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Status of hepatitis C virus vaccination:Recent update

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World Journal of Gastroenterology 2016年第2期22卷 862-873页

作者： kouka saadeldin abdelwahab zeinab nabil ahmed said Department of Microbiology and Immunology Faculty of Medicine(for girls)Al-Azhar UniversityCairo 11435Egypt

Hepatitis C virus(HCV) infection is still a major public health problem worldwide since its first identification in 1989. At the start, HCV infection was post-transfusion viral infection, particularly in developing countries. Recently, due to iv drug abuse, HCV infection became number one health problem in well-developed countries as well. Following acute HCV infection, the innateimmune response is triggered in the form of activated coordinated interaction of NK cells, dendritic cells and interferon α. The acquired immune response is then developed in the form of the antibody-mediated immune response(ABIR) and the cell-mediated immune response(CMIR). Both are responsible for clearance of HCV infection in about 15% of infected patients. However, HCV has several mechanisms to evade these antivirus immune reactions. The current review gives an overview of HCV structure, immune response and viral evasion mechanisms. It also evaluates the available preventive and therapeutic vaccines that induce innate, ABIR, CMIR. Moreover, this review highlights the progress in recent HCV vaccination studies either in preclinical or clinical phases. The unsatisfactory identification of HCV infection by the current screening system and the limitations of currently available treatments, including the ineligibility of some chronic HCV patients to such antiviral agents, mandate the development of an effective HCV vaccine.

关键词： Hepatitis C Viral envelope glycoproteins Immune response Hepatitis C virus vaccine Clinicaltrials

Evaluation of urea breath test as a diagnostic tool for Helicobacter pylori infection in adult dyspeptic patients

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World Journal of Gastroenterology 2024年第17期30卷 2302-2307页

作者： zeinab nabil ahmed said Asmaa Mohamed El-Nasser Department of Medical Microbiology&Immunology Faculty of Medicine for Girls Al-Azhar UniversityNasr City 11754CairoEgypt

In this editorial,we discuss the article in the World Journal of *** article conducts a meta-analysis of the diagnostic accuracy of the urea breath test(UBT),a non-invasive method for detecting Helicobacter pylori(***)infection in *** is based on radionuclide-labeled *** methods,both invasive and non-invasive,are available for diagnosing *** infection,inclu-ding endoscopy with biopsy,serology for immunoglobulin titers,stool antigen analysis,and *** guidelines recommend UBTs as the primary choice for diagnosing *** infection and for reexamining after eradication *** is used to be the first choice non-invasive test due to their high accuracy,specificity,rapid results,and ***,its performance remains unaffected by the distribution of *** in the stomach,allowing a high flow of patients to be *** its widespread use,the performance characteristics of UBT have been inconsistently described and remain incompletely *** are two UBTs available with Food and Drug Administration approval:The 13C and 14C *** tests are affordable and can provide real-time *** may prefer the 13C test because it is non-radioactive,compared to 14C which uses a radioactive isotope,especially in young children and pregnant *** there was heterogeneity among the studies regarding the diagnostic accuracy of both UBTs,13C-UBT consistently outperforms the *** makes the 13C-UBT the preferred diagnostic ***,the provided findings of the meta-analysis emphasize the significance of precise considerations when choosing urea dosage,assessment timing,and measurement techniques for both the 13C-UBT and 14C-UBT,to enhance diagnostic precision.

关键词： Helicobacter pylori Urea breath test Diagnosis Diagnostic test accuracy Meta-analysis

Challenge of managing hepatitis B virus and hepatitis C virus infections in resource-limited settings

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World Journal of Hepatology 2022年第7期14卷 1333-1343页

作者： zeinab nabil ahmed said Manal Hamdy El-Sayed Department of Microbiology&Immunology Faculty of Medicine for Girls Al-Azhar UniversityCairoEgypt Department of Pediatrics Faculty of MedicineAin Shams UniversityCairoEgypt

The global burden of hepatitis B virus(HBV)and hepatitis C virus(HCV)infections and coinfection represents a major public health concern,particularly in resource-limited *** of HCV by 2030 has become foreseeable,with effective direct-acting antiviral oral therapies and the availability of affordable generics in low-and-middle-income countries(LMICs).However,access to oral nucleos(t)ide therapy for HBV remains critical and is limited outside the existing global HIV program platforms despite affordable *** of mother-to-child transmission of HBV through scaling up of birth dose implementation in LMICs is essential to achieve the 2030 elimination *** individuals living with HBV and/or HCV in resource-limited settings are unaware of their infection,and with improved access to medications,the most significant barrier remains access to affordable diagnostics and preventive *** coronavirus disease 2019 pandemic interrupted hepatitis elimination programs,albeit offered opportunities for improved diagnostic capacities and raised political awareness of the critical need for strengthening health care services and universal health *** review underpins the HBV and HCV management challenges in resource-limited settings,highlighting the current status and suggested future elimination strategies in some of these *** efforts should continue to improve awareness and political *** resources should be secured to access and implement comprehensive strategies for diagnosis and linkage to care in resource-constrained settings to fulfill the 2030 elimination goal.

