检索结果-南通市图书馆

Development and application of a multi-physics and multi-scale coupling program for lead-cooled fast reactor

在线全文

学校读者我要写书评

暂无评论

Nuclear Science and Techniques 2022年第2期33卷 40-52页

作者： Xiao Luo Chi Wang ze-ren zou Lian-Kai Cao Shuai Wang Zhao Chen Hong-Li Chen School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China China Nuclear Power Technology Research Institute Co.Ltd Shenzhen 518000China

In this study,a multi-physics and multi-scale coupling program,Fluent/KMC-sub/NDK,was developed based on the user-defined functions(UDF)of Fluent,in which the KMC-sub-code is a sub-channel thermal-hydraulic code and the NDK code is a neutron diffusion *** coupling program framework adopts the"master-slave"mode,in which Fluent is the master program while NDK and KMC-sub are coupled internally and compiled into the dynamic link library(DLL)as slave *** domain decomposition method was adopted,in which the reactor core was simulated by NDK and KMC-sub,while the rest of the primary loop was simulated using Fluent.A simulation of the reactor shutdown process of M2LFR-1000 was carried out using the coupling program,and the code-to-code verification was performed with ATHLET,demonstrating a good agreement,with absolute deviation was smaller than 0.2%.The results show an obvious thermal stratification phenomenon during the shutdown process,which occurs 10 s after shutdown,and the change in thermal stratification phenomena is also captured by the coupling *** the same time,the change in the neutron flux density distribution of the reactor was also obtained.

关键词： Multi-physics and multi-scale coupling method User-defined functions Dynamic link library Thermal stratification Lead-cooled fast reactor

S-(1,3-Dioxoisoindolin-2-yl)O,O-diethyl phosphorothioate (SDDP): A practical electrophilic reagent for the phosphorothiolation of electron-rich compounds

在线全文

学校读者我要写书评

暂无评论

Chinese Chemical Letters 2024年第5期35卷 151-154页

作者： ze-Yuan Ma Mei Xiao Cheng-Kun Li Adedamola Shoberu Jian-Ping zou Key Laboratory of Organic Synthesis of Jiangsu Province College of Chemistry and Chemical EngineeringSoochow UniversitySuzhou 215123China

An efficient synthesis of the electrophilic reagent,S-(1,3-dioxoisoindolin-2-yl)O,O-diethyl phosphorothioate(SDDP)is ***,the synthetic applications of SDDP wherein the transfer of the SP(O)(OEt)_(2) moiety occurs were *** this manner,SDDP underwent facile SP(O)(OEt)_(2) transfer with electron-rich substrates such as ketones,indoles,and thiols to formα-phosphorothiolated ketones,3-phosphorothiolated indoles and S-phosphorothiolated thioethers,respectively.

关键词： Electrophilic reagent Phosphorothiolation Electrophilic substitution

Boosting Hydrogen Storage Performance of MgH_(2) by Oxygen Vacancy-Rich H-V_(2)O_(5) Nanosheet as an Excited H-Pump

在线全文

学校读者我要写书评

暂无评论

Nano-Micro Letters 2024年第8期16卷 398-416页

作者： Li ren Yinghui Li Zi Li Xi Lin Chong Lu Wenjiang Ding Jianxin zou National Engineering Research Center of Light Alloys Net Forming&State Key Laboratory of Metal Matrix Composites Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Shanghai Engineering Research Center of Mg Materials and Applications&School of Materials Science and Engineering Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Center of Hydrogen Science Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China Instrumental Analysis Center of SJTU Shanghai Jiao Tong UniversityShanghai 200240People’s Republic of China

