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Plant Nitrogen Metabolism: Balancing Resilience to Nutritional Stress andAbiotic Challenges

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Phyton-International Journal of Experimental Botany 2024年第3期93卷 581-609页

作者： Muhammad Farhan Manda Sathish Rafia Kiran Aroosa Mushtaq Alaa Baazeem Ammarah Hasnain Fahad Hakim Syed Atif Hasan Naqvi Mustansar Mubeen Yasir Iftikhar Aqleem Abbas Muhammad zeeshan Hassan Mahmoud Moustafa Department of Plant Pathology Faculty of Agricultural Sciences&TechnologyBahauddin Zakariya UniversityMultan60800Pakistan Centro de Investigación de Estudios Avanzados del Maule(CIEAM) Vicerrectoría de Investigación y PostgradoUniversidad Católica del MauleTalca3460000Chile College of Food Science and Nutritional Engineering China Agricultural UniversityBeijingChina Department of Biology College of ScienceTaif UniversityP.O.Box 11099Taif21944Saudi Arabia Department of Biotechnology Faculty of Biological SciencesLahore University of Biological and Applied SciencesLahorePakistan Department of Plant Pathology College of AgricultureUniversity of SargodhaSargodha40100Pakistan Department of Agriculture and Food Technology Karakorum International UniversityGilgitPakistan Department of Biology Faculty of ScienceKing Khalid UniversityAbhaSaudi Arabia

Plant growth and resilience to abiotic stresses,such as soil salinity and drought,depend intricately on nitrogen *** review explores nitrogen’s regulatory role in plant responses to these challenges,unveiling a dynamic interplay between nitrogen availability and abiotic *** the context of soil salinity,a nuanced rela-tionship emerges,featuring both antagonistic and synergistic interactions between salinity and nitrogen ***-induced chlorophyll depletion in plants can be alleviated by optimal nitrogen supplementation;however,excessive nitrogen can exacerbate salinity *** delve into the complexities of this interaction and its agri-cultural ***,a vital element within essential plant structures like chloroplasts,elicits diverse responses based on its *** review comprehensively examines manifestations of nitrogen deﬁciency and toxicity across various crop types,including cereals,vegetables,legumes,and ***,we explore the broader consequences of nitrogen products,such as N_(2)O,NO_(2),and ammonia,on human ***-ing the intricate relationship between nitrogen and salinity,especially chloride accumulation in nitrate-fed plants and sodium buildup in ammonium-fed plants,is pivotal for optimizing crop nitrogen ***,prudent nitrogen use is essential,as overapplication can exacerbate nitrogen-related *** Use Efﬁ-ciency(NUE)is of paramount importance in addressing salinity challenges and enhancing sustainable crop *** this goal requires advancements in crop varieties with efﬁcient nitrogen utilization,pre-cise timing and placement of nitrogen fertilizer application,and thoughtful nitrogen source selection to mitigate losses,particularly urea-based fertilizer *** review article delves into the multifaceted world of plant nitrogen metabolism and its pivotal role in enabling plant resilience to nutritional stress and abiotic chall

关键词： Synthetic nitrogen nitrogen signaling sustainable agriculture eutrophication ammonium nitrate

HPLC-UV method for simultaneous determination of irbesartan, candesartan, gliquidone and pioglitazone in formulations and in human serum

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Journal of Chinese Pharmaceutical Sciences 2018年第4期27卷 273-280页

作者： Agha zeeshan mirza Science and Technology Unit Umm Al-Qura University Makah 21955 KSA

In this study, we reported and validated a novel and sensitive reversed-phase liquid chromatographic method for the simultaneous determination of irbesartan, candesartan, gliquidone and pioglitazone. Separation was performed at 230 nm using a mobile phase consisting of methanol–water(90:10, v/v) with a flow rate of 1 mL/min. p H was adjusted to 3.5 with phosphoric acid. The concentration-response relationship was found linear over a concentration range of 5–25 μg/mL for all of the analytes tested. The limits of detection and quantification were 0.83 and 2.78 for irbesartan, 0.30 and 1.01 for candesartan, 1.11 and 3.93 for gliquidone, and 0.41 and 1.41 μg/mL for pioglitazone, respectively. Described method permitted the successful determination of these drugs in human serum. The developed method was simple, rapid, and it did not require extensive sample purification.

