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COVID-19 vaccine development:milestones,lessons and prospects

Signal Transduction and Targeted Therapy 2022年第6期7卷 1919-1950页

作者： Maochen Li Han Wang Lili Tian zehan pang Qingkun Yang Tianqi Huang Junfen Fan Lihua Song Yigang Tong Huahao Fan College of Life Science and Technology Beijing University of Chemical TechnologyBeijingChina Laboratory for Clinical Immunology Harbin Children’s HospitalHarbinChina College of Materials Science and Engineering Beijing University of Chemical TechnologyBeijingChina Institute of Cerebrovascular Disease Research and Department of Neurology Xuanwu Hospital of Capital Medical UniversityBeijingChina Beijing Advanced Innovation Center for Soft Matter Science and Engineering Beijing University of Chemical TechnologyBeijingChina

With the constantly mutating of SARS-CoV-2 and the emergence of Variants of Concern(VOC),the implementation of vaccination is critically *** SARS-CoV-2 vaccines mainly include inactivated,live attenuated,viral vector,protein subunit,RNA,DNA,and virus-like particle(VLP)*** vector vaccines,protein subunit vaccines,and mRNA vaccines may induce additional cellular or humoral immune regulations,including Th cell responses and germinal center responses,and form relevant memory cells,greatly improving their ***,some viral vector or mRNA vaccines may be associated with complications like thrombocytopenia and myocarditis,raising concerns about the safety of these COVID-19 ***,we systemically assess the safety and efficacy of COVID-19 vaccines,including the possible complications and different effects on pregnant women,the elderly,people with immune diseases and acquired immunodeficiency syndrome(AIDS),transplant recipients,and cancer *** on the current analysis,governments and relevant agencies are recommended to continue to advance the vaccine immunization ***,special attention should be paid to the health status of the vaccines,timely treatment of complications,vaccine development,and ensuring the lives and health of *** addition,available measures such as mix-and-match vaccination,developing new vaccines like nanoparticle vaccines,and optimizing immune adjuvant to improve vaccine safety and efficacy could be considered.

关键词： vaccine vaccination constantly

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Asynchronous gain-scheduled control of deepwater drilling riser system with hybrid event-triggered sampling and unreliable communication

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Frontiers of Information Technology & Electronic Engineering 2024年第2期25卷 272-285页

作者： Na pang Dawei ZHANG Shuqian ZHU School of Mathematics Shandong UniversityJinan250100China

This paper investigates the recoil control of the deepwater drilling riser system with nonlinear tension force and energy-bounded friction force under the circumstances of limited network resources and unreliable *** from the existing linearization modeling method,a triangle-based polytope modeling method is applied to the nonlinear riser *** on the polytope model,to improve resource utilization and accommodate random data loss and communication delay,an asynchronous gain-scheduled control strategy under a hybrid event-triggered scheme is *** asynchronous linear parameter-varying system that blends input delay and impulsive update equation is presented to model the nonlinear networked recoil control system,where the asynchronous deviation bounds of scheduling parameters are *** to the Lyapunov-Krasovskii functional method,some solvable conditions of disturbance attenuation analysis and recoil control design are derived such that the resulting networked system is exponentially mean-square stable with prescribed H∞*** obtained numerical results verified that the proposed nonlinear networked control method can achieve a better recoil response of the riser system with less transmission data compared with the linear control method.

关键词： Riser system Recoil control Asynchronous gain-scheduled control Data loss Event-triggered scheme

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Compositional evolution for mixed aerosols containing gluconic acid and typical nitrate and the effect of multiply factors on hygroscopicity

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Journal of Environmental Sciences 2024年第5期139卷 206-216页

作者： Yue Zhu Shufeng pang Yunhong Zhang School of Chemistry and Chemical Engineering Beijing Institute of TechnologyBeijing 100081China

