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Bioengineering liver tissue by repopulation of decellularised scaffolds

World Journal of Hepatology 2023年第2期15卷 151-179页

作者： zeeshan afzal Emmanuel Laurent Huguet Department of Surgery Addenbrookes HospitalNIHR Comprehensive Biomedical Research and Academic Health Sciences CentreCambridge University Hospitals NHS Foundation TrustCambridge CB20QQUnited Kingdom

Liver transplantation is the only curative therapy for end stage liver disease,but is limited by the organ shortage,and is associated with the adverse consequences of *** of decellularised whole organ scaffolds with appropriate cells of recipient origin offers a theoretically attractive solution,allowing reliable and timely organ sourcing without the need for *** methodologies vary widely but seek to address the conflicting objectives of removing the cellular component of tissues whilst keeping the 3D structure of the extra-cellular matrix intact,as well as retaining the instructive cell fate determining biochemicals contained *** scaffold recellularisation has progressed from small rodent in vitro studies to large animal in vivo perfusion models,using a wide range of cell types including primary cells,cell lines,foetal stem cells,and induced pluripotent stem *** these models,a limited but measurable degree of physiologically significant hepatocyte function has been reported with demonstrable ammonia metabolism in *** repopulation and function have been restricted by challenges relating to the culture and propagations of cholangiocytes,though advances in organoid culture may help address *** vasculature repopulation has enabled sustainable blood perfusion in vivo,but with cell types that would limit clinical applications,and which have not been shown to have the specific functions of liver sinusoidal endothelial *** cell groups such as Kupffer cells and stellate cells have not been *** by repopulation of decellularised scaffolds has significantly progressed,but there remain significant experimental challenges to be addressed before therapeutic applications may be envisaged.

关键词： Regenerative Bioengineering Scaffolds Liver Decellularisation Recellularisation

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Immunogenicity and Protective Efficacy of Probiotics with EtIMP1C against Eimeria tenella Challenge

Immunogenicity and Protective Efficacy of Probiotics with Et...

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2021中国畜牧兽医学会兽医寄生虫学分会第二届青年科学...

作者： Muhammad Mohsin Lina Li Xiaohang Huang Muhammad Tahir Aleem Yusuf Jibril Habib Akram Ismael Shehata Muhammad zeeshan afzal Rao Zahid Abbas Asghar Abbas Guangwen Yin College of Animal Sciences (College of Bee Science) Fujian Agriculture and Forestry University College of Life Science Fujian Agriculture and Forestry University Department of Parasitology University of Agriculture MOE Joint International Research Laboratory of Animal Health and Food Safety College of Veterinary MedicineNanjing Agricultural University Department of Pathology University of Agriculture

Coccidiosis is an endemic problem in broilers inflicting disastrous losses to worldwide poultry *** are generally effective in controlling the infectious diseases;the subunit vaccines effectiveness can hopefully be improved with concurrent use of probiotics as assessed in this experiment using an Eimeria tenella *** mapped protein-1(IMP 1)is a novel immunogenic protein of Apicomplexans,including in Eimeria *** performance of the cumulative effect of probiotics and EtIMP1 C(Part of Eimeria tenella immune mapped protein1) was evaluated based on various parameters such as an intestinal lesion,oocyst scores,feed conversion ratio,and organ *** were also analyzed on both immunological and hematological *** EtIMP1 C and probiotics administered group showed less intestinal lesion,decreased oocyst shedding,satisfactory feed conversion ratio(FCR) and improved hematological parameters as compared to EtIMP1 C emulsified with FCA ***,there was no statistically significant difference between the two groups(P>0.05),in aspect of lesion and oocyst scores,as well as immunological and hematological *** experimental work showed that probiotics could be a good hope due to its antioxidant,immunomodulatory and growth promoting effect against poultry coccidiosis alone or in combination with vaccines,including IMP1 C based vaccine,but further studies are required to formulate its dose with the vaccine as well as a different strain of probiotics effect against coccidiosis.

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