关键词： Candesartan Gliquidone Irbesartan Pioglitazone RP-HPLC Method development

Determination of the best materials for development and designing product using a multi-criteria decision-making

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Railway Sciences 2024年第5期3卷 541-557页

作者： Rabia Hassan zeeshan Ahmad Arfeen Mehreen Kausar Azam Zain ul Abiden Akhtar Abubakar Siddique Department of Management Economicsand Industrial Engineering DIGPolitecnico di MilanoMilanItaly Department of Electrical Engineering College of Engineering and SciencesInstitute of Business Management SindhKarachiPakistan Department of Electrical Engineering The Islamia University of Bahawalpur PakistanBahawalpurPakistan Department of Industrial Manufacturing NED University of Engineering and TechnologyKarachiPakistan Department of Information and Communication Engineering The Islamia University of Bahawalpur PakistanBahawalpurPakistan Department of Electrical Engineering Khwaja Fareed University of Engineering and Information TechnologyRahim Yar KhanPakistan Muhammad Rashid Department of Electrical Engineering Faculty of ScienceThe Islamia University of Bahawalpur PakistanBahawalpurPakistan

Purpose–Material selection,driven by wide and often conflicting objectives,is an important,sometimes difficult problem in material *** this context,multi-criteria decision-making(MCDM)methodologies are *** approach of MCDM is needed to cater to criteria of material assortment *** firms are now concerned about increasing their productivity using mathematical *** occupy a gap in the previous literature this research recommends an integrated MCDM and mathematical Bi-objective model for the selection of *** addition,by using the Technique for Order Preference by Similarity to Ideal Solution(TOPSIS),the inherent ambiguities of decision-makers in paired evaluations are considered in this *** goes on to construct a mathematical bi-objective model for determining the best item to ***/methodology/approach–The entropy perspective is implemented in this paper to evaluate the weight parameters,while the TOPSIS technique is used to determine the best and worst intermediate pipe materials for automotive exhaust *** intermediate pipes are used to join the components of the exhaust *** materials usually used to manufacture intermediate pipe are SUS 436LM,SUS 430,SUS 304,SUS 436L,SUH 409 L,SUS 441 L and SUS *** seven materials are evaluated based on tensile strength(TS),hardness(H),elongation(E),yield strength(YS)and cost(C).A hybrid methodology combining entropy-based criteria weighting,with the TOPSIS for alternative ranking,is pursued to identify the optimal design material for an engineered application in this *** study aims to help while filling the information gap in selecting the most suitable material for use in the exhaust intermediate *** that,the authors searched for and considered eight materials and evaluated them on the following five criteria:(1)TS,(2)YS,(3)H,(4)E and(5)*** first two criteria have been chosen because they can have a lot of influence on the behav

关键词： TOPSIS Multi-criteria decision-making Entropy method Material selection

Viral-host molecular interactions and metabolic modulation:Strategies to inhibit flaviviruses pathogenesis

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World Journal of Virology 2024年第4期13卷 41-50页

作者： zeeshan Ahmad Khan Mukesh Kumar Yadav Dong-Woo Lim Hojun Kim Jing-Hua Wang AbuZar Ansari Biohealth Products Research Center(BPRC) Research Center for Agedlife Redesign(RCAR)Department of Physical TherapyINJE UniversityGimhae 5084South Korea Department of Microbiology Central University of PunjabBathinda 151401India Department of Diagnostics College of Korean MedicineDongguk UniversityGoyang 10326South Korea Division of Rehabilitation Medicine of Korean Medicine Department of Oriental Rehabilitation MedicineDongguk UniversityIlsan HospitalGoyang 10326South Korea Institute of Oriental Medicine Dongguk UniversityGoyang 10326South Korea Department of Obstetrics and Gynecology Ewha Womans UniversitySeoul 07985South Korea

