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World Journal of Hepatology 2017年第5期9卷 270-277页

作者： zeeshan ahmad wani Sonmoon Mohapatra Afaq ahmad Khan Ashutosh Mohapatra Ghulam Nabi Yatoo Department of Gastroenterology and Hepatology Institute of Liver and Biliary Sciences Department of Internal Medicine Rutgers Robert Wood Johnson Medical School Saint Peters University Hospital Department of Hematology and Oncology JLNM hospital Department of Gastroenterology and Hepatology AMRI Hospitals Department of Gastroenterology and Hepatology Sher-i-Kashmir Institute of Medical Sciences

AIMTo determine whether addition of simvastatin could be an important pharmacological rescue therapy for carvedilol non-responders. METHODSOne hundred and two consecutive patients of cirrhosis of liver with significant portal hypertension were included. Hepatic venous pressure gradient (HVPG) was measured at the base line and after proper optimization of dose; chronic response was assessed at 3 mo. Carvedilol non-responders were given simvastatin 20 mg per day (increased to 40 mg per day at day 15). Carvedilol plus simvastatin was continued for 1 mo and hemodynamic response was again measured at 1 mo. RESULTSA total of 102 patients with mean age of 58.3 ± 6.6 years were included. Mean baseline HVPG was 16.75 ± 2.12 mmHg and after optimization of dose and reassessment of HVPG at 3 mo, mean reduction of HVPG from baseline was 5.5 ± 1.7 mmHg and 2.8 ± 1.6 mmHg among responders and non-responders respectively (P CONCLUSIONAddition of simvastatin to carvedilol non-responders may prove to be an excellent rescue therapy in patients with portal hypertension.

关键词： Simvastatin Cirrhosis Carvedilol Liver cirrhosis Portal hypertension Hepatocellular carcinoma

Mechanistic insights toward identification and interaction of plant parasitic nematodes:A review

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Soil Ecology Letters 2024年第1期6卷 11-27页

作者： Bisma Jan Ali Haider Shah Mudasir ahmad Bhat Arif Tasleem Jan Ishfaq ahmad wani Ali Asghar Shah Section of Microbiology Baba Ghulam Shah Badshah UniversityRajouriJ&K185234India Department of Biotechnology Baba Ghulam Shah Badshah University RajouriJ&K185234India Department of Botany Baba Ghulam Shah Badshah University RajouriJ&K185234India Department of Zoology School of Biosciences and BiotechnologyBaba Ghulam Shah Badshah University RajouriJ&K185234India

Nematode identification serves as an important param-eter to study their behaviour,importance and *** of classical morphometric based identifica-tion methods prove to be lacking due to insufficient knowledge on morphological variations among closely related *** approaches such as DNA and protein-based information,microarray,probing,sequence-based methods and others have been used to supplement morphology-based methods for nematode *** and certain protein-based nematode-associated molecular patterns(NAMPs),can be perceived by the host plants,and can initiate a signalling *** review primarily emphasizes on an updated account of different classical and modern tools used for the identification of *** we also summa-rize the mechanism of some important signalling pathways which are involved in the different plant nematode *** constitute most diverse and least studied group of soil inhabiting *** are ecologically and physiologically important,however,wide range of nematodes show harmful impact on the individuals that live within their *** parasitic nematodes(PPNs)are transparent,pseudocoelomate,free living or parasitic *** lack morphometric identification methods due to insufficient knowl-edge on morphological variations among closely related *** such,molecular approaches such as DNA and protein-based information,microarray,probing,sequence-based methods and others have been used to supplement morphology-based methods for their *** invade the defense response of different plant species,parasitic nematodes have evolved different molecular *** and certain protein-based nematode-associated molecular patterns(NAMPs),can be perceived by the host plants,and can initiate a signaling *** overcome the host confrontation and develop certain nematode feeding sites,some members can inject effectors into

关键词： nematode identification plant nematode interaction DNA fingerprinting nematode-associated molecular patterns signaling path-ways

Self-Focusing/Defocusing of Chirped Gaussian Laser Beam in Collisional Plasma with Linear Absorption

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Communications in Theoretical Physics 2016年第9期65卷 349-354页

作者： Manzoor ahmad wani Niti Kant Department of Physics Lovely Professional University

