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Nanomaterials based flexible devices for monitoring and treatment of cardiovascular diseases(CVDs)

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Nano Research 2023年第3期16卷 3939-3955页

作者： zehua xiang Mengdi Han Haixia Zhang National Key Laboratory of Science and Technology on Micro/Nano Fabrication Beijing Advanced Innovation Center for Integrated CircuitsSchool of Integrated CircuitsPeking UniversityBeijing 100871China Academy for Advanced Interdisciplinary Studies Peking UniversityBeijing 100871China Department of Biomedical Engineering College of Future TechnologyPeking UniversityBeijing 100871China

Cardiovascular diseases(CVDs)are one of the most serious diseases threatening human health in the world.Therefore,effective monitoring and treatment of CVDs are urgently needed.Compared with traditional rigid devices,nanomaterials based flexible devices open up new opportunities for further development beneficial from the unique properties of nanomaterials which contribute to excellent performance to better prevent and treat CVDs.This review summarizes recent advances of nanomaterials based flexible devices for the monitoring and treatment of CVDs.First,we review the outstanding characteristics of nanomaterials.Next,we introduce flexible devices based on nanomaterials for practical use in CVDs including in vivo,ex vivo,and in vitro methods.At last,we make a conclusion and discuss the further development needed for nanomaterials and monitoring and treatment devices to better care CVDs.

关键词： cardiovascular diseases(CVDs) monitoring treatment nanomaterials flexible devices

Erratum to:Nanomaterials based flexible devices for monitoring and treatment of cardiovascular diseases(CVDs)

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Nano Research 2023年第5期16卷 8051-8051页

Instead of 1 National Key Laboratory of Science and Technology on Micro/Nano Fabrication,School of Integrated Circuits,Peking University,Beijing 100871,China.

关键词： treatment materials Peking

Platinum nickel alloy-MXene catalyst with inverse opal structure for enhanced hydrogen evolution in both acidic and alkaline solutions

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Nano Research 2023年第1期16卷 195-201页

作者： Wei kong Lihong Li Xiaoxia Yu Zhongyuan xiang Yawei Cao Muhammad Tahir zehua Lu Jinxia Deng Yanlin Song Key Laboratory of Green Printing CAS Research/Education Centre for Excellence in Molecular SciencesInstitute of Chemistry Chinese Academy of Sciences(ICCAS)Beijing 100190China School of Chemistry and Biological Engineering University of Science and Technology BeijingBeijing 100083China State Key Laboratory of Digital Manufacturing Equipment and Technology Huazhong University of Science and TechnologyWuhan 430074China

The development of an efficient Pt-based electrocatalyst in acidic and alkaline electrolytes is of great significance to the field of electrocatalytic hydrogen evolution.Herein,we report a strategy for in situ growth of Pt_(3)Ni truncated octahedrons on Ti3C2Tx nanosheets and then obtain an ordered porous catalyst via a template method.Meanwhile,we use the finite element calculation to clarify the relationship between the component structure and performance and find that the performance of the spherical shell microstructure catalyst is higher than that of the disc structure catalyst,which is also verified by experiments.The experimental analysis shows that the ordered porous catalyst is conducive to enhancing electrocatalytic hydrogen evolution activity in acidic and alkaline electrolytes.In an acidic solution,the overpotential is 25 mV(10 mA·cm^(−2)),and the Tafel slope is 22.86 mV·dec−1.In an alkaline solution,the overpotential is 44.1 mV(10 mA·cm^(−2)),and the Tafel slope is 39.06 mV·dec−1.The synergistic coupling between Ti3C2Tx and Pt_(3)Ni nanoparticles improves the stability of the catalyst.The in situ growth strategy and design of microstructure with its correlation with catalytic performance represent critical steps toward the rational synthesis of catalysts with excellent catalytic activity.

关键词： hydrogen evolution reaction MXene Pt_(3)Ni truncated octahedrons ordered porous structures

Local delivery of superagonist gene based on polymer nanoparticles for cancer immunotherapy

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Chinese Chemical Letters 2023年第3期34卷 356-360页

作者： zehua Hong Xin Zan Ting Yu Yuzhu Hu Hongfeng Gou Songping Zheng xiang Gao Peizhi Zhou Department of Neurosurgery and Institute of Neurosurgery State Key Laboratory of Biotherapy and Cancer CenterWest China HospitalWest China Medical SchoolSichuan UniversityChengdu 610041China

Cancer is the leading cause that threatens human life expectancy due to the lack of effective therapies.Cancer immunotherapy has been explored to improve the body's immune system against cancer and accompanied by promising results in recent years.Interleukin 15(IL-15),a pleiotropic immunomodulator,is critical for immune cells development and displays great anti-tumor potential in both preclinical and clinical trials.In this study,superagonist IL-15 plasmid(psIL-15)consisting of IL-15Rα-sushi-linker-IL-15 was constructed in order to secret superagonist IL-15(sIL-15)in tumor site.A gene delivery system through self-assembly by methylated polyethylene glycol-b-polylactic acid-b-methylated polyethylene glycol(m PEG-PLA-m PEG)and 1,2-dioleoyl-3-trimethylammonium-propane(DOTAP),named DMAM,was designed to deliver psIL-15.Further study showed that DMAM/psIL-15 could successfully deliver psIL-15 to tumor cells and the supernatants of the tumor cells could further stimulate lymphocytes proliferation as well as activation in vitro.Local delivery of DMAM/psIL-15 in animal models demonstrated significant tumor inhibition through enhancing immune cells responses,reducing angiogenesis,promoting tumor cell apoptosis and inhibiting proliferation,with no evidence of system toxicities.These results indicate that DMAM/psIL-15 may be a promising strategy for cancer immunotherapy.

