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Effects of Mg/PTFE pyrotechnic compositions on reignition characteristics of base bleed propellants and heating mechanism

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Defence Technology（防务技术） 2022年第1期18卷 94-108页

作者： Xiao-chun Xue long-ze ma Yong-gang Yu Schooi of Enerey and Power Engineering Nanjing Universiry of Science and Techmology Narine lianesu 210094 China BYD Compary Liruied ShenzheL Guanedong 518118 Chna

The effects of magnesium/polytetrafluoroethylene(Mg/PTFE)pyrotechnic compositions on the coupled flow field and reignition mechanism are important aspects governing the perfommance and range of base bleed projectiles(BBPs).Owing to a decrease in pressure and temperature when the BBP leaves the muzzle,rapid depressurization occurs,which extinguishes the base bleed *** Mg/PTFE py-rotechnic composition pressed in the igniter of the base bleed unit(BBU)provides additional energy to the BBU via a chemical ***,the extinguished base bleed propellant is reignited under the effect of high-temperature combustion gas jets from the *** this study,a numerical analysis is conducted to evaluate the effects of PTFE and Mg granularity as well as Mg/PTFE pyrotechnic *** to the rapid depressurization,the temperature and pressure was found to decrease fordifferent Mg/PIFE pyrotechnic ***,the depressurization time increased as the PTFE granularity increased,the Mg granularity decreased,and the Mg content *** the pressure in the combustion chamber of the BBU decreased to the atmospheric pressure,the combustion gas jets from the igniter expand upstream(rather than downstream).However,these combustion gas jets exhibit different axial and radial expansion characteristics depending on the pyrotechnic compositions used,The results show that the reignition delay time,ta,of the base bleed propellant was 377.608,94.27,387.243,523.966,and 221.094 ms for cases A-E,***,it was concluded that the Mg/PTFE pyrotechnic composition of case B was the most beneficial for the reignition of the base bleed propellant,with the earliest addition of energy and mass to the BBP.

关键词： Thermal effect High-temperature combustion gas Mg/PTFE pyrotechnic Compositions Reignition

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First report on establishment and characterization of the extrahepatic cholangiocarcinoma sarcoma cell line CBC2T-2

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World Journal of Gastroenterology 2023年第41期29卷 5683-5698页

作者： Ning-Zu Jiang Ming-Zhen Bai Chong-Fei Huang ze-long ma Ru-Yang Zhong Wen-Kang Fu long Gao Liang Tian Ning-Ning Mi Hai-Dong ma Ya-Wen Lu Zi-Ang Zhang Jin-Yu Zhao Hai-Ying Yu Bao-Ping Zhang Xian-Zhuo Zhang Yan-Xian Ren Chao Zhang Yong Zhang Ping Yue Yan-Yan Lin Wen-Bo Meng The First Clinical Medical College Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of General Surgery The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Laboratory of Biological Therapy and Regenerative Medicine Transformation Gansu Province The First Hospital of Lanzhou UniversityLanzhou 730000Gansu ProvinceChina Department of General Surgery The First Hospital of Lanzhou University and Laboratory of Biological Therapy and Regenerative Medicine Transformation Gansu ProvinceLanzhou 730000Gansu ProvinceChina

BACKGROUND Extrahepatic cholangiocarcinoma sarcoma is extremely rare in clinical *** cells consist of both epithelial and mesenchymal ***-derived cell lines that maintain tumor characteristics are valuable tools for studying the molecular mechanisms associated with ***,cholangiocarcinoma sarcoma cell lines are not available in cell *** To establish and characterize a new extrahepatic cholangiocarcinoma sarcoma cell line,namely *** We conducted a short tandem repeat(STR)test to confirm the identity of the CBC2T-2 cell ***,we assessed the migratory and invasive properties of the cells and performed clonogenicity assay to evaluate the ability of individual cells to form *** tumorigenic potential of CBC2T-2 cells was tested in vivo using nonobese diabetic/severe combined immunodeficient(NOD/SCID)*** cells were injected subcutaneously and tumor formation was *** addition,immunohistochemical analysis was carried out to examine the expression of epithelial marker CK19 and mesenchymal marker vimentin in both CBC2T-2 cells and *** CBC2T-2 cell line was used to screen the potential therapeutic effects of various clinical agents in patients with cholangiocarcinoma ***,whole-exome sequencing was performed to identify genetic alterations and screen for somatic mutations in the CBC2T-2 cell *** The STR test showed that there was no cross-contamination and the results were identical to those of the original *** cells showed round or oval-shaped epithelioid cells and mesenchymal cells with spindle-shaped or elongated *** cells exhibited a high proliferation ratio with a doubling time of 47.11 *** cell line has migratory,invasive,and clonogenic *** chromosomes in the CBC2T-2 cells were polyploidy,with numbers ranging from 69 to *** subcutaneous tumorigenic assay confirmed the in vivo tumorigenic ability of CBC2T-2 cells in NOD/

关键词： Carcinosarcoma Drug resistance Xenograft Cell line Establishment

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Research and development trends of hydrometallurgy:An overview based on Hydrometallurgy literature from 1975 to 2019

