性和稳定性的影响。通过仿真和试验数据,验证所提控制策略在多种工况下的有效性。研究表明,相比于传统MPC控制,所提出的自适应变参数MPC(Adaptive variable parameter MPC,AMPC)对80~120 km/h双移线湿滑路面、对接路面工况均有良好的跟踪效果,可有效提高轨迹跟踪精度,并能够协调控制跟踪精确性和稳定性,减少控制输出量的波动。

关键词：智能驾驶轨迹跟踪轮胎力估计分布式驱动工况自适应

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基于T-S模糊变权重MPC的智能车轨迹跟踪控制

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机械工程学报 2023年第4期59卷 199-212页

作者：李韶华杨泽坤王雪玮石家庄铁道大学省部共建交通工程结构力学行为与系统安全国家重点实验室石家庄050043 石家庄铁道大学机械工程学院石家庄050043

为了协调智能驾驶车辆的轨迹跟踪精确性和稳定性,提高控制算法对不同工况的自适应能力,提出基于Takagi-Sugeno模糊变权重模型预测控制(Takagi-Sugeno fuzzy model predictive control,T-S FMPC)的轨迹跟踪控制策略。以前轮转角为控制变... 详细信息

为了协调智能驾驶车辆的轨迹跟踪精确性和稳定性,提高控制算法对不同工况的自适应能力,提出基于Takagi-Sugeno模糊变权重模型预测控制(Takagi-Sugeno fuzzy model predictive control,T-S FMPC)的轨迹跟踪控制策略。以前轮转角为控制变量建立MPC控制,并以实时横向位移误差和横摆角误差为模糊输入,通过T-S模糊控制在线优化MPC目标函数权重,协调权重矩阵对轨迹跟踪精确性和稳定性的影响。基于Carsim建立分布式驱动电动汽车的整车动力学模型,基于Simulink建立控制策略,通过双移线工况仿真及实车试验,验证了所提控制策略的有效性。仿真结果表明,相比于传统MPC控制,所提出的T-S模糊变权重MPC控制可降低横向位移误差达62.24%,有效提高轨迹跟踪精度;并且可使前轮转角波动减小37.46%、横摆角误差减小84.19%,显著增强轨迹跟踪稳定性;试验结果表明,在20 km/h、沥青路面双移线工况下,横向位移误差在0.12 m以内,横摆角误差在1°以内,且前轮转角控制曲线平滑,说明所提算法具有良好的控制效果和实用性。

关键词：智能驾驶轨迹跟踪模型预测 T-S模糊工况自适应

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基于相空间三维动态稳定域的重型车辆稳定性控制策略研究

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汽车工程 2023年第4期45卷 637-646,597页

作者：康宇航李韶华杨泽坤石家庄铁道大学省部共建交通工程结构力学行为与系统安全国家重点实验室石家庄050043 湖南大学机械与运载工程学院长沙410082

重型商用车存在转动惯量大、控制响应慢等特点。针对重型商用车,基于质心侧偏角、横摆角速度、垂向载荷转移系数设计了三维相空间分析方法,从而判断车辆的实时稳定状态。针对不同的车辆行驶状态,采用AFS控制和AFS/DYC分级控制,并基于利... 详细信息

重型商用车存在转动惯量大、控制响应慢等特点。针对重型商用车,基于质心侧偏角、横摆角速度、垂向载荷转移系数设计了三维相空间分析方法,从而判断车辆的实时稳定状态。针对不同的车辆行驶状态,采用AFS控制和AFS/DYC分级控制,并基于利用附着系数设计了可拓控制方法,从而补偿前轮转角和横摆力矩的控制输出,以保证控制器在不同工况下的鲁棒性。通过TruckSim/Simulink联合仿真和硬件在环实验验证了该方法的有效性,并在仿真中通过B-ψ^(·)-LTR判断和B-ψ^(·)判断对比证明了相空间动态稳定域的优越性。仿真和实验结果表明:相比单纯以驾驶员意图操纵车辆,所设计的基于可拓H_(∞)的AFS/DYC分级控制策略可以保证车辆在不同工况下的稳定性,尤其在低附着路面上表现出更好的稳定性,可有效降低车辆在极端工况下发生交通事故的概率。

关键词：车辆操纵稳定性相平面分析输出反馈鲁棒H_(∞)控制动态边界可拓决策

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