关键词： IL-15 Immunotherapy Gene therapy Nanoparticles Tumor

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枯竭油藏型储气库库容量化室内实验研究

非常规油气 2024年第4期11卷 89-96页

作者：丁洋洋秦正山何勇明刘文龙向祖平程泽华成都理工大学能源学院成都610000 中国石油天然气股份有限公司长庆油田分公司第六采油厂西安710000 重庆科技学院石油与天然气工程学院重庆401331 中海石油(中国)有限公司天津分公司渤南作业公司天津300450

在油藏改建地下储气库时,为了研究不同初始含水饱和度对库容的影响,利用实际矿场岩心开展了不同初始含水饱和度条件下气驱油水多轮次注采实验,分析了不同初始含水饱和度下气驱油水后的驱替效率及建库效果。结果表明,低含水饱和度条件下... 详细信息

在油藏改建地下储气库时,为了研究不同初始含水饱和度对库容的影响,利用实际矿场岩心开展了不同初始含水饱和度条件下气驱油水多轮次注采实验,分析了不同初始含水饱和度下气驱油水后的驱替效率及建库效果。结果表明,低含水饱和度条件下,油相的相对渗透率显著高于水相而更易被驱替出,因此主要通过气驱油来提高储气空间;中、高含水饱和度时,水相更易被驱替出,储气空间的提高逐渐由被驱替出的原油体积贡献转向于由驱替出的水相体积贡献。相同注采轮次下,由于储层岩石水湿及渗吸作用,高初始含水饱和度时的剩余水饱和度增大,气驱油水总的驱替效率降低,储气库的注采能力和库容相对减小;储层初始含水饱和度增大会降低气驱油水的驱替效率,不利于提高原油采收率及储气库扩容;初始含水饱和度越高,储气库达容时间越久,建库初期的注采能力越低。该研究成果可为油藏型储气库注采能力评价和库容分析提供指导。

关键词：枯竭油藏储气库含水饱和度多轮次注采实验驱替效率储气空间

AAV-ie-K558R mediated cochlear gene therapy and hair cell regeneration

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Signal Transduction and Targeted Therapy 2022年第5期7卷 1764-1772页

作者： Yong Tao Xiaoyi Liu Liu Yang Cenfeng Chu Fangzhi Tan zehua Yu Junzi Ke xiang Li Xiaofei Zheng Xingle Zhao Jieyu Qi Chao-Po Lin Renjie Chai Guisheng Zhong Hao Wu Department of Otolaryngology-Head and Neck Surgery Shanghai Ninth People’s HospitalShanghai Jiao Tong University School of MedicineShanghai 200011PR China Ear Institute Shanghai Jiao Tong University School of MedicineShanghai 200011PR China Shanghai Key Laboratory of Translational Medicine on Ear and Nose Diseases Shanghai 200011PR China iHuman Institute ShanghaiTech UniversityShanghai 201210PR China School of Life Science and Technology ShanghaiTech UniversityShanghai 201210PR China State Key Laboratory of Bioelectronics Department of Otolaryngology Head and Neck SurgeryZhongda HospitalSchool of Life Sciences and TechnologyJiangsu Province High-Tech Key Laboratory for Bio-Medical ResearchSoutheast UniversityNanjing 210096PR China Co-Innovation Center of Neuroregeneration Nantong UniversityNantong 226001PR China Institute for Stem Cell and Regeneration Chinese Academy of ScienceBeijingPR China Beijing Key Laboratory of Neural Regeneration and Repair Capital Medical University100069 BeijingPR China

The cochlea consists of multiple types of cells,including hair cells,supporting cells and spiral ganglion neurons,and is responsible for converting mechanical forces into electric signals that enable hearing.Genetic and environmental factors can result in dysfunctions of cochlear and auditory systems.In recent years,gene therapy has emerged as a promising treatment in animal deafness models.One major challenge of the gene therapy for deafness is to effectively deliver genes to specific cells of cochleae.

