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Contrast enhancement of vascular walls of intracranial high flow malformations in black blood MRI indicates high inflammatory activity

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Chinese Neurosurgical Journal 2018年第2期4卷 89-93页

作者： Athanasios K.Petridis Maxine Dibue-Adjei Jan F.Cornelius Marian Preetham Suresh Lan Li Marcel A.Kamp yousef Abusabha Bernd Turowski Hans Jakob Steiger Rebecca May Department of Neurosurgery Heinrich Heine UniversityDuesseldorfGermany LivaNova Deutschland GmbH(a LivaNova PLC-owned subsidiary) Lindberghstr 25D-80939 MunichGermany Diagnostic and Interventional Neuroradiology Heinrich Heine UniversityDuesseldorfGermany Department of Neurosurgery Niederrhein HospitalDuisburgGermany

Background: There are controversies concerning the natural history of arteriovenous malformations (AVMs) in literature and it is not clear which AVMs should be treated and which should be just observed. Objective criteria beyond growth in serial MRIs or angiographies are needed. The use of black blood MRI is currently under investigation for evaluating the rupture risk of cerebral aneurysms, however its use for assessment of AVMs has yet to be evaluated. We therefore conducted a feasibility study on the application of black blood MRI (bbMRI) in AVMs to assess rupture risk. Methods: Retrospective study of 10 patients with intracranial AVMs and 4 patients with arteriovenous fistulas who received a black blood MRI before treatment. Results: AVM niduses (9/10) show contrast enhancement irrespective of rupture or size. All arteriovenous fistulas (4/4) were contrast enhancing irrespective of rupture. Conclusion: High flow malformations are in a permanent stage of inflammation which does not seem to allow conclusions on their rupture risk at the current stage. BbMRI is a feasible method of identifying inflammation in AVMs and arteriovenous fistulas. However, future prospective studies are needed to evaluate whether bbMRI contrast enhancement correlates with rupture risk.

关键词： Arteriovenous malformation Arteriovenous fistula Black blood MRI Inflammation

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Effectiveness of hepatitis B virus vaccination program in Egypt:Multicenter national project

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World Journal of Hepatology 2015年第22期7卷 2418-2426页

作者： Iman I Salama Samia M Sami zeinab Nabil Ahmed Said Manal H El-Sayed Lobna A El Etreby Thanaa M Rabah Dalia M Elmosalami Amany T Abdel Hamid Somaia I Salama Aida M Abdel Mohsen Hanaa M Emam Safaa M Elserougy Amal I Hassanain Naglaa F Abd Alhalim Fatma A Shaaban Samia A Hemeda Nihad A Ibrahim Ammal M Metwally Community Medicine Research Department National Research Center Child Health Department National Research Center Micro--biology and Immunology Department Faculty of Medicine (for girls)Al-Azhar University Pediatrics Department Faculty of MedicineAin-Shams University Dermatology and Venereology Department National Research Center Environmental and Occupational Medicine Department National Research Center

AIM:To assess the effectiveness of hepatitis B virus(HBV) vaccination program among fully vaccinated ***:A national community based crosssectional study was carried out in 6 governorates representing Egypt. A total of 3600 children aged from 9 mo to 16 years who were fully vaccinated with HBV vaccine during infancy were recruited. Face to face interviews were carried out and sera were evaluated for hepatitis B surface antigen(HBsA g),anti-HBV core antibodies(total) and quantitative detection of hepatitis B surface antibody using enzyme linked immunoassays techniques. Samples positive to HBs Ag/anti-HBV core antibodies were subjected to quantitative HBV-DNA detection by real time polymerase chain reaction with 3.8 IU/L detection limit. RESULTS:Sero-protection was detected among 2059 children(57.2%) with geometric mean titers 75.4 ± 3.6 IU/L compared to 3.1 ± 2.1 IU/L among nonseroprotected children. Multivariate logistic analysis revealed that older age and female gender were the significant predicting variables for having non seroprotective level,with adjusted odds ratio 3.3,9.1and 14.2 among children aged 5 to 0.05. C ON C LU S I ON :T he E gy pt ian c ompuls or y H B V vaccination program provides adequate protection. Occult HBV infection exists among apparently healthy vaccinated children. Adherence to infection control measures is mandatory.

