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Brain region-specific roles of brain-derived neurotrophic factor in social stress-induced depressive-like behavior

Neural Regeneration Research 2025年第1期20卷 159-173页

作者： Man Han Deyang zeng Wei Tan Xingxing Chen Shuyuan Bai Qiong wu Yushan Chen Zhen Wei Yufei Mei Yan zeng Brain Science and Advanced Technology Institute Wuhan University of Science and TechnologyWuhanHubei ProvinceChina Geriatric Hospital Affiliated to wuhan University of Science and Technology WuhanHubei ProvinceChina School of Public Health Wuhan University of Science and TechnologyWuhanHubei ProvinceChina

Brain-derived neurotrophic factor is a key factor in stress adaptation and avoidance of a social stress behavioral *** studies have shown that brain-derived neurotrophic factor expression in stressed mice is brain region–specific,particularly involving the corticolimbic system,including the ventral tegmental area,nucleus accumbens,prefrontal cortex,amygdala,and *** how brain-derived neurotrophic factor participates in stress processing in different brain regions will deepen our understanding of social stress *** this review,we discuss the expression and regulation of brain-derived neurotrophic factor in stress-sensitive brain regions closely related to the pathophysiology of *** focused on associated molecular pathways and neural circuits,with special attention to the brain-derived neurotrophic factor–tropomyosin receptor kinase B signaling pathway and the ventral tegmental area–nucleus accumbens dopamine *** determined that stress-induced alterations in brain-derived neurotrophic factor levels are likely related to the nature,severity,and duration of stress,especially in the above-mentioned brain regions of the corticolimbic ***,BDNF might be a biological indicator regulating stress-related processes in various brain regions.

关键词： amygdala chronic mild stress chronic social defeat stress corticolimbic system depression hippocampus medial prefrontal cortex nucleus accumbens social stress models ventral tegmental area

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Wider frequency domain for negative refraction index in a quantized composite right–left handed transmission line

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Chinese Physics B 2018年第6期27卷 468-472页

作者： Qi-xuan wu Shun-Cai Zhao Faculty of Foreign Languages and Culture Kunming University of Science and Technology Kunming 650500 China Department of Physics Faculty of Science Kunming University of Science and Technology Kunming 650500 China

The refraction index of the quantized lossy composite right-left handed transmission line（CRLH-TL） is deduced in the thermal coherence state. The results show that the negative refraction index（herein the left-handedness） can be implemented by the electric circuit dissipative factors（i.e., the resistances R and conductances G） in a higher frequency band（1.446 GHz≤ ω ≤ 15 GHz）, and flexibly adjusted by the left-handed circuit components（Cl, Ll） and the right-handed circuit components（Cr, Lr） at a lower frequency（ω = 0.995 GHz）. The flexible adjustment for left-handedness in a wider bandwidth will be significant for the microscale circuit design of the CRLH-TL and may make the theoretical preparation for its compact applications.

关键词： quantized composite right-left handed transmission line negative refraction index frequency do- main

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Time in range as a useful marker for evaluating retinal functional changes in diabetic retinopathy patients

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International Journal of Ophthalmology(English edition) 2023年第6期16卷 915-920页

作者： Dan-Dan Zhu xuan wu Xin-xuan Cheng Ning Ding Department of Ophthalmology Nanjing Drum Tower Hospitalthe Affiliated Hospital of Nanjing University Medical SchoolNanjing 210000Jiangsu ProvinceChina Department of Ophthalmology Nanjing Drum Tower Hospital Group Suqian HospitalSuqian 223800Jiangsu ProvinceChina Department of Nutrition and Food Hygiene Nanjing University of Chinese MedicineNanjing 210000Jiangsu ProvinceChina

·AIM:To elucidate the relationship between macular sensitivity and time in range(TIR)obtained from continuous glucose monitoring(CGM)measures in diabetic patients with or without diabetic retinopathy(DR).·METHODS:This was a cross-sectional study including 100 eyes of non-DR patients and 60 eyes of DR *** advanced microperimetry was used to quantitate the retinal mean sensitivity(MS)and fixation stability in central *** of 3.9-10.0 mmol/L was evaluated with *** coefficient analysis and multiple linear regression analysis were used to assess the correlation between TIR and retinal sensitivity.·RESULTS:In a comparison of non-DR patients,significant differences(P0.05).A multivariable linear regression analysis was performed to prove that TIR and SDBG were both independent risk factors for MS reduction in the DR group.·CONCLUSION:TIR is correlated with retinal MS reduction in DR patients,suggesting a useful option for evaluating DR progression.