MgH_(2) is a promising high-capacity solid-state hydrogen storage material,while its application is greatly hindered by the high desorption temperature and sluggish ***,intertwined 2D oxygen vacancy-rich V_(2)O_(5) nanosheets(H-V_(2)O_(5))are specifically designed and used as catalysts to improve the hydrogen storage properties of MgH_(2).The as-prepared MgH_(2)-H-V_(2)O_(5) composites exhibit low desorption temperatures(Tonset=185℃)with a hydrogen capacity of 6.54 wt%,fast kinetics(Ea=84.55±1.37 kJ mol^(-1) H_(2) for desorption),and long cycling ***,hydrogen absorption can be achieved at a temperature as low as 30℃ with a capacity of 2.38 wt%within 60 ***,the composites maintain a capacity retention rate of~99%after 100 cycles at 275℃.Experimental studies and theoretical calculations demonstrate that the in-situ formed VH_(2)/V catalysts,unique 2D structure of H-V_(2)O_(5) nanosheets,and abundant oxygen vacancies positively contribute to the improved hydrogen sorption ***,the existence of oxygen vacancies plays a double role,which could not only directly accelerate the hydrogen ab/de-sorption rate of MgH_(2),but also indirectly affect the activity of the catalytic phase VH_(2)/V,thereby further boosting the hydrogen storage performance of MgH_(2).This work highlights an oxygen vacancy excited“hydrogen pump”effect of VH_(2)/V on the hydrogen sorption of Mg/MgH_(2).The strategy developed here may pave a new way toward the development of oxygen vacancy-rich transition metal oxides catalyzed hydride systems.

关键词： Hydrogen storage MgH_(2) V_(2)O_(5)nanosheets Oxygen vacancies VH_(2)

Matrix stiffening promotes chondrocyte senescence and the osteoarthritis development through downregulating HDAC3

在线全文

学校读者我要写书评

暂无评论

Bone Research 2024年第2期12卷 438-452页

作者： Bowen Fu Jianlin Shen Xuenong zou Nian Sun ze Zhang zengping Liu Canjun zeng Huan Liu Wenhua Huang Guangdong Medical Innovation Platform for Translation of 3D Printing Application The Third Affiliated HospitalSouthern Medical UniversityGuangzhou 510630 GuangdongChina Guangdong Engineering Research Center for Translation of Medical 3D Printing Application Guangdong Provincial Key Laboratory of Digital Medicine and BiomechanicsNational Key Discipline of Human AnatomySchool of Basic Medical SciencesSouthern Medical UniversityGuangzhou 510145 GuangdongChina Department of Foot and Ankle Surgery Center for Orthopedic SurgeryThe Third Affiliated HospitalSouthern Medical UniversityGuangzhou 510630 GuangdongChina Department of Orthopedics Affiliated Hospital of Putian UniversityPutian 351100 FujianChina Central Laboratory Affiliated Hospital of Putian UniversityPutian 351100 FujianChina Guangdong Provincial Key Laboratory of Orthopedics and Traumatology Department of Spinal SurgeryThe First Affiliated Hospital of Sun Yat-sen UniversityGuangzhou 510080 GuangdongChina Nanfang Hospital Southern Medical UniversityGuangzhou 510515 GuangdongChina Guangzhou Blood Center Guangzhou 510095 GuangdongChina Department of Orthopedics The Affiliated Traditional Chinese Medicine HospitalSouthwest Medical UniversityLuzhou 646000 SichuanChina

Extracellular matrix(ECM)stiffening is a typical characteristic of cartilage aging,which is a quintessential feature of knee osteoarthritis(KOA).However,little is known about how ECM stiffening affects chondrocytes and other molecules *** study mimicked the physiological and pathological stiffness of human cartilage using polydimethylsiloxane(PDMS)*** demonstrated that epigenetic Parkin regulation by histone deacetylase 3(HDAC3)represents a new mechanosensitive mechanism by which the stiffness matrix affected chondrocyte *** found that ECM stiffening accelerated cultured chondrocyte senescence in vitro,while the stiffness ECM downregulated HDAC3,prompting Parkin acetylation to activate excessive mitophagy and accelerating chondrocyte senescence and osteoarthritis(OA)in ***,intra-articular injection with an HDAC3-expressing adeno-associated virus restored the young phenotype of the aged chondrocytes stimulated by ECM stiffening and alleviated OA in *** findings indicated that changes in the mechanical ECM properties initiated pathogenic mechanotransduction signals,promoted the Parkin acetylation and hyperactivated mitophagy,and damaged chondrocyte *** results may provide new insights into chondrocyte regulation by the mechanical properties of ECM,suggesting that the modification of the physical ECM properties may be a potential OA treatment strategy.

