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Asian Agricultural Research 2021年第1期13卷 58-63页

作者： zefang LU Qinghua CHEN Tao JIN College of Horticulture and Gardening Yangtze university Jingzhou 434025 China Engineering Research Center of Ecology and Agricultural Use of Wetland Ministry of Education Yangtze University Jingzhou 434025 China

Soil and water loss has been a major environmental problem in the Danjiangkou Reservoir Region.A study of 14°sloping farmland was performed on impact of different contour hedgerows on runoff,losses of soil and nutrients during 2008 and 2011,with five treatments and three *** winter wheat and summer maize were used as the test *** consisted of four hedgerows:Amorpha(Amorpha fruticosa L.),Honeysuckle(Lonicera japonica Thunb.),Day-lily flower(Hemerocallis citrina Baroni.),and Sabaigrass(Eulaliopsis binata),and a control without *** showed that the runoff under the control treatment was much higher than that of *** could reduce the runoff by 35.2%compared with the *** losses in four hedgerows showed significant reduction in four years(e.g.,Amorpha:78.3%;Honeysuckle:77.1%).Nutrient losses in winter were much higher than that in summer,especially total nitrogen,total phosphorus and total potassium,even though there was an abundant precipitation in *** greatly affected the soil and nutrient losses on slopping farmland compared with the control treatment,especially Amorpha *** present study found that the Amorpha could be used as the hedgerow species for reducing soil and water loss in the Danjiangkou Reservoir Region.

关键词： Contour hedgerow Soil and water loss Nutrient loss Sloping farmland Danjiangkou Reservoir Region

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设缝方钢管混凝土短柱轴压力学性能研究

山西建筑 2025年第2期51卷 33-36页

作者：彭培宇周绍财朱泽文梁玉雄林泽方赣州高速公路有限责任公司江西赣州341000 江西省交通科学研究院有限公司江西南昌330000 华东交通大学江西南昌330000

为改善方钢管混凝土柱受力后钢管容易发生屈曲的缺陷,使用设缝钢管代替通长钢管制作相关构件并进行了轴向压力实验对两类试件的力学性能进行研究。通过研究发现钢管设缝后不承受轴向荷载作用、不发生屈曲。随着荷载增加,钢管对核心混凝... 详细信息

为改善方钢管混凝土柱受力后钢管容易发生屈曲的缺陷,使用设缝钢管代替通长钢管制作相关构件并进行了轴向压力实验对两类试件的力学性能进行研究。通过研究发现钢管设缝后不承受轴向荷载作用、不发生屈曲。随着荷载增加,钢管对核心混凝土的约束效果明显,荷载位移曲线上构件B表现出良好的延性;构件B的承载力略低于构件A。实验后剖开构件发现,核心混凝土表现为被压溃破坏,但在外部钢管约束下,压溃后的构件依然能够承受荷载。相关试验现象说明设缝后钢管对核心混凝土的约束作用更明显,改善了混凝土的受力特点,核心混凝土在外部钢管的约束作用下不但核心承载力得到了进一步提高,还表现出了良好的延性。

关键词：钢管混凝土设缝约束模式力学性能

Terahertz Spectroscopy for Accurate Identification of Panax quinquefolium Basing on Nonconjugated 24(R)-Pseudoginsenoside F_(11)

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Plant Phenomics 2021年第1期3卷 57-64页

作者： Tianyi Kou Ji Ye Jing Wang Yan Peng zefang Wang Chenjun Shi Xu Wu Xitian Hu Haihong Chen Ling Zhang Xiaohong Chen Yiming Zhu Huiliang Li Songlin Zhuang Terahertz Technology Innovation Research Institute Shanghai Key Lab of Modern Optical SystemTerahertz Science Cooperative Innovation CenterUniversity of Shanghai for Science and TechnologyShanghai Institute of Intelligent Science and TechnologyShanghaiChina Department of Pharmacy Second Military Medical UniversityShanghaiChina School of Pharmacy Nanjing Medical UniversityNanjingChina Shanghai Institute of Intelligent Science and Technology Tongji University ShanghaiChina

Panax quinquefolium is a perennial herbaceous plant that contains many beneficial ginsenosides with diverse pharmacological effects.24(R)-pseudoginsenoside F_(11)is specific to ***,a useful biomarker for distinguishing this species from other related ***,because of its nonconjugated property and the complexity of existing detection methods,this biomarker cannot be used as the identification *** herein present a stable 24(R)-pseudoginsenoside F_(11)fingerprint spectrum in the terahertz band,thereby proving that F_(11)can be detected and quantitatively analyzed via terahertz *** also analyzed the sample by high-performance liquid chromatography-triple quadrupole mass *** difference between the normalized data for the two analytical methods was less than 5%.Furthermore,*** from different areas and other substances can be clearly distinguished based on these terahertz spectra with a standard principal component *** method is a fast,simple,and cost-effective approach for identifying and quantitatively analyzing ***.

