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Development and application of a multi-physics and multi-scale coupling program for lead-cooled fast reactor

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Nuclear Science and Techniques 2022年第2期33卷 40-52页

作者： Xiao Luo Chi Wang ze-ren zou Lian-Kai Cao Shuai Wang Zhao Chen Hong-Li Chen School of Nuclear Science and Technology University of Science and Technology of ChinaHefei 230026China China Nuclear Power Technology Research Institute Co.Ltd Shenzhen 518000China

In this study,a multi-physics and multi-scale coupling program,Fluent/KMC-sub/NDK,was developed based on the user-defined functions(UDF)of Fluent,in which the KMC-sub-code is a sub-channel thermal-hydraulic code and the NDK code is a neutron diffusion *** coupling program framework adopts the"master-slave"mode,in which Fluent is the master program while NDK and KMC-sub are coupled internally and compiled into the dynamic link library(DLL)as slave *** domain decomposition method was adopted,in which the reactor core was simulated by NDK and KMC-sub,while the rest of the primary loop was simulated using Fluent.A simulation of the reactor shutdown process of M2LFR-1000 was carried out using the coupling program,and the code-to-code verification was performed with ATHLET,demonstrating a good agreement,with absolute deviation was smaller than 0.2%.The results show an obvious thermal stratification phenomenon during the shutdown process,which occurs 10 s after shutdown,and the change in thermal stratification phenomena is also captured by the coupling *** the same time,the change in the neutron flux density distribution of the reactor was also obtained.

关键词： Multi-physics and multi-scale coupling method User-defined functions Dynamic link library Thermal stratification Lead-cooled fast reactor

Phase stability of Fe_(23)Zr_(6)and thermodynamic reassessment of Fe-Zr system

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Journal of Iron and Steel Research International 2021年第11期28卷 1375-1389页

作者： ze-ting Du Lei zou Cui-ping Guo Xue-ping ren Chang-rong Li Department of Materials Science and Engineering University of Science and Technology BeijingBeijing 100083China Northwest Institute for Nonferrous Metal Research Xi’an 710016ShaanxiChina

The stability of the Fe_(23)Zr_(6)phase in Fe–Zr system was studied,and the partial Fe–Zr phase diagram was revised by means of X-ray diffraction,electron probe microanalysis and differential thermal analysis *** the basis of the experimental results in the present work and literature,the Fe–Zr system was reassessed using CALculation of PHAse Diagram(CALPHAD)*** phases,liquid,fcc,bcc and hcp,are modeled as the substitutional *** intermetallic compounds,hex.-Fe_(2)Zr,Fe_(2)Zr,FeZr_(2)and FeZr3 phases,are treated as Fe_(2)(Fe,Zr)1,(Fe,Zr)2(Fe,Zr)1,(Fe,Zr)1Zr_(2)and(Fe,Zr)1(Fe,Zr)3 by a two-sublattice model,*** Fe_(23)Zr_(6)phase is treated as stoichiometric compound.A set of self-consistent thermodynamic parameters of the Fe–Zr system was *** results confirm the stability of Fe_(23)Zr_(6)phase,improve the phase diagram of the Fe–Zr system and provide a theoretical reference for the development of Zr alloys.

关键词： Fe_(23)Zr_(6) Fe–Zr system Thermodynamic parameter CALPHAD method

Induced neural stem cells regulate microglial activation through Akt-mediated upregulation of CXCR4 and Crry in a mouse model of closed head injury

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Neural Regeneration Research 2025年第5期20卷 1416-1430页

作者： Mou Gao Qin Dong Dan zou Zhijun Yang Lili Guo Ruxiang Xu Department of Neurosurgery Sichuan Academy of Medical Sciences and Sichuan Provincial People’s HospitalSchool of MedicineUniversity of Electronic Science and Technology of ChinaChengduSichuan ProvinceChina Department of Neurosurgery Chinese PLA General HospitalBeijingChina Department of Neurology Fu Xing HospitalCapital Medical UniversityBeijingChina