关键词： Hepatitis B virus Immunization Seroprotection Brea

2019版Bosniak分级：一项CT与MRI诊断效能比较的前瞻性研究

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国际医学放射学杂志 2023年第2期 246-247页

作者： Y.E.Almalki M.A.A.Basha R.Refaat S.K.Alduraibi A.A.E.H.M.Abdalla H.Y.yousef 李琼

摘要目的评价2019版CT和MRI Bosniak分级系统（BCv2019）的诊断准确性和一致性。方法该项前瞻性多机构研究共纳入63例病人，包括了由超声检查发现的67个复杂

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“进博会”——抓住中国与沙特阿拉伯经贸投资新机遇

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现代商业 2021年第3期 62-64页

作者：游赛夫上海大学经济学院上海200444

中沙建交始于1990年,同年正式开启了贸易往来,因为两国在外贸发展中具有互补性,中国作为能源消耗大国,需要沙特提供稳定的石油输入,而中国作为沙特外贸第一合作伙伴,其对于中国产品的需求也逐步扩大。近些年,随着中国经济发展逐步快中求... 详细信息

中沙建交始于1990年,同年正式开启了贸易往来,因为两国在外贸发展中具有互补性,中国作为能源消耗大国,需要沙特提供稳定的石油输入,而中国作为沙特外贸第一合作伙伴,其对于中国产品的需求也逐步扩大。近些年,随着中国经济发展逐步快中求稳,在外贸投资上更为注重合作共赢理念,而“进博会”作为契机,分析和借助中沙经贸投资的影响因素,有效的开启了中沙之间的又一轮外贸投资新机遇。

关键词：经贸投资中沙贸易进博会对外贸易

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联合CT和MRI方案是否提高了LI-RADS在肝脏观察分类中的诊断效能?

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国际医学放射学杂志 2018年第4期 498-499页

作者： M.A.A.Basha M.Z.Al Azzazy A.F.Ahmed H.Y.yousef S.M.Shehata D.A.E.A.EI Sammak 吴迪 Department of Diagnostic Radiology Zagazig UniversityDepartment of Tropical MedicineZagazig UniversityDepartment of Clinical OncologyZagazig UniversityDepartment of PathologyZagazig University

目的参考LI-RADS分类系统,比较CT、MRI和联合CT/MRI的诊断性能和一致性,以对超声筛查期间肝脏病人的肝脏观察结果进行分类。方法 240例病人在超声监测过程中检测到296项肝脏观察结果,对其进行肝脏CT和MRI检查、组织病理学检查以及临床... 详细信息

目的参考LI-RADS分类系统,比较CT、MRI和联合CT/MRI的诊断性能和一致性,以对超声筛查期间肝脏病人的肝脏观察结果进行分类。方法 240例病人在超声监测过程中检测到296项肝脏观察结果,对其进行肝脏CT和MRI检查、组织病理学检查以及临床和放射学随访。由6名放射科医师使用LI-RADS 2014版本独立评估观察结果,并使用CT、MRI和联合CT/MRI为每项观察指定一个LIRADS分类。结果 LI-RADS联合CT和MRI诊断肝癌的准确度(91.29%)、敏感度(90.71%)和特异度(92.31%)比单独的MRI或CT更好;MRI的准确度、敏感度和特异度分别下降到85.37%、86.34%和83.65%,CT的分别下降到67.6%、54.10%和91.35%。CT、MRI和联合CT/MRI之间LI-RADS评分的内分类结果良好[κ=0.9624(95%CI:0.9318～0.9806)]。结论 CT和MRI可以相互补充。联合CT/MRI能够更精确地确定肝脏观察的LI-RADS类别。但是,考虑额外费用增加,组合方法仅适用于疑似HCC病例。

关键词： MRI LI-RADS CT

Injury Pattern among Road Traffic Accidents’ Victims in Najran City, Saudi Arabia

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International Journal of Clinical Medicine 2018年第4期9卷 270-280页

作者： Mahdi Yahya Al-Zamanan Abdullah Saleh Al-Yami Ali Abdullah Al-Najrani Mansour yousef Al-Asmari Abdulrahman Alamri Manaa Awad Mohammed Al-Qahtani Mohammed Helmy Faris Shalayel Abdulhadi Mohamed Elbashir Saeed Ali Alsareii College of Medicine Najran University Najran Saudi Arabia Department of Surgery College of Medicine Najran University Najran Saudi Arabia Department of Surgery College of Medicine Najran University Najran Saudi Arabia Department of Family and Community Medicine College of Medicine Najran University Najran Saudi Arabia