The aging process of atmospheric aerosols usually leads to a mixture of inorganic salts and organic compounds of anthropogenic *** organic compounds,polyhydroxy organic acids are important components,however,the study on composition and hygroscopic properties of the mixture containing inorganics and polyhydroxy organic acids is *** this study,gluconic acid,the proxy of polyhydroxy organic acids,is mixed with the representative nitrate(Mg(NO_(3))_(2),Ca(NO_(3))_(2))to form ***-FTIR and optical microscopy are employed to study the component changes and hygroscopicity as a function of relative *** relative humidity fluctuates,the FTIR-ATR spectra display that the internal mixed gluconic acid(CH_(2)(CH)_(4)(OH)_(5)COOH)and nitrate can react to release acidic gases,forming relevant gluconate and further affecting the *** specific presentation is particles cannot be recovered to their original size after the dehydration-hydration process and there will be some disparities in GF for mixed *** the gluconic acid-Ca(NO_(3))_(2)/Mg(NO_(3))_(2)mixtures with molar ratios of 1:1,higher degree of reaction resulting in the production of large amounts of gluconate should be responsible to the lower hygroscopicity compared to ZSR *** 1:2 gluconic acid-nitrate mixed systems(with higher nitrate content),the hygroscopicity of mixtures are higher than the ZSR prediction.A possible reason could be‘salt-promoting effect’on the organic fractions of the surplus inorganic salt in the *** data can improve the chemical composition list evaluation,in turn hygroscopic properties and phase state of atmospheric aerosol,and then the climate effect.

关键词： Hygroscopicity Gluconic acid Reaction ZSR simulation Size growth factors

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Ionic liquid-assisted preparation of hydroxyapatite and its catalytic performance for decarboxylation of itaconic acid

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Chinese Journal of Chemical Engineering 2024年第3期67卷 9-15页

作者： Shutong pang Hualiang An Xinqiang Zhao Yanji Wang Hebei Provincial Key Laboratory of Green Chemical Technology and Efficient Energy Saving Tianjin Key Laboratory of Chemical Process SafetySchool of Chemical Engineering and TechnologyHebei University of TechnologyTianjin 300130China

The synthesis of methacrylic acid from biomass-derived itaconic acid is a green route,for it can get rid of the dependence on fossil *** order to solve the problems on this route such as use of a preciousmetal catalyst and a corrosive homogeneous alkali,we prepared a series of hydroxyapatite catalysts by an ionic liquid-assisted hydrothermal method and evaluated their catalytic *** results showed that the ionic liquid[Bmim]BF_(4) can affect the crystal growth of hydroxyapatite,provide fluoride ion for fluorination of hydroxyapatite,and adjust the surface acidity and basicity,morphology,textural properties,crystallinity,and composition of ***[Bmim]BF4 dosage and hydrothermal temperature can affect the fluoride ion concentration in the hydrothermal system,thus changing the degree of fluoridation of *** fluoride-ion concentration can lead to the formation of CaF_(2) and thus significantly decrease the catalytic performance of *** hydrothermal time mainly affects the growth of hydroxyapatite crystals on the c axis,leading to different catalytic *** suitable conditions for the preparation of this fluoridized hydroxyapatite are as follows:a mass ratio of[Bmim]BF4 to calcium salt=0.2:1,a hydrothermal time of 12 h,and a hydrothermal temperature of 130℃.A maximal methacrylic acid yield of 54.7%was obtained using the fluoridized hydroxyapatite under relatively mild reaction conditions(250℃ and 2 MPa of N_(2))in the absence of a precious-metal catalyst and a corrosive homogeneous alkali.

关键词： Ionic liquid Hydroxyapatite Itaconic acid Methacrylic Decarboxylation reaction

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Rational Design of Capping Ligands of Quantum Dots for Biosensing

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Chemical Research in Chinese Universities 2024年第2期40卷 162-172页

作者： XU Xinran LIU An-an pang Daiwen State Key Laboratory of Medicinal Chemical Biology Tianjin Key Laboratory of Biosensing and Molecular RecognitionResearch Center for Analytical SciencesCollege of ChemistryNankai UniversityTianjin300071P.R.China

Quantum dots have been widely applied in biosensing due to their outstanding optical *** emissions of quantum dots are mainly determined by their composition and size,as described by the Brus’s ***,in this case,their emissions are hardly regulated reversibly and responsively,which are unsuitable for biosensing and *** the last decade,capping ligands have been used for designing biosensors because of their responsive regulation on the photoluminescence of quantum ***,we first summarize the advances in characterization and calculation specific for ligands,which have helped to provide insights into the photoluminescence process and energy band theory of quantum *** then review two ways of ligand design that influence the optical properties of quantum dots:affecting the process of photoluminescence,or the orbital/electronic *** the latter case,the atoms on both the ligand and the surface of the quantum dot interact to affect the energy band structure of the quantum dot *** are presented of how these quantum dots that possess responsive properties due to the design of the ligands have been applied to *** further exploration,we hope to see advances in the fundamental understanding of the energy band structures and practical applications of these quantum dots.