Flaviviruses,which include globally impactful pathogens,such as West Nile virus,yellow fever virus,Zika virus,Japanese encephalitis virus,and dengue virus,contribute significantly to human *** the ongoing emergence and resurgence of flavivirus-mediated pathogenesis,the absence of specific therapeutic options remains a challenge in the prevention and treatment of flaviviral *** the intricate processes of fusion,transcription,replication,and maturation,the complex interplay of viral and host metabolic interactions affects *** interactions involve metabolic molecules,such as amino acids,glucose,fatty acids,and nucleotides,each playing a pivotal role in the replication and maturation of *** viral-host metabolic molecular interactions hijack and modulate the molecular mechanisms of host metabolism.A comprehensive understanding of these intricate metabolic pathways offers valuable insights,potentially unveiling novel targets for therapeutic interventions against flaviviral *** review emphasizes promising avenues for the development of therapeutic agents that target specific metabolic molecules,such as amino acids,glucose,fatty acids,and nucleotides,which interact with flavivirus replication and are closely linked to the modulation of host *** clinical limitations of current drugs have prompted the development of new inhibitory strategies for flaviviruses based on an understanding of the molecular interactions between the virus and the host.

关键词： Flavivirus Nonstructural proteins Virus-host interaction Metabolism Inhibitors Vaccines

Preparation and antibacterial activities of metal complexes of norfloxacin

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Journal of Chinese Pharmaceutical Sciences 2021年第10期30卷 838-844页

作者： Ahsan Zamir Siddiqi Muneeba Akhtar Agha zeeshan mirza Research Institute of Pharmaceutical Sciences Department of Pharmaceutical ChemistryFaculty of PharmacyUniversity of KarachiKarachi-75270Pakistan Highnoon Laboratories Limited LahorePakistan Department of Pharmaceutics Faculty of PharmacyUniversity of Central PunjabLahore-54782Pakistan Chemistry Department Faculty of Applied SciencesUmm Al-Qura UniversityMakkahSaudi Arabia

The metal complexes of norfloxacin were prepared, and their structures were characterized using spectroscopic techniques like IR, 1H NMR, UV, atomic absorption, and CHN analysis. The solubility, melting point, and conductance measurements were also performed. These studies suggested that norfloxacin formed complexes with the metals utilizing carbonyl oxygen atom of the ring and carboxylic group oxygen atom. The antibacterial activities of these metal complexes against 14 different Gram-positive and Gram-negative microorganisms were studied by the disk susceptibility method. It was observed that the complexes of norfloxacin with magnesium, calcium, cobalt, nickel, and copper showed improved activity compared with the stated drug.

关键词： Norfloxacin Metal complexes Characterization Antibacterial activities

UV Spectroscopic Method for Optimization and Determination of Glibenclamide in Bulk,Pharmaceutical Dosage Form and its Application for In Vitro Interaction Studies

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Journal of Analysis and Testing 2020年第4期4卷 281-290页

作者： Faiza Akhtar Somia Gul Salman Ashfaq Iqra Rehman Agha zeeshan mirza Department of Pharmaceutical Chemistry Faculty of PharmacyJinnah University for WomenKarachi 74600Pakistan Department of Pharmaceutical Chemistry Faculty of PharmacyZiauddin UniversityKarachi 75600Pakistan Department of Pharmaceutics Faculty of PharmacyUniversity of KarachiKarachi 75270Pakistan Chemistry Department Faculty of Applied SciencesUmm Al-Qura UniversityMecca 21955Saudi Arabia