关键词： chondrocyte osteoarthritis stiffness

Achieving 500X Acceleration for Adversarial Robustness Verification of Tree-Based Smart Grid Dynamic Security Assessment

在线全文

学校读者我要写书评

暂无评论

IEEE/CAA Journal of Automatica Sinica 2024年第3期11卷 800-802页

作者： Chao ren Chunran zou zehui Xiong Han Yu Zhao-Yang Dong Niyato Dusit Nanyang Technological University Singapore 639798Singapore Nanjing University of Aeronautics and Astronautics Nanjing 211106China Singapore University of Technology and Design Singapore 487372Singapore

Dear Editor,This letter presents a novel and efficient adversarial robustness verification method for tree-based smart grid dynamic security assessment(DSA).Based on tree algorithms technique,the data-driven smart gri... 详细信息

关键词： Smart smart Dynamic

Super-resolution imaging for in situ monitoring sub-cellular micro-dynamics of small molecule drug

在线全文

学校读者我要写书评

暂无评论

Acta Pharmaceutica Sinica B 2024年第4期14卷 1864-1877页

作者： Huimin Chen Guiqian Fang Youxiao ren Weiwei zou Kang Ying Zhiwei Yang Qixin Chen School of Pharmaceutical Sciences&Institute of Materia Medica Medical Science and Technology Innovation CenterShandong First Medical University&Shandong Academy of Medical SciencesJinan 250062China MOE Key Laboratory for Nonequilibrium Synthesis and Modulation of Condensed Matter School of PhysicsXi'an Jiaotong UniversityXi'an 710049China Reproductive Medicine Center Department of Obstetrics and Gynecologythe First Affiliated Hospital of Anhui Medical UniversityHefei 230022China

Small molecule drugs play a pivotal role in the arsenal of anticancer pharmacological agents. Nonetheless, their small size poses a challenge when directly visualizing their localization, distribution, mechanism of action (MOA), and target engagement at the subcellular level in real time. We propose a strategy for developing triple-functioning drug beacons that seamlessly integrate therapeutically relevant bioactivity, precise subcellular localization, and direct visualization capabilities within a single molecular entity. As a proof of concept, we have meticulously designed and constructed a boronic acid fluorescence drug beacon using coumarin–hemicyanine (CHB). Our CHB design includes three pivotal features: a boronic acid moiety that binds both adenosine triphosphate (ATP) and adenosine diphosphate (ADP), thus depleting their levels and disrupting the energy supply within mitochondria;a positively charged component that targets the drug beacon to mitochondria;and a sizeable conjugated luminophore that emits fluorescence, facilitating the application of structured illumination microscopy (SIM). Our study indicates the exceptional responsiveness of our proof-of-concept drug beacon to ADP and ATP, its efficacy in inhibiting tumor growth, and its ability to facilitate the tracking of ADP and ATP distribution around the mitochondrial cristae. Furthermore, our investigation reveals that the micro-dynamics of CHB induce mitochondrial dysfunction by causing damage to the mitochondrial cristae and mitochondrial DNA. Altogether, our findings highlight the potential of SIM in conjunction with visual drug design as a potent tool for monitoring the in situ MOA of small molecule anticancer compounds. This approach represents a crucial advancement in addressing a current challenge within the field of small molecule drug discovery and validation.

关键词： Mitochondrial Drug beacon Sub-cellular Small molecule Energy supply Anti-tumor

Analyzing the Dissemination of News by Model Averaging and Subsampling

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Systems Science & Complexity 2024年第5期37卷 2104-2131页

作者： zou Jiahui School of Statistics Capital University of Economics and Business

The dissemination of news is a vital topic in management science, social science and data science. With the development of technology, the sample sizes and dimensions of digital news data increase remarkably. To alleviate the computational burden in big data, this paper proposes a method to deal with massive and moderate-dimensional data for linear regression models via combing model averaging and subsampling methodologies. The author first samples a subsample from the full data according to some special probabilities and split covariates into several groups to construct candidate models. Then, the author solves each candidate model and calculates the model-averaging weights to combine these estimators based on this subsample. Additionally, the asymptotic optimality in subsampling form is proved and the way to calculate optimal subsampling probabilities is *** author also illustrates the proposed method via simulations, which shows it takes less running time than that of the full data and generates more accurate estimations than uniform subsampling. Finally,the author applies the proposed method to analyze and predict the sharing number of news, and finds the topic, vocabulary and dissemination time are the determinants.

