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Mitochondrial protective and anti-apoptotic effects of Rhodiola crenulata extract on hippocampal neurons in a rat model of Alzheimer's disease

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Neural Regeneration Research 2017年第12期12卷 2025-2034页

作者： Jun-mei Wang ze-qiang qu Jin-lang Wu Peter Chung Yuan-shan zeng Department of Histology and Embryology Zhongshan School of Medicine Sun Yat-sen University Guangzhou Guangdong Province China Department of Electron Microscope Zhongshan School of Medicine Sun Yat-sen University Guangzhou Guangdong Province China Shanghai Ninth People's Hospital Shanghai liao Tong University School of Medicine Shanghai China Institute of Spinal Cord In)ury Sun Yat-sen University Guangzhou Guangdong Province China Co-innovation Center of Neuroregeneration Nantong University Nantong Jiangsu Province China Guangdong Province Key Laboratory of Brain Function and Disease Zhongshan School of Medicine Sun Yat-sen University Guangzhou Guangdong Province China

In our previous study, we found that the edible alcohol extract of the root of the medicinal plant Rhodiola crenulata（RCE） improved spatial cognition in a rat model of Alzheimer＇s disease. Another study from our laboratory showed that RCE enhanced neural cell proliferation in the dentate gyrus of the hippocampus and prevented damage to hippocampal neurons in a rat model of chronic stress-induced depression. However, the mechanisms underlying the neuroprotective effects of RCE are unclear. In the present study, we investigated the anti-apoptotic effect of RCE and its neuroprotective mechanism of action in a rat model of Alzheimer＇s disease established by intracerebroventricular injection of streptozotocin. The rats were pre-administered RCE at doses of 1.5, 3.0 or 6.0 g/kg for 21 days before model establishment. ATP and cytochrome c oxidase levels were significantly decreased in rats with Alzheimer＇s disease. Furthermore, neuronal injury was obvious in the hippocampus, with the presence of a large number of apoptotic neurons. In comparison, in rats given RCE pretreatment, ATP and cytochrome c oxidase levels were markedly increased, the number of apoptotic neurons was reduced, and mitochondrial injury was mitigated. The 3.0 g/kg dose of RCE had the optimal effect. These findings suggest that pretreatment with RCE prevents mitochondrial dysfunction and protects hippocampal neurons from apoptosis in rats with Alzheimer＇s disease.

关键词： nerve regeneration Alzheimer's disease intracerebroventricular injection streptozotocin neuronal apoptosis neuroprotection cytochrome c oxidase adenosine triphosphate caspase-3 NeuN neural regeneration

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Emerging progress: photochemical transformation of nitroso compounds

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Science China Chemistry 2025年第1期68卷 118-133页

作者： ze-Le Chen qiang-qiang Li Armido Studer Jun Xuan Anhui Province Key Laboratory of Chemistry for Inorganic/Organic Hybrid Functionalized Materials School of Chemistry & Chemical Engineering Anhui University Organisch-Chemisches Institut Universitat Münster

Nitroso compounds have emerged as highly valuable reaction partners or reagents in organic synthesis due to their rich *** versatile profile of these compounds allows them to function as electrophiles, nucleophiles, diradicals, and radical acceptors in diverse transformations. In recent years, notable progress has been made in harnessing photochemical reactions with nitroso compounds to prepare N,O-containing structures using mild and eco-friendly conditions. Various nitroso compounds like nitrosoarenes, acyloxy nitroso compounds, N-nitrosoamines and nitrites have received significant attention for their ability to introduce NO moieties into complex molecules that are otherwise difficult to access. In this review, we provide an overview of the recent advancements in the visible light-induced conversion of nitroso compounds, with particular emphasis on their role as bifunctional reagents and acceptors of radicals, carbenes and nitrenes.

关键词： nitroso compounds photochemistry radical reaction carbene transformation nitrosoarenes

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Modular assembly of complex C-alkyl glycoside enabled via cooperative NHC and photoredox catalysis

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Science China Chemistry 2025年

作者： Rui-qiang Jiao Ming Li Xi Chen Mei-ze Xu Tian Ding Xiao-Ping Gong Zhuo-Mei Li Xue-Yuan Liu Yong-Min Liang State Key Laboratory of Applied Organic Chemistry Lanzhou University College of Chemistry and Chemical Engineering Northwest Normal University

C-Alkyl glycosides are found in natural products and are indispensable in drug development programs,owing to their diverse range of medicinal ***-component reactions involving glycosyl radical addition are well documented and proved efficient for the C-alkyl glycosides ***,multicomponent reactions for the rapid and controllable construction of structurally diversified C-alkyl glycosides in a single step remains a significant challenge due to the issues associated with balancing reactivity,compatibility,and ***,we report an NHC and photoredox co-catalyzed three-component method to access complex and valuable C-alkyl *** protocol exhibits broad substrate scope and excellent chemoand ***,nine types of sugars are compatible with this *** addition,the generality of this catalytic strategy was further highlighted by the potential for scalable production,the feasibility of further modifications of the products and its successful application in the late-stage functionalization of pharmaceutical skeletons.