关键词： diabetic retinopathy time in range microperimetry continuous glucose monitoring

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Synthesis of BaFe_(12)O_(19)/MFe_(2)O_(4)(M=Co,Mn)by sol-gel method

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Rare Metals 2006年第Z1期25卷 462-465页

作者： HAN Zhidong DONG Limin ZHANG Dawei wu ze ZHANG Xianyou College of Materials Science and Engineering Harbin University of Science and TechnologyHarbin 150040China

Composites of M-type hexaferrite BaFe_(12)O_(19) and spinel ferrites MFe_(2)O_(4)(M=Co,Mn)were directly synthesized by sol-gel *** structure of composites was analyzed by X-ray diffraction(XRD)and scanning electron microscopy(SEM).The formation of BaFe_(12)O_(19)/CoFe_(2)O_(4) composite was proved by XRD patterns with coexistence of diffraction peaks of the two kinds of ferrites,BaFe_(12)O_(19) and CoFe_(2)O_(4).Compared with BaFe_(12)O_(19),the diffraction peaks of CoFe_(2)O_(4) are fairly weak,revealing the dominant structure of hexaferrite in the *** micrographs provide further evidence and the particle size of composites is about several hundred nanometer,meaning that the co-synthesizing sol-gel method can be in favor of the formation of finer ***,the diffraction peaks of MnFe_(2)O_(4) can be hardly found in BaFe_(12)O_(19)/MnFe_(2)O_(4) composite,revealing the synthesis conditions are not favorable for the formation of MnFe_(2)O_(4).Substitution reaction of Ba or Fe by Mn may be proposed.

关键词： sol-gel method hexaferrites spinel ferrite

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Numerical Simulation of Recirculating Flow and Decarburization in RH Vacuum Refining Degasser

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Journal of Iron and Steel Research International 2005年第2期12卷 20-24页

作者： ZHUMiao-yong wuYong-lai DUCheng-wu HUANGZong-ze NortheasternUniversity Shenyang110004China BaoshanIronandSteelGroupCo Shanghai201900China

Based on the principle of RH process and the mechanism of decarburization, a three-dimensional mathematical model to represent the flow and decarburization of molten steel was established. The model was verified and t... 详细信息

关键词： RH vacuum refining fluid flow decarburization numerical simulation

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Theoretical Studies on the Interactions of Cations with Diazine

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Chinese Journal of Structural Chemistry 2006年第11期25卷 1321-1330页

作者： CHEN Xing wu Wen-Peng ZHANG Jing-Lai CAO ze-Xing Institute of Fine Chemistry and Engineering Henan University Kaifeng 475001 China Department of Chemistry and State Key Laboratory for Physical Chemist~ of Solid Surfaces College of Chemistry and Chemical Engineering Xiamen University Xiamen 361005 China

Density functional theory and MP2 calculations have been used to determine the geometries, stabilities, binding energies, and dissociative properties of cation-diazine complexes M^n＋-C4H4N2 （M^n＋= Li^＋, B^＋, Al^＋, Be^2＋, Mg^2＋, Ca^2＋）. The calculated results indicate that most complexes are stable except the π complexes of Ca^2＋-pyridazine, Ca^2＋-pyrazine, Al^＋-pyrimidine and Al^＋-pyrimidine. The a complexes are generally much more stable than their π counterparts. Among the π complexes, the cation-pyrazine π complexes have slightly higher stability. The nature of the ion-molecule interactions has been discussed by the natural bond orbital analysis and frontier molecular orbital interactions. In these a complexes, there is stronger covalent interaction between B^＋ and diazine. In the selected π complexes, B^＋ and Be^2＋ have stronger covalent interaction with diazine, while the other cations mainly have electrostatic interaction with diazine.

关键词： DFT and MP2 calculations cation-diazine complexes cation-molecule interactions

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A time-sharing multi-channel pulse amplitude analyzer

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Nuclear Science and Techniques 2017年第4期28卷 91-96页

作者： Lian-Jun Jiang Xiang Zhou Tong-Yu wu ze-Jie Yin State Key Laboratory of Particle Detection and Electronics University of Science and Technology of China Department of Modern Physics University of Science and Technology of China

A conventional multi-channel pulse amplitude analyzer acquires single energy spectrum,but provides no information on its tendency with *** address the limitation,we propose a scheme of time-sharing multichannel pulse amplitude analyzer(TSMCA).A dual-port random access memory is divided into two storage spaces,one for current energy spectrum data acquisition and another for previous energy spectrum data *** two tasks can be performed simultaneously,and the time-related variation tendency of energy spectrum can be obtained.A prototype system of TSMCA is *** performs nicely,with maximum channel number of 4096 in capacity of 2^(32)/Ch,minimal time-sharing slice of 25 ms,the differential nonlinearity of <1.5%,and the integral nonlinearity of <0.3%.