关键词： ginsenoside conjugated thereby

Comparison on Chromosome Number among Ussuri Raccoon Dogs with Three Different Coat Colors

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Agricultural Biotechnology 2013年第6期2卷 63-67页

作者： Yanpeng LI zefang MA Yanfei ZHU Jinhai SUN College of Animal Science and Technology Qingdao Agricultural University

[ Objective] This study aimed to lay theoretical foundation for establishing the database of biological characteristics of raccoon dogs with different coat colors. [Method] Reddish-brown ussuri raccoon dogs, wild ussuri raccoon dogs and Jilln white raccoon dogs were used as experimental materials in this study. Chromosome specimens were prepared by peripheral blood lymphocyte culture, to analyze chromosome number of ussuri raccoon dogs with different coat colors. [ Result] Frequencies of cells with diploid chromosome number of 56 in reddish-brown ussuri raccoon dogs and wild ussuri raccoon dogs were 86% and 83% re- spectively, indicating that the chromosome number of reddish-brown ussuri raccoon dogs and wild ussuri raccoon dogs was 56. The frequency of cells with diploid chromosome number of 56 in Jilin white raccoom dogs was 70%, which was lower than that of other two varieties, while the frequency of cells with 2n = 57 was high- er than that of other two varieties. [Conclusion] The chromosome number was 56 for reddish-brown ussuri raccoon dogs and wild ussuri raccoon dogs, and it was 56 or 57 for Jllin white raccoon dogs, which represented pelymorphism.

关键词： Ussuri raccoon dog Chromosome-number Diploidi Chimera

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估值视角下人民币国际化风险影响因素研究

金融与经济 2022年第8期 21-29页

作者：杨灿廖泽芳上海海洋大学经济管理学院

基于估值视角,梳理了汇率、资产价格等对人民币国际化风险的影响机制,分阶段测算了1982—2019年和2010Q1—2020Q2期间的中国净国外资产估值收益,并采用OLS和分位数回归分析了宏观经济变量对人民币国际化风险的影响。研究表明,近年来人... 详细信息

基于估值视角,梳理了汇率、资产价格等对人民币国际化风险的影响机制,分阶段测算了1982—2019年和2010Q1—2020Q2期间的中国净国外资产估值收益,并采用OLS和分位数回归分析了宏观经济变量对人民币国际化风险的影响。研究表明,近年来人民币国际化风险的波动幅度明显增加,与国际市场的关联性增强;实际有效汇率、波动性指数是人民币国际化风险的长期影响因素;经济发展速度、通货膨胀在2010年之前影响作用明显,但在2015年汇改之后,外汇储备的影响作用更强;货币供应量、投资组合等会短暂降低人民币国际化风险。

关键词：估值效应人民币国际化金融风险管控分位数回归

黄病毒NS2B-NS3pro蛋白酶的结构研究进展

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微生物学报 2019年第4期59卷 601-611页

作者：武晨杨海涛王泽方天津大学生命科学学院天津300072

黄病毒能引起严重的人类疾病,但是并无特定药物来治疗病毒感染。黄病毒非结构蛋白NS3的N端区域及其辅因子NS2B构成蛋白酶,该酶切割病毒的多聚蛋白形成成熟的结构蛋白和非结构蛋白来帮助病毒完成增殖过程。NS2B-NS3pro蛋白酶在黄病毒生... 详细信息

黄病毒能引起严重的人类疾病,但是并无特定药物来治疗病毒感染。黄病毒非结构蛋白NS3的N端区域及其辅因子NS2B构成蛋白酶,该酶切割病毒的多聚蛋白形成成熟的结构蛋白和非结构蛋白来帮助病毒完成增殖过程。NS2B-NS3pro蛋白酶在黄病毒生命周期中起关键的作用,使之成为抗病毒药物研发的重要靶标。本文综述了黄病毒属中寨卡病毒、登革热病毒、西尼罗病毒的NS2B-NS3pro蛋白酶结构的研究进展,并介绍了相关抑制剂与蛋白酶形成的复合物结构,以期为研发抗黄病毒药物提供必要的参考。

关键词：黄病毒蛋白酶抑制剂晶体结构

Carbazole and tetrahydro-carboline derivatives as dopamine D_(3) receptor antagonists with the multiple antipsychotic-like properties

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Acta Pharmaceutica Sinica B 2023年第11期13卷 4553-4577页

作者： Zhongtang Li Fan Fang Yiyan Li Xuehui Lv Ruqiu Zheng Peili Jiao Yuxi Wang Guiwang Zhu zefang Jin Xiangqing Xu Yinli Qiu Guisen Zhang Zhongjun Li Zhenming Liu Liangren Zhang State Key Laboratory of Natural and Biomimetic Drugs School of Pharmaceutical SciencesPeking UniversityBeijing 100191China Jiangsu Nhwa Pharmaceutical Co. Ltd.Xuzhou 221116China Jiangsu Key Laboratory of Marine Biological Resources and Environment Jiangsu Key Laboratory of Marine Pharmaceutical Compound ScreeningSchool of PharmacyJiangsu Ocean UniversityLianyungang 222005China