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A level set based immersed boundary method for simulation of non-isothermal viscoelastic melt filling process

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Chinese Journal of Chemical Engineering 2021年第4期34卷 119-133页

作者： qiang Li Fangcao qu School of Mathematics and Information Science Henan Polytechnic UniversityJiaozuo 454003China

In this work,the polymer melt filling process is simulated by using a coupled finite volume and levelset based immersed boundary(LSIB)***,based on a shape level set(LS)function to represent the mold boundary,a LSIB method is developed to model the complex mold *** the nonisothermal melt filling process is simulated based on nonNewtonian viscoelastic equations with different Reynolds numbers in a circular cavity with a solid core,and the effects of Reynolds number on the flow patterns of polymer melt are presented and compared with each *** then for a true polymer melt with a small Reynolds number that varies with melt viscosity,the moving interface,the temperature distributions and the molecular deformation are shown and analyzed in *** last,as a commonly used application case,a socket cavity with seven inserts is *** corresponding physical quantities,such as the melt velocity,molecular deformation,normal stresses,first normal stress difference,temperature distributions and frozen layer are analyzed and *** results could provide some predictions and guidance for the polymer processing industry.

关键词： LS-IB method Non-isothermal filling Non-Newtonian fluids Multiscale Numerical simulation

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Admission Control of VL in AFDX Under HRT Constraints

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Chinese Journal of Aeronautics 2011年第2期24卷 195-201页

作者： ZHOU qiang qu Zhenliang LIN Hengqing School of Electronics and Information Engineering Beihang University Beijing 100191 China System Engineering Research Institute China State Shipbuilding Corporation Beijing 100036 China

Avionics full duplex switched ethernet（AFDX） is a switched interconnection technology developed to provide reliable data exchange with strong data transmission time guarantees in internal communication of the spacecraft or *** link（VL） is an important concept of AFDX to meet quality of service（QoS） requirements in terms of end-to-end message deadlines.A VL admission control algorithm in AFDX network under hard real-time（HRT） constraints is *** on the scheduling prin-ciple of AFDX protocol,a packet scheduling scheme under HRT constraints is proposed,and after that an efficient VL admission control algorithm is *** proof that the algorithm can effectively determine whether VL should be admitted is *** simulative examples are presented to promote the conclusion.

关键词： avionics avionics full duplex switched ethernet virtual link switch hard real-time admission control

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Pulse-to-pulse periodic signal sorting features and feature extraction in radar emitter pulse sequences

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Journal of Systems Engineering and Electronics 2010年第3期21卷 382-389页

作者： qiang Guo Zhenshen qu Changhong Wang College of Information and Communication Engineering Harbin Engineering University Harbin 150001 R R. China Space Control and Inertial Technology Research Center Harbin Institute of Technology Harbin 150001 R R. China

A novel class of periodically changing features hidden in radar pulse sequence environment,named G features,is *** fractal theory and Hilbert-Huang transform,the features are extracted using changing characteristics of pulse parameters in radar emitter *** features can be applied in modern complex electronic warfare environment to address the issue of signal sorting when radar emitter pulse signal parameters severely or even completely *** results show that the proposed feature class and feature extraction method can discriminate periodically changing pulse sequence signal sorting features from radar pulse signal flow with complex variant features,therefore provide a new methodology for signal sorting.

关键词： signal sorting fractal geometry Hilbert-Huang transform(HHT) G feature extraction.

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CSO CO(2–1) and Spitzer IRAC observations of a bipolar outflow in high-mass star-forming region IRAS 22506+5944

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Research in Astronomy and Astrophysics 2018年第2期18卷 73-82页

作者： ze-qiang Xie Ke-Ping Qiu School of Astronomy and Space Science Nanjing University Nanjing 210023 China Key Laboratory of modern Astronomy and Astrophysics (Nanjing University) Ministry of Education Nanjing 210023 China

We present Caltech Submillimeter Observatory CO （2-1） and Spitzer IRAC observations toward IRAS 22506＋5944, which is a 104 Lo massive star-forming region. The CO （2-1） maps show an east-west bipolar molecular outflow originating from the 3 mm dust continuum peak. The Spitzer IRAC color-composite image reveals a pair of bow-shaped tips which are prominent in excess 4.5 p.m emission and are located at the leading fronts of the bipolar outflow, providing compelling evidence for the existence of bow-shocks as the driving agents of the molecular outflow. By comparing our CO （2- 1） observations with previously published CO （1-0） data, we find that the CO （2-1）/（1-0） line ratio increases from low （-5 km s- 1） to moderate （- 8-12 km s- 1） velocities, and then decreases at higher velocities. This is qualitatively consistent with the scenario that the molecular outflow is driven by multiple bow-shocks. We also revisit the position-velocity diagram of the CO （1-0） data, and find two spur structures along the outflow axis, which are further evidence for the presence of multiple jet bow- shocks. Finally, power-law fittings to the mass spectrum of the outflow gives power law indexes more consistent with the jet bow-shock model than the wide-angle wind model.