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Transactions of Nonferrous Metals Society of China 2020年第11期30卷 3147-3160页

作者： Li-pan JIA Jiang-jiang HUANG ze-long ma Xu-heng LIU Xing-yu CHEN Jiang-tao LI Li-hua HE Zhong-wei ZHAO School of Metallurgy and Environment Central South UniversityChangsha 410083China Hunan Key Laboratory for Metallurgy and material Processing of Rare Metals Changsha 410083China

Modern hydrometallurgy has been developing for more than 100 years and the related articles keep piling *** on a bibliometric analysis of the articles in Hydrometallurgy,the most authoritative journal in the field of hydrometallurgy,we try to catch the research and development trends from a global ***,keywords burstness shows that rare earth,recycling,lithium,ionic liquid,and thorium are the hotspots in recent years,and the economic and technological reasons behind them were discussed in ***,the proportion of biohydrometallurgy grows fast from 5%to 13%and the related articles are almost all about *** are some new directions such as direct preparation of materials in hydrometallurgical processes and ion-imprinted ***,the advanced instrument analysis methods such as XAFS(X-ray absorption fine structure),gene sequencing,and micro-CT promote the deep understanding of hydrometallurgy ***,the cooperation network and contribution of the main institutes were mapped.

关键词： development trends leaching solvent extraction biohydrometallurgy electro-hydrometallurgy CiteSpace

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Research on the balance optimization algorithm of image recognition accuracy and speed based on autocollimator measurement

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Optoelectronics Letters 2025年第2期21卷 121-128页

作者： LI Renpu ma long CUI Jiwen GUO Junqi Andrei KULIKOV WEN Dandan Chongqing Engineering Research Center of Intelligent Sensing Technology and Microsystem Chongqing University of Post and Telecommunications School of Instrumentation Science and Engineering Harbin Institute of Technology Higher School of Engineering and Technology ITMO University

The autocollimator is an important device for achieving precise,small-angle,non-contact *** primarily obtains angular parameters of a plane target mirror indirectly by detecting the position of the imaging *** is limited report on the core algorithmic techniques in current commercial products and recent scientific *** paper addresses the performance requirements of coordinate reading accuracy and operational speed in autocollimator image *** proposes a cross-image center recognition scheme based on the Hough transform and another based on zernike moments and the least squares *** experimental evaluation of the accuracy and speed of both schemes,the optimal image recognition scheme balancing measurement accuracy and speed for the autocollimator is *** these,the center recognition method based on zernike moments and the least squares method offers higher measurement accuracy and stability,while the Hough transform-based method provides faster measurement speed.

关键词： Least squares approximations

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Small extracellular vesicles derived from human induced pluripotent stem cell-differentiated neural progenitor cells mitigate retinal ganglion cell degeneration in a mouse model of optic nerve injury

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Neural Regeneration Research 2025年第2期20卷 587-597页

作者： Tong Li Hui-Min Xing Hai-Dong Qian Qiao Gao Sheng-Lan Xu Hua ma Zai-long Chi State Key Laboratory of Ophthalmology Optometry and Visual ScienceEye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina National Clinical Research Center for Ocular Diseases Eye HospitalWenzhou Medical UniversityWenzhouZhejiang ProvinceChina

Several studies have found that transplantation of neural progenitor cells(NPCs)promotes the survival of injured ***,a poor integration rate and high risk of tumorigenicity after cell transplantation limits their clinical *** extracellular vesicles(sEVs)contain bioactive molecules for neuronal protection and *** studies have shown that stem/progenitor cell-derived sEVs can promote neuronal survival and recovery of neurological function in neurodegenerative eye diseases and other eye *** this study,we intravitreally transplanted sEVs derived from human induced pluripotent stem cells(hiPSCs)and hiPSCs-differentiated NPCs(hiPSC-NPC)in a mouse model of optic nerve *** results show that these intravitreally injected sEVs were ingested by retinal cells,especially those localized in the ganglion cell *** with hiPSC-NPC-derived sEVs mitigated optic nerve crush-induced retinal ganglion cell degeneration,and regulated the retinal microenvironment by inhibiting excessive activation of *** analysis further revealed that hiPSC-NPC derived sEVs transported neuroprotective and anti-inflammatory miRNA cargos to target cells,which had protective effects on RGCs after optic nerve *** findings suggest that sEVs derived from hiPSC-NPC are a promising cell-free therapeutic strategy for optic neuropathy.

关键词： exosome miRNA neural progenitor cell neurodegeneration neuroinflammation neuroprotection optic nerve crush optic neuropathy retinal ganglion cell small extracellular vesicles

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Substrate bias effects in p-channel GaN-on-Si transistors

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Science China(Information Sciences) 2025年第1期68卷 404-405页

作者： Mengyao ZHAO Jie ma Lanlan YANG Chuanqi PAN Denggui WANG Jianjun ZHOU Sheng LI Jiaxing WEI long ZHANG Siyang LIU Weifeng SUN National ASIC System Engineering Research Center School of Integrated Circuits Southeast University National Center of Technology Innovation for Electronic Design Automation Southeast University National Key Laboratory of Solid-State Microwave Devices and Circuits

The drain current （ID） of the n-channel GaN field-effecttransistor （n-FET） is influenced by the substrate-to-source bias voltage (VBS)（substrate bias effect）[1].Actually,nonzero VBSis also likely to occur in p-FET in real application,because the source electrode of p-FET is usually connected to high *** study reports the dependency between IDand VBSin p-FET for the first time,and analyzes the underlying mechanisms from the perspective of vertical electric field （EF） distribution.