Dopamine D_(3) receptor(D_(3)R)is implicated in multiple psychotic *** the D_(3)R selectivity over dopamine D_2 receptor(D_2R)would facilitate the antipsychotic ***,novel carbazole and tetrahydro-carboline derivatives were reported as D_(3)R selective *** a structure-based virtual screen,ZLG-25(D_(3)R K_i=685 nmol/L;D_2R K_i>10,000 nmol/L)was identified as a novel D_(3)R selective bitopic ligand with a carbazole *** hopping led to the discovery of novel D_(3)R-selective analogs with tetrahydro-β-carboline or tetrahydro-γ-carboline *** functional studies showed that most derivatives acted as h D_(3)R-selective *** lead compounds could dose-dependently inhibit the MK-801-induced *** investigation revealed that 23j and 36b could decrease the apomorphine-induced climbing without cataleptic ***,36b demonstrated unusual antidepressant-like activity in the forced swimming tests and the tail suspension tests,and alleviated the MK-801-induced disruption of novel object recognition in ***,preliminary studies confirmed the favorable PK/PD profiles,no weight gain and limited serum prolactin levels in *** results revealed that 36b provided potential opportunities to new antipsychotic drugs with the multiple antipsychotic-like properties.

关键词： Dopamine D_(3)receptor Carbazole derivatives Tetrahydro-carboline Bitopic ligand Antipsychotic

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NDM-1结构功能及抑制剂的抑制机理

微生物学报 2021年第1期61卷 41-57页

作者：崔灿杨海涛王泽方天津大学生命科学学院结构生物学实验中心天津300072 上海科技大学生命科学与技术学院上海免疫化学研究所上海201210

在过去的10年中,以新德里金属β-内酰胺酶-1(NDM-1)为代表的金属β-内酰胺酶在全球范围内广泛传播,对公共卫生安全产生了较大的威胁。尤其是近些年这些酶的突变体的出现使得耐药菌给人类健康造成了更加复杂和困难的挑战。目前,临床上仍... 详细信息

在过去的10年中,以新德里金属β-内酰胺酶-1(NDM-1)为代表的金属β-内酰胺酶在全球范围内广泛传播,对公共卫生安全产生了较大的威胁。尤其是近些年这些酶的突变体的出现使得耐药菌给人类健康造成了更加复杂和困难的挑战。目前,临床上仍然缺乏有效的治疗药物和手段。研发有效广谱的抑制剂成为解决此问题的重点。因此本文将针对NDM-1及其相关抑制剂复合物的三维结构解析工作进行综述,希望从生物学机制研究的角度带给相关研究人员一点启发和帮助。

关键词：新德里β 内酰胺酶-1 金属β-内酰胺酶抑制剂抑制机制复合物晶体结构

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食可以群——试论叙事作品中的共食书写

江西师范大学学报（哲学社会科学版） 2021年第6期54卷 58-64页

作者：钟泽芳江西师范大学文学院江西南昌330022

中外叙事作品中均有不少同餐共饮活动的书写,这些聚食的场面不仅构成了故事情节不可或缺的部分,其背后还蕴含着深刻的社会意义。从共食的社会功能角度来看,分享食物是群体得以建立与维系的重要纽带,而纽带是否牢固与如何巧妙利用同食的... 详细信息

中外叙事作品中均有不少同餐共饮活动的书写,这些聚食的场面不仅构成了故事情节不可或缺的部分,其背后还蕴含着深刻的社会意义。从共食的社会功能角度来看,分享食物是群体得以建立与维系的重要纽带,而纽带是否牢固与如何巧妙利用同食的手段密不可分。通过考察叙事作品中的共食维群事件,发现共食在群体的建立与维系中只是充当了一种表象功能,食可以群的本质在于共食者的善行美德感化他人,飨食享德方能真正凝聚人心,结而为群。

关键词：共食叙事群体维系

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聚对苯二甲酸乙二醇酯降解酶的研究进展

微生物学报 2019年第12期59卷 2251-2262页

作者：李秀杨海涛王泽方天津大学生命科学学院

聚对苯二甲酸乙二醇酯(Polyethylene terephthalate,PET)因其良好的耐用性和可塑性,已在世界范围内的工业领域和日常生活中得到广泛应用。目前自然环境中大量PET使用废弃物的积累和迁移给全球生态系统带来了严重负担,因此PET的降解问题... 详细信息

聚对苯二甲酸乙二醇酯(Polyethylene terephthalate,PET)因其良好的耐用性和可塑性,已在世界范围内的工业领域和日常生活中得到广泛应用。目前自然环境中大量PET使用废弃物的积累和迁移给全球生态系统带来了严重负担,因此PET的降解问题已成为全球性的热点问题。微生物酶降解法目前被认为是一种理想绿色PET降解方法,有希望应用于大规模降解PET废弃物降解处理。传统的PET降解酶主要包括脂肪酶、酯酶和角质酶等,但这些酶的PET降解活性相对不高。近期科学家从Ideonella sakaiensis细菌中分离了一种新型水解酶PETase,能够特异性高效降解PET。本文从结构生物学角度对多种PET降解酶进行梳理,重点总结了新近发现的PETase催化机制,为发展改造更有效的PET降解酶提供理论依据。

关键词：聚对苯二甲酸乙二醇酯 PET降解酶结构研究降解机制