A simple,easy and cost-efficient UV spectroscopic method was developed and validated for glibenclamide,the second generation of sulfonylureas,using 0.1 N NaOH as a *** proposed method is linear(R^(2)>0.999)with the range 5-25μg mL^(−1),accurate(99.60%),precise(inter and intraday variation 0.241 and 0.019%,respectively)and robust(<1%).The quantification and detection limit were 1.46 and 0.48μg mL^(−1),*** validated method was applied for in vitro interaction studies of glibenclamide(GLB)with commonly prescribed quinolones(ciprofloxacin,levofloxacin,moxifloxacin,and gemifloxacin)and nonsteroidal anti-inflammatory drugs(NSAIDs)(diclofenac sodium,ibuprofen,mefenamic acid,and aspirin)using UV *** in vitro interaction studies were carried out in different artificially prepared physiological buffers at 37°C for 2 *** showed raised level of glibenclamide when interacted with gemifloxacin(pH 7.4),levofloxacin(pH 9),ciprofloxacin(pH 4.5)and with moxifloxacin(pH 4.5,7.4 and 9).Interaction with NSAIDs results in increased%availability of glibenclamide in the presence of diclofenac sodium,ibuprofen,and mefenamic acid at pH *** anticipated method can be successfully applied for the routine analysis and also for the interaction of glibenclamide with other drugs.

关键词： Glibenclamide Interaction Quinolones NSAIDS UV spectroscopy

Chlorinated Polyfluoroalkyl Ether Sulfonic Acids(Cl-PFESAs)Are Associated with Eye Diseases in Humans and Eye Toxicity in Zebrafish

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Environment & Health 2024年第6期2卷 390-400页

作者： Lu-Yin Wu Li-Xia Liang Yang Zhou zeeshan Mohammed Zhengmin Min Qian Stephen Edward McMillin Maya Tabet Chu Chu Yuan-Yuan Fan Jia-Xin Zhou Jing-Wen Huang Wei-Hong Tan Guang-Hui Dong Li-Zi Lin Joint International Research Laboratory of Environment and Health Ministry of EducationGuangdong Provincial Engineering Technology Research Center of Environmental Pollution and Health Risk AssessmentDepartment of Occupational and Environmental HealthSchool of Public HealthSun Yat-sen UniversityGuangzhou 510080China State Environmental Protection Key Laboratory of Environmental Pollution Health Risk Assessment South China Institute of Environmental SciencesMinistry of Environmental ProtectionGuangzhou 510655China Department of Developmental Biology&Genetics School of Biological SciencesIndian Institute of ScienceBangalore 400060India Department of Epidemiology and Biostatistics College for Public Health&Social JusticeSaint Louis UniversitySt.LouisMissouri 63104United States School of Social Work Saint Louis UniversitySt.LouisMissouri 63103United States College of Global Population Health University of Health Sciences and Pharmacy in St.LouisSt.LouisMissouri 63110United States Guangdong Cardiovascular Institute Department of Reproductive MedicineDepartment of Obstetrics and GynecologyGuangdong Provincial People’s HospitalGuangdong Academy of Medical SciencesGuangzhou 510080China Department of Reproductive Medicine and Genetics Center The People’s Hospital of Guangxi Zhuang Autonomous RegionNanning 530021China

Evidence from animal experiments has shown that chlorinated polyfluoroalkyl ether sulfonic acids(Cl-PFESAs)can induce vision dysfunction in ***,environmental epidemiological evidence supporting this hypothesis remains *** our case−control study,samples collected from 270 individuals(135 controls and 135 cases)from the Isomers of C8 Health Project data were analyzed for *** also repeated our analysis on zebrafish to support our findings in humans and to decipher the mechanism underlying Cl-PFESA eye *** serum levels of per-and polyfluoroalkyl substances(PFASs)and alternatives were significantly higher in the cases than in the *** serum Cl-PFESA levels were associated with greater odds of eye diseases,and the trend showed a statistically significant dose-dependent *** Shapley additive explanations(SHAP)value indicated that 8:2 Cl-PFESA was the dominant eye disease risk factor among the 13 studied *** zebrafish experiments,Cl-PFESAs induced eye toxicity in adult zebrafish by oxidative damage and cell *** to the control group,there was significantly reduced thicknesses of the inner plexiform layer(IPL),outer plexiform layer(OPL),and retinal tissue in the zebrafish exposed to *** study provides human clinical and animal experimental data,showing that exposure to PFASs increases the odds of the development of eye toxicity.