Microglial activation that occurs rapidly after closed head injury may play important and complex roles in neuroinflammation-associated neuronal damage and *** previously reported that induced neural stem cells can modulate the behavior of activated microglia via CXCL12/CXCR4 signaling,influencing their activation such that they can promote neurological ***,the mechanism of CXCR4 upregulation in induced neural stem cells remains *** this study,we found that nuclear factor-κB activation induced by closed head injury mouse serum in microglia promoted CXCL12 and tumor necrosis factor-αexpression but suppressed insulin-like growth factor-1 ***,recombinant complement receptor 2-conjugated Crry(CR2-Crry)reduced the effects of closed head injury mouse serum-induced nuclear factor-κB activation in microglia and the levels of activated microglia,CXCL12,and tumor necrosis factor-α.Additionally,we observed that,in response to stimulation(including stimulation by CXCL12 secreted by activated microglia),CXCR4 and Crry levels can be upregulated in induced neural stem cells via the interplay among CXCL12/CXCR4,Crry,and Akt signaling to modulate microglial *** agreement with these in vitro experimental results,we found that Akt activation enhanced the immunoregulatory effects of induced neural stem cell grafts on microglial activation,leading to the promotion of neurological recovery via insulin-like growth factor-1 secretion and the neuroprotective effects of induced neural stem cell grafts through CXCR4 and Crry upregulation in the injured cortices of closed head injury ***,these beneficial effects of Akt activation in induced neural stem cells were positively correlated with the therapeutic effects of induced neural stem cells on neuronal injury,cerebral edema,and neurological disorders post–closed head *** conclusion,our findings reveal that Akt activation may enhance the immunoregulatory effects of induced neura

关键词： Akt signaling cerebral edema closed head injury Crry CXCR4 induced neural stem cell microglia neuroinflammation

Trends and Potential of Machine Learning and Deep Learning in Drug Study at Single-Cell Level

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Research 2023年第4期2023卷 145-162页

作者： ren Qi Quan zou Yangtze Delta Region Institute(Quzhou) University of Electronic Science and Technology of ChinaQuzhou 324000China School of Life Science and Technology University of Electronic Science and Technology of ChinaChengduChina Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengduChina.

Cancer treatments always face challenging problems,particularly drug resistance due to tumor cell *** existing datasets include the relationship between gene expression and drug sensitivities;however,the majority are based on tissue-level *** drugs at the single-cell level are perspective to overcome minimal residual disease caused by subclonal resistant cancer cells retained after initial curative ***,machine learning techniques can help us understand how different types of cells respond to different cancer drugs from the perspective of single-cell gene *** modeling using single-cell data and drug response information will not only improve machine learning for cell-drug outcome prediction but also facilitate the discovery of drugs for specific cancer subgroups and specific cancer *** this paper,we review machine learning and deep learning approaches in drug *** analyzing the application of these methods on cancer cell lines and single-cell data and comparing the technical gap between single-cell sequencing data analysis and single-cell drug sensitivity analysis,we hope to explore the trends and potential of drug research at the single-cell data level and provide more inspiration for drug research at the single-cell *** anticipate that this review will stimulate the innovative use of machine learning methods to address new challenges in precision medicine more broadly.

关键词： drugs expression overcome

String kernels construction and fusion:a survey with bioinformatics application

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Frontiers of Computer Science 2022年第6期16卷 145-158页

作者： ren QI Fei GUO Quan zou College of Intelligence and Computing Tianjin UniversityTianjin300350China Institute of Fundamental and Frontier Sciences University of Electronic Science and Technology of ChinaChengdu610056China Hainan Key Laboratory for Computational Science and Application Hainan Normal UniversityHaikou571158China

The kernel method,especially the kernel-fusion method,is widely used in social networks,computer vision,bioinformatics,and other *** deals effectively with nonlinear classification problems,which can map linearly inseparable biological sequence data from low to high-dimensional space for more accurate differentiation,enabling the use of kernel methods to predict the structure and function of ***,the kernel method is significant in the solution of bioinformatics *** kernels applied in bioinformatics are explained clearly,which can help readers to select proper kernels to distinguish *** biological sequence data occur in practical *** of the use of machine learning methods to obtain knowledge,and how to explore the structure and function of biological methods for theoretical prediction,have always been emphasized in *** kernel method has gradually become an important learning algorithm that is widely used in gene expression and biological sequence *** review focuses on the requirements of classification tasks of biological sequence *** studies kernel methods and optimization algorithms,including methods of constructing kernel matrices based on the characteristics of biological sequences and kernel fusion methods existing in a multiple kernel learning framework.