关键词： Quantum dot Ligand Photoluminescence Responsiveness Sensor

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Slip distribution inversion of seismic sub-fault dip iteration using gradient based optimizer algorithm

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Geodesy and Geodynamics 2024年第2期15卷 114-121页

作者： Leyang Wang Han Li Ming pang Key Laboratory of Mine Environmental Monitoring and Improving Around Poyang Lake of Ministry of Natural Resources East China University of TechnologyNanchang 330013China School of Surveying and Geoinformation Engineering East China University of TechnologyNanchang 330013China College of Resources and Environment Shandong Agricultural UniversityTaian 271018China

This paper considers setting different dips for different sub-faults to fit the actual rupture situation based on the fault rupture of the 2013 Lushan M_(S)7.0 ***,combined with the coseismic GNSS data of the Lushan earthquake,the source parameters and sliding distribution of the Lushan earthquake fault are ***,we use the gradient based optimizer(GBO)in nonlinear inversion to obtain the source parameters of this seismic *** inversion results indicate that the strike of the fault is 206.52°,the dip is 44.10°,the length is 21.92 km,and the depth is 12.79 *** refine the sliding distribution of the seismic fault,the seismic fault is divided into 3×3 ***,we fix the central sub-fault dip of 44.10°;the dip of other sub-faults is obtained by *** that,the model is further divided into a fault layer model composed of 23×19 sub fault slices,and using the Matlab fitting function is used to fit the dip of the 23×19 sub ***,the Lushan seismic fault plane is established as a shovel structure with steep upper and gentle lower,steep south and gentle *** slip distribution inversion results indicate that the depth of the slip peak is 13 km,the corresponding maximum slip momentum is 0.67 m,the seismic moment is 1.10×10^(19)N·m and the corresponding moment magnitude is *** results above are consistent with the research results of seismology.

关键词： Gradient basedoptimizer(GBO) Lushan earthquake Non-planefault model Slid distribution

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Study on a conical bearing for acceleration-sensitive equipment

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Earthquake Engineering and Engineering Vibration 2024年第1期23卷 103-128页

作者： pang Hui Xu Wen Dai Junwu Jiang Tao Key Laboratory of Earthquake Engineering and Engineering Vibration Institute of Engineering MechanicsChina Earthquake AdministrationHarbin 150080China Key Laboratory of Earthquake Disaster Mitigation Ministry of Emergency ManagementHarbin 150080China School of Civil Engineering and Transportation Beihua UniversityJilin 132013China

Seismic isolation effectively reduces seismic demands on building structures by isolating the superstructure from ground vibrations during ***,isolation strategies give less attention to acceleration-sensitive systems or ***,as the isolation layer’s displacement grows,the stiffness and frequency of traditional rolling and sliding isolation bearings increases,potentially causing self-centering and resonance *** a result,a new conical pendulum bearing has been selected for acceleration-sensitive equipment to increase self-centering capacity,and additional viscous dampers are incorporated to enhance system ***,the theoretical formula for conical pendulum bearings is supplied to analyze the device’s dynamic parameters,and shake table experiments are used to determine the proposed device’s isolation efficiency under various *** to the test results,the newly proposed devices have remarkable isolation performance in terms of minimizing both acceleration and displacement ***,a numerical model of the isolation system is provided for further research,and the accuracy is demonstrated by the aforementioned experiments.

关键词： seismic isolation acceleration-sensitive equipment the conical pendulum bearing shake table tests isolation performance,numerical model

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An impact sensitivity assessment method of spacecraft based on virtual exterior wall

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Defence Technology（防务技术） 2024年第1期31卷 142-157页

作者： Runqiang Chi Yuyan Liu Diqi Hu Baojun pang Hypervelocity Impact Research Center Harbin Institute Of TechnologyHarbin150080China

The impact sensitivity assessment of spacecraft is to obtain the probability of spacecraft encountering the OD/M(orbital debris or meteoroid),which is a prerequisite for survivability assessment of on-orbit *** impact sensitivity assessment method of spacecraft based on virtual exterior wall was proposed to improve the computational *** method eliminates determination of the outermost surface elements of the spacecraft before generating the debris rays,which are assumed to originate from a non-concave virtual wall that completely wraps the *** Dist Mesh method was adopted for the generating of the virtual wall to ensure its mesh *** influences of the sizes,mesh densities,shapes of the virtual wall on the efficiency and accuracy were considered to obtain the best combination of the size and mesh density of the wall and *** results of this method were compared with those of S3DE(Survivability of Spacecraft in Space Debris Environment),BUMPER,MDPANTO,ESABASE2/Debris to verify the feasibility of the *** PCHIP(Piecewise Cubic Hermite Interpolating Polynomial)was used to fit the size *** relationship of the space debris to acquire the impact probability of OD/M with arbitrary size on the spacecraft.