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Hydration, Microstructure, and Properties of Sulphoaluminate Cement in Pure Water and Simulated Seawater

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Journal of Wuhan University of Technology(materials Science) 2025年第1期40卷 187-193页

作者： ma Jie China Railway Design Corporation Tianjin 300250China

Paste and mortar specimens were prepared with sulfoaluminate cement(SAC),P⋅O 42.5 ordinary Portland cement(OPC),and standard sand,and mixed and cured with pure water and artificial seawater,*** mechanical properties of mortar specimens were *** and microstructure of paste specimens were also investigated using X-ray diffraction(XRD),scanning electron microscope(SEM),and 27Al nuclear magnetic resonance(NMR),*** results indicate that SAC mortar samples mixed and cured by seawater have faster strength growth before 28 d and higher compressive strength than OPC mortar *** to curing in deionized water,the hydration products of SAC are somewhat coarser when cured in simulated *** evolution of aluminum phase hydration products during the hydration process of SAC mixed and cured in simulated seawater is quite different from that of *** 3 to 28 d,the content of each aluminum phase hydration product in SAC paste cured in simulated seawater changed little,while that in OPC paste changed significantly;for example,from 7 to 28 d,the content of ettringite(AFt)in OPC paste increased *** type of AFt formed loosely,harming the mortar's microstructure.

关键词： sulfoaluminate cement seawater mixing and curing 27Al NMR AFt

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Recent advances in exploring new blood-based biomarkers for the early diagnosis of gastric cancer

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Science China Chemistry 2025年第1期68卷 35-45页

作者： Xinyu Peng Qian ma Da Han School of Life Science Shanghai University Institute of Molecular Medicine Shanghai Key Laboratory for Nucleic Acid Chemistry and Nanomedicine State Key Laboratory of Oncogenes and Related Genes Renji Hospital School of Medicine Shanghai Jiao Tong University Department of Research and Development Intellinosis Biotechnologies Co.Ltd.

Gastric cancer(GC) is a prevalent and lethal malignancy worldwide, and the 5-year survival rate is less than 30%. The absence of distinctive symptoms often leads to late-stage diagnosis, contributing to a grim prognosis. Early detection is pivotal for improving the survival rates and outcomes of GC patients. Traditional diagnostic methods, including gastroscopy and histopathological examination, are restricted in the early diagnosis of GC. Conventional protein biomarkers, such as carcinoembryonic antigen(CEA), carbohydrate antigen 19-9(CA19-9), and carbohydrate antigen 72-4(CA72-4), exhibit insufficient sensitivity and specificity for GC screening, which diminishes their clinical value. Recently, novel circulating biomarkers, such as circulating tumor cells(CTCs), circulating tumor cell DNA(ct DNA), and circulating free RNA(cf RNA), have emerged as promising candidates in the burgeoning field of liquid biopsy due to their superior sensitivity and specificity. This review focuses on the latest research on blood-based biomarkers for GC diagnosis and examines the clinical potentials and challenges associated with these emerging biomarkers.

关键词： gastric cancer early diagnosis blood

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Transient receptor potential channels and calcium dysregulation: a pathogenic duo in Parkinson's disease

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Neural Regeneration Research 2025年第3期20卷 808-810页

作者： Iqira Saeed Linlin ma Griffith Institute for Drug Discovery Griffith UniversityNathanBrisbaneQLDAustralia School of Environment and Science Griffith University NathanBrisbaneQLDAustralia

Parkinson's disease(PD) has a complex and multifactorial pathophysiology. Various studies, conducted both in pre-clinical models and PD patients, have reported a link between the disruption of calcium(Ca^(2+)) homeostasis and the subsequent development of PD. Ca^(2+) regulation is crucial for neuronal survival, differentiation,exocytosis at synapses,gene transcription,and proliferation.

关键词： homeostasis clinical subsequent

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Harnessing therapeutic potential of induced pluripotent stem cell–derived endothelial cells for remyelination in the central nervous system

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Neural Regeneration Research 2025年第6期20卷 1715-1716页

作者： Dan ma Nona Pop Aston Medical School College of Health and Life SciencesAston UniversityBirminghamUK

Myelin is the protective sheath surrounding nerve fibers, and its damage(demyelination) occurs in many central nervous system(CNS) diseases, including multiple sclerosis(MS), traumatic injury, neurodegenerative diseases such as Alzheimer's disease, and mental disorders such as schizophrenia(Barateiro et al., 2016). Repair of damaged myelin sheaths(remyelination) often fails in MS, leading to neuronal loss and irreversible functional deficits.

关键词： myelin protective diseases

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