关键词： multiple kernel learning kernel fusion methods support vector machines biological sequences analysis

The Citron homology domain of MAP4Ks improves outcomes of traumatic brain injury

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Neural Regeneration Research 2025年第11期20卷 3233-3244页

作者： Xiaoling Zhong Wenjiao Tai Meng-Lu Liu Shuaipeng Ma Tianjin Shen Yuhua zou Chun-Li Zhang Department of Molecular Biology University of Texas Southwestern Medical CenterDallasTXUSA Hamon Center for Regenerative Science and Medicine University of Texas Southwestern Medical CenterDallasTXUSA Peter O’Donnell Jr.Brain Institute University of Texas Southwestern Medical CenterDallasTXUSA

The mitogen-activated protein kinase kinase kinase kinases(MAP4Ks)signaling pathway plays a pivotal role in axonal regrowth and neuronal degeneration following *** targeting this pathway is beneficial to brain injury remains *** this study,we showed that adeno-associated virus-delivery of the Citron homology domain of MAP4Ks effectively reduces traumatic brain injury-induced reactive gliosis,tauopathy,lesion size,and behavioral *** inhibition of MAP4Ks replicated the ameliorative effects observed with expression of the Citron homology ***,the Citron homology domain acted as a dominant-negative mutant,impeding MAP4K-mediated phosphorylation of the dishevelled proteins and thereby controlling the Wnt/β-catenin *** findings implicate a therapeutic potential of targeting MAP4Ks to alleviate the detrimental effects of traumatic brain injury.

关键词： adeno-associated virus Citron homology Citron homology domain gene therapy mitogen-activated protein kinase kinase kinase kinases traumatic brain injury

Synthesis of 1-acyl-5-aryl biurets

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Chinese Journal of Chemistry 1995年第4期13卷 358-362页

作者： zou, JP LU, ze CHEN, KQ SUZHOU UNIV DEPT CHEMSUZHOU 215006PEOPLES R CHINA

Fourteen new 1-acyl-5-aryl biurets were synthesized by the reaction of aryl ureas with acylisocynantes. The latter was obtained from acyl. chloride and lead cyanate in dichloromethane, using pyridine as catalyst. The ... 详细信息

关键词： 1-ACYL-5-ARYL BIURET ACYLISOCYANATE ARYLUREA SYNTHESIS

Changes in Regional Heavy Rainfall Events in China during 1961–2012

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Advances in Atmospheric Sciences 2015年第5期32卷 704-714页

作者： zou Xukai ren Fumin National Climate Center State Key Laboratory of Severe Weather Chinese Academy of Meteorological Sciences Jiangsu Collaborative Innovation Center for Climate Change

A new technique for identifying regional climate events, the Objective Identification Technique for Regional Extreme Events（OITREE）, was applied to investigate the characteristics of regional heavy rainfall events in China during the period1961–2012. In total, 373 regional heavy rainfall events（RHREs） were identified during the past 52 years. The East Asian summer monsoon（EASM） had an important influence on the annual variations of China＇s RHRE activities, with a significant relationship between the intensity of the RHREs and the intensity of the Mei-yu. Although the increase in the frequency of those RHREs was not significant, China experienced more severe and extreme regional rainfall events in the 1990 s. The middle and lower reaches of the Yangtze River and the northern part of South China were the regions in the country most susceptible to extreme precipitation events. Some stations showed significant increasing trends in the southern part of the middle and lower reaches of the Yangtze River and the northern part of South China, while parts of North China, regions between Guangxi and Guangdong, and northern Sichuan showed decreasing trends in the accumulated intensity of *** spatial distribution of the linear trends of events＇ accumulated intensity displayed a similar so-called ＂southern flooding and northern drought＂ pattern over eastern China in recent decades.

关键词： China regional heavy rainfall events

Projection-based High-dimensional Sign Test

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Acta Mathematica Sinica,English Series 2022年第4期38卷 683-708页

作者： Hui CHEN Chang Liang zou Run ze LI School of Statistics and Data Science Nankai UniversityTianjin 300071P.R.China Department of Statistics and Methodology Center Pennsylvania State University201 Old MainUniversity ParkPA 16802USA

This article is concerned with the high-dimensional location testing *** highdimensional settings,traditional multivariate-sign-based tests perform poorly or become infeasible since their Type I error rates are far away from nominal *** modifications have been proposed to address this challenging issue and shown to perform ***,most of modified sign-based tests abandon all the correlation information,and this results in power loss in certain *** propose a projection weighted sign test to utilize the correlation *** mild conditions,we derive the optimal direction and weights with which the proposed projection test possesses asymptotically and locally best power under *** from using the sample-splitting idea for estimating the optimal direction,the proposed test is able to retain type-I error rates pretty well with asymptotic distributions,while it can be also highly competitive in terms of *** advantage relative to existing methods is demonstrated in numerical simulations and a real data example.

关键词： High dimensional location test problem locally optimal test nonparametric test sample-splitting spatial sign test