Traffic accidents constitute the substantial cause of disability and mortality in the young Saudi individuals reaching horrible figures. The aim of this study was to review and identify the pattern of injury among road traffic accident (RTA) victims as well as the peak time of accidents and their implications. This retrospective hospital-based cross-sectional study was carried out in the period between April 2016 to March 2017 in King Khalid Hospital, Maternity and Children Hospital and Najran General Hospital, Najran, Saudi Arabia. All RTA victims admitted to the emergency departments of the pre-mentioned hospitals. Data collected from 435 Saudis and non-Saudis’ files were statistically analyzed with regard to age, gender, the timing of road traffic accidents, injury pattern, and neurological deficits incidence. Most of the RTAs’ cases (92%) were male victims with the highest peak in the age group 20 - 29 years. 58% of the RTAs happened in the evening (6:00 PM-9:00 PM) while 20% occurred in the morning. Head injury represented the most frequent pattern (36%) followed by the spinal injury (23%), lower limb injury (23%), upper limb injury (20%), thoracic injury (17%), pelvic injury and abdominal injury (8%). 4.4% of RTAs resulted in death whilst 9% of cases experienced neurological deficits. In conclusion, young male drivers in Najran recorded the highest frequency of RTAs. Initiation of road safety education and expansion of speed detectors (Saher) system deployment is highly recommended.

关键词： Road Traffic Accidents (RTA) Road Traffic Injuries (RTIs) Disability

Role of Vascular Endothelial Growth Factor-C during Stem Cell Therapy Using Autologous Bone Marrow Mononuclear Cells in Patients with Lower Limb Lymphedema

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Stem Cell Discovery 2023年第1期13卷 1-16页

作者： Ahmed M. Ismail Said M. Abdou Amira yousef Yousra Sameh M. Attia Ahmed Badran Mohamed I. Adel El Eissawy Asmaa E. Bedeer Wesam M. Salama Ahmed O. Korany Vascular Surgery Department Faculty of Medicine Tanta University Tanta Egypt Clinical Pathology Department Faculty of Medicine Tanta University Tanta Egypt Pathology Department Faculty of Medicine Tanta University Tanta Egypt Faculty of Science Tanta University Tanta Egypt Vascular Surgery Department Alexandria University Alexandria Egypt

Introduction: Vascular endothelial growth factor-C (VEGF-C) is the primary lymphangiogenic factor that stimulates lymphangiogenesis by signaling via specific receptor, vascular endothelial growth factor receptor 3 (VEGFR3). This study was conducted to evaluate the change in the level of VEGF-C before and after autologous bone marrow mononuclear cell transplantation for treatment of Lower limb lymphedema. Patient and methods: Forty patients with lower limb lymphedema were divided into two groups. Group I included 20 patients with chronic lower limb lymphedema who underwent autologous bone marrow mononuclear cell transplantation. Group II included 20 patients with chronic lower limb lymphedema who were exposed only to compression therapy as a control group. VEGF-C level in the diseased limbs was measured in both groups at the beginning of the study then 3 and 6 months respectively. Results: Group I included 20 patients, 8 patients were male (40%) and 12 patients were females (60%) with mean age 29.5 ± 12.15 while group II included 20, 10 patients were male (50%) and 10 patients were females (50%) with mean age 39.5 ± 11.5. In group I, the specimens were taken at 3 and 6 months after transplantation showed a marked decrease in the VEGF-C level with statistically significant p value, 0.02 and 0.001 respectively. In group II the level of VEGF-C after compression therapy alone at 3 and 6 months interval showed fluctuation with statistically non-significant p value, 0.64 and 0.55 respectively. Conclusion: VEGF-C is essential for regulation of lymphangiogenesis. The level of VEGF-C was found elevated in patients with lymphedema and decrease after autologous mononuclear bone marrow cells, however these results were statically non-significant.

关键词： Lymphangiogenesis VEGF-C Bone Marrow Mononuclear Cells

Exome sequencing identifies a likely causative variant in 53%of families with ciliopathy-related features on renal ultrasound after excluding NPHP1 deletions

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Genes & Diseases 2024年第5期11卷 40-43页