This paper presents an investigation on the self-focusing/defocusing of chirped Gaussian laser beam in collisional plasma with linear absorption. We have derived the differential equation for the beam width parameter by using WKB and paraxial approximations and solved it numerically. The effect of chirp and other laser plasma parameters is seen on the behavior of beam width parameter with dimensionless distance of propagation. The results are discussed and presented graphically. Our simulation results show that the amplitude of oscillations decreases with the distance of propagation. Due to collisional frequency, the laser beam shows fast divergence which can be minimized by the introduction of chirp parameter. The chirp decreases the effect of defocusing and increases the ability of self-focusing of laser beam in collisional plasma.

关键词： self-focusing/defocusing chirped Gaussian laser beam collisional plasma linear absorption

Density Transition Based Self-Focusing of cosh-Gaussian Laser Beam in Plasma with Linear Absorption

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Communications in Theoretical Physics 2015年第7期64卷 103-107页

作者： Niti Kant Manzoor ahmad wani Department of Physics Lovely Professional University

Density transition based self-focusing of cosh-Gaussian laser beam in plasma with linear absorption has been studied. The field distribution in the plasma is expressed in terms of beam width parameter, decentered parameter,and linear absorption coefficient. The differential equation for the beam width parameter is solved by following Wentzel–Kramers–Brillouin(WKB) and paraxial approximation through parabolic wave equation approach. The behaviour of beam width parameter with dimensionless distance of propagation is studied at optimum values of plasma density,decentered parameter and with different absorption levels in the medium. The results reveal that these parameters can affect the self-focusing significantly.

关键词： self-focusing cosh-Gaussian beam plasma density ra

Generalized*-Lie Higher Derivable Mappings on*-Rings

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Algebra Colloquium 2020年第3期27卷 415-432页

作者： Mohammad Ashraf Mohd Shuaib Akhtar Bilal ahmad wani Department of Mathematics Aligarh Muslim UniversityAligarh 202002India

Let R be a*-ring with the center Z(R)and N be the set of nonnegative *** this paper,it is shown that if R contains a nontrivial self-adjoint idempotent which admits a generalized Lie higher derivable mapping△={G_(n)}_(n∈N)associated with a*-Lie higher derivable mapping L={L_(n)}_(n∈N),then for any X,Y in R and for each n in N there exists an element Z_(X,Y)(depending on X and Y)in the center Z(R)such that G_(n)(X+Y)=G_(n)(X)+G_(n)(Y)+Z_(X,Y).

关键词： rings derivations *-Lie higher derivable mappings generalized*-Lie higher derivable mappings

Geochemistry of metasedimentary rocks of the Sonakhan and Mahakoshal greenstone belts,Central India:Implications for paleoweathering,paleogeography and mechanisms of greenstone belt development

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Acta Geochimica 2022年第1期41卷 64-83页

作者： Hamidullah wani M.E.A.Mondal Iftikhar ahmad Department of Geology Government Degree College for Women PulwamaJammu and Kashmir 192301India Department of Geology Aligarh Muslim UniversityAligarhUttar Pradesh 202002India

A comparative study of the Precambrian Sonakhan(SGB)and Mahakoshal(MGB)greenstones belts of Central India has been undertaken to decipher their provenance,paleoweathering,paleogeography,and *** compared to the Upper Continental Crust(UCC),the MGB samples are enriched while the SGB samples are depleted in mafic elements indicating the presence of mafic rocks in the source of the *** is complemented by the Ni–Cr *** REE concentrations,LREE fractionated patterns and negative Eu anomalies of the MGB and SGB samples indicate derivation of sediments from a highly fractionated granitic *** MGB samples also contain the geochemical signature of mafic rocks,it is,therefore proposed that the MGB clastic load were derived from two sources(mafic+felsic)with arc *** is attested by Cr and Zr relationships,and LILE enrichment,and HFSE *** features suggest that the SGB developed as autochthonous while the MGB developed as an allochthonous *** chemical alteration indices such as chemical index of alteration(CIA),plagioclase index of alteration(PIA),and index of compositional variability for MGB samples indicate that they were dominantly derived as the first cycle(with minor recycled)sediments from bimodal sources(dominantly continental arcs)by intense chemical weathering as compared to the SGB samples,which were derived from felsic sources(dominantly cratonic rocks),and partly by recycling through a low chemical *** CIA and PIA values of the samples reveal a change in the climatic conditions from Late Archean to Late *** change is interpreted in terms of migration of the Indian plate from high latitudes in the Late Archean to lower latitudes during the Late *** is consistent with the paleomagnetic data that placed India in the configuration of 2.45 Ga Ur and 1.78 Ga Columbia supercontinents.