关键词： Hepatitis B virus/hepatitis C virus Chronic hepatitis Resource-limited settings HBV and HCV elimination

COVID-19-induced transaminitis and hyperbilirubinemia:Presentation and outcomes

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World Journal of Gastroenterology 2023年第7期29卷 1123-1130页

作者： zeinab nabil ahmed said Safinaz Adel El Habashy Samy Zaky ESCMID Study Group for Viral Hepatitis Department of Medical Microbiology and Immunology Faculty of Medicine(For Girls)Al-Azhar UniversityCairo 11754Nasr CityEgypt Department of Pediatrics Ain Shams UniversityCairo 11391AbbaseiaEgypt Department of Hepato-gastroenterology and Infectious Diseases Faculty of Medicine(For Girls)Al-Azhar UniversityCairo 11754Egypt 不详

The risk of liver injury in patients with coronavirus disease 2019(COVID-19)infection is quite ***,liver function test abnormalities are still detected in COVID-19 patients despite the development of antivirals and the availability of several types of *** editorial describes liver involvement during COVID-19 infection in patients with or without preexisting liver injury,such as chronic liver disease,to elucidate COVID-19-induced liver function abnormalities and their severity,pathophysiology,clinical manifestations,and clinical and laboratory *** also discuss the effect of vaccination against COVID-19 to better understand host factors,such as age,gender,and race,on the incidence and severity of liver dysfunction at initial presentation and during the ***,we summarize the results of relevant meta-analyses published to date and highlight the importance of adequate liver function monitoring in the current climate of the overwhelming COVID-19 pandemic.

关键词： COVID-19 SARS-CoV-2 Liver injury Transaminases Hyperbilirubinemia Pathophysiology

Induced immunity against hepatitis B virus

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World Journal of Hepatology 2015年第12期7卷 1660-1670页

作者： zeinab nabil ahmed said Kouka Saadeldin Abdelwahab Department of Microbiology and Immunology Faculty of Medicine (for girls) Al-Azhar University

Prevention of hepatitis B virus(HBV) infection with its consequent development of HBV chronic liver disease and hepatocellular carcinoma is a global mandatory goal. Fortunately, safe and effective HBV vaccines are currently available. Universal hepatitis B surface antigen HBV vaccination coverage is almost done. Growing knowledge based upon monitoring and surveillance ofHBV vaccination programs has accumulated and the policy of booster vaccination has been evaluated. This review article provides an overview of the natural history of HBV infection, immune responses and the future of HBV infection. It also summarizes the updated sources, types and uses of HBV vaccines, whether in the preclinical phase or in the post-field vaccination.

关键词： Hepatitis B surface antigen Hepatitis Bvirus vaccines Immunological memory Hepatitis Bvirus Booster and therapeutic vaccination

Effectiveness of hepatitis B virus vaccination program in Egypt:Multicenter national project

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World Journal of Hepatology 2015年第22期7卷 2418-2426页

作者： Iman I Salama Samia M Sami zeinab nabil ahmed said Manal H El-Sayed Lobna A El Etreby Thanaa M Rabah Dalia M Elmosalami Amany T Abdel Hamid Somaia I Salama Aida M Abdel Mohsen Hanaa M Emam Safaa M Elserougy Amal I Hassanain Naglaa F Abd Alhalim Fatma A Shaaban Samia A Hemeda Nihad A Ibrahim Ammal M Metwally Community Medicine Research Department National Research Center Child Health Department National Research Center Micro--biology and Immunology Department Faculty of Medicine (for girls)Al-Azhar University Pediatrics Department Faculty of MedicineAin-Shams University Dermatology and Venereology Department National Research Center Environmental and Occupational Medicine Department National Research Center

AIM:To assess the effectiveness of hepatitis B virus(HBV) vaccination program among fully vaccinated ***:A national community based crosssectional study was carried out in 6 governorates representing Egypt. A total of 3600 children aged from 9 mo to 16 years who were fully vaccinated with HBV vaccine during infancy were recruited. Face to face interviews were carried out and sera were evaluated for hepatitis B surface antigen(HBsA g),anti-HBV core antibodies(total) and quantitative detection of hepatitis B surface antibody using enzyme linked immunoassays techniques. Samples positive to HBs Ag/anti-HBV core antibodies were subjected to quantitative HBV-DNA detection by real time polymerase chain reaction with 3.8 IU/L detection limit. RESULTS:Sero-protection was detected among 2059 children(57.2%) with geometric mean titers 75.4 ± 3.6 IU/L compared to 3.1 ± 2.1 IU/L among nonseroprotected children. Multivariate logistic analysis revealed that older age and female gender were the significant predicting variables for having non seroprotective level,with adjusted odds ratio 3.3,9.1and 14.2 among children aged 5 to 0.05. C ON C LU S I ON :T he E gy pt ian c ompuls or y H B V vaccination program provides adequate protection. Occult HBV infection exists among apparently healthy vaccinated children. Adherence to infection control measures is mandatory.