关键词： Sensitivity OD/M Spacecraft Virtual exterior wall

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Microstructure and mechanical properties stability of pre-hardening treatment in Al-Cu alloys for pre-hardening forming process

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International Journal of Minerals,Metallurgy and Materials 2024年第3期31卷 539-551页

作者： Liping Tang Pengfei Wei Zhili Hu Qiu pang Hubei Longzhong laboratory Xiangyang 441000China Hubei Key Laboratory of Advanced Technology for Automotive Components School of Automotive EngineeringWuhan University of TechnologyWuhan 430070China Hubei Engineering Research Center for Green&Precision Material Forming Wuhan University of TechnologyWuhan 430070China Key Laboratory of Metallurgical Equipment and Control Technology of Ministry of Education School of Machinery and AutomationWuhan University of Science and TechnologyWuhan 430081China

The stability of the microstructure and mechanical properties of the pre-hardened sheets during the pre-hardening forming(PHF)process directly determines the quality of the formed *** microstructure stability of the pre-hardened sheets was in-vestigated by differential scanning calorimetry(DSC),transmission electron microscopy(TEM),and small angle X-ray scattering(SAXS),while the mechanical properties and formability were analyzed through uniaxial tensile tests and formability *** results in-dicate that the mechanical properties of the pre-hardened alloys exhibited negligible changes after experiencing 1-month natural aging(NA).The deviations of ultimate tensile strength(UTS),yield strength(YS),and sheet formability(Erichsen value)are all less than 2%.Also,after different NA time(from 48 h to 1 month)is applied to alloys before pre-hardening treatment,the pre-hardened alloys possess stable microstructure and mechanical properties as ***,with the extension of NA time before pre-hardening treatment from 48 h to 1 month,the contribution of NA to the pre-hardening treatment is *** a yield strength increment of 20 MPa is achieved,with no loss in *** limited enhancement is mainly attributed to the fact that only a limited number of clusters are transformed into Guinier-Preston(GP)zones at the early stage of pre-hardening treatment,and the formation ofθ''phase inhibits the nucleation and growth of GP zones as the precipitated phase evolves.

关键词： Al-Cu alloy pre-hardened alloy natural aging mechanical properties microstructure

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Temporal Unfolding of Racial Ingroup Bias in Neural Responses to Perceived Dynamic Pain in Others

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Neuroscience Bulletin 2024年第2期40卷 157-170页

作者： Chenyu pang Yuqing Zhou Shihui Han School of Psychological and Cognitive Sciences PKU-IDG/McGovern Institute for Brain ResearchBeijing Key Laboratory of Behavior and Mental HealthPeking UniversityBeijing 100081China CAS Key Laboratory of Behavioral Science Institute of PsychologyChinese Academy of SciencesBeijing 100101China Department of Psychology University of Chinese Academy of SciencesBeijing 100049China

In this study,we investigated how empathic neural responses unfold over time in different empathy networks when viewing same-race and other-race individuals in dynamic painful *** recorded magnetoencephalography signals from Chinese adults when viewing video clips showing a dynamic painful(or non-painful)stimulation to Asian and White models’faces to trigger painful(or neutral)*** found that perceived dynamic pain in Asian models modulated neural activities in the visual cortex at 100 ms–200 ms,in the orbitofrontal and subgenual anterior cingulate cortices at 150 ms–200 ms,in the anterior cingulate cortex around 250 ms–350 ms,and in the temporoparietal junction and middle temporal gyrus around 600 ms after video *** dynamic pain in White models modulated activities in the visual,anterior cingulate,and primary sensory cortices after 500 *** findings unraveled earlier dynamic activities in multiple neural circuits in response to same-race(vs other-race)individuals in dynamic painful situations.

关键词： Empathy Race Magnetoencephalography Dynamic pain Cingulate cortex

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