作者： Konstantin Deutsch Verena Klambt Thomas M.Kitzler Tilman Jobst-Schwan Ronen Schneider Florian Buerger Steve Seltzsam Sherif El Desoky Jameela A.Kari Farkhanda Hafeez Maria Szczepanska Loai A.Eid Hazem S.Awad Muna Al-Saffar Neveen A.Soliman Velibor Tasic Camille Nicolas-Frank Kirollos yousef Luca M.Schierbaum Sophia Schneider Abdul Halawi Izzeldin Elmubarak Katharina Lemberg Shirlee Shril Shrikant M.Mane Nancy Rodig Friedhelm Hildebrandt Division of Nephrology Department of PediatricsBoston Children’s HospitalHarvard Medical SchoolBostonMA 02215USA Department of Pediatric Gastroenterology Nephrology and Metabolic DiseasesCharite Universitatsmedizin BerlinBerlin 13353Germany Berlin Institute of Health at Charitee Universitatsmedizin Berlin BIH Biomedical Innovation AcademyBIH Charite Clinician Scientist ProgramBerlin 10178Germany Department of Nephrology and Hypertension FriedrichAlexander-Universitat Erlangen-NurnbergErlangen 91054Germany Department of Pediatrics Faculty of Medicine King Abdulaziz UniversityPediatric Nephrology Center of ExcellenceKing Abdulaziz University HospitalJeddah 21589Saudi Arabia Department of Pediatric Nephrology The Children’s Hospital and Institute of Child HealthLahore 54000Pakistan Department of Pediatrics Faculty of Medical Sciences in ZabrzeMedical University of Silesia in KatowiceKatowice 40-752Poland Dubai Hospital and Al-Jalila Children’s Specialty Hospital Kidney Center of ExcellenceDubai 4545United Arab Emirates Department of Genetics and Genomics UAE UniversityAbu Dhabi 15551United Arab Emirates Department of Pediatrics Division of Genetics and GenomicsBoston Children’s HospitalHarvard Medical SchoolBostonMA 02215USA Department of Pediatrics Center of Pediatric Nephrology and TransplantationKasr Al Ainy School of MedicineCairo UniversityCairo 11562Egypt Egypt Center for Research and Regenerative Medicine(ECRRM) Cairo 11511Egypt Medical Faculty Skopje University Children’s HospitalSkopje 1000North Macedonia Department of Genetics Yale University School of MedicineNew HavenCT 06520USA

Nephronophthisis-related ciliopathies(NPHP-RC)represent one of the most common causes of chronic kidney disease in the first three decades of life and are characterized by a broad genetic and clinical heterogeneity.1 To date,more than 90 genes have been identified that cause autosomalrecessive NPHP-RC if mutated,accounting for up to 60%of cases.1 Among these,homozygous deletions of NPHP1 are the most common *** genes localize to primary cilia,basal bodies,or the centrosome and lead to a primary ciliary disruption if mutated,thereby causing a broad phenotypical spectrum.1 Patients that suffer from NPHP-RC can either have an isolated renal phenotype,such as polyuria,polydipsia,decreased urinary concentration ability,and secondary enuresis due to loss of tubular function,or present with extrarenal symptoms including retinal degeneration,cerebellar vermis hypoplasia,or hepatic *** are often diagnosed in early adolescence,reaching end-stage renal disease before 25 years of age,but early onset and rapidly progressive forms of NPHP-RC also exist.1 Renal ultrasound indicates kidneys of normal or reduced renal length with increased echogenicity and corticomedullary cysts.

关键词： degeneration urinary likely

用原位杂交法检测肠道病毒基因组同源性的研究

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空军军医大学学报 1987年第3期 182-183页

作者：张红毅,汪美先,姜绍谆,yousef G,Mowbray J F,Mann G 第四军医大学微生物学教研室第四军医大学微生物学教研室第四军医大学微生物学教研室伦敦大学圣玛丽医院医学院伦敦大学圣玛丽医院医学院伦敦大学卫生与热带病医学院

人类肠道病毒属于微小RNA病毒科,包括脊髓灰质炎病毒(PV)、柯萨奇A组(CAV)、B组病毒(CBV),埃可病毒(EV)4组病毒和肠道病毒68-72型。72型为肠道病毒的新成员甲型肝炎病毒(HAV)。肠道病毒是一组与人类多种疾病密切相关较为复杂的病毒。属... 详细信息

人类肠道病毒属于微小RNA病毒科,包括脊髓灰质炎病毒(PV)、柯萨奇A组(CAV)、B组病毒(CBV),埃可病毒(EV)4组病毒和肠道病毒68-72型。72型为肠道病毒的新成员甲型肝炎病毒(HAV)。肠道病毒是一组与人类多种疾病密切相关较为复杂的病毒。属内各组病毒基因同源关系尚未完全清楚。而HAV与传统肠道病毒的

关键词：原位杂交基因组肠道病毒探针柯萨奇病毒B组甲型肝炎病毒