关键词： Central Indian Shield Sonakhan and Mahakoshal greenstone belts Paleoweathering and paleogeography Greenstone belt development

Relativistic Self-Focusing of Hermite-cosine-Gaussian Laser Beam in Collisionless Plasma with Exponential Density Transition

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Communications in Theoretical Physics 2019年第6期71卷 736-740页

作者： Vishal Thakur Manzoor ahmad wani Niti Kant Department of Physics Lovely Professional UniversityPhagwara-144411PunjabIndia Govt.Higher Secondary School Waterhail Budgam-191111J&KIndia

This work reveals an exploration of self-focusing of Hermite-cosine-Gaussian laser beam in a collisionless plasma under relativistic nonlinearity. Self-focusing along with self-trapping of Hermite-cosine-Gaussian laser beam are analyzed for different values of laser intensity, plasma density, and decentered parameters. Mathematical analysis displays that these parameters play a major role in achieving the stronger and earlier self-focusing. Further, a comparative study between self-focusing of Hermite-cosine-Gaussian laser beam with and without exponential density ramp profile is introduced. Plasma density transition with exponential profile is found to be more effective in order to have stronger self-focusing. The present analysis may lead to very useful applications in the field of efficient harmonic generation, laser driven fusion etc.

关键词： self-focusing collisionless plasma exponential plasma density ramp Hermite-cosine-Gaussian laser beam

Enhanced photocatalytic degradation of organic dyes from aqueous environment using neodymium-doped mesoporous layered double hydroxide

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Journal of Rare Earths 2022年第10期40卷 1554-1563页

作者： Ajaz ahmad wani Amjad Mumtaz Khan Yahiya Kadaf Manea Mansour A.S.Salem Department of Chemistry Aligarh Muslim UniversityAMUAligarh202002India

Neodymium-doped Zn-Al layered double hydroxide(Nd/Zn-Al LDH) with excellent photocatalytic activity was prepared by a one-step hydrothermal method. The morphology and physicochemical properties of as-synthesized photocatalysts were well analyzed by Fourier transform infrared(FT-IR), X-ray diffraction(XRD), scanning electron microscopy(SEM), transmission electron microscopy(TEM), photoluminescence(PL), UV-diffuse reflectance spectroscopy(UV-DRS), and Brunauer-Emmett-Teller(BET)surface analysis. Doping Nd^(3+) into Zn-Al LDH enhances the overall catalytic activity of the nanocomposite, like better electron-hole pair separation, increase in interplanar distance, fast electron transfer, and large surface area. The as-prepared nanocomposite shows excellent degradation of three different dyes under visible light irradiation. The degradation efficiency of these dyes follows the order of Congo red > rose Bengal > fast green. Furthermore, liquid chromatography-mass spectrometry(LC-MS)was employed to propose a possible photocatalytic degradation pathway for Congo Red and Rose Bengal dyes by Nd/Zn-Al LDH. With the help of radical trapping experiments, it is revealed that during the photoexcitation process, the primary reactive intermediates are hydroxyl radicals.

关键词： Organic pollutants Degradation Multifunctional Mesoporous LC-MS Rare earths

Guinea pigs as an animal model for sciatic nerve injury

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Neural Regeneration Research 2017年第3期12卷 452-457页

作者： Malik Abu Rafee Amarpal Prakash Kinjavdekar Hari Prasad Aithal Sajad ahmad wani Irfan ahmad Bhat Division of Surgery Indian Veterinary Research InstituteIzatnagarBareillyUPIndia Division of Veterinary Biotechnology Indian Veterinary Research InstituteIzatnagarBareillyUPIndia Division of Veterinary Physiology Indian Veterinary Research InstituteIzatnagarBareillyUPIndia