关键词： Asymptotic optimality dissemination of news linear regression models model averaging optimal subsampling

Exciting lattice oxygen of nickel–iron bi-metal alkoxide for efficient electrochemical oxygen evolution reaction

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Journal of Energy Chemistry 2024年第1期88卷 194-201,I0005页

作者： Saihang Zhang Senchuan Huang Fengzhan Sun Yinghui Li Li ren Hao Xu Zhao Li Yifei Liu Wei Li Lina Chong Jianxin zou National Engineering Research Center of Light Alloy Net Forming&State Key Laboratory of Metal Matrix Composites Center of Hydrogen ScienceSchool of Materials Science and EngineeringShanghai Jiao Tong UniversityShanghai 200240China Department of Chemistry Laboratory of Advanced MaterialsShanghai Key Laboratory of Molecular Catalysis and Innovative MaterialsiChEM and State Key Laboratory of Molecular Engineering of PolymersCollege of Chemistry and MaterialsFudan UniversityShanghai 200433China

High efficiency,cost-effective and durable electrocatalysts are of pivotal importance in energy conversion and storage *** electro-oxidation of water to oxygen plays a crucial role in such energy conversion ***,we report a robust method for the synthesis of a bimetallic alkoxide for efficient oxygen evolution reaction(OER)for alkaline electrolysis,which yields current density of 10 mA cm^(-2)at an overpotential of 215 mV in 0.1 M KOH *** catalyst demonstrates an excellent durability for more than 540 h operation with negligible degradation in *** spectra revealed that the catalyst underwent structure reconstruction during OER,evolving into oxyhydroxide,which was the active site proceeding OER in alkaline ***-situ synchrotron X-ray absorption experiment combined with density functional theory calculation suggests a lattice oxygen involved electrocatalytic reaction mechanism for the in-situ generated nickel–iron bimetal-oxyhydroxide *** mechanism together with the synergy between nickel and iron are responsible for the enhanced catalytic activity and *** findings provide promising strategies for the rational design of nonnoble metal OER catalysts.

关键词： Oxygen evolution reaction Nickel-iron bi-metal alkoxide Lattice oxygen-mediated reaction mechanism Alkaline electrolysis Electrocatalysts

Landscape ecological risk assessment and its driving factors in the Weihe River basin,China

在线全文

学校读者我要写书评

暂无评论

Journal of Arid Land 2024年第5期16卷 603-614页

作者： CHANG Sen WEI Yaqi DAI Zhenzhong XU Wen WANG Xing DUAN Jiajia zou Liang ZHAO Guorong ren Xiaoying FENG Yongzhong College of Agronomy Northwest A&F UniversityYangling 712100China

Weihe River basin is of great significance to analyze the changes of land use pattern and landscape ecological risk and to improve the ecological basis of regional *** on land use data of the Weihe River basin in 2000,2010,and 2020,with the support of Aeronautical Reconnaissance Coverage Geographic Information System(ArcGIS),GeoDa,and other technologies,this study analyzed the spatial-temporal characteristics and driving factors of land use pattern and landscape ecological *** showed that land use structure of the Weihe River basin has changed significantly,with the decrease of cropland and the increase of forest land and construction *** the past 20 a,cropland has decreased by 7347.70 km2,and cropland was mainly converted into forest land,grassland,and construction *** fragmentation and dispersion of ecological landscape pattern in the Weihe River basin were improved,and land use pattern became more ***,landscape ecological risk of the Weihe River basin has been *** landscape ecological risk area decreased by 19,177.87 km2,high landscape ecological risk area decreased by 3904.35 km2,and moderate and low landscape ecological risk areas continued to *** is worth noting that landscape ecological risks in the upper reaches of the Weihe River basin are still relatively serious,especially in the contiguous areas of high ecological risk,such as Tianshui,Pingliang,Dingxi areas and some areas of Ningxia Hui Autonomous *** ecological risk showed obvious spatial dependence,and high ecological risk area was *** the driving factors,population density,precipitation,normalized difference vegetation index(NDVI),and their interactions are the most important factors affecting the landscape ecological risk of the Weihe River *** findings significantly contribute to our understanding of the ecological dynamics in the Weihe River basin,providing crucial insights for sustainable mana

关键词： land use ecological risk spatiotemporal distribution geographic detector driving factors