关键词： Hepatitis B virus Immunization Seroprotection Brea

Diagnosis and management of choledochal cyst: 20 years of single center experience

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World Journal of Gastroenterology 2014年第22期20卷 7061-7066页

作者： nabil Gadelhak ahmed Shehta Hosam Hamed Department of Surgery Gastrointestinal Surgical CenterMansoura UniversityManoura 35516DakahleyyaEgypt

We report the first case series from Africa and the Middle East on choledochal cyst, a disease which shows significant geographical distribution with high incidence in the Asian population. In this study, the epidemiological data of the patients are presented and analyzed. Attention was paid to diagnostic imaging and its accuracy in the diagnosis and classification of choledochal cyst. Most cases of choledochal cyst disease have type I and IV-A cysts according to the Todani classification system, which support the etiological theories of choledochal cyst, especially Babbitt’s theory of the anomalous pancreaticobiliary duct junction, which are clearly stated. The difficulties and hazards of surgical management and methods used to avoid operative complications are clarified. Early and late postoperative complications are also included. This study should be followed by multicenter studies throughout Egypt to help assess the incidence of choledochal cysts in one of the largest populations in Africa and the Middle East.

关键词： Choledochal cyst Hepatic cyst Hepaticojejunostomy Caroli disease Hepatectomy

Swarming Behavior of Harris Hawks Optimizer for Arabic Opinion Mining

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Computers, Materials & Continua 2021年第12期69卷 4129-4149页

作者： Diaa Salam Abd Elminaam nabil Neggaz Ibrahim Abdulatief ahmed ahmed El Sawy Abouelyazed Department of Information Systems Faculty of Computers and Artificial IntelligenceBenha University12311Egypt Department of Computer Science Faculty of Computer ScienceMisr International UniversityEgypt Universite des Sciences at de la Technologie d’Oran Mohamed Boudiaf USTO-MBBP 1505EL M’naouer31000 OranLaboratoire Signal Image Parole(SIMPA)Department d’informatiqueFaculte des Mathematiques et InformatiqueAlgerie Department of Computer Science Faculty of Computers and Artificial IntelligenceBenha University12311Egypt Department of Computer Science Obour High Institute for Computers and InformaticsEgypt

At present,the immense development of social networks allows generating a significant amount of textual data,which has facilitated researchers to explore the field of opinion *** addition,the processing of textual opinions based on the term frequency-inverse document frequency method gives rise to a dimensionality *** study aims to detect the nature of opinions in the Arabic language employing a swarm intelligence(SI)-based algorithm,Harris hawks algorithm,to select the most relevant *** experimental study has been tested on two datasets:Arabic Jordanian General Tweets and Opinion Corpus for *** terms of accuracy and number of features,the results are better than those of other SI based algorithms,such as grey wolf optimizer and grasshopper optimization algorithm,and other algorithms in the literature,such as differential evolution,genetic algorithm,particle swarm optimization,basic and enhanced whale optimizer algorithm,slap swarm algorithm,and ant–lion optimizer.

关键词： Arabic opinion mining Harris hawks optimizer feature selection AJGT and OCA datasets

Machine learning-supported seismic stratigraphy of the Paleozoic Nubia Formation(SW Gulf of Suez-rift):Implications for paleoenvironmentpetroleum geology of a lacustrine-fan delta

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Petroleum 2023年第2期9卷 301-315页

作者： Mohammad A.Abdelwahhab nabil A.Abdelhafez ahmed M.Embabi Geology Department Faculty of ScienceAl-Azhar UniversityNasr CityCairoEgypt

Steeply dipping prograding fan deltas possess high reservoir quality facies that could be excellent targets while exploring for *** to their complex stacking nature,and limited examples,delineating their architectural elements is still *** this paper we mainly performed sedimentary facies analysis;applying various disciplines *** stratigraphy,seismic stratigraphy,GR-log motifs,and seismic waveform segmentation;so as to adequately depict the reservoir heterogeneity and quality of the Paleozoic Nubia clastics in West Esh El Mallaha Concession(southwest Gulf of Suez rift).Organic maturity prediction,to confirm the hydrocarbon charging from source units to reservoir intervals,was also of most importance in this ***,1D basin model was established to define the past geologic events;subsidence,and thermal maturity;and their controls on sedimentary basin evolution and associated petroleum *** utilized several key-information scales;*** logs,and seismic *** different disciplines applied in this study points to a successful integrated reservoir characterization workflow capable of unfolding ancient environments and the associated hydrocarbon *** results show that Nubia Formation was built during the lowstandtransgressive phase of a 3rd order depositional *** encompasses fluvio-lacustrine system with eight sedimentary facies associations;form source to *** channels and mouth bars,settled in subaerial and subaqueous settings respectively,represent the most significant reservoir facies in the *** best hydrocarbon-reservoir quality,the deltaic mouth bars ought to attract attention of further oilfield development plans and be considered while investigating similar settings.

关键词： Seismic stratigraphy Nubia formation Paleoenvironment Petroleum geology West Esh El Mallaha concession Gulf of Suez