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Mass Consumerism in Global Perspective

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北大史学 2009年第1期 175-228,452页

作者： Emily s.rosenberg American history at University of California Irvine

本文阐释了大众消费主义在美国的兴起以及向全球,特别是中国传播的历史。论文第一部分考察了20世纪初期美国大众消费主义的特征以及随着消费主义开始重塑美国人的生活而引发的争论,认为美国消费主义的兴起实际上与美国人对丰裕社会中生... 详细信息

本文阐释了大众消费主义在美国的兴起以及向全球,特别是中国传播的历史。论文第一部分考察了20世纪初期美国大众消费主义的特征以及随着消费主义开始重塑美国人的生活而引发的争论,认为美国消费主义的兴起实际上与美国人对丰裕社会中生产过剩问题的担心有关,同时也是不断扩大市场的需要。第二部分考察了美国大众消费品向海外的出口、美国形象的输出以及随之而来的关于美国化的争论。在第三部分,作者认为,美国的消费主义模式在输出过程中逐渐适应当地的社会与文化,到20世纪70和80年代,世界各地的消费主义实际上越来越多样化,人们不再像过去那样把消费主义的扩张等同于美国化,相反,消费主义被认为是一种支持,而不是消弱了国家和个人身份多样性的现象。实际上,正是这种多元地方消费主义的扩张在一定程度上促进了冷战的结束。作者在结论中指出,关于大众消费主义的争论在世界各地仍然在继续,但争论的焦点不再是对"美国化"或"文化帝国主义"的恐惧,而更关注环境的可持续性和财富的分配等问题。尽管大众消费主义可以在全球范围内通过适应不同地区的文化而产生强大的吸引力,但它所反映的仍然是20世纪初期美国人的观念,而这一观念越来越落后于时代,那就是:在一个资源丰裕的世界里,需要不断地刺激人们的欲望和需求。

关键词：大众消费品 advertising consumer goods 输出过程 leisure 个人身份 companies 财富的分配 abundance

抗疟药物氯奎、阿的平、四氢-9-氨基(口了)啶与双链小牛胸腺DNA的结合

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生物化学杂志 1989年第6期5卷 549-554页

作者： stephen G.schulman Leonard s.rosenberg 佛罗里达大学药学院美国佛罗里达盖恩斯维尔

本文用体相微量量热计所得数据,估算了两种抗疟药物(antimalarial)分子和两种结构上相似的分子与DNA结合时的标准结合热焓。根据在不同离子强度下测定的表观结合常数获得了热力学结合常数。根据这些数据以及标准结合热焓计算出标准结合... 详细信息

本文用体相微量量热计所得数据,估算了两种抗疟药物(antimalarial)分子和两种结构上相似的分子与DNA结合时的标准结合热焓。根据在不同离子强度下测定的表观结合常数获得了热力学结合常数。根据这些数据以及标准结合热焓计算出标准结合自由能、标准结合熵。结果发现凡与DNA结合的分子,具有线性芳环结构的,结合时主要取决于热焓的大小。具有脂肪链或脂肪环结构的,结合时主要取决于熵变。

关键词：抗疟药物胸腺DNA 结合熵

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新一代航天器推进用高性能发动机

控制工程 1993年第3期 54-61+34页

作者： s.rosenberg L.schoenman 殷书平

一种新型的高性能可贮存双组元推进剂发动机的技术准备工作已经在三种不同的推力级上得到论证。经改进的高温材料和燃烧室设计可以在不牺牲脉冲占空比灵活性条件下免除燃料膜冷却,及与之相连的污染和性能损失。与使用二硅化物涂层的现... 详细信息

一种新型的高性能可贮存双组元推进剂发动机的技术准备工作已经在三种不同的推力级上得到论证。经改进的高温材料和燃烧室设计可以在不牺牲脉冲占空比灵活性条件下免除燃料膜冷却,及与之相连的污染和性能损失。与使用二硅化物涂层的现有铌燃烧室发动机设计相比较,以铼为基的燃烧室材料将允许工作温度提高到2204℃(4000℉)。用于喷注器、燃烧室和大面积比裙的不同材料间焊接的相应技术也已得到论证,并且已引入飞行型发动机设计中。本文讨论了5-,15-和100-Lbf 推力3种发动机的性能和寿命特性。5-和15-Lbf 推力发动机能够在面积比为150:1的情况下提供超过310Lbf/Lbm 的稳态比冲和优良的脉冲性能。100-Lbf 推力发动机在面积比为250:1的情况下提供320Lbf-sec/Lbm 的稳态比冲。

关键词：双组元推进剂面积比喷注器发动机燃烧室热风炉比冲比推力

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恶性淋巴瘤治疗的进展

中国肿瘤临床 1987年第3期 169-172页

作者： s.rosenberg stanford大学医学院教授

分两部分,一、何杰金淋巴瘤(简称HD)的治疗,二、非何杰金淋巴瘤(简称NHL)的治疗。根据stanford大学医学中心,加利福利亚州和苏格兰三处治疗恶性淋巴瘤的材料概括介绍。

关键词：淋巴瘤低度恶性 NHL 淋巴结外

Revisiting cerebral endothelial cells in Alzheimer’s disease

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Neural Regeneration Research 2025年第10期20卷 2911-2912页

作者： Amira s.Hanafy Department of Neurosurgery University Hospital BonnBonnGermany

Alzheimer’s disease(AD)is the most common neurodegenerative disorder characterized by slow and progressive decline of cognitive and memory *** only approximately 5%of the cases,AD is familial,as often predisposed by genetic mutations(Hoogmartens et al.,2021),while sporadic AD accounts for approximately 95%of the *** amyloid cascade hypothesis is one of the fundamental hypotheses put out to explain AD pathogenesis as dysregulated homeostasis of amyloid-β(Aβ)peptides that leads to the accumulation of Aβplaques in the parenchyma,an anatomical hallmark of AD.