关键词： cochlear auditory deafness

Black phosphorus inverter devices enabled by in-situ aluminum surface modification

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Nano Research 2019年第3期12卷 531-536页

作者： Yue Zheng zehua Hu Cheng Han Rui Guo Du xiang Bo Lei Yanan Wang Jun He Min Lai Wei Chen School of Physics and Optoelectronic Engineering Nanjing University of Information Science & Technology Nanjing 210044 China Department of Physics National University of Singapore Singapore 117542 Singapore SZU-NUS Collaborative Innovation Center for Optoelectronic Science and Technology Shenzhen University Shenzhen 518060 China Department of Chemistry National University of Singapore Singapore 117543 Singapore School of Physics and Electronics Central South University Changsha 410083 China National University of Singapore (Suzhou) Research Institute Suzhou 215123 China

Two-dimensional black phosphorus (BP) generally exhibits a hole-dominated transport characteristic when configured as field-effect transistor devices. The effective control of charge carrier type and concentration is very crucial for the application of BP in complementary electronics. Herein, we report a facile and effective electron doping methodology on BP, through in situ surface modification with aluminum (Al). The electron mobility of few-layer BP is found to be largely enhanced to ~ 10.6 cm^2·V^–1·s^–1 by over 6 times after aluminum modification. In situ photoelectron spectroscopy characterization reveals the formation of Al–P covalent bond at the interface, which can also serve as local gate to tune the transport properties in BP layers. Finally, a spatially-controlled aluminum doping technique is employed to establish a p–n homojunction on a single BP flake, and hence to realize the complementary inverter devices, where the highest gain value of ~ 33 is obtained.

关键词： black phosphorus aluminum surface doping electron mobility inverter

Synthesis of large-scale atomic-layer SnS2 through chemical vapor deposition

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Nano Research 2017年第7期10卷 2386-2394页

作者： Gonglan Ye Yongji Gong Sidong Lei Yongmin He Bo Li xiang Zhang zehua Jin Liangliang Dong Jun Lou Robert Vajtai Wu Zhou Pulickel M. Ajayan Department of Materials Science & NanoEngineering Rice University Houston Texas 77005 USA Department of Chemistry Rice University Houston Texas 77005 USA Department of Applied Physics Rice University Houston Texas 77005 USA Materials Science & Technology Division Oak Ridge National Lab Oak Ridge TN 37831 USA School of Materials Science and Engineering Beihang University Beijing 100191 China

Two-dimensional layers of metal dichalcogenides have attracted much attention because of their ultrathin thickness and potential applications in electronics and optoelectronics. Monolayer SnS2, with a band gap of -2.6 eV, has an octahedral lattice made of two atomic layers of sulfur and one atomic layer of tin. Till date, there have been limited reports on the growth of large-scale and high quality SnS2 atomic layers and the investigation of their properties as a semiconductor. Here, we report the chemical vapor deposition （CVD） growth of atomic-layer SnS2 with a large crystal size and uniformity. In addition, the number of layers can be changed from a monolayer to few layers and to bulk by changing the growth time. Scanning transmission electron microscopy was used to analyze the atomic structure and demonstrate the 2H stacking poly-type of different layers. The resultant SnS2 crystals is used as a photodetector with external quantum efficiency as high as 150%, suggesting promise for optoelectronic applications.

关键词： metal dichalcogenides,tin disulfide,two-dimensional materials,chemical vapor deposition,photodetector

MiR-139-5p inhibits migration and invasion of colorectal cancer by downregulating AMFR and NOTCH1

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Protein & Cell 2014年第11期5卷 851-861页

作者： Mingxu Song Yuan Yin Jiwei Zhang Binbin Zhang zehua Bian Chao Quan Leyuan Zhou Yaling Hu Qifeng Wang Shujuan Ni Bojian Fei Weili Wang xiang Du Dong Hua Zhaohui Huang Wuxi Oncology Institute the Affiliated Hospital of Jiangnan University Wuxi 214062 China Department of Surgical Oncology the Affiliated Hospital of Jiangnan University Wuxi 214062 China Department of Radiation Oncology the Affiliated Hospital of Jiangnan University Wuxi 214062 China Department of Pathology Fudan University Shanghai Cancer Center Shanghai 200032 China

MicroRNAs （miRNAs） that exert function by posttran- scriptional suppression have recently brought insight in our understanding of the role of non.protein-coding RNAs in carcinogenesis and metastasis. In this study, we described the function and molecular mechanism of miR-139-5p in colorectal cancer （CRC） and its potential clinical application in CRC. We found that miR-139-5p was significantly downregulated in 73.8% CRC samples compared with adjacent noncancerous tissues （NCTs）, and decreased miR-139-5p was associated with poor prognosis. Functional analyses demonstrated that ectopic expression of miR-139-5p suppressed CRC cell migration and invasion in vitro and metastasis in vivo. Mechanistic investigations revealed that miR-139-5p suppress CRC cell invasion and metastasis by targeting AMFR and NOTCH1. Knockdown of the two genes phe- nocopied the inhibitory effect of miR-139-5p on CRC metastasis. Furthermore, the protein levels of the two genes were upregulated in CRC samples compared with NCTs, and inversely correlated with the miR-139-5p expression. Increased NOTCH1 protein expression was correlated with poor prognosis of CRC patients. Together, our data indicate that miR-139-5p is a potentialtumor suppressor and prognostic factor for CRC, and targeting miR-139-5p may repress the metastasis of CRC and improve survival.

关键词： miR-139-5p AMFR NOTCH1 colorectalcancer metastasis prognosis