关键词： Multi-channel pulse amplitude analyzer MCA Time-sharing ADC Dual-port RAM

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Research of air-cushion isolation effects on high arch dam reservoir

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Acta Mechanica Sinica 2011年第5期27卷 675-686页

作者： Shao-Jie Zhang Jiang Chen Yuan-ze Zhang Hao-wu Liu College of Hydraulic ＆ Hydroelectric Engineering Sichuan University610065 Chengdu China Scientific Research Institute of Kunming Investigationand Design Institute China Hydropower Engineering Consultation Group Company650033 Kunming China Institute of Mountain Harzards and Environment Chinese Academy of Sciences610041 Chengdu China

A three-dimensional （3D） finite element model of air-cushion isolated arch dam is presented with the nonlinear gas-liquid-solid multi-field dynamic coupling effect taken into *** this model,the displacement formulation in Lagrange method,pressure formulation in Euler method,nonlinear contact model based on Coulomb friction law are applied to the air-cushion,reservoir and contraction joint domain,*** dynamic response of Jinping I arch dam with a height of 305 m is analyzed using the seismic records of the Wenchuan Earthquake in *** results show that the air-cushion isolation reduces significantly the hydrodynamic pressure as well as the opening width for the contraction joints of high arch dam.

关键词： Air-cushion · Gas-liquid-solid multi-field coupling · Contraction (transverse) joint · Hydrodynamic pressure · Wenchuan Earthquake

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Production of Transgenic Anliucheng Sweet Orange(Citrus sinensis Osbeck) with Xa21 Gene for Potential Canker Resistance

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Journal of Integrative Agriculture 2014年第11期13卷 2370-2377页

作者： LI Ding-li XIAO xuan GUO Wen-wu Key Laboratory of Horticultural Plant Biology Ministry of Education/College of Horticulture & Forestry Sciences Huazhong Agricultural University College of Life and Environmental Sciences Gannan Normal University

Citrus canker, an epidemic quarantine disease caused by Xanthomonas axonopodis pv. citri, has brought a great damage in citrus production worldwide. Herein, a rice PRR （pattern recognition receptor） gene Xa21 together with GUS reporter gene and hygromycin phosphotransferase gene （HPT） was introduced into Anliucheng sweet orange （Citrus sinensis Osbeck） via Agrobacterium-mediated transformation of embryogenic callus. The transgenic calluses were screened on MT basal medium containing hygromycin （HYG） and detected by histochemical GUS staining. The transgenic plantlets were recovered through somatic embryogenesis pathway. The regenerated plantlets were accustomed to and maintained in the greenhouse. The transgene integration of recovered plantlets was identiifed by PCR and Southern blot hybridization. It showed that all the transgenic plantlets tested had undergone single copy integration, the expression of Xa21 in eight different transgenic lines detected by qRT-PCR can be divided into three grades, high for T5 and T6, middle for T4 and low for the rest. The tolerance to citrus canker disease of the three recovered transgenic lines T2, T4 and T6 was assessed by in vitro pin-puncture inoculation. The results showed that all the three transgenic lines conferred improved resistance to citrus canker bacterium infection and the T4 transgenic line displayed the highest resistance. The mechanism and feasibility of rice Xa21 in triggering innate immunity in citrus was brielfy discussed.

关键词： citrus canker Xa21 sweet orange pattern recognition receptors (PRRs)

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Significantly enhanced varistor properties of CaCu_(3)Ti_(4)O_(12) based ceramics by designing superior grain boundary:Deepening and broadening interface states

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Journal of Materials Science & Technology 2022年第13期108卷 82-89页

作者： Zhuang Tang Kai Ning Zhiyao Fu ze Lian Kangning wu Shoudao Huang State Key Laboratory of Disaster Prevention and Reduction for Power Grid Transmission and Distribution Equipment SGCC(State Grid Corporation of China)Changsha 410000China College of Electrical and Information Engineering Hunan UniversityChangsha 410082China State Grid Shanxi Electric Power Research Institute Taiyuan 030001China State Key Laboratory of Electrical Insulation and Power Equipment Xi'an Jiaotong UniversityXi’an 710049China

Significantly enhanced varistor properties via tailoring interface states were obtained in Ca_(1-2x/3)Y_(x)Cu_(3)Ti_(4)O_(12)-SrCu_(3)Ti_(4)O_(12) composite *** breakdown field was improved to 35.8 kV cm^(-1) and the nonlinear coefficient in 0.1-1 mA cm^(-2) was enhanced to 14.6 for Ca_(0.67)Y_(0.5)Cu_(3)Ti_(4)O_(12)-SrCu_(3)Ti_(4)O_(12).Noticeably,the withstand voltage of single grain boundary reached up to 24 V while the reported ones were constant to about 3 *** improved properties were attributed to the formation of superior grain boundary rather than the reduced grain ***,with distinct discrepancy of nonlinear performance in the composites,the resistance and activation energy of grain boundary exhibited little *** on the double Schottky barrier at grain boundary and the field-assisted thermal emission model,it was found that the excellent electrical nonlinearity arose from the formation of deeper and broader interface states at grain *** this case,interface states were not easily entirely filled and the barrier could maintain its height under applied *** work provides a novel routine for enhancing the varistor properties of CaCu_(3)Ti_(4)O_(12) based ceramics by manipulating interface states at grain boundary.

关键词： Schottky barrier Grain boundary Varistor ceramics Interface states

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