关键词： ISM: jets and outflows - stars: formation - stars: massive -- stars: protostars

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DISPERSION STABILITY AND RHEOLOGICAL BEHAVIOR OF SUSPENSIONS OF POLYSTYRENE COATED FUMED SILICA PARTICLES IN POLYSTYRENE SOLUTIONS

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Chinese Journal of Polymer Science 2012年第1期30卷 26-35页

作者： Xian-ze Yin Ye-qiang Tan Yi-hu Song qiang Zheng Key Laboratory of Macromolecular Synthesis and Functionalization of Ministry of Education Zhejiang University Hangzhou 310027 China Department of Polymer Science and Engineering Zhejiang University Hangzhou 310027 China

Polystyrene coated silica（SiO_2@PS） core-shell composite particles with averaged diameter of about 290 nm were prepared by in situ emulsion polymerization of styrene on the surface ofγ-methacryloxypropyltrimethoxysilane grafted SiO_2 nanoparticles of 20-50 nm in *** behavior and dispersion stability of SiO_2@PS suspension in 10 wt%PS solution were compared with suspensions of untreated SiO_2 and silane modified SiO_2 *** of the untreated and the silane modified SiO_2 exhibited obvious shear *** SiO-2@PS suspension exhibits shear viscosity considerably smaller than suspensions of untreated and silane modified SiO_2 at low shear *** electron microscopy showed that the composite particles can uniformly and stably disperse in PS solution compared to other suspensions,implying that the PS shell can effectively enhance the particle compatibility with PS macromolecules in solution.

关键词： Fumed SiO_2 Polystyrene Composite particles Suspension Steady rheology

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Ruthenium Nanoparticles Loaded on Carbon as Effective Catalyst for Highly Selective Hydrogenation of 4,4′-Methylenedianiline

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Chemical Research in Chinese Universities 2012年第5期28卷 882-885页

作者： DU Wen-qiang RONG ze-ming LU Xin-yi WANG Yi-fan LU Lian-hai qu Jing-ping State Key Laboratory of Fine Chemicals School of Chemical EngineeringDalian University of TechnologyDalian 116024P.R.China

Supported Ru-based catalysts, prepared by a surfactant-stabilized colloidal method, exhibited a good selectivity to bis（4-aminocyclohexyl）methane via the hydrogenation of 4,4′-methylenedianiline. Transmission electron microscopy（TEM） and X-ray diffraction（XRD） characterization showed Ru nanoparticles were well-dispersed on activated carbon, leading to the high activity and selectivity to the product.

关键词： Ruthenium-based catalyst 4 4′-Methylenedianiline Hydrogenation Selectivity

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Effect of trace boron on corrosion resistance of rust layer of high-strength low-alloy steel in 3.5 wt.% NaCl solution

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Journal of Iron and Steel Research International 2023年第10期30卷 2080-2090页

作者： Yan-hui Hou ze-kun Xu Guang-qiang Li The State Key Laboratory of Refractories and Metallurgy Wuhan University of Science and TechnologyWuhan 430081HubeiChina Key Laboratory for Ferrous Metallurgy and Resources Utilization of Ministry of Education Wuhan University of Science and TechnologyWuhan 430081HubeiChina

The influence mechanism of trace boron on the corrosion resistance of high-strength low-alloy(HSLA)steel in a simulated marine environment was studied by combining first-principles calculation with *** effect of boron on the corrosion properties and corrosion morphology of the rust layer formed on the surface of HSLA steel was studied by means of corrosion weightlessness method,polarization curve,scanning electron microscopy(SEM)and X-ray diffraction(XRD)*** mass loss measurements and polarization curves revealed that the corrosion resistance of HSLA steel is improved by adding trace *** and SEM results show that the rust layer is produced byα-FeOOH(the main protective phase),Fe_(3)O_(4) andγ-FeOOH,and boron contributes to stability ofα-*** on the first-principles calculation,the solid solution of B atom in the corrosion product is beneficial to the fixation of Cl atom and to the reduction of the corrosion of Cl atom to the steel matrix.

关键词： Boron High-strength low-alloy steel Corrosion resistance NaCl solution Rust layer First-principles calculation

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