关键词： Alzheimer Aβ cerebral

A systematic review of progenitor survival and maturation in Parkinsonian models

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Neural Regeneration Research 2025年第11期20卷 3172-3178页

作者： Giulia Comini Eilís Dowd Pharmacology&Therapeutics and Galway Neuroscience Center University of GalwayGalwayIreland

stem cell-based brain repair is a promising emergent therapy for Parkinson's disease based on years of foundational research using human fetal donors as a cell *** current therapeutic options for patients,this approach has the potential to provide longterm stem cell–derived reconstruction and restoration of the dopaminergic input to denervated regions of the brain allowing for restoration of certain functions to *** ultimate clinical success of stem cell–derived brain repair will depend on both the safety and efficacy of the approach and the latter is dependent on the ability of the transplanted cells to survive and differentiate into functional dopaminergic neurons in the Parkinsonian *** the pre-clinical literature suggests that there is considerable variability in survival and differentiation between studies,the aim of this systematic review was to assess these parameters in human stem cell-derived dopaminergic progenitor transplant studies in animal models of Parkinson's disease.A defined systematic search of the PubMed database was completed to identify relevant studies published up to March *** screening,76 articles were included in the analysis from which 178 separate transplant studies were *** these,graft survival could be assessed in 52 studies and differentiation in 129 ***,we found that graft survival ranged froms transplanted,with a median of 51%of transplanted cells surviving in the brain;while dopaminergic differentiation of the cells ranged from 0% to 46% of cells transplanted with a median of 3%.This systematic review suggests that there is considerable scope for improvement in the differentiation of stem cell-derived dopaminergic progenitors to maximize the therapeutic potential of this approach for patients.

关键词： cell replacement therapy differentiation embryonic stem cells graft induced pluripotent stem cells Parkinson's disease survival transplant

Deciphering the mechanobiology of microglia in traumatic brain injury with advanced microsystems

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Neural Regeneration Research 2025年第8期20卷 2304-2306页

作者： Anthony Procès sylvain Gabriele Univ.Grenoble Alpes InsermU1216Grenoble Institut des NeurosciencesGrenobleFrance Mechanobiology&Biomaterials Group CIRMAPResearch Institute for BiosciencesUniversity of MonsMonsBelgium

Advanced microsystems in traumatic brain injury research:Traumatic brain injury(TBI)results from a mechanical insult to the brain,leading to neuronal and axonal damage and subsequently causing a secondary *** minutes ... 详细信息

关键词： traumatic injury damage

Emerging structures and dynamic mechanisms ofγ-secretase for Alzheimer’s disease

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Neural Regeneration Research 2025年第1期20卷 174-180页

作者： Yinglong Miao Michael s.Wolfe Computational Medicine Program and Department of Pharmacology University of North Carolina–Chapel HillChapel HillNCUSA Department of Medicinal Chemistry University of KansasLawrenceKSUSA

γ-secretase,called“the proteasome of the membrane,”is a membrane-embedded protease complex that cleaves 150+peptide substrates with central roles in biology and medicine,including amyloid precursor protein and the Notch family of cell-surface *** inγ-secretase and amyloid precursor protein lead to early-onset familial Alzheimer’s disease.γ-secretase has thus served as a critical drug target for treating familial Alzheimer’s disease and the more common late-onset Alzheimer’s disease as ***,critical gaps remain in understanding the mechanisms of processive proteolysis of substrates,the effects of familial Alzheimer’s disease mutations,and allosteric modulation of substrate cleavage byγ-*** this review,we focus on recent studies of structural dynamic mechanisms ofγ-*** mechanisms,including the“Fit-stay-Trim,”“sliding-Unwinding,”and“Tilting-Unwinding,”have been proposed for substrate proteolysis of amyloid precursor protein byγ-secretase based on all-atom molecular dynamics *** an incorrect registry of the Notch1 substrate was identified in the cryo-electron microscopy structure of Notch1-boundγ-secretase,molecular dynamics simulations on a resolved model of Notch1-boundγ-secretase that was reconstructed using the amyloid precursor protein-boundγ-secretase as a template successfully capturedγ-secretase activation for proper cleavages of both wildtype and mutant Notch,being consistent with biochemical experimental *** approach could be potentially applied to decipher the processing mechanisms of various substrates byγ-*** addition,controversy over the effects of familial Alzheimer’s disease mutations,particularly the issue of whether they stabilize or destabilizeγ-secretase-substrate complexes,is ***,an outlook is provided for future studies ofγ-secretase,including pathways of substrate binding and product release,effects of modulators on familial Alzheimer’s disease mutations

关键词： Alzheimer’s disease amyloid precursor protein cryo-EM structures drug design intramembrane proteolysis molecular dynamics Notch

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全球视野下的消费主义(英文)

全球视野下的消费主义(英文)