The overwhelming use of rat models in nerve regeneration studies is likely to induce skewness in treatment *** address the problem,this study was conducted in 8 adult guinea pigs of either sex to investigate the suitability of guinea pig as an alternative model for nerve regeneration studies.A crush injury was inflicted to the sciatic nerve of the left limb,which led to significant decrease in the pain perception and neurorecovery up to the 4th *** of foot print and shortening of toe spread were observed in the paw after nerve injury.A 3.49 ± 0.35 fold increase in expression of neuropilin 1（NRP1） gene and 2.09 ± 0.51 fold increase in neuropilin 2（NRP2） gene were recorded 1 week after nerve injury as compared to the normal *** of gastrocnemius muscle weight and volume of the experimental limb to control limb showed more than 50% decrease on the 30 th ***,vacuolated appearance of the nerve was observed with presence of degenerated myelin debris in digestion *** muscle also showed degenerative *** electron microscopy revealed loose and rough arrangement of connective tissue fibrils and presence of large spherical globules in crushed sciatic *** findings suggest that guinea pigs could be used as an alternative animal model for nerve regeneration studies and might be preferred over rats due to their cooperative nature while recording different parameters.

关键词： nerve regeneration Guinea pigs animal model sciatic nerve injury foot print length neuropilin histopathology neural regeneration

A study on p53 gene alterations in esophageal squamous cell carcinoma and their correlation to common dietary risk factors among population of the Kashmir valley

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World Journal of Gastroenterology 2006年第25期12卷 4033-4037页

作者： Imtiyaz Murtaza Dhuha Mushtaq Mushtaq A Margoob Amit Dutt Nisar ahmad wani Ishfaq ahmad Mohan Lal Bhat Biochemistry and Molecular Biotechnology Laboratory Division of PHT S.K.University of Agricultural Sciences and Technology of KashmirShalimar CampusSrinagarKashmirIndia Department of Biotechnology University of Kashmir SrinagarKashmirIndia Department of Psychiatry Government Medical College SrinagarKashmirIndia Broad Institute of Harvard and MIT 320 Charles St CambridgeMA-02141United States Department of Surgery Government Medical College SrinagarKashmirIndia Department of Pathology Government Medical College SrinagarKashmirIndia

AIM： To systematically examine the extent of correlation of risk factors, such as age, consumed dietary habit and familial predisposition with somatic Tp53 molecular lesion causal to elevate carcinogenesis severity of esophageal squamous cell carcinoma （ESCC） among the Kashmiri population of Northern India. METHODS： All cases （n = 51） and controls （n = 150） were permanent residents of the Kashmir valley. Genetic alterations were determined in exons 5-8 of Tp53 tumor suppressor gene among 45 ESCC cases histologically confirmed by PCR-SSCP analysis. Data for individual cancer cases （n = 45） and inpatient controls （n = 150） with non-cancer disease included information on family history of cancer, thirty prevailing common dietary risk factors along with patient＇s age group. Correlation of genetic lesion in p53 exons to animistic data from these parameters was generated by Chi-square test to all 45 histologically confirmed ESCC cases along with healthy controls.RESULTS： Thirty-five of 45 （77.8%） histologically characterized tumor samples had analogous somatic mutation as opposed to 1 of 45 normal sample obtained from adjacent region from the same patient showed gerrnline mutation. The SSCP analysis demonstrated that most common p53 gene alterations were found in exon 6 （77.7%）, that did not correlate with the age of the individual and clinicopathological parameters but showed significant concordance （P 〈 0.05） with familial history of cancer （CD = 58）, suggesting germline predisposition at an unknown locus, and dietary habit of consuming locally grown Brassica vegetable ＂Hakh＂（CD = 19.5）, red chillies （CD = 20.2）, hot salty soda tea （CD = 2.37） and local baked bread （CD = 1.1）. CONCLUSION： Our study suggests that somatic chromosomal mutations, especially in exon 6 of Tp53 gene, among esophageal cancer patients of an ethnically homogenous population of Kashmir valley are closely related to continued exposure to various common dietary risk factors, especially hot sa

关键词： Case-controls Esophageal squamous cell carcinoma Dietary carcinogens p53 alterations