关键词： eye diseases chlorinated polyfluoroalkyl ether sulfonic acids(Cl-PFESAs) case−control study shapley additive explanations(SHAP) zebrafish experiment

Synthesis and antibacterial studies of ciprofloxacin-metal complexes

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Journal of Chinese Pharmaceutical Sciences 2019年第6期28卷 422-429页

作者： Najma Sultana M.Saeed Arayne Ahsan Zamir Siddiqi Agha zeeshan mirza Research Institute of Pharmaceutical Sciences Department of Pharmaceutical ChemistryFaculty of PharmacyUniversity ofKarachiKarachi-75270Pakistan Department of Chemistry University of Karachi Chemistry Department Faculty of Applied SciencesUmm Al-Qura UniversityMakkahSaudi Arabia Research Laboratories Centre Faculty of Applied SciencesUmm Al-Qura UniversityMakkahSaudi Arabia

Metal complexes of ciprofloxacin were synthesized to study the effect of the drug on the metals present in the body or metals co-administered as multivitamin therapy. These complexes were then characterized by IR, UV, 1 H NMR, CHN and AA analyses. It was found that the metals coordinated through the β-keto carboxylic group, forming four coordinated complexes having square planar geometry. The effect of the antibacterial activity of these complexes with respect to parent drug was also studied against 14 different Gram + ve and Gram – ve organisms by the disk susceptibility technique. Some complexes showed improve activity as compared with the stated drug.

关键词： Ciprofloxacin IR UV ~1H NMR CHN AA analysis

Changes in Germination and Seedling Traits of Sesame under Simulated Drought

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Phyton-International Journal of Experimental Botany 2022年第4期91卷 713-726页

作者： Mukhtar Ahmed Ahmed M.S.Kheir Muhammad zeeshan Mehmood Shakeel Ahmad mirza Hasanuzzaman Department of Agronomy PMAS-Arid Agriculture UniversityRawalpindi46300Pakistan International Center for Biosaline Agriculture Directorate of ProgramsDubai14660United Arab Emirates Soils Water and Environment Research InstituteAgricultural Research CenterCairo UniversityGiza12613Egypt Department of Agronomy Bahauddin Zakariya UniversityMultan60800Pakistan Department of Agronomy Sher-e-Bangla Agricultural UniversityDhaka1207Bangladesh

Drought is considered one of the leading abiotic constraints to agricultural crop production *** study was conducted to assess the effects of different drought treatments(***,10%PEG,and 20%PEG)on seed germination,germination indices,seedling traits,and drought tolerance indices of *** results showed that maximum reduction in the studied parameters was observed at higher PEG concentration(i.e.,20%PEG).As compared to control,the drought treatments viz.10%and 20%PEG decreased the values for germination indices,such as germination percentage,coefficient of variation of germination time,germination index,and seedling vigor ***,for seedling traits,the values were decreased for root length,shoot length,root shoot ratio,root fresh weight,shoot fresh weight,root dry weight and shoot dry weight under 10%and 20%PEG treatments significantly in comparison with ***,relative to control,the values for drought tolerance indices,such as germination drought tolerance index,root length drought tolerance index,shoot length drought tolerance index,total seedling length drought tolerance index,root fresh weight drought tolerance index,shoot fresh weight drought tolerance index,total fresh weight drought tolerance index,root dry weight drought tolerance index,shoot dry weight drought tolerance index and total dry weight drought tolerance index were also reduced under 10%and 20%PEG treatments,*** results confirms that drought impact on seed germination and seedling traits could be quantified by using different indices which can further help to design drought adaptation and mitigation *** on these results it can be concluded that germination indices,seedling traits,and drought tolerance indices have great potential to simulate drought stress impacts on different crop traits thus they should be used in all kinds of stress related studies.

关键词： Sesame drought stress PEG germination indices seedling traits drought tolerance indices